JP2004510847A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004510847A5 JP2004510847A5 JP2002532495A JP2002532495A JP2004510847A5 JP 2004510847 A5 JP2004510847 A5 JP 2004510847A5 JP 2002532495 A JP2002532495 A JP 2002532495A JP 2002532495 A JP2002532495 A JP 2002532495A JP 2004510847 A5 JP2004510847 A5 JP 2004510847A5
- Authority
- JP
- Japan
- Prior art keywords
- polymerization
- reaction
- initiator
- water
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000006116 polymerization reaction Methods 0.000 description 140
- 239000000178 monomer Substances 0.000 description 131
- 238000006243 chemical reaction Methods 0.000 description 120
- 239000003999 initiator Substances 0.000 description 116
- 229920000642 polymer Polymers 0.000 description 91
- 238000000034 method Methods 0.000 description 80
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 66
- 229910052723 transition metal Inorganic materials 0.000 description 55
- 239000000243 solution Substances 0.000 description 54
- 150000003624 transition metals Chemical class 0.000 description 53
- 239000003446 ligand Substances 0.000 description 52
- 239000000203 mixture Substances 0.000 description 47
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 45
- 238000010560 atom transfer radical polymerization reaction Methods 0.000 description 43
- 125000000524 functional group Chemical group 0.000 description 40
- 150000003254 radicals Chemical class 0.000 description 40
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 38
- IVRMZWNICZWHMI-UHFFFAOYSA-N azide group Chemical group [N-]=[N+]=[N-] IVRMZWNICZWHMI-UHFFFAOYSA-N 0.000 description 37
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 36
- 238000007323 disproportionation reaction Methods 0.000 description 35
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 33
- 239000002904 solvent Substances 0.000 description 32
- 239000010949 copper Substances 0.000 description 29
- JKNCOURZONDCGV-UHFFFAOYSA-N 2-(dimethylamino)ethyl 2-methylprop-2-enoate Chemical compound CN(C)CCOC(=O)C(C)=C JKNCOURZONDCGV-UHFFFAOYSA-N 0.000 description 28
- 125000004429 atom Chemical group 0.000 description 25
- 229920001400 block copolymer Polymers 0.000 description 24
- 239000003054 catalyst Substances 0.000 description 24
- 238000003786 synthesis reaction Methods 0.000 description 24
- 230000015572 biosynthetic process Effects 0.000 description 23
- 229920001223 polyethylene glycol Polymers 0.000 description 23
- 150000001540 azides Chemical class 0.000 description 22
- 238000012546 transfer Methods 0.000 description 22
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 description 20
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 20
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 18
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 18
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 17
- 238000002474 experimental method Methods 0.000 description 17
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 16
- 230000003647 oxidation Effects 0.000 description 16
- 238000007254 oxidation reaction Methods 0.000 description 16
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 15
- 229910052802 copper Inorganic materials 0.000 description 15
- 239000011541 reaction mixture Substances 0.000 description 15
- 229910002476 CuII Inorganic materials 0.000 description 14
- XLYOFNOQVPJJNP-ZSJDYOACSA-N Heavy water Chemical compound [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 14
- 238000004519 manufacturing process Methods 0.000 description 14
- 239000000463 material Substances 0.000 description 14
- -1 transition metal salts Chemical class 0.000 description 14
- 150000002148 esters Chemical class 0.000 description 13
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 12
- 239000002253 acid Substances 0.000 description 12
- 239000000047 product Substances 0.000 description 12
- 238000010526 radical polymerization reaction Methods 0.000 description 12
- ZPAICLPTNKAJHB-UHFFFAOYSA-M sodium;4-ethenylbenzoate Chemical compound [Na+].[O-]C(=O)C1=CC=C(C=C)C=C1 ZPAICLPTNKAJHB-UHFFFAOYSA-M 0.000 description 12
- 238000003756 stirring Methods 0.000 description 11
- 125000001424 substituent group Chemical group 0.000 description 11
- 238000005160 1H NMR spectroscopy Methods 0.000 description 10
- BSULWPSUVMOMAN-UHFFFAOYSA-N 2-azidoethanol Chemical compound OCCN=[N+]=[N-] BSULWPSUVMOMAN-UHFFFAOYSA-N 0.000 description 10
- 102100026735 Coagulation factor VIII Human genes 0.000 description 10
- 229910021591 Copper(I) chloride Inorganic materials 0.000 description 10
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 10
- OXBLHERUFWYNTN-UHFFFAOYSA-M copper(I) chloride Chemical compound [Cu]Cl OXBLHERUFWYNTN-UHFFFAOYSA-M 0.000 description 10
- 230000000977 initiatory effect Effects 0.000 description 10
- 230000008569 process Effects 0.000 description 10
- 150000003839 salts Chemical class 0.000 description 10
