JP2004516928A5 - - Google Patents
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- JP2004516928A5 JP2004516928A5 JP2002554197A JP2002554197A JP2004516928A5 JP 2004516928 A5 JP2004516928 A5 JP 2004516928A5 JP 2002554197 A JP2002554197 A JP 2002554197A JP 2002554197 A JP2002554197 A JP 2002554197A JP 2004516928 A5 JP2004516928 A5 JP 2004516928A5
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- 239000003446 ligand Substances 0.000 description 288
- 239000000126 substance Substances 0.000 description 117
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- 150000002500 ions Chemical class 0.000 description 52
- 230000003993 interaction Effects 0.000 description 49
- 238000001179 sorption measurement Methods 0.000 description 48
- 229920002684 Sepharose Polymers 0.000 description 43
- 238000005342 ion exchange Methods 0.000 description 41
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- 150000003839 salts Chemical class 0.000 description 36
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 35
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- 239000000872 buffer Substances 0.000 description 33
- 238000006467 substitution reaction Methods 0.000 description 33
- -1 sulfopropyl groups Chemical group 0.000 description 31
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 30
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- 239000002585 base Substances 0.000 description 26
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| US6908770B1 (en) * | 1998-07-16 | 2005-06-21 | Board Of Regents, The University Of Texas System | Fluid based analysis of multiple analytes by a sensor array |
| US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
| US7214660B2 (en) * | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| CA2515305A1 (en) * | 2003-02-07 | 2004-08-26 | John T. Mcdevitt | Multi-shell microspheres with integrated chomatographic and detection layers for use in array sensors |
| US20070026485A1 (en) | 2003-04-09 | 2007-02-01 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
| US7943393B2 (en) * | 2003-07-14 | 2011-05-17 | Phynexus, Inc. | Method and device for extracting an analyte |
| US9005625B2 (en) | 2003-07-25 | 2015-04-14 | Novo Nordisk A/S | Antibody toxin conjugates |
| GB2407783A (en) * | 2003-11-07 | 2005-05-11 | Novexin Ltd | Chromatographic separation |
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| US8101431B2 (en) * | 2004-02-27 | 2012-01-24 | Board Of Regents, The University Of Texas System | Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems |
| US8105849B2 (en) * | 2004-02-27 | 2012-01-31 | Board Of Regents, The University Of Texas System | Integration of fluids and reagents into self-contained cartridges containing sensor elements |
| EP1771066A2 (en) | 2004-07-13 | 2007-04-11 | Neose Technologies, Inc. | Branched peg remodeling and glycosylation of glucagon-like peptide-1 glp-1 |
| EP1807205B1 (en) | 2004-10-21 | 2012-09-26 | GE Healthcare Bio-Sciences AB | A method of antibody purification |
| JP5948627B2 (ja) | 2004-10-29 | 2016-07-20 | レイショファーム ゲーエムベーハー | 線維芽細胞成長因子（ｆｇｆ）のリモデリングと糖質ペグ化 |
| EP1693108A1 (en) * | 2004-12-04 | 2006-08-23 | MERCK PATENT GmbH | Mixed-modal anion-exchange type separation material |
| NZ556436A (en) * | 2005-01-10 | 2010-11-26 | Biogenerix Ag | Glycopegylated granulocyte colony stimulating factor |
| WO2006121569A2 (en) * | 2005-04-08 | 2006-11-16 | Neose Technologies, Inc. | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
| WO2006127973A2 (en) * | 2005-05-24 | 2006-11-30 | Waters Inverstments Limited | Methods for separating and analyzing anionic compounds |
| AU2006309284B2 (en) | 2005-05-31 | 2012-08-02 | Board Of Regents, The University Of Texas System | Methods and compositions related to determination and use of white blood cell counts |
| US20070105755A1 (en) * | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
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| US9375499B2 (en) * | 2006-07-14 | 2016-06-28 | Wisconsin Alumni Research Foundation | Adsorptive membranes for trapping viruses |
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| EP2054521A4 (en) * | 2006-10-03 | 2012-12-19 | Novo Nordisk As | PROCESS FOR CLEANING POLYPEPTIDE CONJUGATES |
| HUE036502T2 (hu) * | 2006-10-04 | 2018-07-30 | Novo Nordisk As | Glicerinhez kapcsolódó pegilált cukrok és glükopeptidek |
| US20080207487A1 (en) * | 2006-11-02 | 2008-08-28 | Neose Technologies, Inc. | Manufacturing process for the production of polypeptides expressed in insect cell-lines |
| US7999085B2 (en) * | 2007-01-09 | 2011-08-16 | Bio-Rad Laboratories, Inc. | Enhanced capacity and purification of protein by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers |
