JP2004508317A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004508317A5 JP2004508317A5 JP2002524467A JP2002524467A JP2004508317A5 JP 2004508317 A5 JP2004508317 A5 JP 2004508317A5 JP 2002524467 A JP2002524467 A JP 2002524467A JP 2002524467 A JP2002524467 A JP 2002524467A JP 2004508317 A5 JP2004508317 A5 JP 2004508317A5
- Authority
- JP
- Japan
- Prior art keywords
- skin
- estrogen
- mmpi
- composition
- wrinkles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 description 16
- 239000000262 estrogen Substances 0.000 description 14
- 210000003491 skin Anatomy 0.000 description 14
- 229940011871 estrogen Drugs 0.000 description 13
- 229940121386 matrix metalloproteinase inhibitor Drugs 0.000 description 12
- 239000003771 matrix metalloproteinase inhibitor Substances 0.000 description 12
- 239000003075 phytoestrogen Substances 0.000 description 10
- 230000037303 wrinkles Effects 0.000 description 10
- NITYDPDXAAFEIT-DYVFJYSZSA-N ilomastat Chemical compound C1=CC=C2C(C[C@@H](C(=O)NC)NC(=O)[C@H](CC(C)C)CC(=O)NO)=CNC2=C1 NITYDPDXAAFEIT-DYVFJYSZSA-N 0.000 description 8
- 229960003696 ilomastat Drugs 0.000 description 8
- 239000012049 topical pharmaceutical composition Substances 0.000 description 8
- 229940124761 MMP inhibitor Drugs 0.000 description 6
- 239000002537 cosmetic Substances 0.000 description 5
- 230000000391 smoking effect Effects 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 4
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 3
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 230000032683 aging Effects 0.000 description 3
- 210000002744 extracellular matrix Anatomy 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 238000003780 insertion Methods 0.000 description 3
- 230000037431 insertion Effects 0.000 description 3
- 239000000419 plant extract Substances 0.000 description 3
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 102000002274 Matrix Metalloproteinases Human genes 0.000 description 2
- 108010000684 Matrix Metalloproteinases Proteins 0.000 description 2
- 235000019504 cigarettes Nutrition 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 239000003687 estradiol congener Substances 0.000 description 2
- 230000001076 estrogenic effect Effects 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 150000007949 saponins Chemical class 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 description 1
- ZKRFOXLVOKTUTA-KQYNXXCUSA-N 9-(5-phosphoribofuranosyl)-6-mercaptopurine Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N1C(NC=NC2=S)=C2N=C1 ZKRFOXLVOKTUTA-KQYNXXCUSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 108060005980 Collagenase Proteins 0.000 description 1
- 102000029816 Collagenase Human genes 0.000 description 1
- 108010016626 Dipeptides Proteins 0.000 description 1
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 description 1
- 108010026132 Gelatinases Proteins 0.000 description 1
- 102000013382 Gelatinases Human genes 0.000 description 1
- 101000669513 Homo sapiens Metalloproteinase inhibitor 1 Proteins 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 102000000422 Matrix Metalloproteinase 3 Human genes 0.000 description 1
- 102100039364 Metalloproteinase inhibitor 1 Human genes 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 108010005246 Tissue Inhibitor of Metalloproteinases Proteins 0.000 description 1
- 102000005876 Tissue Inhibitor of Metalloproteinases Human genes 0.000 description 1
- 241000234314 Zingiber Species 0.000 description 1
- 235000006886 Zingiber officinale Nutrition 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- XFILPEOLDIKJHX-QYZOEREBSA-N batimastat Chemical compound C([C@@H](C(=O)NC)NC(=O)[C@H](CC(C)C)[C@H](CSC=1SC=CC=1)C(=O)NO)C1=CC=CC=C1 XFILPEOLDIKJHX-QYZOEREBSA-N 0.000 description 1
- 229950001858 batimastat Drugs 0.000 description 1
- 229940061349 black cohosh extract Drugs 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 229960002424 collagenase Drugs 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 229960005309 estradiol Drugs 0.000 description 1
- 229960002568 ethinylestradiol Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 235000008397 ginger Nutrition 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- GOMNOOKGLZYEJT-UHFFFAOYSA-N isoflavone Chemical compound C=1OC2=CC=CC=C2C(=O)C=1C1=CC=CC=C1 GOMNOOKGLZYEJT-UHFFFAOYSA-N 0.000 description 1