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 9
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 9
- 125000002091 cationic group Chemical group 0.000 description 9
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
- 239000003153 chemical reaction reagent Substances 0.000 description 8
- 239000000306 component Substances 0.000 description 8
- SHFJWMWCIHQNCP-UHFFFAOYSA-M hydron;tetrabutylazanium;sulfate Chemical compound OS([O-])(=O)=O.CCCC[N+](CCCC)(CCCC)CCCC SHFJWMWCIHQNCP-UHFFFAOYSA-M 0.000 description 8
- 239000003444 phase transfer catalyst Substances 0.000 description 8
- 238000006479 redox reaction Methods 0.000 description 8
- 239000007787 solid Substances 0.000 description 8
- 239000002202 Polyethylene glycol Substances 0.000 description 7
- 238000010521 absorption reaction Methods 0.000 description 7
- IOLQWGVDEFWYNP-UHFFFAOYSA-N ethyl 2-bromo-2-methylpropanoate Chemical compound CCOC(=O)C(C)(C)Br IOLQWGVDEFWYNP-UHFFFAOYSA-N 0.000 description 7
- 238000005755 formation reaction Methods 0.000 description 7
- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 description 7
- 230000000379 polymerizing effect Effects 0.000 description 7
- 239000002244 precipitate Substances 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 150000003623 transition metal compounds Chemical class 0.000 description 7
- 229920003169 water-soluble polymer Polymers 0.000 description 7
- IRQWEODKXLDORP-UHFFFAOYSA-N 4-ethenylbenzoic acid Chemical compound OC(=O)C1=CC=C(C=C)C=C1 IRQWEODKXLDORP-UHFFFAOYSA-N 0.000 description 6
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 6
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 6
- 238000005481 NMR spectroscopy Methods 0.000 description 6
- 150000001412 amines Chemical group 0.000 description 6
- 150000003863 ammonium salts Chemical class 0.000 description 6
- 239000007864 aqueous solution Substances 0.000 description 6
- 229920001577 copolymer Polymers 0.000 description 6
- 238000009826 distribution Methods 0.000 description 6
- MBZXZCVEFCLXRV-UHFFFAOYSA-N ethyl 2-azido-2-methylpropanoate Chemical compound CCOC(=O)C(C)(C)N=[N+]=[N-] MBZXZCVEFCLXRV-UHFFFAOYSA-N 0.000 description 6
- 239000005457 ice water Substances 0.000 description 6
- 150000002500 ions Chemical class 0.000 description 6
- 229920002521 macromolecule Polymers 0.000 description 6
- UKODFQOELJFMII-UHFFFAOYSA-N pentamethyldiethylenetriamine Chemical compound CN(C)CCN(C)CCN(C)C UKODFQOELJFMII-UHFFFAOYSA-N 0.000 description 6
- 239000012429 reaction media Substances 0.000 description 6
- FPGGTKZVZWFYPV-UHFFFAOYSA-M tetrabutylammonium fluoride Chemical compound [F-].CCCC[N+](CCCC)(CCCC)CCCC FPGGTKZVZWFYPV-UHFFFAOYSA-M 0.000 description 6
- XXSPGBOGLXKMDU-UHFFFAOYSA-N 2-bromo-2-methylpropanoic acid Chemical compound CC(C)(Br)C(O)=O XXSPGBOGLXKMDU-UHFFFAOYSA-N 0.000 description 5
- GAWAYYRQGQZKCR-UHFFFAOYSA-N 2-chloropropionic acid Chemical compound CC(Cl)C(O)=O GAWAYYRQGQZKCR-UHFFFAOYSA-N 0.000 description 5
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 5
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 5
- 229910052794 bromium Inorganic materials 0.000 description 5
- 230000003197 catalytic effect Effects 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 150000004699 copper complex Chemical class 0.000 description 5
- 230000007423 decrease Effects 0.000 description 5
- 238000001035 drying Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 150000004820 halides Chemical class 0.000 description 5
- 230000001965 increasing effect Effects 0.000 description 5
- 230000003993 interaction Effects 0.000 description 5
- 239000001301 oxygen Substances 0.000 description 5
- 229910052760 oxygen Inorganic materials 0.000 description 5
- 230000002441 reversible effect Effects 0.000 description 5
- 238000007086 side reaction Methods 0.000 description 5
- 238000001228 spectrum Methods 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- KOFFFKMEMKRWMT-UHFFFAOYSA-N 1-azidoethylbenzene Chemical compound [N-]=[N+]=NC(C)C1=CC=CC=C1 KOFFFKMEMKRWMT-UHFFFAOYSA-N 0.000 description 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 4
- MONMFXREYOKQTI-UHFFFAOYSA-N 2-bromopropanoic acid Chemical compound CC(Br)C(O)=O MONMFXREYOKQTI-UHFFFAOYSA-N 0.000 description 4
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- HEMHJVSKTPXQMS-DYCDLGHISA-M Sodium hydroxide-d Chemical compound [Na+].[2H][O-] HEMHJVSKTPXQMS-DYCDLGHISA-M 0.000 description 4
- 125000000129 anionic group Chemical group 0.000 description 4
- 125000000751 azo group Chemical group [*]N=N[*] 0.000 description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 4
- 238000007334 copolymerization reaction Methods 0.000 description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
- 238000010348 incorporation Methods 0.000 description 4
- 230000001404 mediated effect Effects 0.000 description 4
