JP2004514139A5 - - Google Patents
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- Publication number
- JP2004514139A5 JP2004514139A5 JP2002542878A JP2002542878A JP2004514139A5 JP 2004514139 A5 JP2004514139 A5 JP 2004514139A5 JP 2002542878 A JP2002542878 A JP 2002542878A JP 2002542878 A JP2002542878 A JP 2002542878A JP 2004514139 A5 JP2004514139 A5 JP 2004514139A5
- Authority
- JP
- Japan
- Prior art keywords
- molecular weight
- alkyl
- group
- substituted
- fluorescent molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 125000004432 carbon atom Chemical group C* 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 150000004697 chelate complex Chemical class 0.000 claims 5
- 239000002184 metal Substances 0.000 claims 5
- 229910021645 metal ion Inorganic materials 0.000 claims 5
- -1 sulfo, carboxy Chemical group 0.000 claims 5
- 230000007704 transition Effects 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 230000003993 interaction Effects 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 238000004132 cross linking Methods 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 238000005259 measurement Methods 0.000 claims 2
- 125000003884 phenylalkyl group Chemical group 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- BCHZICNRHXRCHY-UHFFFAOYSA-N 2h-oxazine Chemical compound N1OC=CC=C1 BCHZICNRHXRCHY-UHFFFAOYSA-N 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- 239000012491 analyte Substances 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 150000004893 oxazines Chemical class 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 150000003732 xanthenes Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00124995 | 2000-11-16 | ||
| PCT/EP2001/013152 WO2002041001A1 (de) | 2000-11-16 | 2001-11-14 | Farbstoffpaare für fluoreszenz-resonanz-energie-transfer (fret) messungen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004514139A JP2004514139A (ja) | 2004-05-13 |
| JP2004514139A5 true JP2004514139A5 (https=) | 2005-04-14 |
| JP3905838B2 JP3905838B2 (ja) | 2007-04-18 |
Family
ID=8170391
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002542878A Expired - Fee Related JP3905838B2 (ja) | 2000-11-16 | 2001-11-14 | 蛍光共鳴エネルギー転移（ｆｒｅｔ）測定用ダイペア |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6908769B2 (https=) |
| EP (1) | EP1337851B1 (https=) |
| JP (1) | JP3905838B2 (https=) |
| AT (1) | ATE300050T1 (https=) |
| AU (1) | AU2002221848A1 (https=) |
| CA (1) | CA2426479C (https=) |
| DE (1) | DE50106822D1 (https=) |
| ES (1) | ES2245995T3 (https=) |
| WO (1) | WO2002041001A1 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE518913T1 (de) * | 2000-09-06 | 2011-08-15 | Evotec Ag | Verfahren zur gezielten markierung mittels affinitätsmarkierter detektionsmarker |
| US20040053399A1 (en) * | 2002-07-17 | 2004-03-18 | Rudolf Gilmanshin | Methods and compositions for analyzing polymers using chimeric tags |
| GB2421412B (en) * | 2003-02-26 | 2007-08-29 | Tomtom Bv | Navigation device with touch screen |
| BRPI0413703A (pt) * | 2003-08-18 | 2006-10-17 | Novartis Ag | derivados de 3h-fenoxazina adequados como agentes formadores de imagem do infravermelho próximo, preparação e uso dos mesmos |
| DE602004015629D1 (de) * | 2003-10-01 | 2008-09-18 | Wallac Oy | Ansfertest |
| US8105849B2 (en) * | 2004-02-27 | 2012-01-31 | Board Of Regents, The University Of Texas System | Integration of fluids and reagents into self-contained cartridges containing sensor elements |
| WO2005089524A2 (en) * | 2004-03-19 | 2005-09-29 | U.S. Genomics, Inc. | Compositions and methods for detection of single molecules |
| US8883486B2 (en) | 2004-05-04 | 2014-11-11 | Universite De Montreal | Arrestin biosensor |
| CN100473988C (zh) * | 2004-07-08 | 2009-04-01 | 厦门大学 | 具有荧光共振能量转移特点的蛋白组合及其用途 |
| US20090298196A1 (en) * | 2005-01-28 | 2009-12-03 | Uwabe Ken-Ichiro | Quantitative measurement method for recombinant protein |
| WO2006125855A1 (en) * | 2005-05-24 | 2006-11-30 | Hidex Oy | Correction method and measurement device for anti-stokes photoluminescence measurement |
| WO2007016975A1 (en) | 2005-07-29 | 2007-02-15 | F. Hoffmann-La Roche Ag | Kinase and phosphatase assays based on fret |
| FR2890174B1 (fr) * | 2005-08-30 | 2009-04-24 | Cis Bio Internat Sa | Procede pour la mise en evidence d'un processus biologique par mesure d'un fret |
| US20100035247A1 (en) * | 2005-11-04 | 2010-02-11 | U.S. Genomics, Inc. | Heterogeneous Assay of Analytes in Solution Using Polymers |
| US8178360B2 (en) | 2006-05-18 | 2012-05-15 | Illumina Cambridge Limited | Dye compounds and the use of their labelled conjugates |
