US6569861B2
(en)
|
2000-07-06 |
2003-05-27 |
Neurogen Corporation |
Melanin concentrating hormone receptor ligands
|
EP1392298B1
(en)
|
2001-05-04 |
2009-02-18 |
Amgen Inc. |
Fused heterocyclic compounds
|
US6809104B2
(en)
|
2001-05-04 |
2004-10-26 |
Tularik Inc. |
Fused heterocyclic compounds
|
EP1389189A2
(en)
|
2001-05-22 |
2004-02-18 |
Neurogen Corporation |
Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues
|
EP1450801A4
(en)
|
2001-11-27 |
2010-10-27 |
Merck Sharp & Dohme |
2-AMINOQUINOLINE COMPOUNDS
|
CA2473236A1
(en)
|
2002-01-10 |
2003-07-24 |
Neurogen Corporation |
Melanin concentrating hormone receptor ligands: substituted 2-(4-benzyl-piperazin-1-ylmethyl)- and 2-(4-benzyl-diazepan-1-ylmethyl)-1h-benzoimidazole analogues
|
US6906075B2
(en)
|
2002-01-10 |
2005-06-14 |
Neurogen Corp. |
Melanin concentrating hormone receptor ligands: substituted benzoimidazole analogues
|
US7105526B2
(en)
|
2002-06-28 |
2006-09-12 |
Banyu Pharmaceuticals Co., Ltd. |
Benzimidazole derivatives
|
DE10238865A1
(de)
*
|
2002-08-24 |
2004-03-11 |
Boehringer Ingelheim International Gmbh |
Neue Carbonsäureamid-Verbindungen mit MCH-antagonistischer Wirkung, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
|
US7351719B2
(en)
|
2002-10-31 |
2008-04-01 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds
|
CA2505372A1
(en)
|
2002-11-06 |
2004-05-27 |
Tularik Inc. |
Fused heterocyclic compounds
|
US7772188B2
(en)
|
2003-01-28 |
2010-08-10 |
Ironwood Pharmaceuticals, Inc. |
Methods and compositions for the treatment of gastrointestinal disorders
|
AU2004209505B2
(en)
*
|
2003-02-10 |
2009-07-23 |
Banyu Pharmaceutical Co., Ltd. |
Melanin-concentrating hormone receptor antagonists containing piperidine derivatives as the active ingredient
|
US7601868B2
(en)
|
2003-02-12 |
2009-10-13 |
Takeda Pharmaceutical Company Limited |
Amine derivative
|
EP1654225A4
(en)
*
|
2003-08-13 |
2007-11-28 |
Amgen Inc |
HORMONE RECEPTOR ANTAGONISTS CONCENTRATING MELANIN
|
CA2533112A1
(en)
*
|
2003-08-13 |
2005-03-03 |
Christopher Hulme |
Melanin concentrating hormone receptor antagonist
|
EP1669350B1
(en)
|
2003-09-22 |
2012-02-29 |
Msd K.K. |
Piperidine derivatives
|
US20060247239A1
(en)
*
|
2003-10-01 |
2006-11-02 |
Hu Xiufeng E |
Melanin concentrating hormone antagonists
|
RU2006110272A
(ru)
|
2003-10-01 |
2007-11-10 |
Дзе Проктер Энд Гэмбл Компани (US) |
Антагонисты гормона, концентрирующего меланин
|
US7592373B2
(en)
|
2003-12-23 |
2009-09-22 |
Boehringer Ingelheim International Gmbh |
Amide compounds with MCH antagonistic activity and medicaments comprising these compounds
|
WO2005097127A2
(en)
|
2004-04-02 |
2005-10-20 |
Merck & Co., Inc. |
Method of treating men with metabolic and anthropometric disorders
|
US20050239791A1
(en)
*
|
2004-04-07 |
2005-10-27 |
Hutchison Alan J |
Substituted 1-heteroaryl-4-substituted piperazine and piperidine analogues
|
WO2005110982A2
(en)
*
|
2004-04-07 |
2005-11-24 |
Neurogen Corporation |
Substituted 1-benzyl-4-substituted piperazine analogues
|
US7524862B2
(en)
|
2004-04-14 |
2009-04-28 |
Boehringer Ingelheim International Gmbh |
Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
|
DE102004017934A1
(de)
|
2004-04-14 |
2005-11-03 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel
|
TW200609219A
(en)
*
|
2004-06-17 |
2006-03-16 |
Neurogen Corp |
Aryl-substituted piperazine derivatives
|
US7063034B2
(en)
*
|
2004-08-10 |
2006-06-20 |
Watermark Paddlesports, Inc. |
Spray skirt for watercraft
|
AU2005272627A1
(en)
|
2004-08-13 |
2006-02-23 |
Amgen Inc. |
Substituted benzofused heterocycles
|
US8394765B2
(en)
|
2004-11-01 |
2013-03-12 |
Amylin Pharmaceuticals Llc |
Methods of treating obesity with two different anti-obesity agents
|
BRPI0518241A
(pt)
|
2004-11-01 |
2008-04-22 |
Amylin Pharmaceuticals Inc |
métodos para tratar obesidade e doenças e distúrbios relacionados à obesidade
|
US7737155B2
(en)
|
2005-05-17 |
2010-06-15 |