- 239000002609 medium Substances 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- OIRDBPQYVWXNSJ-UHFFFAOYSA-N methyl trifluoromethansulfonate Chemical compound COS(=O)(=O)C(F)(F)F OIRDBPQYVWXNSJ-UHFFFAOYSA-N 0.000 description 4
- 230000011987 methylation Effects 0.000 description 4
- 238000007069 methylation reaction Methods 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 4
- 239000012044 organic layer Substances 0.000 description 4
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 description 4
- 238000001556 precipitation Methods 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 4
- SEDZOYHHAIAQIW-UHFFFAOYSA-N trimethylsilyl azide Chemical compound C[Si](C)(C)N=[N+]=[N-] SEDZOYHHAIAQIW-UHFFFAOYSA-N 0.000 description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 3
- ROFVEXUMMXZLPA-UHFFFAOYSA-N Bipyridyl Chemical group N1=CC=CC=C1C1=CC=CC=N1 ROFVEXUMMXZLPA-UHFFFAOYSA-N 0.000 description 3
- 235000006506 Brasenia schreberi Nutrition 0.000 description 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 3
- 229910021589 Copper(I) bromide Inorganic materials 0.000 description 3
- VMQMZMRVKUZKQL-UHFFFAOYSA-N Cu+ Chemical compound [Cu+] VMQMZMRVKUZKQL-UHFFFAOYSA-N 0.000 description 3
- 238000005033 Fourier transform infrared spectroscopy Methods 0.000 description 3
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 3
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 230000002378 acidificating effect Effects 0.000 description 3
- 229910052782 aluminium Inorganic materials 0.000 description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 239000012736 aqueous medium Substances 0.000 description 3
- 239000000460 chlorine Substances 0.000 description 3
- 229910052801 chlorine Inorganic materials 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 229910001431 copper ion Inorganic materials 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 238000005886 esterification reaction Methods 0.000 description 3
- 239000011888 foil Substances 0.000 description 3
- 230000008014 freezing Effects 0.000 description 3
- 238000007710 freezing Methods 0.000 description 3
- 229920001519 homopolymer Polymers 0.000 description 3
- 230000007062 hydrolysis Effects 0.000 description 3
- 238000006460 hydrolysis reaction Methods 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- AMZGOPVHQLKMPR-UHFFFAOYSA-M methanesulfonate;trimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azanium Chemical compound CS([O-])(=O)=O.CC(=C)C(=O)OCC[N+](C)(C)C AMZGOPVHQLKMPR-UHFFFAOYSA-M 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 230000035484 reaction time Effects 0.000 description 3
- 230000009257 reactivity Effects 0.000 description 3
- 229910052938 sodium sulfate Inorganic materials 0.000 description 3
- 235000011152 sodium sulphate Nutrition 0.000 description 3
- XFTALRAZSCGSKN-UHFFFAOYSA-M sodium;4-ethenylbenzenesulfonate Chemical compound [Na+].[O-]S(=O)(=O)C1=CC=C(C=C)C=C1 XFTALRAZSCGSKN-UHFFFAOYSA-M 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- HSXAMLBRNJRCFI-UHFFFAOYSA-M trifluoromethanesulfonate;trimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azanium Chemical compound [O-]S(=O)(=O)C(F)(F)F.CC(=C)C(=O)OCC[N+](C)(C)C HSXAMLBRNJRCFI-UHFFFAOYSA-M 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- YKPFXAHKQLQHCJ-UHFFFAOYSA-N 1-azidopropan-2-ol Chemical compound CC(O)CN=[N+]=[N-] YKPFXAHKQLQHCJ-UHFFFAOYSA-N 0.000 description 2
- IINOTNZQTDMTGM-UHFFFAOYSA-N 2-azidoethyl 2-bromopropanoate Chemical compound CC(Br)C(=O)OCCN=[N+]=[N-] IINOTNZQTDMTGM-UHFFFAOYSA-N 0.000 description 2
- LDLCZOVUSADOIV-UHFFFAOYSA-N 2-bromoethanol Chemical compound OCCBr LDLCZOVUSADOIV-UHFFFAOYSA-N 0.000 description 2
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 2
- 239000005711 Benzoic acid Substances 0.000 description 2
- SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- 229920000028 Gradient copolymer Polymers 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 150000001350 alkyl halides Chemical class 0.000 description 2
- JWZBOJUPGSZUHH-UHFFFAOYSA-N azidoethane 2-methylpropanoic acid Chemical compound CCN=[N+]=[N-].CC(C)C(O)=O JWZBOJUPGSZUHH-UHFFFAOYSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 235000010233 benzoic acid Nutrition 0.000 description 2
- 238000009739 binding Methods 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000010668 complexation reaction Methods 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 150000001879 copper Chemical class 0.000 description 2
- 238000004132 cross linking Methods 0.000 description 2
- 230000009849 deactivation Effects 0.000 description 2
- 238000007872 degassing Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- OWMBTIRJFMGPAC-UHFFFAOYSA-N dimethylamino 2-methylprop-2-enoate Chemical compound CN(C)OC(=O)C(C)=C OWMBTIRJFMGPAC-UHFFFAOYSA-N 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 239000003480 eluent Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 238000004817 gas chromatography Methods 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000006897 homolysis reaction Methods 0.000 description 2
