JP2004512810A5 - - Google Patents

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Publication number
JP2004512810A5
JP2004512810A5 JP2001520859A JP2001520859A JP2004512810A5 JP 2004512810 A5 JP2004512810 A5 JP 2004512810A5 JP 2001520859 A JP2001520859 A JP 2001520859A JP 2001520859 A JP2001520859 A JP 2001520859A JP 2004512810 A5 JP2004512810 A5 JP 2004512810A5
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JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001520859A
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English (en)
Japanese (ja)
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JP2004512810A (ja
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Publication date
Priority claimed from US09/474,432 external-priority patent/US6528640B1/en
Priority claimed from US09/476,387 external-priority patent/US6617438B1/en
Application filed filed Critical
Priority claimed from PCT/US2000/023998 external-priority patent/WO2001016312A2/en
Publication of JP2004512810A publication Critical patent/JP2004512810A/ja
Publication of JP2004512810A5 publication Critical patent/JP2004512810A5/ja
Pending legal-status Critical Current

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JP2001520859A 1999-08-31 2000-08-30 核酸に基づく遺伝子発現の調節剤 Pending JP2004512810A (ja)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US15171399P 1999-08-31 1999-08-31
US40664399A 1999-09-27 1999-09-27
US15646799P 1999-09-27 1999-09-27
US15623699P 1999-09-27 1999-09-27
US43643099A 1999-11-08 1999-11-08
US16910099P 1999-12-06 1999-12-06
US17361299P 1999-12-29 1999-12-29
US09/474,432 US6528640B1 (en) 1997-11-05 1999-12-29 Synthetic ribonucleic acids with RNAse activity
US09/476,387 US6617438B1 (en) 1997-11-05 1999-12-30 Oligoribonucleotides with enzymatic activity
US49882400A 2000-02-04 2000-02-04
US53102500A 2000-03-20 2000-03-20
US19776900P 2000-04-14 2000-04-14
US57822300A 2000-05-23 2000-05-23
US63638500A 2000-08-09 2000-08-09
PCT/US2000/023998 WO2001016312A2 (en) 1999-08-31 2000-08-30 Nucleic acid based modulators of gene expression

Publications (2)

Publication Number Publication Date
JP2004512810A JP2004512810A (ja) 2004-04-30
JP2004512810A5 true JP2004512810A5 (OSRAM) 2005-01-06

Family

ID=27585071

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001520859A Pending JP2004512810A (ja) 1999-08-31 2000-08-30 核酸に基づく遺伝子発現の調節剤

Country Status (4)

Country Link
EP (1) EP1212416A2 (OSRAM)
JP (1) JP2004512810A (OSRAM)
CA (1) CA2403243A1 (OSRAM)
WO (1) WO2001016312A2 (OSRAM)

Families Citing this family (54)

