JP2004516314A5 - - Google Patents

Download PDF

Info

Publication number
JP2004516314A5
JP2004516314A5 JP2002552906A JP2002552906A JP2004516314A5 JP 2004516314 A5 JP2004516314 A5 JP 2004516314A5 JP 2002552906 A JP2002552906 A JP 2002552906A JP 2002552906 A JP2002552906 A JP 2002552906A JP 2004516314 A5 JP2004516314 A5 JP 2004516314A5
Authority
JP
Japan
Prior art keywords
alkyl
group
compound
alkoxy
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2002552906A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004516314A (ja
JP4025200B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2001/049301 external-priority patent/WO2002051809A1/en
Publication of JP2004516314A publication Critical patent/JP2004516314A/ja
Publication of JP2004516314A5 publication Critical patent/JP2004516314A5/ja
Application granted granted Critical
Publication of JP4025200B2 publication Critical patent/JP4025200B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2002552906A 2000-12-22 2001-12-17 ピペリジンmchアンタゴニストおよび肥満の処置におけるそれらの使用 Expired - Fee Related JP4025200B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25787300P 2000-12-22 2000-12-22
PCT/US2001/049301 WO2002051809A1 (en) 2000-12-22 2001-12-17 Piperidine mch antagonists and their use in the treatment of obesity

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2007195250A Division JP2007284451A (ja) 2000-12-22 2007-07-26 ピペリジンmchアンタゴニストおよび肥満の処置におけるそれらの使用

Publications (3)

Publication Number Publication Date
JP2004516314A JP2004516314A (ja) 2004-06-03
JP2004516314A5 true JP2004516314A5 (US06894165-20050517-C00155.png) 2005-04-14
JP4025200B2 JP4025200B2 (ja) 2007-12-19

Family

ID=22978138

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002552906A Expired - Fee Related JP4025200B2 (ja) 2000-12-22 2001-12-17 ピペリジンmchアンタゴニストおよび肥満の処置におけるそれらの使用
JP2007195250A Pending JP2007284451A (ja) 2000-12-22 2007-07-26 ピペリジンmchアンタゴニストおよび肥満の処置におけるそれらの使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2007195250A Pending JP2007284451A (ja) 2000-12-22 2007-07-26 ピペリジンmchアンタゴニストおよび肥満の処置におけるそれらの使用

Country Status (20)