- 238000011065 in-situ storage Methods 0.000 description 2
- 238000002329 infrared spectrum Methods 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 150000002496 iodine Chemical class 0.000 description 2
- 125000003010 ionic group Chemical group 0.000 description 2
- 238000012886 linear function Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- AMXOYNBUYSYVKV-UHFFFAOYSA-M lithium bromide Chemical compound [Li+].[Br-] AMXOYNBUYSYVKV-UHFFFAOYSA-M 0.000 description 2
- 238000010550 living polymerization reaction Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 description 2
- VUQUOGPMUUJORT-UHFFFAOYSA-N methyl 4-methylbenzenesulfonate Chemical compound COS(=O)(=O)C1=CC=C(C)C=C1 VUQUOGPMUUJORT-UHFFFAOYSA-N 0.000 description 2
- 150000004702 methyl esters Chemical class 0.000 description 2
- MBABOKRGFJTBAE-UHFFFAOYSA-N methyl methanesulfonate Chemical compound COS(C)(=O)=O MBABOKRGFJTBAE-UHFFFAOYSA-N 0.000 description 2
- 239000012022 methylating agents Substances 0.000 description 2
- 230000001035 methylating effect Effects 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 239000013110 organic ligand Substances 0.000 description 2
- 239000011698 potassium fluoride Substances 0.000 description 2
- 235000003270 potassium fluoride Nutrition 0.000 description 2
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 2
- 229920005604 random copolymer Polymers 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 150000003871 sulfonates Chemical class 0.000 description 2
- SYZCZDCAEVUSPM-UHFFFAOYSA-M tetrahexylazanium;bromide Chemical compound [Br-].CCCCCC[N+](CCCCCC)(CCCCCC)CCCCCC SYZCZDCAEVUSPM-UHFFFAOYSA-M 0.000 description 2
- 238000004448 titration Methods 0.000 description 2
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 2
- USFMMZYROHDWPJ-UHFFFAOYSA-N trimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azanium Chemical class CC(=C)C(=O)OCC[N+](C)(C)C USFMMZYROHDWPJ-UHFFFAOYSA-N 0.000 description 2
- XIXDXIUWZQJVHJ-UHFFFAOYSA-M trimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azanium;iodide Chemical compound [I-].CC(=C)C(=O)OCC[N+](C)(C)C XIXDXIUWZQJVHJ-UHFFFAOYSA-M 0.000 description 2
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 description 1
- AZUYLZMQTIKGSC-UHFFFAOYSA-N 1-[6-[4-(5-chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methylindazol-5-yl)pyrazol-1-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one Chemical compound ClC=1C(=C2C=NNC2=CC=1C)C=1C(=NN(C=1C)C1CC2(CN(C2)C(C=C)=O)C1)C=1C=C2C=NN(C2=CC=1)C AZUYLZMQTIKGSC-UHFFFAOYSA-N 0.000 description 1
- FIESNUCMUZFYRR-UHFFFAOYSA-N 2-(2-bromopropanoyloxy)propyl-diazonioazanide Chemical compound N#[N+][N-]CC(C)OC(=O)C(C)Br FIESNUCMUZFYRR-UHFFFAOYSA-N 0.000 description 1
- OZAIFHULBGXAKX-UHFFFAOYSA-N 2-(2-cyanopropan-2-yldiazenyl)-2-methylpropanenitrile Chemical compound N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 description 1
- RIVUDQMCBGGPRV-UHFFFAOYSA-N 2-azidopropan-1-ol Chemical compound OCC(C)N=[N+]=[N-] RIVUDQMCBGGPRV-UHFFFAOYSA-N 0.000 description 1
- ILLHORFDXDLILE-UHFFFAOYSA-N 2-bromopropanoyl bromide Chemical compound CC(Br)C(Br)=O ILLHORFDXDLILE-UHFFFAOYSA-N 0.000 description 1
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
- BTIOTEXEMRKBPQ-UHFFFAOYSA-N 4-azido-2-bromo-2,3-dimethylbutanoic acid Chemical compound CC(CN=[N+]=[N-])C(C)(C(=O)O)Br BTIOTEXEMRKBPQ-UHFFFAOYSA-N 0.000 description 1
- OZAIFHULBGXAKX-VAWYXSNFSA-N AIBN Substances N#CC(C)(C)\N=N\C(C)(C)C#N OZAIFHULBGXAKX-VAWYXSNFSA-N 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- 229910021592 Copper(II) chloride Inorganic materials 0.000 description 1
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 101100379079 Emericella variicolor andA gene Proteins 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 102100037924 Insulin-like growth factor 2 mRNA-binding protein 1 Human genes 0.000 description 1
- 101710126181 Insulin-like growth factor 2 mRNA-binding protein 1 Proteins 0.000 description 1
- VVBXKASDRZXWON-UHFFFAOYSA-N N=[PH3] Chemical compound N=[PH3] VVBXKASDRZXWON-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- OKJPEAGHQZHRQV-UHFFFAOYSA-N Triiodomethane Natural products IC(I)I OKJPEAGHQZHRQV-UHFFFAOYSA-N 0.000 description 1
- IXKSXJFAGXLQOQ-XISFHERQSA-N WHWLQLKPGQPMY Chemical compound C([C@@H](C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)NC(=O)[C@@H](N)CC=1C2=CC=CC=C2NC=1)C1=CNC=N1 IXKSXJFAGXLQOQ-XISFHERQSA-N 0.000 description 1
- LZPHUOHZNMEPCJ-UHFFFAOYSA-N [azido(phenyl)methyl] acetate Chemical compound C(C)(=O)OC(C1=CC=CC=C1)N=[N+]=[N-] LZPHUOHZNMEPCJ-UHFFFAOYSA-N 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000002168 alkylating agent Substances 0.000 description 1
- 229940100198 alkylating agent Drugs 0.000 description 1
- 230000002152 alkylating effect Effects 0.000 description 1