| US7691980B2 (en) | 2007-01-09 | 2010-04-06 | Bio-Rad Laboratories, Inc. | Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers |
| US9050304B2 (en) * | 2007-04-03 | 2015-06-09 | Ratiopharm Gmbh | Methods of treatment using glycopegylated G-CSF |
| WO2008154639A2 (en) | 2007-06-12 | 2008-12-18 | Neose Technologies, Inc. | Improved process for the production of nucleotide sugars |
| EP2167229A4 (en) * | 2007-07-25 | 2012-02-01 | Ge Healthcare Bio Sciences Ab | SEPARATION MATRIX |
| EP2242505A4 (en) * | 2008-01-08 | 2012-03-07 | Biogenerix Ag | GLYCOCONJUGATION OF POLYPEPTIDES USING OLIGOSACCHARYLTRANSFERASES |
| ES2476690T3 (es) | 2008-02-27 | 2014-07-15 | Novo Nordisk A/S | Moléculas conjugadas del Factor VIII |
| EP2265129B1 (en) * | 2008-04-08 | 2015-10-28 | Bio-Rad Laboratories, Inc. | Chromatography purification of antibodies |
| SG178173A1 (en) * | 2009-07-28 | 2012-03-29 | Instraction Gmbh | Specific sorbent for binding proteins and peptides, and separation method using the same |
| JP5826180B2 (ja) * | 2009-10-12 | 2015-12-02 | ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ | 分離マトリックス |
| CN102762268B (zh) | 2009-12-07 | 2015-07-08 | 弗雷塞尼斯医疗保健控股公司 | 使用锆离子交换吸附剂的水净化筒 |
| US9061267B2 (en) * | 2009-12-17 | 2015-06-23 | Instraction Gmbh | Specific sorbent for binding proteins and peptides, and separation method using the same |
| EP2674753B1 (en) * | 2011-02-10 | 2020-05-13 | Sekisui Medical Co., Ltd. | Method for separating and detecting a nucleic acid strand |
| JP2012211110A (ja) * | 2011-03-31 | 2012-11-01 | Asahi Kasei Medical Co Ltd | 多孔質吸着膜 |
| EP2570181A1 (en) * | 2011-09-15 | 2013-03-20 | InstrAction GmbH | Sorbent comprising its surface an aliphatic unit having an anionic or deprotonizable group for the purfication of organic molecules |
| GB2521524B (en) | 2012-05-15 | 2018-12-05 | Waters Technologies Corp | Chromatographic materials |
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| JP6469574B2 (ja) * | 2012-09-17 | 2019-02-13 | ダブリュー・アール・グレース・アンド・カンパニー−コーンＷ Ｒ Ｇｒａｃｅ ＆ Ｃｏ−Ｃｏｎｎ | 官能化粒状保持体ならびにその製造法及び使用法 |
| IN2015DN02055A (cg-RX-API-DMAC7.html) | 2012-09-17 | 2015-08-14 | Grace W R & Co | |
| JP2016513245A (ja) * | 2013-02-06 | 2016-05-12 | エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ | タンパク質製剤の凝集体含有量を減少させる混合多官能金属親和性表面 |
| US10023608B1 (en) | 2013-03-13 | 2018-07-17 | Amgen Inc. | Protein purification methods to remove impurities |
| EP3094390B1 (en) | 2014-01-16 | 2021-07-07 | W.R. Grace & CO. - CONN. | Affinity chromatography media and chromatography devices |
| PL3137209T3 (pl) | 2014-05-02 | 2023-01-02 | W.R. Grace & Co. - Conn. | Funkcjonalizowany materiał nośnikowy i sposoby wytwarzania oraz stosowania funkcjonalizowanego materiału nośnikowego |
| PL3302784T3 (pl) | 2015-06-05 | 2022-01-17 | W.R. Grace & Co.-Conn. | Adsorbentowe środki klarujące do bioprzetwarzania oraz sposoby ich wytwarzania i stosowania |
| CN110844886A (zh) * | 2019-12-02 | 2020-02-28 | 锦西化工研究院有限公司 | 一种二硫化钠水溶液的合成方法 |
| CN111617747B (zh) * | 2020-05-11 | 2022-05-31 | 贵州大学 | 一种壳聚糖/纳米金属复合水凝胶及其制备方法和应用 |
| US11731108B2 (en) * | 2021-03-17 | 2023-08-22 | Bio-Rad Laboratories, Inc. | Mixed mode cation exchange chromatography ligands based on 1,3-dioxoisoindolin-2-yl structures |
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| US4767670A (en) * | 1987-01-21 | 1988-08-30 | E. I. Du Pont De Nemours And Company | Chromatographic supports for separation of oligonucleotides |
| JPH0564748A (ja) * | 1991-09-06 | 1993-03-19 | Tosoh Corp | イオン交換体 |
| US5652348A (en) * | 1994-09-23 | 1997-07-29 | Massey University | Chromatographic resins and methods for using same |
| SE9600590D0 (sv) | 1996-02-19 | 1996-02-19 | Pharmacia Biotech Ab | Sätt för kromatografisk separation av peptider och nukleinsyra samt ny högaffin jonbytesmatris |
| SE9802214D0 (sv) | 1998-06-18 | 1998-06-18 | Amersham Pharm Biotech Ab | Jonbytare och användning därav |
| US6310199B1 (en) | 1999-05-14 | 2001-10-30 | Promega Corporation | pH dependent ion exchange matrix and method of use in the isolation of nucleic acids |
| SE9904197D0 (sv) | 1999-11-22 | 1999-11-22 | Amersham Pharm Biotech Ab | A method for anion exchange adsorption on matrices carrying mixed mode ligands |
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2000
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2001
- 2001-12-17 US US10/451,192 patent/US7008542B2/en not_active Expired - Lifetime
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- 2001-12-17 EP EP01985893A patent/EP1345695A2/en not_active Withdrawn
- 2001-12-17 AU AU2002235786A patent/AU2002235786B2/en not_active Expired
- 2001-12-17 WO PCT/EP2001/014895 patent/WO2002053252A2/en not_active Ceased
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