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 description 1
- 235000008696 isoflavones Nutrition 0.000 description 1
- OCSMOTCMPXTDND-OUAUKWLOSA-N marimastat Chemical compound CNC(=O)[C@H](C(C)(C)C)NC(=O)[C@H](CC(C)C)[C@H](O)C(=O)NO OCSMOTCMPXTDND-OUAUKWLOSA-N 0.000 description 1
- 229950008959 marimastat Drugs 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000955 prescription drug Substances 0.000 description 1
- 235000004252 protein component Nutrition 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 108091007196 stromelysin Proteins 0.000 description 1
- 239000012622 synthetic inhibitor Substances 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- -1 triterpenoid glycosides Chemical class 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21508700P | 2000-06-29 | 2000-06-29 | |
| US60/215,087 | 2000-06-29 | ||
| PCT/US2001/020945 WO2002019982A2 (en) | 2000-06-29 | 2001-06-29 | Cosmetic composition and method for reducing or preventing wrinkling |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004508317A JP2004508317A (ja) | 2004-03-18 |
| JP2004508317A5 true JP2004508317A5 (enExample) | 2008-08-14 |
| JP5106739B2 JP5106739B2 (ja) | 2012-12-26 |
Family
ID=22801588
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002524467A Expired - Fee Related JP5106739B2 (ja) | 2000-06-29 | 2001-06-29 | 化粧品組成物および方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6713074B2 (enExample) |
| EP (1) | EP1359897A2 (enExample) |
| JP (1) | JP5106739B2 (enExample) |
| AU (2) | AU7311501A (enExample) |
| CA (1) | CA2414247C (enExample) |
| WO (1) | WO2002019982A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030083321A1 (en) * | 2001-09-25 | 2003-05-01 | Lerner David S. | Composition and method for minimizing or avoiding adverse effects of vesicants |
| US20080139512A1 (en) * | 2002-09-25 | 2008-06-12 | Quick-Med Technologies, Inc. | Method for minimizing or avoiding adverse effects of vesicants |
| US7060304B2 (en) * | 2003-04-16 | 2006-06-13 | Access Business Group International Llc | Skin whitening compositions containing black cohosh extract |
| US6994874B2 (en) * | 2003-04-16 | 2006-02-07 | Access Business Group International, Llc | Skin whitening compositions containing asparagus extract |
| CA2526222A1 (en) * | 2003-05-16 | 2004-12-02 | Arriva Pharmaceuticals, Inc. | Treatment of respiratory disease associated with matrix metalloprotease inhibitors |
| FR2859908A1 (fr) * | 2003-09-24 | 2005-03-25 | Oreal | Composition comprenant au moins un inhibiteur de metalloproteinase et au moins un agent myorelaxant ou relaxant |
| JP4803698B2 (ja) * | 2004-11-02 | 2011-10-26 | 丸善製薬株式会社 | 抗老化剤、エストロゲン様作用剤、抗男性ホルモン剤、育毛剤、テストステロン５α−レダクターゼ阻害剤、皮膚化粧料及び頭髪化粧料 |
| BRPI0615588A2 (pt) * | 2005-08-31 | 2011-05-24 | Serentis Ltd | uso de um inibidor de aureolisina para o tratamento de condições inflamatórias da pele caracterizadas por colonização com staphylococcus aureus |
| US20070142905A1 (en) * | 2005-12-16 | 2007-06-21 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
| JP5661994B2 (ja) * | 2008-01-04 | 2015-01-28 | クラシエ製薬株式会社 | 抗ストレス・疲労防止、肌のキメ改善又はシワ改善・防止効果を有する組成物又は内服剤 |
| US20090299466A1 (en) * | 2008-06-02 | 2009-12-03 | Medtronic Vascular, Inc. | Local Delivery of Matrix Metalloproteinase Inhibitors |
| US8435541B2 (en) | 2010-09-02 | 2013-05-07 | Bath & Body Works Brand Management, Inc. | Topical compositions for inhibiting matrix metalloproteases and providing antioxidative activities |
| GB201110777D0 (en) | 2011-06-24 | 2011-08-10 | Aqua Bio Technology Asa | Methods and uses |
| EP3973967A1 (en) | 2012-12-21 | 2022-03-30 | Astellas Institute for Regenerative Medicine | Methods for production of platelets from pluripotent stem cells and compositions thereof |
| TWI480057B (zh) * | 2013-07-08 | 2015-04-11 | Univ China Medical | 咖啡酸醯胺衍生物之應用 |
| US10166412B2 (en) | 2014-12-30 | 2019-01-01 | Conopco, Inc. | Skin lightening composition comprising 4-hexylresorcinol and ilomastat |
| CA2971907C (en) * | 2014-12-30 | 2023-08-15 | Unilever Plc | A skin lightening composition comprising niacinamide and ilomastat |
| KR102124065B1 (ko) * | 2018-08-17 | 2020-06-17 | 서울대학교산학협력단 | 식물 추출물을 함유하는 피부 주름 개선용 조성물 |
| CN114516917B (zh) * | 2020-11-20 | 2022-11-18 | 广东东阳光药业有限公司 | 人源化抗TrkA的抗体及其应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5892112A (en) | 1990-11-21 | 1999-04-06 | Glycomed Incorporated | Process for preparing synthetic matrix metalloprotease inhibitors |