- 238000005275 alloying Methods 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 229920000469 amphiphilic block copolymer Polymers 0.000 description 1
- 150000001649 bromium compounds Chemical class 0.000 description 1
- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 150000001768 cations Chemical group 0.000 description 1
- 150000001805 chlorine compounds Chemical class 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 210000001520 comb Anatomy 0.000 description 1
- 238000010960 commercial process Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 230000000536 complexating effect Effects 0.000 description 1
- 239000008139 complexing agent Substances 0.000 description 1
- 239000004567 concrete Substances 0.000 description 1
- 150000004696 coordination complex Chemical class 0.000 description 1
- 230000037029 cross reaction Effects 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000000412 dendrimer Substances 0.000 description 1
- 229920000736 dendritic polymer Polymers 0.000 description 1
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical group CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
- VAYGXNSJCAHWJZ-UHFFFAOYSA-N dimethyl sulfate Chemical compound COS(=O)(=O)OC VAYGXNSJCAHWJZ-UHFFFAOYSA-N 0.000 description 1
- 238000001663 electronic absorption spectrum Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 229920001002 functional polymer Polymers 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 229920000578 graft copolymer Polymers 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 231100000086 high toxicity Toxicity 0.000 description 1
- 238000010505 homolytic fission reaction Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-M iodide Chemical compound [I-] XMBWDFGMSWQBCA-UHFFFAOYSA-M 0.000 description 1
- 150000004694 iodide salts Chemical class 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 150000002497 iodine compounds Chemical class 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- KQNPFQTWMSNSAP-UHFFFAOYSA-M isobutyrate Chemical compound CC(C)C([O-])=O KQNPFQTWMSNSAP-UHFFFAOYSA-M 0.000 description 1
- KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical group CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 239000012280 lithium aluminium hydride Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000008204 material by function Substances 0.000 description 1
- 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- OKKJLVBELUTLKV-VMNATFBRSA-N methanol-d1 Chemical compound [2H]OC OKKJLVBELUTLKV-VMNATFBRSA-N 0.000 description 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000013365 molecular weight analysis method Methods 0.000 description 1
- WHQSYGRFZMUQGQ-UHFFFAOYSA-N n,n-dimethylformamide;hydrate Chemical compound O.CN(C)C=O WHQSYGRFZMUQGQ-UHFFFAOYSA-N 0.000 description 1
- 238000012705 nitroxide-mediated radical polymerization Methods 0.000 description 1
- 239000012454 non-polar solvent Substances 0.000 description 1
- 230000000269 nucleophilic effect Effects 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 229940045681 other alkylating agent in atc Drugs 0.000 description 1
- 150000002924 oxiranes Chemical class 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 229940049953 phenylacetate Drugs 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- AQSJGOWTSHOLKH-UHFFFAOYSA-N phosphite(3-) Chemical class [O-]P([O-])[O-] AQSJGOWTSHOLKH-UHFFFAOYSA-N 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- OENLEHTYJXMVBG-UHFFFAOYSA-N pyridine;hydrate Chemical compound [OH-].C1=CC=[NH+]C=C1 OENLEHTYJXMVBG-UHFFFAOYSA-N 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- OIIWPAYIXDCDNL-UHFFFAOYSA-M sodium 3-(trimethylsilyl)propionate Chemical class [Na+].C[Si](C)(C)CCC([O-])=O OIIWPAYIXDCDNL-UHFFFAOYSA-M 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- SONHXMAHPHADTF-UHFFFAOYSA-M sodium;2-methylprop-2-enoate Chemical compound [Na+].CC(=C)C([O-])=O SONHXMAHPHADTF-UHFFFAOYSA-M 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 238000007614 solvation Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 229920006250 telechelic polymer Polymers 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 238000006276 transfer reaction Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23880900P | 2000-10-06 | 2000-10-06 | |
| US60/238,809 | 2000-10-06 | ||
| PCT/US2001/031323 WO2002028913A2 (en) | 2000-10-06 | 2001-10-05 | Polymerization process for ionic monomers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008182957A Division JP2009013414A (ja) | 2000-10-06 | 2008-07-14 | イオンモノマーの重合方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004510847A JP2004510847A (ja) | 2004-04-08 |
| JP2004510847A5 true JP2004510847A5 (enExample) | 2012-05-10 |
| JP5005155B2 JP5005155B2 (ja) | 2012-08-22 |
Family
ID=22899396
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002532495A Expired - Fee Related JP5005155B2 (ja) | 2000-10-06 | 2001-10-05 | イオンモノマーの重合方法 |