Country Link
US (1) US6472394B1 (US06894165-20050517-C00155.png)
EP (1) EP1343761B1 (US06894165-20050517-C00155.png)
JP (2) JP4025200B2 (US06894165-20050517-C00155.png)
KR (1) KR20040011447A (US06894165-20050517-C00155.png)
CN (1) CN1273451C (US06894165-20050517-C00155.png)
AR (1) AR031930A1 (US06894165-20050517-C00155.png)
AT (1) ATE302185T1 (US06894165-20050517-C00155.png)
AU (1) AU2002231097B2 (US06894165-20050517-C00155.png)
CA (1) CA2431953A1 (US06894165-20050517-C00155.png)
DE (1) DE60112791T2 (US06894165-20050517-C00155.png)
ES (1) ES2243588T3 (US06894165-20050517-C00155.png)
HK (1) HK1054390B (US06894165-20050517-C00155.png)
HU (1) HUP0302582A2 (US06894165-20050517-C00155.png)
IL (1) IL155772A0 (US06894165-20050517-C00155.png)
MX (1) MXPA03005744A (US06894165-20050517-C00155.png)
MY (1) MY134017A (US06894165-20050517-C00155.png)
NZ (1) NZ525723A (US06894165-20050517-C00155.png)
PE (1) PE20020658A1 (US06894165-20050517-C00155.png)
WO (1) WO2002051809A1 (US06894165-20050517-C00155.png)
ZA (1) ZA200303638B (US06894165-20050517-C00155.png)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6569861B2 (en) 2000-07-06 2003-05-27 Neurogen Corporation Melanin concentrating hormone receptor ligands
EP1392298B1 (en) 2001-05-04 2009-02-18 Amgen Inc. Fused heterocyclic compounds
US6809104B2 (en) 2001-05-04 2004-10-26 Tularik Inc. Fused heterocyclic compounds
EP1389189A2 (en) 2001-05-22 2004-02-18 Neurogen Corporation Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues
EP1450801A4 (en) 2001-11-27 2010-10-27 Merck Sharp & Dohme 2-AMINOQUINOLINE COMPOUNDS
CA2473236A1 (en) 2002-01-10 2003-07-24 Neurogen Corporation Melanin concentrating hormone receptor ligands: substituted 2-(4-benzyl-piperazin-1-ylmethyl)- and 2-(4-benzyl-diazepan-1-ylmethyl)-1h-benzoimidazole analogues
US6906075B2 (en) 2002-01-10 2005-06-14 Neurogen Corp. Melanin concentrating hormone receptor ligands: substituted benzoimidazole analogues
US7105526B2 (en) 2002-06-28 2006-09-12 Banyu Pharmaceuticals Co., Ltd. Benzimidazole derivatives
DE10238865A1 (de) * 2002-08-24 2004-03-11 Boehringer Ingelheim International Gmbh Neue Carbonsäureamid-Verbindungen mit MCH-antagonistischer Wirkung, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US7351719B2 (en) 2002-10-31 2008-04-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds
CA2505372A1 (en) 2002-11-06 2004-05-27 Tularik Inc. Fused heterocyclic compounds
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
AU2004209505B2 (en) * 2003-02-10 2009-07-23 Banyu Pharmaceutical Co., Ltd. Melanin-concentrating hormone receptor antagonists containing piperidine derivatives as the active ingredient
US7601868B2 (en) 2003-02-12 2009-10-13 Takeda Pharmaceutical Company Limited Amine derivative
EP1654225A4 (en) * 2003-08-13 2007-11-28 Amgen Inc HORMONE RECEPTOR ANTAGONISTS CONCENTRATING MELANIN
CA2533112A1 (en) * 2003-08-13 2005-03-03 Christopher Hulme Melanin concentrating hormone receptor antagonist
EP1669350B1 (en) 2003-09-22 2012-02-29 Msd K.K. Piperidine derivatives
US20060247239A1 (en) * 2003-10-01 2006-11-02 Hu Xiufeng E Melanin concentrating hormone antagonists
RU2006110272A (ru) 2003-10-01 2007-11-10 Дзе Проктер Энд Гэмбл Компани (US) Антагонисты гормона, концентрирующего меланин
US7592373B2 (en) 2003-12-23 2009-09-22 Boehringer Ingelheim International Gmbh Amide compounds with MCH antagonistic activity and medicaments comprising these compounds
WO2005097127A2 (en) 2004-04-02 2005-10-20 Merck & Co., Inc. Method of treating men with metabolic and anthropometric disorders
US20050239791A1 (en) * 2004-04-07 2005-10-27 Hutchison Alan J Substituted 1-heteroaryl-4-substituted piperazine and piperidine analogues
WO2005110982A2 (en) * 2004-04-07 2005-11-24 Neurogen Corporation Substituted 1-benzyl-4-substituted piperazine analogues
US7524862B2 (en) 2004-04-14 2009-04-28 Boehringer Ingelheim International Gmbh Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
DE102004017934A1 (de) 2004-04-14 2005-11-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel
TW200609219A (en) * 2004-06-17 2006-03-16 Neurogen Corp Aryl-substituted piperazine derivatives
US7063034B2 (en) * 2004-08-10 2006-06-20 Watermark Paddlesports, Inc. Spray skirt for watercraft
AU2005272627A1 (en) 2004-08-13 2006-02-23 Amgen Inc. Substituted benzofused heterocycles
US8394765B2 (en) 2004-11-01 2013-03-12 Amylin Pharmaceuticals Llc Methods of treating obesity with two different anti-obesity agents
BRPI0518241A (pt) 2004-11-01 2008-04-22 Amylin Pharmaceuticals Inc métodos para tratar obesidade e doenças e distúrbios relacionados à obesidade
US7737155B2 (en) 2005-05-17 2010-06-15 Schering Corporation Nitrogen-containing heterocyclic compounds and methods of use thereof
AU2006253312B2 (en) 2005-05-30 2011-08-18 Msd K.K. Novel piperidine derivative
EP1891065A4 (en) * 2005-05-31 2010-07-28 Astrazeneca Ab NEW MCHR1 ANTAGONISTS AND THEIR USE FOR THE TREATMENT OF SUFFERING AND ILLEGAL DISORDERS PROVIDED BY MCHR1
AU2006277253A1 (en) 2005-08-10 2007-02-15 Msd K.K. Pyridone compound
EP2330125A3 (en) 2005-08-11 2012-12-12 Amylin Pharmaceuticals, Inc. Hybrid polypeptides with selectable properties
AU2006279680B2 (en) 2005-08-11 2012-12-06 Amylin Pharmaceuticals, Llc Hybrid polypeptides with selectable properties
JPWO2007024004A1 (ja) 2005-08-24 2009-03-05 萬有製薬株式会社 フェニルピリドン誘導体
EP1939194A4 (en) 2005-09-07 2010-12-08 Banyu Pharma Co Ltd AROMATIC SUBSTITUTED BICYLIC PYRIDONE DERIVATIVE