Schering Corporation |
Nitrogen-containing heterocyclic compounds and methods of use thereof
|
AU2006253312B2
(en)
|
2005-05-30 |
2011-08-18 |
Msd K.K. |
Novel piperidine derivative
|
EP1891065A4
(en)
*
|
2005-05-31 |
2010-07-28 |
Astrazeneca Ab |
NEW MCHR1 ANTAGONISTS AND THEIR USE FOR THE TREATMENT OF SUFFERING AND ILLEGAL DISORDERS PROVIDED BY MCHR1
|
AU2006277253A1
(en)
|
2005-08-10 |
2007-02-15 |
Msd K.K. |
Pyridone compound
|
EP2330125A3
(en)
|
2005-08-11 |
2012-12-12 |
Amylin Pharmaceuticals, Inc. |
Hybrid polypeptides with selectable properties
|
AU2006279680B2
(en)
|
2005-08-11 |
2012-12-06 |
Amylin Pharmaceuticals, Llc |
Hybrid polypeptides with selectable properties
|
JPWO2007024004A1
(ja)
|
2005-08-24 |
2009-03-05 |
萬有製薬株式会社 |
フェニルピリドン誘導体
|
EP1939194A4
(en)
|
2005-09-07 |
2010-12-08 |
Banyu Pharma Co Ltd |
AROMATIC SUBSTITUTED BICYLIC PYRIDONE DERIVATIVE
|
KR20080048502A
(ko)
|
2005-09-29 |
2008-06-02 |
머크 앤드 캄파니 인코포레이티드 |
멜라노코르틴-4 수용체 조절제로서의 아실화스피로피페리딘 유도체
|
AU2006298852A1
(en)
|
2005-09-30 |
2007-04-12 |
F. Hoffmann-La Roche Ag |
Indane derivatives as MCH receptor antagonists
|
EP2332526A3
(en)
|
2005-10-21 |
2011-10-12 |
Novartis AG |
Combination of a renin-inhibitor and an anti-dyslipidemic agent and/or an antiobesity agent
|
WO2007049798A1
(ja)
|
2005-10-27 |
2007-05-03 |
Banyu Pharmaceutical Co., Ltd. |
新規ベンゾオキサチイン誘導体
|
JP4371164B2
(ja)
|
2005-11-10 |
2009-11-25 |
萬有製薬株式会社 |
アザ置換スピロ誘導体
|
WO2007087066A2
(en)
*
|
2005-12-28 |
2007-08-02 |
Vertex Pharmaceuticals Incorporated |
1-(benzo [d] [1,3] di0x0l-5-yl) -n- (phenyl) cyclopropane- carboxamide derivatives and related compounds as modulators of atp-binding cassette transporters for the treatment of cystic fibrosis
|
US7671221B2
(en)
*
|
2005-12-28 |
2010-03-02 |
Vertex Pharmaceuticals Incorporated |
Modulators of ATP-Binding Cassette transporters
|
US20080027072A1
(en)
*
|
2006-04-20 |
2008-01-31 |
Ampla Pharmaceuticals, Inc. |
Potentiation of MC4 receptor activity
|
CA2664113C
(en)
|
2006-09-22 |
2013-05-28 |
Merck & Co., Inc. |
Use of platencin and platensimycin as fatty acid synthesis inhibitors to treat obesity, diabetes and cancer
|
WO2008038692A1
(fr)
|
2006-09-28 |
2008-04-03 |
Banyu Pharmaceutical Co., Ltd. |
dÉrivÉ de diarylcÉtimine
|
ES2627221T3
(es)
|
2006-12-28 |
2017-07-27 |
Rigel Pharmaceuticals, Inc. |
Compuestos de heterocicloalquiloxibenzamida N-sustituidos y métodos de uso
|
WO2008120653A1
(ja)
|
2007-04-02 |
2008-10-09 |
Banyu Pharmaceutical Co., Ltd. |
インドールジオン誘導体
|
US8198307B2
(en)
*
|
2007-05-11 |
2012-06-12 |
Korea Research Institute Of Chemical Technology |
Imidazole derivatives having aryl piperidine substituent, method for preparation thereof and pharmaceutical compositions containing same
|
US8969514B2
(en)
|
2007-06-04 |
2015-03-03 |
Synergy Pharmaceuticals, Inc. |
Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
|
AU2008261102B2
(en)
|
2007-06-04 |
2013-11-28 |
Bausch Health Ireland Limited |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
|
WO2009110510A1
(ja)
|
2008-03-06 |
2009-09-11 |
萬有製薬株式会社 |
アルキルアミノピリジン誘導体
|
US20110015198A1
(en)
|
2008-03-28 |
2011-01-20 |
Banyu Pharmaceutical Co., Inc. |
Diarylmethylamide derivative having melanin-concentrating hormone receptor antagonism
|
EP2328910B1
(en)
|
2008-06-04 |
2014-08-06 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
|
CA2727914A1
(en)
|
2008-06-19 |
2009-12-23 |
Banyu Pharmaceutical Co., Ltd. |
Spirodiamine-diaryl ketoxime derivative technical field
|
EP3241839B1
(en)
|
2008-07-16 |
2019-09-04 |
Bausch Health Ireland Limited |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
|
EP2319841A1
(en)
|
2008-07-30 |
2011-05-11 |
Msd K.K. |
(5-membered)-(5-membered) or (5-membered)-(6-membered) fused ring cycloalkylamine derivative
|
MX2011004258A
(es)
|
2008-10-22 |
2011-06-01 |
Merck Sharp & Dohme |
Derivados de bencimidazol ciclicos novedosos utiles como agentes anti-diabeticos.