| US9006283B2 (en) | 2007-07-12 | 2015-04-14 | Acumen Pharmaceuticals, Inc. | Methods of modifying amyloid β oligomers using non-peptidic compounds |
| WO2009009127A2 (en) * | 2007-07-12 | 2009-01-15 | U.S. Genomics, Inc. | Method and system for transferring and/or concentrating a sample |
| US8962677B2 (en) * | 2007-07-12 | 2015-02-24 | Acumen Pharmaceuticals, Inc. | Methods of restoring cognitive ability using non-peptidic compounds |
| US20110098309A1 (en) * | 2007-07-12 | 2011-04-28 | Acumen Pharmaceuticals, Inc. | Methods of inhibiting the formation of amyloid-beta diffusable ligands using acylhydrazide compounds |
| WO2009079566A2 (en) | 2007-12-18 | 2009-06-25 | Acumen Pharmaceuticals, Inc. | Novel addl receptor polypeptides, polynucleotides and host cells for recombinant production |
| WO2010117420A2 (en) | 2009-03-30 | 2010-10-14 | Pacific Biosciences Of California, Inc. | Fret-labeled compounds and uses therefor |
| CA2759885A1 (fr) * | 2009-04-30 | 2010-11-04 | Etienne Doumazane | Procede de detection de composes modulateurs de dimeres de proteines membranaires a domaine vft |
| WO2012037361A2 (en) | 2010-09-15 | 2012-03-22 | Endacea, Inc. | Methods of use and kit for measurement of lipopolysaccharide with a time resolved fluorescence based assay |
| EP2619316B1 (en) | 2010-09-23 | 2016-12-07 | Woundchek Laboratories B.V. | Ultrasensitive detection of beta hemolytic streptococcus |
| US8569254B2 (en) | 2010-12-10 | 2013-10-29 | National Yang Ming University | Methods for modulating the expression and aggregation of CAG-expanded gene product in cells and methods for identifying agents useful for doing the same |
| GB201714748D0 (en) * | 2017-09-13 | 2017-10-25 | Univ Oxford Innovation Ltd | Single-molecule phenotyping and sequencing of nucleic acid molecules |
| CN109752552A (zh) * | 2017-11-05 | 2019-05-14 | 江苏维赛科技生物发展有限公司 | 检测联苯的时间分辨荧光免疫试剂盒及其检测方法 |
| WO2019212946A1 (en) | 2018-04-30 | 2019-11-07 | Ribon Therapeutics Inc. | Screening methods for parp modulators |
| KR102267067B1 (ko) * | 2020-01-16 | 2021-06-21 | 경희대학교 산학협력단 | 다이에틸싸이아노포스포네이트 검출용 형광 프로브 화합물 및 이의 용도 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0076695B1 (en) | 1981-10-06 | 1985-02-20 | The Board Of Trustees Of The Leland Stanford Junior University | Fluorescent conjugates for analysis of molecules and cells |
| US4822733A (en) * | 1985-05-28 | 1989-04-18 | Amoco Corporation | Lifetime-resolved assay procedures |
| DE4137934A1 (de) | 1991-11-18 | 1993-05-19 | Boehringer Mannheim Gmbh | Neue pentacyklische verbindungen und ihre verwendung als absorptions- oder fluoreszenzfarbstoffe |
| US5246867A (en) * | 1992-01-17 | 1993-09-21 | University Of Maryland At Baltimore | Determination and quantification of saccharides by luminescence lifetimes and energy transfer |
| US5622821A (en) * | 1994-06-29 | 1997-04-22 | The Regents Of The University Of California | Luminescent lanthanide chelates and methods of use |
| EP1033411B1 (en) * | 1996-06-04 | 2006-02-22 | University of Utah Research Foundation | Fluorescent donor-acceptor pair |
| WO1998043072A1 (en) * | 1997-03-25 | 1998-10-01 | Photonic Research Systems Limited | Luminescence assays |
| AU3487499A (en) * | 1998-04-08 | 1999-10-25 | Regents Of The University Of California, The | Methods and reagents for targeting organic compounds to selected cellular locations |
| GB9811483D0 (en) * | 1998-05-29 | 1998-07-29 | Photonic Research Systems Limi | Luminescence assay using cyclical excitation wavelength sequence |
| US5998146A (en) * | 1998-07-17 | 1999-12-07 | Wallac Oy | Homogeneous luminescence assay method based on energy transfer |
| WO2000047693A1 (en) * | 1999-02-12 | 2000-08-17 | Ljl Biosystems, Inc. | Luminescent metal-ligand complexes |
-
2001
- 2001-11-14 EP EP01996741A patent/EP1337851B1/de not_active Expired - Lifetime
- 2001-11-14 JP JP2002542878A patent/JP3905838B2/ja not_active Expired - Fee Related
- 2001-11-14 AT AT01996741T patent/ATE300050T1/de active
- 2001-11-14 US US10/432,132 patent/US6908769B2/en not_active Expired - Fee Related
- 2001-11-14 WO PCT/EP2001/013152 patent/WO2002041001A1/de not_active Ceased
- 2001-11-14 DE DE50106822T patent/DE50106822D1/de not_active Expired - Lifetime
- 2001-11-14 AU AU2002221848A patent/AU2002221848A1/en not_active Abandoned
- 2001-11-14 ES ES01996741T patent/ES2245995T3/es not_active Expired - Lifetime
- 2001-11-14 CA CA002426479A patent/CA2426479C/en not_active Expired - Fee Related
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