| JP2008182957A Pending JP2009013414A (ja) | 2000-10-06 | 2008-07-14 | イオンモノマーの重合方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008182957A Pending JP2009013414A (ja) | 2000-10-06 | 2008-07-14 | イオンモノマーの重合方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US6624262B2 (enExample) |
| EP (2) | EP1337563B1 (enExample) |
| JP (2) | JP5005155B2 (enExample) |
| AU (1) | AU2002216619A1 (enExample) |
| DE (1) | DE60125409T2 (enExample) |
| WO (1) | WO2002028913A2 (enExample) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5807937A (en) | 1995-11-15 | 1998-09-15 | Carnegie Mellon University | Processes based on atom (or group) transfer radical polymerization and novel (co) polymers having useful structures and properties |
| US7125938B2 (en) * | 1997-03-11 | 2006-10-24 | Carnegie Mellon University | Atom or group transfer radical polymerization |
| JP5264030B2 (ja) * | 1999-03-23 | 2013-08-14 | カーネギー−メロン ユニバーシティ | フリーラジカル的に（共）重合可能なモノマーの制御された重合のための触媒法、およびそれによって製造される官能性高分子系 |
| US7049373B2 (en) * | 1999-08-06 | 2006-05-23 | Carnegie Mellon University | Process for preparation of graft polymers |
| US7332550B2 (en) * | 2000-10-06 | 2008-02-19 | Carnegie Mellon University | Stabilization of transition metal complexes for catalysis in diverse environments |
| AU2001296670A1 (en) | 2000-10-06 | 2002-04-15 | Carnegie-Mellon University | A catalyst system for controlled polymerization |
| AU2002307151A1 (en) * | 2001-04-06 | 2002-10-21 | Carnegie Mellon University | A process for the preparation of nanostructured materials |
| WO2002090409A2 (fr) * | 2001-05-04 | 2002-11-14 | Rhodia Chimie | Copolymeres a blocs tensioactifs prepares par polymerisation radicalaire controlee |
| WO2003031481A2 (en) * | 2001-10-12 | 2003-04-17 | Carnegie Mellon University | Simultaneous reverse and normal initiation of atrp |
| US7064166B2 (en) * | 2001-10-12 | 2006-06-20 | Carnegie Mellon University | Process for monomer sequence control in polymerizations |
| US20030216528A1 (en) * | 2002-03-13 | 2003-11-20 | Krzysztof Matyjaszewski | Novel (co)polymers and a novel polymerization process based on atom (or group) transfer radical polymerization |
| US7300991B2 (en) * | 2002-03-27 | 2007-11-27 | Hitachi, Ltd. | Cationic conductor, its intermediate, and lithium secondary battery using the conductor |
| EP1534764B1 (en) * | 2002-08-09 | 2014-07-16 | Carnegie Mellon University | Polymers, supersoft elastomers and methods for preparing the same |
| US7893174B2 (en) | 2004-03-05 | 2011-02-22 | Carnegie Mellon University | Atom transfer radical polymerization process |
| US7795355B2 (en) * | 2004-03-05 | 2010-09-14 | Carnegie Mellon University | Preparation of functional polymers |
| US7902321B2 (en) * | 2004-11-17 | 2011-03-08 | Cornell Research Foundation, Inc. | One-pot, one-step in situ living polymerization from silicate anchored multifunctional initiator |
| EP1833958A4 (en) * | 2005-01-04 | 2009-01-14 | Intezyne Technologies Inc | SYNTHESIS OF HYBRID BLOCK COPOLYMERS AND USES THEREOF |
| EP1928919B1 (en) | 2005-08-23 | 2010-02-17 | Carnegie-Mellon University | Atom transfer radical polymerization in microemulsion and true emulsion polymerization |
| CN101379091B (zh) * | 2005-08-26 | 2012-05-30 | 卡内基梅隆大学 | 在催化剂再生下的聚合方法 |
| US20070123646A1 (en) * | 2005-09-13 | 2007-05-31 | Lele Bhalchandra S | Protein-polymer conjugates and synthesis thereof |
| US7914844B2 (en) * | 2005-11-18 | 2011-03-29 | Northwestern University | Stable dispersions of polymer-coated graphitic nanoplatelets |
| FI20051226A7 (fi) | 2005-12-01 | 2007-06-02 | Upm Kymmene Oyj | Nanorakenteinen hylkivä kuitumateriaali |
| KR100738580B1 (ko) * | 2005-12-23 | 2007-07-11 | 제일모직주식회사 | 스티렌계 고분자-실리카 나노복합체의 제조방법 |
| EP1988910B1 (en) | 2006-02-28 | 2017-12-06 | Kodiak Sciences Inc. | Acryloyloxyethylphosphorylcholine containing polymer conjugates and their preparation |
| US8349410B2 (en) * | 2006-08-17 | 2013-01-08 | University of Pittsburgh—of the Commonwealth System of Higher Education | Modification of surfaces with polymers |
| WO2008057163A2 (en) | 2006-10-09 | 2008-05-15 | Carnegie Mellon University | Preparation of functional gel particles with a dual crosslink network |
| GB2463199B (en) | 2007-05-23 | 2012-09-26 | Univ Carnegie Mellon | Atom transfer dispersion polymerization |
| US8865797B2 (en) | 2007-05-23 | 2014-10-21 | Carnegie Mellon University | Hybrid particle composite structures with reduced scattering |
| US20090074709A1 (en) * | 2007-09-14 | 2009-03-19 | Koepsel Richard R | Methods, devices and systems for biocidal surface activity |
| DE102008043666A1 (de) * | 2008-11-12 | 2010-05-20 | Evonik Röhm Gmbh | Verfahren zur Herstellung von AB-Diblockcopolymeren mit einem bimodalen verteilten A-Block |
| US8541621B2 (en) * | 2008-12-05 | 2013-09-24 | Electronics And Telecommunications Research Institute | Polymerization initiator having aryl azide and surface modification method of cyclic olefin copolymer using the same |