|
EA201170624A1
(ru)
|
2008-10-30 |
2011-12-30 |
Мерк Шарп Энд Домэ Корп. |
Изоникотинамидные антагонисты рецепторов орексинов
|
EP2362731B1
(en)
|
2008-10-31 |
2016-04-06 |
Merck Sharp & Dohme Corp. |
Novel cyclic benzimidazole derivatives useful anti-diabetic agents
|
US20110245209A1
(en)
|
2008-12-16 |
2011-10-06 |
Schering Corporation |
Pyridopyrimidine derivatives and methods of use thereof
|
EP2379562A1
(en)
|
2008-12-16 |
2011-10-26 |
Schering Corporation |
Bicyclic pyranone derivatives as nicotinic acid receptor agonists
|
WO2011106273A1
(en)
|
2010-02-25 |
2011-09-01 |
Merck Sharp & Dohme Corp. |
Novel cyclic benzimidazole derivatives useful anti-diabetic agents
|
US9616097B2
(en)
|
2010-09-15 |
2017-04-11 |
Synergy Pharmaceuticals, Inc. |
Formulations of guanylate cyclase C agonists and methods of use
|
WO2012116145A1
(en)
|
2011-02-25 |
2012-08-30 |
Merck Sharp & Dohme Corp. |
Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents
|
AR088352A1
(es)
|
2011-10-19 |
2014-05-28 |
Merck Sharp & Dohme |
Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
|
JP2015525782A
(ja)
|
2012-08-02 |
2015-09-07 |
メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. |
抗糖尿病性三環式化合物
|
CN104994848A
(zh)
|
2013-02-22 |
2015-10-21 |
默沙东公司 |
抗糖尿病二环化合物
|
US9650375B2
(en)
|
2013-03-14 |
2017-05-16 |
Merck Sharp & Dohme Corp. |
Indole derivatives useful as anti-diabetic agents
|
AU2014235209B2
(en)
|
2013-03-15 |
2018-06-14 |
Bausch Health Ireland Limited |
Guanylate cyclase receptor agonists combined with other drugs
|
WO2014151206A1
(en)
|
2013-03-15 |
2014-09-25 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase and their uses
|
BR112015030326A2
(pt)
|
2013-06-05 |
2017-08-29 |
Synergy Pharmaceuticals Inc |
Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos
|
WO2015051496A1
(en)
|
2013-10-08 |
2015-04-16 |
Merck Sharp & Dohme Corp. |
Antidiabetic tricyclic compounds
|
KR102431436B1
(ko)
|
2014-08-29 |
2022-08-10 |
테스 파마 에스.알.엘. |
α-아미노-β-카복시뮤콘산 세미알데히드 데카복실라제의 억제제
|
BR112019007543A2
(pt)
|
2016-10-14 |
2019-07-02 |
Tes Pharma S R L |
inibidores de ácido alfa-amino-beta-carboximuconico semialdeido decarboxilase
|
US11072602B2
(en)
|
2016-12-06 |
2021-07-27 |
Merck Sharp & Dohme Corp. |
Antidiabetic heterocyclic compounds
|
US10968232B2
(en)
|
2016-12-20 |
2021-04-06 |
Merck Sharp & Dohme Corp. |
Antidiabetic spirochroman compounds
|
AU2019385644A1
(en)
|
2018-11-20 |
2021-06-03 |
Tes Pharma S.R.L. |
Inhibitors of α-Amino-β-carboxymuconic acid semialdehyde decarboxylase
|
US11098029B2
(en)
|
2019-02-13 |
2021-08-24 |
Merck Sharp & Dohme Corp. |
5-alkyl pyrrolidine orexin receptor agonists
|
EP4010314B1
(en)
|
2019-08-08 |
2024-02-28 |
Merck Sharp & Dohme LLC |
Heteroaryl pyrrolidine and piperidine orexin receptor agonists
|
MX2023001840A
(es)
|
2020-08-18 |
2023-03-13 |
Merck Sharp & Dohme Llc |
Agonistas de bicicloheptano pirrolidina de los receptores de orexina.
|