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US6617438B1 (en) * 1997-11-05 2003-09-09 Sirna Therapeutics, Inc. Oligoribonucleotides with enzymatic activity
US6482932B1 (en) * 1997-11-05 2002-11-19 Ribozyme Pharmaceuticals, Incorporated Nucleoside triphosphates and their incorporation into oligonucleotides
US7179796B2 (en) 2000-01-18 2007-02-20 Isis Pharmaceuticals, Inc. Antisense modulation of PTP1B expression
US20020055479A1 (en) * 2000-01-18 2002-05-09 Cowsert Lex M. Antisense modulation of PTP1B expression
US20030190635A1 (en) * 2002-02-20 2003-10-09 Mcswiggen James A. RNA interference mediated treatment of Alzheimer's disease using short interfering RNA
US7125660B2 (en) 2000-09-13 2006-10-24 Archemix Corp. Nucleic acid sensor molecules and methods of using same
US9994853B2 (en) 2001-05-18 2018-06-12 Sirna Therapeutics, Inc. Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
WO2003070983A1 (en) * 2002-02-20 2003-08-28 Sirna Therapeutics, Inc RNA INTERFERENCE MEDIATED INHIBITION OF PROTEIN KINASE C ALPHA (PKC-ALPHA) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
EP1390472A4 (en) * 2001-05-29 2004-11-17 Sirna Therapeutics Inc NUCLEIC ACID TREATMENT OF DISEASES OR SIDES RELATED TO RAS, HER2 AND HIV LEVELS
CA2478681A1 (en) * 2001-10-22 2003-05-01 University Of Rochester Telomerase interference
US9657294B2 (en) 2002-02-20 2017-05-23 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US9181551B2 (en) 2002-02-20 2015-11-10 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
AU2003215161A1 (en) * 2002-02-20 2003-09-09 Ribozyme Pharmaceuticals, Inc. RNA INTERFERENCE MEDIATED INHIBITION OF TELOMERASE GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
WO2003097815A2 (en) * 2002-05-17 2003-11-27 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention Molecular identification of aspergillus species
US7507808B2 (en) 2002-12-12 2009-03-24 Isis Pharmaceuticals, Inc. Modulation of endothelial lipase expression
US7618948B2 (en) 2002-11-26 2009-11-17 Medtronic, Inc. Devices, systems and methods for improving and/or cognitive function through brain delivery of siRNA
US7605249B2 (en) 2002-11-26 2009-10-20 Medtronic, Inc. Treatment of neurodegenerative disease through intracranial delivery of siRNA
US7829694B2 (en) * 2002-11-26 2010-11-09 Medtronic, Inc. Treatment of neurodegenerative disease through intracranial delivery of siRNA
FR2848573B1 (fr) * 2002-12-13 2005-04-08 Exonhit Therapeutics Sa Compositions et methodes pour la detection et le traitement de pathologies neurodegeneratives
US7994149B2 (en) 2003-02-03 2011-08-09 Medtronic, Inc. Method for treatment of Huntington's disease through intracranial delivery of sirna
US7846906B2 (en) 2003-02-28 2010-12-07 Isis Pharmaceuticals, Inc. Modulation of growth hormone receptor expression and insulin-like growth factor expression
US7803781B2 (en) 2003-02-28 2010-09-28 Isis Pharmaceuticals, Inc. Modulation of growth hormone receptor expression and insulin-like growth factor expression
AU2003225410A1 (en) 2003-03-21 2004-10-11 Academisch Ziekenhuis Leiden Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure
EP1732945B1 (en) * 2004-04-08 2014-12-24 Sangamo BioSciences, Inc. Methods and compositions for modulating cardiac contractility
US10508277B2 (en) 2004-05-24 2019-12-17 Sirna Therapeutics, Inc. Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
WO2006064519A2 (en) * 2004-12-14 2006-06-22 National Institute Of Immunology Dnazymes for inhibition of japanese encephalitis virus replication
JP2008532950A (ja) 2005-03-08 2008-08-21 バイオタ サイエンティフィック マネージメント ピーティーワイ リミテッド 治療薬としての二環式ヌクレオシドおよび二環式ヌクレオチド
US9133517B2 (en) 2005-06-28 2015-09-15 Medtronics, Inc. Methods and sequences to preferentially suppress expression of mutated huntingtin
