JP2004509076A5 - - Google Patents
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- Publication number
- JP2004509076A5 JP2004509076A5 JP2002512129A JP2002512129A JP2004509076A5 JP 2004509076 A5 JP2004509076 A5 JP 2004509076A5 JP 2002512129 A JP2002512129 A JP 2002512129A JP 2002512129 A JP2002512129 A JP 2002512129A JP 2004509076 A5 JP2004509076 A5 JP 2004509076A5
- Authority
- JP
- Japan
- Prior art keywords
- mmol
- biphenyl
- pyrrolidinylcarbamate
- aminopyrrolidinyl
- carbonitrile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 2
- XJAINPOVVPZLBI-UHFFFAOYSA-N 2-methylbutan-2-yl carbonochloridate Chemical compound CCC(C)(C)OC(Cl)=O XJAINPOVVPZLBI-UHFFFAOYSA-N 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 description 1
- 125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61515100A | 2000-07-13 | 2000-07-13 | |
| PCT/US2001/021929 WO2002006223A1 (en) | 2000-07-13 | 2001-07-11 | 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004509076A JP2004509076A (ja) | 2004-03-25 |
| JP2004509076A5 true JP2004509076A5 (enExample) | 2009-09-24 |
| JP4516717B2 JP4516717B2 (ja) | 2010-08-04 |
Family
ID=24464202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002512129A Expired - Fee Related JP4516717B2 (ja) | 2000-07-13 | 2001-07-11 | ヒスタミン−３受容体リガンドとしての１，３−二置換ピロリジン及び１，３，３−三置換ピロリジン並びにそれらの治療的応用 |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1301480B1 (enExample) |
| JP (1) | JP4516717B2 (enExample) |
| AR (1) | AR030939A1 (enExample) |
| AT (1) | ATE372981T1 (enExample) |
| AU (1) | AU2001273384A1 (enExample) |
| BR (1) | BR0108088A (enExample) |
| CA (1) | CA2415396C (enExample) |
| CY (1) | CY1107815T1 (enExample) |
| DE (1) | DE60130460T2 (enExample) |
| DK (1) | DK1301480T3 (enExample) |
| ES (1) | ES2292603T3 (enExample) |
| MX (1) | MXPA02012851A (enExample) |
| PE (1) | PE20020191A1 (enExample) |
| PT (1) | PT1301480E (enExample) |
| WO (1) | WO2002006223A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6620839B2 (en) * | 2000-07-13 | 2003-09-16 | Abbott Laboratories | 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications |
| US6316475B1 (en) * | 2000-11-17 | 2001-11-13 | Abbott Laboratories | Aminoalkoxybiphenylcarboxamides as histamine-3 receptor ligands and their therapeutic applications |
| JP4619655B2 (ja) | 2001-09-14 | 2011-01-26 | ハイ・ポイント・ファーマスーティカルズ、エルエルシー | 新規アミノアゼチジン、−ピロリジンおよび−ピペリジン誘導体 |
| US6673829B2 (en) | 2001-09-14 | 2004-01-06 | Novo Nordisk A/S | Aminoazetidine,-pyrrolidine and -piperidine derivatives |
| US7314937B2 (en) | 2002-03-21 | 2008-01-01 | Eli Lilly And Company | Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses |
| GB0224084D0 (en) * | 2002-10-16 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
| GB0308333D0 (en) * | 2003-04-10 | 2003-05-14 | Glaxo Group Ltd | Novel compounds |
| US7595316B2 (en) | 2003-06-27 | 2009-09-29 | Banyu Pharmaceutical Co., Ltd. | Heteroaryloxy nitrogenous saturated heterocyclic derivative |
| FR2866647B1 (fr) * | 2004-02-20 | 2006-10-27 | Servier Lab | Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US7456164B2 (en) | 2004-05-07 | 2008-11-25 | Pfizer, Inc | 3- or 4-monosubtituted phenol and thiophenol derivatives useful as H3 ligands |
| AP2353A (en) * | 2004-05-07 | 2012-02-16 | Warner Lambert Co | 3- or 4-monosubstituted phenol and thiophenol derivatives useful as H3 ligands. |
| EP1593679A1 (en) * | 2004-05-07 | 2005-11-09 | Warner-Lambert Company LLC | 3- Or 4-monosubstituted phenol derivatives useful as H3 ligands |
| EP1595881A1 (en) | 2004-05-12 | 2005-11-16 | Pfizer Limited | Tetrahydronaphthyridine derivates useful as histamine H3 receptor ligands |
| WO2006059778A1 (ja) * | 2004-12-01 | 2006-06-08 | Banyu Pharmaceutical Co., Ltd. | 置換ピリドン誘導体 |
| GB0514811D0 (en) * | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
| GB0514812D0 (en) * | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
| US7728031B2 (en) | 2006-02-24 | 2010-06-01 | Abbott Laboratories | Octahydro-pyrrolo[3,4-b]pyrrole derivatives |
| CN101809021B (zh) | 2007-09-11 | 2013-04-24 | 雅培制药有限公司 | 八氢-吡咯并[3,4-b]吡咯n-氧化物 |
| US8383657B2 (en) | 2007-12-21 | 2013-02-26 | Abbott Laboratories | Thiazolylidine urea and amide derivatives and methods of use thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3522790B2 (ja) * | 1993-06-08 | 2004-04-26 | 花王株式会社 | Ｈ３−レセプター刺激薬 |
| US5585492A (en) * | 1994-10-11 | 1996-12-17 | G. D. Searle & Co. | LTA4 Hydrolase inhibitors |
| WO1996032937A1 (en) * | 1995-04-21 | 1996-10-24 | Eli Lilly And Company | Benzothiophenes with novel basic side chains |
| AU3176297A (en) * | 1996-06-25 | 1998-01-14 | Novartis Ag | Substituted 7-amino-pyrrolo{3,2-d}pyrimidines and the use thereof |
| EP0978512A1 (en) * | 1998-07-29 | 2000-02-09 | Societe Civile Bioprojet | Non-imidazole aryloxy (or arylthio) alkylamines as histamine H3-receptor antagonists and their therapeutic applications |
-
2001
- 2001-07-11 JP JP2002512129A patent/JP4516717B2/ja not_active Expired - Fee Related
- 2001-07-11 MX MXPA02012851A patent/MXPA02012851A/es active IP Right Grant
- 2001-07-11 WO PCT/US2001/021929 patent/WO2002006223A1/en not_active Ceased
- 2001-07-11 CA CA2415396A patent/CA2415396C/en not_active Expired - Fee Related
- 2001-07-11 AU AU2001273384A patent/AU2001273384A1/en not_active Abandoned
- 2001-07-11 EP EP01952653A patent/EP1301480B1/en not_active Expired - Lifetime
- 2001-07-11 DE DE60130460T patent/DE60130460T2/de not_active Expired - Lifetime
- 2001-07-11 PT PT01952653T patent/PT1301480E/pt unknown
- 2001-07-11 AT AT01952653T patent/ATE372981T1/de not_active IP Right Cessation
- 2001-07-11 DK DK01952653T patent/DK1301480T3/da active
- 2001-07-11 ES ES01952653T patent/ES2292603T3/es not_active Expired - Lifetime
- 2001-07-11 BR BR0108088-1A patent/BR0108088A/pt not_active Application Discontinuation
- 2001-07-12 PE PE2001000701A patent/PE20020191A1/es not_active Application Discontinuation
- 2001-07-12 AR ARP010103321A patent/AR030939A1/es unknown
-
2007
- 2007-11-29 CY CY20071101525T patent/CY1107815T1/el unknown
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