| US8822610B2 (en) | 2008-12-22 | 2014-09-02 | ATRP Solutions, Inc. | Control over controlled radical polymerization processes |
| US8815971B2 (en) | 2008-12-22 | 2014-08-26 | ATRP Solutions, Inc. | Control over controlled radical polymerization processes |
| WO2010111708A1 (en) | 2009-03-27 | 2010-09-30 | Carnegie Mellon University | Preparation of functional star macromolecules |
| US8173750B2 (en) | 2009-04-23 | 2012-05-08 | ATRP Solutions, Inc. | Star macromolecules for personal and home care |
| US8569421B2 (en) | 2009-04-23 | 2013-10-29 | ATRP Solutions, Inc. | Star macromolecules for personal and home care |
| US9783628B2 (en) | 2009-04-23 | 2017-10-10 | ATRP Solutions, Inc. | Dual-mechanism thickening agents for hydraulic fracturing fluids |
| WO2011075185A1 (en) | 2009-12-18 | 2011-06-23 | Oligasis | Targeted drug phosphorylcholine polymer conjugates |
| US8816001B2 (en) | 2010-09-10 | 2014-08-26 | Franklin And Marshall College | Genetically encoded initiator for polymer growth from proteins |
| US9587064B2 (en) | 2010-12-08 | 2017-03-07 | ATRP Solutions, Inc. | Salt-tolerant star macromolecules |
| US9644042B2 (en) | 2010-12-17 | 2017-05-09 | Carnegie Mellon University | Electrochemically mediated atom transfer radical polymerization |
| JP5881317B2 (ja) * | 2011-06-14 | 2016-03-09 | Ｋｊケミカルズ株式会社 | 不飽和第４級アンモニウム塩化合物の製造方法及びそれからなる帯電防止剤と帯電防止組成物 |
| US20140275420A1 (en) | 2011-08-22 | 2014-09-18 | Carnegie Mellon University | Atom transfer radical polymerization under biologically compatible conditions |
| US9790305B2 (en) | 2011-09-09 | 2017-10-17 | Franklin And Marshall College | Site specifically incorporated initiator for growth of polymers from proteins |
| WO2013158183A2 (en) | 2012-01-27 | 2013-10-24 | Carnegie Mellon University | Processable self-organizing nanoparticles |
| WO2013126745A2 (en) | 2012-02-23 | 2013-08-29 | Carnegie Mellon University | Ligands designed to provide highly active catalyst complexes |
| ITMI20120808A1 (it) * | 2012-05-11 | 2013-11-12 | Versalis Spa | "procedimento per la preparazione di polibutadiene ramificato ad alto contenuto in unita' 1,4-cis" |
| US8975346B2 (en) | 2012-05-18 | 2015-03-10 | Sabic Global Technologies B.V. | Polycarbonate copolymers via controlled radical polymerization |
| JP6294885B2 (ja) | 2012-08-30 | 2018-03-14 | エーティーアールピー ソリューションズ インコーポレイテッドＡＴＲＰ Ｓｏｌｕｔｉｏｎｓ，Ｉｎｃ． | 星形高分子、星形高分子組成物および星形高分子の製造方法 |
| WO2014116672A1 (en) | 2013-01-22 | 2014-07-31 | Carnegie Mellon University | Lignin-containing polymers and compositions including lignin-containing polymers |
| CA2899349C (en) | 2013-02-04 | 2021-09-21 | ATRP Solutions, Inc. | Salt-tolerant star macromolecules |
| US9765169B2 (en) | 2013-04-18 | 2017-09-19 | Carnegie Mellon University | Functionalized polymer hybrids |
| AU2014269004B2 (en) | 2013-05-22 | 2018-03-15 | Triblue Corporation | Methods of forming a polymer layer on a polymer surface |
| DK3041513T3 (da) | 2013-09-08 | 2020-10-26 | Kodiak Sciences Inc | Zwitterioniske faktor viii-polymerkonjugater |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| MX385886B (es) | 2014-07-03 | 2025-03-18 | Pilot Polymer Tech Inc | Macromoleculas estrellas compatibles con tensoactivos. |
| KR102210104B1 (ko) | 2014-10-17 | 2021-02-01 | 코디악 사이언시스 인코포레이티드 | 부티릴콜린에스테라제 양성이온성 중합체 컨쥬게이트 |
| US9982070B2 (en) | 2015-01-12 | 2018-05-29 | Carnegie Mellon University | Aqueous ATRP in the presence of an activator regenerator |
| US10382746B1 (en) * | 2015-09-22 | 2019-08-13 | Rockwell Collins, Inc. | Stereoscopic augmented reality head-worn display with indicator conforming to a real-world object |
| KR20250057128A (ko) | 2015-12-30 | 2025-04-28 | 코디악 사이언시스 인코포레이티드 | 항체 및 이의 접합체 |
| CN105670343B (zh) * | 2016-01-08 | 2017-05-03 | 厦门大学 | 一种含硅氮阻燃型聚合物染料及其制备方法 |
| WO2017132137A1 (en) | 2016-01-25 | 2017-08-03 | Carnegie Mellon University | Composite composition and modification of inorganic particles for use in composite compositions |
| US10982266B2 (en) | 2016-11-03 | 2021-04-20 | Carnegie Mellon University | Nucleic acid-polymer conjugates for bright fluorescent tags |
| WO2018132696A2 (en) | 2017-01-12 | 2018-07-19 | Russell Alan J | Stomach acid-stable and mucin-binding protein-polymer conjugates |
| WO2018132582A1 (en) | 2017-01-12 | 2018-07-19 | Carnegie Mellon University | Surfactant assisted formation of a catalyst complex for emulsion atom transfer radical polymerization processes |
| CN107540028B (zh) * | 2017-08-16 | 2020-07-10 | 中国石油天然气集团公司 | 一种聚磺钻井废弃物无害化处理剂及其制备方法与应用 |
| MX2020009152A (es) | 2018-03-02 | 2020-11-09 | Kodiak Sciences Inc | Anticuerpos de il-6 y constructos de fusion y conjugados de los mismos. |
| US10853014B2 (en) | 2018-04-17 | 2020-12-01 | Rockwell Collins, Inc. | Head wearable device, system, and method |