| US5268384A (en) | 1990-11-21 | 1993-12-07 | Galardy Richard E | Inhibition of angiogenesis by synthetic matrix metalloprotease inhibitors |
| FR2717389B1 (fr) * | 1994-03-18 | 1996-06-07 | Lvmh Rech | Utilisation du ginsénoside Ro ou d'un extrait végétal en contenant pour stimuler la synthèse du collagène. |
| US5837224A (en) * | 1996-01-19 | 1998-11-17 | The Regents Of The University Of Michigan | Method of inhibiting photoaging of skin |
| US5665367A (en) * | 1996-09-27 | 1997-09-09 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Skin care compositions containing naringenin and/or quercetin and a retinoid |
| US6338855B1 (en) * | 1996-10-25 | 2002-01-15 | The Procter & Gamble Company | Cleansing articles for skin and/or hair which also deposit skin care actives |
| TWI234467B (en) | 1997-06-04 | 2005-06-21 | Univ Michigan | Composition for inhibiting photoaging of skin |
| US5885596A (en) | 1997-07-23 | 1999-03-23 | Bristol-Myers Squibb Company | Methods and compositions for fine lines and/or wrinkles |
| US6270780B1 (en) * | 1997-07-25 | 2001-08-07 | Chesebrough-Pond's Usa Co., Division Of Conopco | Cosmetic compositions containing resveratrol |
| US6030620A (en) * | 1997-07-25 | 2000-02-29 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Skin care compositions containing an organic extract of chick pea |
| DE19812204A1 (de) * | 1998-03-19 | 1999-11-04 | Plantamed Arzneimittel Gmbh | Verwendung von Extrakten aus Cimicifuga racemosa und Belamcanda sinensis als estrogenartiges organselektives Arzneimittel ohne uterotrope Wirkung |
| FR2782919B1 (fr) * | 1998-09-04 | 2001-05-25 | Roc Sa | Composition contre le vieillissement et son utilisation |
| JP2002533404A (ja) | 1998-12-23 | 2002-10-08 | ジー・ディー・サール・アンド・カンパニー | 新生物形成の治療における組合わせ療法としてインテグリン拮抗剤及び放射線治療を使用する方法 |
| US6139828A (en) | 1999-06-02 | 2000-10-31 | Hair Associates, Llc | Hair care formulations |
| US6358517B1 (en) * | 1999-10-22 | 2002-03-19 | Unilever Home & Personal Care Usa, Division Of Conopco | Cosmetic compositions containing resveratrol and retinoids |
| WO2001043711A1 (en) * | 1999-12-14 | 2001-06-21 | Unilever Plc | Cosmetic skin conditioning compositions containing red yeast rice extract |
| US20020010162A1 (en) * | 2000-03-02 | 2002-01-24 | Raul Fleischmajer | Treatment of psoriasis with matrix metalloproteinase inhibitors |
-
2001
- 2001-06-29 AU AU7311501A patent/AU7311501A/xx active Pending
- 2001-06-29 WO PCT/US2001/020945 patent/WO2002019982A2/en not_active Ceased
- 2001-06-29 EP EP01952355A patent/EP1359897A2/en not_active Withdrawn
- 2001-06-29 US US09/896,566 patent/US6713074B2/en not_active Expired - Lifetime
- 2001-06-29 CA CA2414247A patent/CA2414247C/en not_active Expired - Fee Related
- 2001-06-29 AU AU2001273115A patent/AU2001273115C1/en not_active Ceased
- 2001-06-29 JP JP2002524467A patent/JP5106739B2/ja not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2004508317A5 (enExample) | ||
| JP5106739B2 (ja) | 化粧品組成物および方法 | |
| HUP0102899A2 (hu) | Eljárás gyulladásgátló, különösen fertőtlenítő hatású és/vagy sebgyógyulást elősegítő szerek alsó légutakba történő beadására szolgáló készítmények előállítására | |
| AU707853B2 (en) | Dermatological preparation and method for treating actinic keratoses | |
| JP2009519940A (ja) | 皮膚科学的状態を処置するための組成物および方法 | |
| AU2001273115A1 (en) | Cosmetic composition and method | |
| EP1383540A4 (en) | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR Wounds Healing | |
| JPH07215848A (ja) | 皮膚外用剤及び皮膚化粧料 | |
| US5599546A (en) | Medicinal facial mask | |
| JP2004520447A (ja) | ローズマリー抽出物およびｄｈａを含有する化粧品組成物 | |
| JP2001240547A (ja) | 花粉症抑制剤 | |
| US20040185127A1 (en) | Cosmetic composition and method | |
| WO1996014840A1 (en) | Use of menthyl lactate as a pain reliever | |
| JPH11246329A (ja) | 皮膚外用剤 | |
| US6726922B1 (en) | Process and composition for temporarily suppressing pain | |
| JP4176992B2 (ja) | 化粧及び医薬の用途のための組成物 | |
| JP2003160462A (ja) | バリアー機能を有する機能性皮膚外用剤 | |
| JP2000212090A (ja) | 皮膚改質剤 | |
| JP2826142B2 (ja) | フケ抑制剤組成物 | |
| JPS63188619A (ja) | 口腔用組成物 | |
| JP2001187741A (ja) | 皮膚外用医薬組成物 | |
| JP2909919B2 (ja) | 化粧水 | |
| JP2826141B2 (ja) | フケ抑制剤組成物 | |
| JP2022051525A (ja) | 外用組成物 | |
| GB2246954A (en) | Pharmaceutical anti-infective composition containing metronidazole |