KR20080048502A (ko) 2005-09-29 2008-06-02 머크 앤드 캄파니 인코포레이티드 멜라노코르틴-4 수용체 조절제로서의 아실화스피로피페리딘 유도체
AU2006298852A1 (en) 2005-09-30 2007-04-12 F. Hoffmann-La Roche Ag Indane derivatives as MCH receptor antagonists
EP2332526A3 (en) 2005-10-21 2011-10-12 Novartis AG Combination of a renin-inhibitor and an anti-dyslipidemic agent and/or an antiobesity agent
WO2007049798A1 (ja) 2005-10-27 2007-05-03 Banyu Pharmaceutical Co., Ltd. 新規ベンゾオキサチイン誘導体
JP4371164B2 (ja) 2005-11-10 2009-11-25 萬有製薬株式会社 アザ置換スピロ誘導体
WO2007087066A2 (en) * 2005-12-28 2007-08-02 Vertex Pharmaceuticals Incorporated 1-(benzo [d] [1,3] di0x0l-5-yl) -n- (phenyl) cyclopropane- carboxamide derivatives and related compounds as modulators of atp-binding cassette transporters for the treatment of cystic fibrosis
US7671221B2 (en) * 2005-12-28 2010-03-02 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
US20080027072A1 (en) * 2006-04-20 2008-01-31 Ampla Pharmaceuticals, Inc. Potentiation of MC4 receptor activity
CA2664113C (en) 2006-09-22 2013-05-28 Merck & Co., Inc. Use of platencin and platensimycin as fatty acid synthesis inhibitors to treat obesity, diabetes and cancer
WO2008038692A1 (fr) 2006-09-28 2008-04-03 Banyu Pharmaceutical Co., Ltd. dÉrivÉ de diarylcÉtimine
ES2627221T3 (es) 2006-12-28 2017-07-27 Rigel Pharmaceuticals, Inc. Compuestos de heterocicloalquiloxibenzamida N-sustituidos y métodos de uso
WO2008120653A1 (ja) 2007-04-02 2008-10-09 Banyu Pharmaceutical Co., Ltd. インドールジオン誘導体
US8198307B2 (en) * 2007-05-11 2012-06-12 Korea Research Institute Of Chemical Technology Imidazole derivatives having aryl piperidine substituent, method for preparation thereof and pharmaceutical compositions containing same
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
AU2008261102B2 (en) 2007-06-04 2013-11-28 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2009110510A1 (ja) 2008-03-06 2009-09-11 萬有製薬株式会社 アルキルアミノピリジン誘導体
US20110015198A1 (en) 2008-03-28 2011-01-20 Banyu Pharmaceutical Co., Inc. Diarylmethylamide derivative having melanin-concentrating hormone receptor antagonism
EP2328910B1 (en) 2008-06-04 2014-08-06 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CA2727914A1 (en) 2008-06-19 2009-12-23 Banyu Pharmaceutical Co., Ltd. Spirodiamine-diaryl ketoxime derivative technical field
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
EP2319841A1 (en) 2008-07-30 2011-05-11 Msd K.K. (5-membered)-(5-membered) or (5-membered)-(6-membered) fused ring cycloalkylamine derivative
MX2011004258A (es) 2008-10-22 2011-06-01 Merck Sharp & Dohme Derivados de bencimidazol ciclicos novedosos utiles como agentes anti-diabeticos.
EA201170624A1 (ru) 2008-10-30 2011-12-30 Мерк Шарп Энд Домэ Корп. Изоникотинамидные антагонисты рецепторов орексинов
EP2362731B1 (en) 2008-10-31 2016-04-06 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
US20110245209A1 (en) 2008-12-16 2011-10-06 Schering Corporation Pyridopyrimidine derivatives and methods of use thereof
EP2379562A1 (en) 2008-12-16 2011-10-26 Schering Corporation Bicyclic pyranone derivatives as nicotinic acid receptor agonists
WO2011106273A1 (en) 2010-02-25 2011-09-01 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
WO2012116145A1 (en) 2011-02-25 2012-08-30 Merck Sharp & Dohme Corp. Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents
AR088352A1 (es) 2011-10-19 2014-05-28 Merck Sharp & Dohme Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
JP2015525782A (ja) 2012-08-02 2015-09-07 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. 抗糖尿病性三環式化合物
CN104994848A (zh) 2013-02-22 2015-10-21 默沙东公司 抗糖尿病二环化合物
US9650375B2 (en) 2013-03-14 2017-05-16 Merck Sharp & Dohme Corp. Indole derivatives useful as anti-diabetic agents
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
BR112015030326A2 (pt) 2013-06-05 2017-08-29 Synergy Pharmaceuticals Inc Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
KR102431436B1 (ko) 2014-08-29 2022-08-10 테스 파마 에스.알.엘. α-아미노-β-카복시뮤콘산 세미알데히드 데카복실라제의 억제제
BR112019007543A2 (pt) 2016-10-14 2019-07-02 Tes Pharma S R L inibidores de ácido alfa-amino-beta-carboximuconico semialdeido decarboxilase
US11072602B2 (en) 2016-12-06 2021-07-27 Merck Sharp & Dohme Corp. Antidiabetic heterocyclic compounds
US10968232B2 (en) 2016-12-20 2021-04-06 Merck Sharp & Dohme Corp. Antidiabetic spirochroman compounds
AU2019385644A1 (en) 2018-11-20 2021-06-03 Tes Pharma S.R.L. Inhibitors of α-Amino-β-carboxymuconic acid semialdehyde decarboxylase
US11098029B2 (en) 2019-02-13 2021-08-24 Merck Sharp & Dohme Corp. 5-alkyl pyrrolidine orexin receptor agonists
EP4010314B1 (en) 2019-08-08 2024-02-28 Merck Sharp & Dohme LLC Heteroaryl pyrrolidine and piperidine orexin receptor agonists
MX2023001840A (es) 2020-08-18 2023-03-13 Merck Sharp & Dohme Llc Agonistas de bicicloheptano pirrolidina de los receptores de orexina.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5595872A (en) 1992-03-06 1997-01-21 Bristol-Myers Squibb Company Nucleic acids encoding microsomal trigyceride transfer protein
IL117149A0 (en) 1995-02-23 1996-06-18 Schering Corp Muscarinic antagonists
US5908830A (en) 1996-10-31 1999-06-01 Merck & Co., Inc. Combination therapy for the treatment of diabetes and obesity
US6040318A (en) * 1997-06-25 2000-03-21 Novo Nordisk A/S Tricycle substituted with azaheterocyclic carboxylic acids
EP1153013B1 (en) * 1999-02-10 2007-10-31 Eli Lilly And Company 5-ht1f agonists
EP1204664A1 (en) * 1999-07-28 2002-05-15 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor

Similar Documents

Publication Publication Date Title
JP2004516314A5 (US06894165-20050517-C00155.png)
JP2008510691A5 (US06894165-20050517-C00155.png)
JP2007515405A5 (US06894165-20050517-C00155.png)
JP2005506352A5 (US06894165-20050517-C00155.png)
JP2010530881A5 (US06894165-20050517-C00155.png)
JP2007516180A5 (US06894165-20050517-C00155.png)
RU2005107314A (ru) Пиримидопроизводные, характеризующиеся антипролиферативной активностью
JP2005523922A5 (US06894165-20050517-C00155.png)
JP2018135343A5 (US06894165-20050517-C00155.png)
CA2545427A1 (en) Selective kinase inhibitors
JP2006526590A5 (US06894165-20050517-C00155.png)
JP2005526857A5 (US06894165-20050517-C00155.png)
JP2009520695A5 (US06894165-20050517-C00155.png)
JP2009507896A5 (US06894165-20050517-C00155.png)
JP2010511721A5 (US06894165-20050517-C00155.png)
JP2006182786A5 (US06894165-20050517-C00155.png)
JP2007534636A5 (US06894165-20050517-C00155.png)
JP2005508905A5 (US06894165-20050517-C00155.png)
RU2008109914A (ru) Применение производных тиенопиридона в качестве активаторов амфк и фармацевтические композиции, которые их содержат
JP2010514786A5 (US06894165-20050517-C00155.png)
JP2009536660A5 (US06894165-20050517-C00155.png)
JP2010501478A5 (US06894165-20050517-C00155.png)
JP2005536503A5 (US06894165-20050517-C00155.png)
JP2007519654A5 (US06894165-20050517-C00155.png)
JP2003503449A5 (US06894165-20050517-C00155.png)