| WO2019204799A1 (en) | 2018-04-20 | 2019-10-24 | University Of Pittsburgh -Of The Commonwealth System Of Higher Education | Cationic amphiphilic polymers for codelivery of hydrophobic agents and nucleic acids |
| US11472894B2 (en) | 2018-07-23 | 2022-10-18 | Carnegie Mellon University | Enzyme-assisted ATRP procedures |
| WO2020028715A1 (en) | 2018-08-01 | 2020-02-06 | Russell Alan J | Amino-reactive positively charged atrp initiators that maintain their positive charge during synthesis of biomacro-initiators |
| CA3112451A1 (en) | 2018-10-12 | 2020-04-16 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Small polymeric carriers for delivery of agents |
| CN114786731A (zh) | 2019-10-10 | 2022-07-22 | 科达制药股份有限公司 | 治疗眼部病症的方法 |
| US20250188325A1 (en) * | 2022-04-22 | 2025-06-12 | Purdue Research Foundation | Positively charged adhesives |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62292806A (ja) * | 1986-06-10 | 1987-12-19 | イ−・アイ・デユポン・ド・ネモア−ス・アンド・コンパニ− | 原子団移動重合法およびリビングポリマ− |
| GB8803765D0 (en) * | 1988-02-18 | 1988-03-16 | Ici Plc | Polymerisation process |
| US5444135A (en) * | 1992-12-17 | 1995-08-22 | Exxon Chemical Patents Inc. | Direct synthesis by living cationic polymerization of nitrogen-containing polymers |
| US5763548A (en) | 1995-03-31 | 1998-06-09 | Carnegie-Mellon University | (Co)polymers and a novel polymerization process based on atom (or group) transfer radical polymerization |
| US5807937A (en) * | 1995-11-15 | 1998-09-15 | Carnegie Mellon University | Processes based on atom (or group) transfer radical polymerization and novel (co) polymers having useful structures and properties |
| US5789487A (en) * | 1996-07-10 | 1998-08-04 | Carnegie-Mellon University | Preparation of novel homo- and copolymers using atom transfer radical polymerization |
| US5886118C1 (en) * | 1997-04-14 | 2001-02-20 | Univ Case Western Reserve | Process for polymerizing acrylonitrile |
| FR2771407B1 (fr) * | 1997-11-25 | 2001-06-01 | Nalco Chemical Co | Materiau precurseur de ceramique non cuit et procede de preparation d'un materiau ceramique a partir de celui-ci |
| GB9725455D0 (en) | 1997-12-02 | 1998-01-28 | Univ Warwick | Supported polymerisation catalyst |
| US6121371A (en) | 1998-07-31 | 2000-09-19 | Carnegie Mellon University | Application of atom transfer radical polymerization to water-borne polymerization systems |
| US20010047065A1 (en) | 1999-06-03 | 2001-11-29 | Sun-Chueh Kao | Method for preparing a supported catalyst system and its use in a polymerization process |
| US6441066B1 (en) * | 1999-12-16 | 2002-08-27 | Ppg Industries Ohio, Inc. | Pigment dispersions containing dispersants prepared by controlled radical polymerization and having pendent hydrophobic polymeric segments |
-
2001
- 2001-10-05 AU AU2002216619A patent/AU2002216619A1/en not_active Abandoned
- 2001-10-05 US US09/972,260 patent/US6624262B2/en not_active Expired - Lifetime
- 2001-10-05 EP EP01986304A patent/EP1337563B1/en not_active Expired - Lifetime
- 2001-10-05 WO PCT/US2001/031323 patent/WO2002028913A2/en not_active Ceased
- 2001-10-05 JP JP2002532495A patent/JP5005155B2/ja not_active Expired - Fee Related
- 2001-10-05 EP EP06025550A patent/EP1801129A3/en not_active Withdrawn
- 2001-10-05 DE DE60125409T patent/DE60125409T2/de not_active Expired - Lifetime
-
2003
- 2003-07-23 US US10/625,890 patent/US20040044152A1/en not_active Abandoned
-
2008
- 2008-07-14 JP JP2008182957A patent/JP2009013414A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5005155B2 (ja) | イオンモノマーの重合方法 | |
| JP2004510847A5 (enExample) | ||
| CN102099382B (zh) | 用于受控自由基聚合的装置和方法 | |
| US7125938B2 (en) | Atom or group transfer radical polymerization | |
| JP5171248B2 (ja) | 原子移動ラジカル重合法 | |
| EP2257573B1 (en) | Improved controlled radical polymerization processes | |
| EP1322674B1 (en) | Control agents for living-type free radical polymerization, methods of polymerizing, emulsions and polymers with same | |
| JP5597325B2 (ja) | 電子求引性側基を含む活性化及び非活性化モノマーのリビングラジカル重合 | |
| US20110060107A1 (en) | Preparation of functional polymers | |
| EP1399488B1 (en) | Improved heterocycle containing control agents for living-type free radical polymerization | |
| WO2004081020A1 (en) | Transition metal complexes, especially iron complexes, used as a catalyst component in the polymerisation of olefins | |
| CN103354815A (zh) | 对受控自由基聚合工艺的改进控制 | |
| KR20100075904A (ko) | 실란-개질된 공중합체의 제조 방법 | |
| US9862789B2 (en) | Polymerization of diene monomers | |
| JP2003238609A (ja) | ラジカル重合性モノマーから成る重合体の製造方法 | |
| Woodruff et al. | Synthesis of Star Polymers with Epoxide-Containing Highly Branched Cores by Low-Catalyst Concentration Atom Transfer Radical Polymerization and Post-Polymerization Modifications | |
| Matyjaszewski | 1 New catalysts for controlled/living atom transfer radical polymerization (ATRP) | |
| ATRP et al. | ISTANBUL TECHNICAL UNIVERSITY★ INSTITUTE OF SCIENCE AND TECHNOLOGY | |
| VIA | ENGINEERING AND TECHNOLOGY | |
| Gülay | HETEROARM H-SHAPED TERPOLYMERS THROUGH CLICK REACTION |