JP2004509121A - チアゾリジン誘導体および抗真菌剤としてのその使用 - Google Patents

チアゾリジン誘導体および抗真菌剤としてのその使用 Download PDF

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Publication number
JP2004509121A
JP2004509121A JP2002526865A JP2002526865A JP2004509121A JP 2004509121 A JP2004509121 A JP 2004509121A JP 2002526865 A JP2002526865 A JP 2002526865A JP 2002526865 A JP2002526865 A JP 2002526865A JP 2004509121 A JP2004509121 A JP 2004509121A
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JP
Japan
Prior art keywords
phenyl
oxo
methylene
thioxo
branched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2002526865A
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English (en)
Japanese (ja)
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JP2004509121A5 (enExample
Inventor
マイケル・グレン・オーチャード
ジュディ・シャーロット・ノイス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford Glycosciences (UK) Ltd
Original Assignee
Oxford Glycosciences (UK) Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxford Glycosciences (UK) Ltd filed Critical Oxford Glycosciences (UK) Ltd
Publication of JP2004509121A publication Critical patent/JP2004509121A/ja
Publication of JP2004509121A5 publication Critical patent/JP2004509121A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2002526865A 2000-08-31 2001-08-30 チアゾリジン誘導体および抗真菌剤としてのその使用 Pending JP2004509121A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0021419.7A GB0021419D0 (en) 2000-08-31 2000-08-31 Compounds
PCT/GB2001/003860 WO2002022612A1 (en) 2000-08-31 2001-08-30 Thiazolidine derivatives and its use as antifungal agent

Publications (2)

Publication Number Publication Date
JP2004509121A true JP2004509121A (ja) 2004-03-25
JP2004509121A5 JP2004509121A5 (enExample) 2005-03-03

Family

ID=9898614

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002526865A Pending JP2004509121A (ja) 2000-08-31 2001-08-30 チアゾリジン誘導体および抗真菌剤としてのその使用

Country Status (9)

Country Link
US (1) US6740670B2 (enExample)
EP (1) EP1313731B1 (enExample)
JP (1) JP2004509121A (enExample)
AT (1) ATE482954T1 (enExample)
AU (1) AU2001284188A1 (enExample)
DE (1) DE60143165D1 (enExample)
ES (1) ES2353685T3 (enExample)
GB (1) GB0021419D0 (enExample)
WO (1) WO2002022612A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ544820A (en) * 2003-08-11 2009-02-28 Hoffmann La Roche Piperazine with or-substituted phenyl group and their use as GlyT1 inhibitors
KR101166342B1 (ko) 2004-03-15 2012-07-18 얀센 파마슈티카 엔.브이. 아편계 약물 수용체 조절자로서의 신규의 화합물
PL1828154T3 (pl) 2004-12-09 2009-10-30 Hoffmann La Roche Pochodne fenylopiperazynometanonu
MX2007006896A (es) 2004-12-15 2007-06-26 Hoffmann La Roche Fenil-metanonas bi- y triciclicas sustituidas como inhibidores del transportador 1 de glicina (glyt-1) para el tratamiento de la enfermedad de alzheimer.
US7485637B2 (en) 2005-01-04 2009-02-03 Hoffmann-La Roche Inc. Benzoyl-tetrahydropiperidine derivatives
ATE472327T1 (de) 2005-01-07 2010-07-15 Hoffmann La Roche Ä4-(heteroaryl)piperazin-1-ylü-(2,5-substituier e phenyl)methanon-derivate als glycin-transporter 1 (glyt-1) hemmer zur behandlung von neurologischen und neuropsychiatrischen erkrankungen
DE602006007682D1 (de) 2005-01-18 2009-08-20 Hoffmann La Roche 2,5-disubstituierte phenylmethanonderivative als glycintransporter-1-inhibitoren (glyt-1) zur behandlung von neurologischen und neuropsychiatrischen störungen
BRPI0607241A2 (pt) 2005-01-26 2009-08-25 Hoffmann La Roche derivados de fenil metanona e o uso dos mesmos como inibidores do transportador de glicina 1
WO2006082001A1 (en) 2005-02-07 2006-08-10 F.Hoffmann-La Roche Ag Heterocyclic substituted phenyl methanones as inhibitors of the glycine transporter 1
ATE536347T1 (de) 2008-05-20 2011-12-15 Merck Sharp & Dohme Effiziente herstellung heterologer proteine unter verwendung von mannosyltransferaseinhibitoren
US10059723B2 (en) 2011-02-28 2018-08-28 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
US8957066B2 (en) 2011-02-28 2015-02-17 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
RU2662153C1 (ru) * 2017-04-20 2018-07-24 Общество С Ограниченной Ответственностью "Дермавитал Групп" Гибридные эфиры на основе производных тиазолидин-2,4-диона и азолов (1н-1,3-имидазола и 1н-1,3,4-триазола) и их применение
RU2690161C1 (ru) * 2018-06-28 2019-05-31 Общество С Ограниченной Ответственностью "Дермавитал Групп" 3,5-Замещенные производные тиазолидин-2,4-диона, обладающие противомикробной активностью
RU2703997C1 (ru) * 2018-12-13 2019-10-23 Общество с ограниченной ответственностью "Л-Био" Гибридные амиды на основе триазола и тиазолидина, обладающие антимикробной активностью
US11292776B2 (en) 2019-12-12 2022-04-05 University Of Sharjah Small molecule inhibitors of fungal hyphae and biofilm formation

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5740478A (en) * 1980-08-22 1982-03-06 Ono Pharmaceut Co Ltd Rhodanine derivative, its preparation and aldose reductase inhibitor containing rhodanine derivative
WO1994029287A1 (de) * 1993-06-04 1994-12-22 Boehringer Mannheim Gmbh Aryliden-4-oxo-2-thioxo-3-thiazolidincarbonsäuren, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
WO2000008747A1 (de) * 1998-08-05 2000-02-17 Robert Bosch Gmbh Gesteuerte gleichrichterbrücke mit überspannungsschutz
WO2000018747A1 (en) * 1998-09-30 2000-04-06 Roche Diagnostics Gmbh Rhodanine carboxylic acid derivatives for the treatment and prevention of metabolic bone disorders

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US47109A (en) * 1865-04-04 Improvement in governors
FR1604530A (enExample) * 1967-06-06 1971-11-29

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5740478A (en) * 1980-08-22 1982-03-06 Ono Pharmaceut Co Ltd Rhodanine derivative, its preparation and aldose reductase inhibitor containing rhodanine derivative
WO1994029287A1 (de) * 1993-06-04 1994-12-22 Boehringer Mannheim Gmbh Aryliden-4-oxo-2-thioxo-3-thiazolidincarbonsäuren, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
WO2000008747A1 (de) * 1998-08-05 2000-02-17 Robert Bosch Gmbh Gesteuerte gleichrichterbrücke mit überspannungsschutz
WO2000018747A1 (en) * 1998-09-30 2000-04-06 Roche Diagnostics Gmbh Rhodanine carboxylic acid derivatives for the treatment and prevention of metabolic bone disorders

Also Published As

Publication number Publication date
EP1313731B1 (en) 2010-09-29
ES2353685T3 (es) 2011-03-04
GB0021419D0 (en) 2000-10-18
US20030216453A1 (en) 2003-11-20
EP1313731A1 (en) 2003-05-28
DE60143165D1 (de) 2010-11-11
WO2002022612A1 (en) 2002-03-21
WO2002022612A8 (en) 2002-05-23
US6740670B2 (en) 2004-05-25
AU2001284188A1 (en) 2002-03-26
ATE482954T1 (de) 2010-10-15

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