JP2004514139A5 - - Google Patents
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- Publication number
- JP2004514139A5 JP2004514139A5 JP2002542878A JP2002542878A JP2004514139A5 JP 2004514139 A5 JP2004514139 A5 JP 2004514139A5 JP 2002542878 A JP2002542878 A JP 2002542878A JP 2002542878 A JP2002542878 A JP 2002542878A JP 2004514139 A5 JP2004514139 A5 JP 2004514139A5
- Authority
- JP
- Japan
- Prior art keywords
- molecular weight
- alkyl
- group
- substituted
- fluorescent molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 125000004432 carbon atom Chemical group C* 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 150000004697 chelate complex Chemical class 0.000 claims 5
- 239000002184 metal Substances 0.000 claims 5
- 229910021645 metal ion Inorganic materials 0.000 claims 5
- -1 sulfo, carboxy Chemical group 0.000 claims 5
- 230000007704 transition Effects 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 230000003993 interaction Effects 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 238000004132 cross linking Methods 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 238000005259 measurement Methods 0.000 claims 2
- 125000003884 phenylalkyl group Chemical group 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- BCHZICNRHXRCHY-UHFFFAOYSA-N 2h-oxazine Chemical compound N1OC=CC=C1 BCHZICNRHXRCHY-UHFFFAOYSA-N 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- 239000012491 analyte Substances 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 150000004893 oxazines Chemical class 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 150000003732 xanthenes Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00124995 | 2000-11-16 | ||
| PCT/EP2001/013152 WO2002041001A1 (de) | 2000-11-16 | 2001-11-14 | Farbstoffpaare für fluoreszenz-resonanz-energie-transfer (fret) messungen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004514139A JP2004514139A (ja) | 2004-05-13 |
| JP2004514139A5 true JP2004514139A5 (https=) | 2005-04-14 |
| JP3905838B2 JP3905838B2 (ja) | 2007-04-18 |
Family
ID=8170391
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002542878A Expired - Fee Related JP3905838B2 (ja) | 2000-11-16 | 2001-11-14 | 蛍光共鳴エネルギー転移（ｆｒｅｔ）測定用ダイペア |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6908769B2 (https=) |
| EP (1) | EP1337851B1 (https=) |
| JP (1) | JP3905838B2 (https=) |
| AT (1) | ATE300050T1 (https=) |
| AU (1) | AU2002221848A1 (https=) |
| CA (1) | CA2426479C (https=) |
| DE (1) | DE50106822D1 (https=) |
| ES (1) | ES2245995T3 (https=) |
| WO (1) | WO2002041001A1 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1317511B1 (de) * | 2000-09-06 | 2005-01-19 | Evotec OAI AG | Oxazinderivate |
| EP1543155A4 (en) * | 2002-07-17 | 2006-08-16 | Us Genomics Inc | METHOD AND COMPOSITIONS FOR THE ANALYSIS OF POLYMERS USING CHIMERIC TAGS |
| DE602004006733T2 (de) * | 2003-02-26 | 2008-01-31 | Tomtom International B.V. | Navigationseinheit und verfahren zum anzeigen alternativer routen |
| WO2005016934A1 (en) * | 2003-08-18 | 2005-02-24 | Novartis Ag | 3h-phenoxazine derivatives suitable as near-infrared imaging agents, preparation an use thereof |
| CA2541075C (en) * | 2003-10-01 | 2010-04-27 | Wallac Oy | Homogeneous time-resolved energy transfer assay |
| US8105849B2 (en) * | 2004-02-27 | 2012-01-31 | Board Of Regents, The University Of Texas System | Integration of fluids and reagents into self-contained cartridges containing sensor elements |
| WO2005089524A2 (en) * | 2004-03-19 | 2005-09-29 | U.S. Genomics, Inc. | Compositions and methods for detection of single molecules |
| US8883486B2 (en) | 2004-05-04 | 2014-11-11 | Universite De Montreal | Arrestin biosensor |
| CN100473988C (zh) * | 2004-07-08 | 2009-04-01 | 厦门大学 | 具有荧光共振能量转移特点的蛋白组合及其用途 |
| US20090298196A1 (en) * | 2005-01-28 | 2009-12-03 | Uwabe Ken-Ichiro | Quantitative measurement method for recombinant protein |
| US7826052B2 (en) | 2005-05-24 | 2010-11-02 | Hidex Oy | Correction method and measurement device for anti-stokes photoluminescence measurement |
| WO2007016975A1 (en) | 2005-07-29 | 2007-02-15 | F. Hoffmann-La Roche Ag | Kinase and phosphatase assays based on fret |
| FR2890174B1 (fr) * | 2005-08-30 | 2009-04-24 | Cis Bio Internat Sa | Procede pour la mise en evidence d'un processus biologique par mesure d'un fret |
| WO2007056250A2 (en) * | 2005-11-04 | 2007-05-18 | U.S. Genomics, Inc. | Heterogeneous assay of analytes in solution using polymers |