US9273356B2 (en) 2006-05-24 2016-03-01 Medtronic, Inc. Methods and kits for linking polymorphic sequences to expanded repeat mutations
WO2008017473A2 (en) 2006-08-08 2008-02-14 Gunther Hartmann Structure and use of 5' phosphate oligonucleotides
US9375440B2 (en) 2006-11-03 2016-06-28 Medtronic, Inc. Compositions and methods for making therapies delivered by viral vectors reversible for safety and allele-specificity
USRE48468E1 (en) 2007-10-26 2021-03-16 Biomarin Technologies B.V. Means and methods for counteracting muscle disorders
PL2203173T3 (pl) 2007-10-26 2016-06-30 Academisch Ziekenhuis Leiden Środki i sposoby przeciwdziałania zaburzeniom mięśni
EP2119783A1 (en) 2008-05-14 2009-11-18 Prosensa Technologies B.V. Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means
US9738680B2 (en) 2008-05-21 2017-08-22 Rheinische Friedrich-Wilhelms-Universität Bonn 5′ triphosphate oligonucleotide with blunt end and uses thereof
WO2010123369A1 (en) 2009-04-24 2010-10-28 Prosensa Technologies B.V. Oligonucleotide comprising an inosine for treating dmd
JP5892938B2 (ja) 2009-10-16 2016-03-30 グラクソ グループ リミテッドGlaxo Group Limited Hbvアンチセンス阻害剤
JP6106085B2 (ja) 2010-08-24 2017-03-29 サーナ・セラピューティクス・インコーポレイテッドSirna Therapeutics,Inc. 内部非核酸スペーサーを含む一本鎖RNAi剤
ES2663009T3 (es) 2010-10-29 2018-04-10 Sirna Therapeutics, Inc. Inhibición de la expresión génica mediada por interferencia por ARN utilizando ácidos nucleicos de interferencia cortos (ANic)
WO2012066549A1 (en) * 2010-11-15 2012-05-24 Ramot At Tel-Aviv University Ltd. Dipeptide analogs for treating conditions associated with amyloid fibril formation
EP2508530A1 (en) 2011-03-28 2012-10-10 Rheinische Friedrich-Wilhelms-Universität Bonn Purification of triphosphorylated oligonucleotides using capture tags
AU2012242642A1 (en) 2011-04-13 2013-05-02 Ionis Pharmaceuticals, Inc. Antisense modulation of PTP1B expression
EP3505528B1 (en) 2011-04-21 2020-11-25 Ionis Pharmaceuticals, Inc. Modulation of hepatitis b virus (hbv) expression
JP2015509922A (ja) 2012-01-27 2015-04-02 プロセンサ テクノロジーズ ビー.ブイ.Prosensa Technologies B.V. デュシェンヌ型及びベッカー型筋ジストロフィーの治療のための改善された特徴を有するrna調節オリゴヌクレオチド
JP2015528013A (ja) * 2012-07-27 2015-09-24 ビアル−ポルテラ エ コンパニア,ソシエダッド アノニマ 置換ウレア化合物の合成方法
EP2712870A1 (en) 2012-09-27 2014-04-02 Rheinische Friedrich-Wilhelms-Universität Bonn Novel RIG-I ligands and methods for producing them
GB201408623D0 (en) 2014-05-15 2014-07-02 Santaris Pharma As Oligomers and oligomer conjugates
DE102015113038B3 (de) * 2015-07-13 2017-01-19 Simone Kann Oligonucleotide und deren Verwendung
EP3350328A1 (en) * 2015-09-14 2018-07-25 Alnylam Pharmaceuticals, Inc. Polynucleotide agents targeting patatin-like phospholipase domain containing 3 (pnpla3) and methods of use thereof
WO2019079195A1 (en) * 2017-10-16 2019-04-25 University Of Pittsburgh - Of The Commonwealth System Of Higher Education GENETICALLY MODIFIED MESENCHYMAL STEM CELLS FOR USE IN CARDIOVASCULAR PROSTHESES
GB201817990D0 (en) 2018-11-02 2018-12-19 Univ Of Essex Enterprise Limited Enzymatic nucleic acid molecules
JP2024506351A (ja) * 2021-02-11 2024-02-13 アイオーニス ファーマシューティカルズ, インコーポレーテッド Plnの発現を低減するための化合物及び方法
US12409230B2 (en) * 2023-06-30 2025-09-09 Avidity Biosciences, Inc. Compositions comprising PLN-targeting anti-transferrin receptor antibody-polynucleotides and methods of use thereof to treat cardiomyopathy

Family Cites Families (3)

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WO1997026270A2 (en) * 1996-01-16 1997-07-24 Ribozyme Pharmaceuticals, Inc. Synthesis of methoxy nucleosides and enzymatic nucleic acid molecules
EP0902836A4 (en) * 1996-04-02 2004-12-22 Gene Shears Pty Ltd HAMMER HEAD ASYMMETRIC RIBOZYMES
EP2275546A3 (en) * 1997-04-29 2013-06-05 The Scripps Research Institute Enzymatic DNA molecules

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