| USRE49362E1 (en) | 2006-05-18 | 2023-01-10 | Illumina Cambridge Limited | Dye compounds and the use of their labelled conjugates |
| US20110098309A1 (en) * | 2007-07-12 | 2011-04-28 | Acumen Pharmaceuticals, Inc. | Methods of inhibiting the formation of amyloid-beta diffusable ligands using acylhydrazide compounds |
| US8962677B2 (en) * | 2007-07-12 | 2015-02-24 | Acumen Pharmaceuticals, Inc. | Methods of restoring cognitive ability using non-peptidic compounds |
| US20100294665A1 (en) * | 2007-07-12 | 2010-11-25 | Richard Allen | Method and system for transferring and/or concentrating a sample |
| US9006283B2 (en) | 2007-07-12 | 2015-04-14 | Acumen Pharmaceuticals, Inc. | Methods of modifying amyloid β oligomers using non-peptidic compounds |
| US9217024B2 (en) | 2007-12-18 | 2015-12-22 | Acumen Pharmaceuticals, Inc. | ADDL receptor polypeptides, polynucleotides and host cells for recombinant production |
| WO2010117420A2 (en) | 2009-03-30 | 2010-10-14 | Pacific Biosciences Of California, Inc. | Fret-labeled compounds and uses therefor |
| WO2010125314A1 (fr) * | 2009-04-30 | 2010-11-04 | Cis-Bio International | Procede de detection de composes modulateurs de dimeres de proteines membranaires a domaine vft |
| JP6043288B2 (ja) | 2010-09-15 | 2016-12-14 | エンダセア， インコーポレイテッド | 時間分解蛍光ベースのアッセイによるリポ多糖の測定のための使用方法およびキット |
| BR112013006951A2 (pt) | 2010-09-23 | 2017-05-23 | Eci Biotech Inc | detecção ultrassensível de streptococcus beta hemolítico |
| US8569254B2 (en) | 2010-12-10 | 2013-10-29 | National Yang Ming University | Methods for modulating the expression and aggregation of CAG-expanded gene product in cells and methods for identifying agents useful for doing the same |
| GB201714748D0 (en) * | 2017-09-13 | 2017-10-25 | Univ Oxford Innovation Ltd | Single-molecule phenotyping and sequencing of nucleic acid molecules |
| CN109752552A (zh) * | 2017-11-05 | 2019-05-14 | 江苏维赛科技生物发展有限公司 | 检测联苯的时间分辨荧光免疫试剂盒及其检测方法 |
| US11293927B2 (en) | 2018-04-30 | 2022-04-05 | Ribon Therapeutics, Inc. | Screening methods for PARP modulators |
| KR102267067B1 (ko) * | 2020-01-16 | 2021-06-21 | 경희대학교 산학협력단 | 다이에틸싸이아노포스포네이트 검출용 형광 프로브 화합물 및 이의 용도 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0076695B1 (en) | 1981-10-06 | 1985-02-20 | The Board Of Trustees Of The Leland Stanford Junior University | Fluorescent conjugates for analysis of molecules and cells |
| US4822733A (en) * | 1985-05-28 | 1989-04-18 | Amoco Corporation | Lifetime-resolved assay procedures |
| DE4137934A1 (de) | 1991-11-18 | 1993-05-19 | Boehringer Mannheim Gmbh | Neue pentacyklische verbindungen und ihre verwendung als absorptions- oder fluoreszenzfarbstoffe |
| US5246867A (en) * | 1992-01-17 | 1993-09-21 | University Of Maryland At Baltimore | Determination and quantification of saccharides by luminescence lifetimes and energy transfer |
| US5622821A (en) * | 1994-06-29 | 1997-04-22 | The Regents Of The University Of California | Luminescent lanthanide chelates and methods of use |
| JP4540754B2 (ja) * | 1996-06-04 | 2010-09-08 | ユニバーシティ オブ ユタ リサーチ ファウンデーション | Ｐｃｒ中のハイブリダイゼーションのモニタリング |
| WO1998043072A1 (en) | 1997-03-25 | 1998-10-01 | Photonic Research Systems Limited | Luminescence assays |
| AU3487499A (en) | 1998-04-08 | 1999-10-25 | Regents Of The University Of California, The | Methods and reagents for targeting organic compounds to selected cellular locations |
| GB9811483D0 (en) * | 1998-05-29 | 1998-07-29 | Photonic Research Systems Limi | Luminescence assay using cyclical excitation wavelength sequence |
| US5998146A (en) * | 1998-07-17 | 1999-12-07 | Wallac Oy | Homogeneous luminescence assay method based on energy transfer |
| WO2000047693A1 (en) | 1999-02-12 | 2000-08-17 | Ljl Biosystems, Inc. | Luminescent metal-ligand complexes |
-
2001
- 2001-11-14 AT AT01996741T patent/ATE300050T1/de active
- 2001-11-14 ES ES01996741T patent/ES2245995T3/es not_active Expired - Lifetime
- 2001-11-14 DE DE50106822T patent/DE50106822D1/de not_active Expired - Lifetime
- 2001-11-14 JP JP2002542878A patent/JP3905838B2/ja not_active Expired - Fee Related
- 2001-11-14 AU AU2002221848A patent/AU2002221848A1/en not_active Abandoned
- 2001-11-14 EP EP01996741A patent/EP1337851B1/de not_active Expired - Lifetime
- 2001-11-14 WO PCT/EP2001/013152 patent/WO2002041001A1/de not_active Ceased
- 2001-11-14 US US10/432,132 patent/US6908769B2/en not_active Expired - Fee Related
- 2001-11-14 CA CA002426479A patent/CA2426479C/en not_active Expired - Fee Related
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