JP2004507486A5 - - Google Patents
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- Publication number
- JP2004507486A5 JP2004507486A5 JP2002522855A JP2002522855A JP2004507486A5 JP 2004507486 A5 JP2004507486 A5 JP 2004507486A5 JP 2002522855 A JP2002522855 A JP 2002522855A JP 2002522855 A JP2002522855 A JP 2002522855A JP 2004507486 A5 JP2004507486 A5 JP 2004507486A5
- Authority
- JP
- Japan
- Prior art keywords
- nitrite
- alkaline earth
- composition
- pharmacologically acceptable
- alkali metal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 alkali metal nitrite Chemical class 0.000 description 13
- 239000000203 mixture Substances 0.000 description 13
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 12
- BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 description 8
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 description 8
- 229960004194 lidocaine Drugs 0.000 description 8
- 239000002535 acidifier Substances 0.000 description 7
- 229910052783 alkali metal Inorganic materials 0.000 description 7
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 7
- 239000013543 active substance Substances 0.000 description 6
- 239000002243 precursor Substances 0.000 description 6
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 description 5
- 229960002372 tetracaine Drugs 0.000 description 5
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 description 5
- ZKMNUMMKYBVTFN-HNNXBMFYSA-N (S)-ropivacaine Chemical compound CCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C ZKMNUMMKYBVTFN-HNNXBMFYSA-N 0.000 description 4
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 description 4
- 230000003444 anaesthetic effect Effects 0.000 description 4
- 229960005274 benzocaine Drugs 0.000 description 4
- 229960003150 bupivacaine Drugs 0.000 description 4
- 229960003920 cocaine Drugs 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 229960002409 mepivacaine Drugs 0.000 description 4
- INWLQCZOYSRPNW-UHFFFAOYSA-N mepivacaine Chemical compound CN1CCCCC1C(=O)NC1=C(C)C=CC=C1C INWLQCZOYSRPNW-UHFFFAOYSA-N 0.000 description 4
- 230000036407 pain Effects 0.000 description 4
- MVFGUOIZUNYYSO-UHFFFAOYSA-N prilocaine Chemical compound CCCNC(C)C(=O)NC1=CC=CC=C1C MVFGUOIZUNYYSO-UHFFFAOYSA-N 0.000 description 4
- 229960001807 prilocaine Drugs 0.000 description 4
- 229960001549 ropivacaine Drugs 0.000 description 4
- 229940072358 xylocaine Drugs 0.000 description 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 150000007524 organic acids Chemical group 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- IOVCWXUNBOPUCH-UHFFFAOYSA-N Nitrous acid Chemical compound ON=O IOVCWXUNBOPUCH-UHFFFAOYSA-N 0.000 description 2
- 150000001340 alkali metals Chemical class 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- BSYNRYMUTXBXSQ-FOQJRBATSA-N 59096-14-9 Chemical compound CC(=O)OC1=CC=CC=C1[14C](O)=O BSYNRYMUTXBXSQ-FOQJRBATSA-N 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 229940035674 anesthetics Drugs 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003193 general anesthetic agent Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 230000001861 immunosuppressant effect Effects 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 238000002690 local anesthesia Methods 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000002691 topical anesthesia Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0021317.3 | 2000-08-30 | ||
| GBGB0021317.3A GB0021317D0 (en) | 2000-08-30 | 2000-08-30 | Transdermal pharmaceutical delivery composition |
| PCT/GB2001/003863 WO2002017881A2 (en) | 2000-08-30 | 2001-08-30 | Transdermal pharmaceutical delivery composition |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004507486A JP2004507486A (ja) | 2004-03-11 |
| JP2004507486A5 true JP2004507486A5 (https=) | 2008-10-16 |
| JP4869540B2 JP4869540B2 (ja) | 2012-02-08 |
Family
ID=9898548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002522855A Expired - Fee Related JP4869540B2 (ja) | 2000-08-30 | 2001-08-30 | 経皮的製剤送達用組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US8128964B2 (https=) |
| EP (1) | EP1328252B1 (https=) |
| JP (1) | JP4869540B2 (https=) |
| AT (1) | ATE347879T1 (https=) |
| AU (2) | AU8419101A (https=) |
| DE (1) | DE60125217T2 (https=) |
| ES (1) | ES2275716T3 (https=) |
| GB (1) | GB0021317D0 (https=) |
| WO (1) | WO2002017881A2 (https=) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0021317D0 (en) * | 2000-08-30 | 2000-10-18 | Queen Mary & Westfield College | Transdermal pharmaceutical delivery composition |
| ES2294543T3 (es) | 2003-07-09 | 2008-04-01 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Heal | Uso de sales de nitrilo para el tratamiento de afecciones cardiovasculares. |
| WO2006084911A2 (en) * | 2005-02-11 | 2006-08-17 | Nolabs Ab | Improved device for application of medicaments, manufacturing method therefor, and method of treatment |
| WO2006125123A2 (en) * | 2005-05-19 | 2006-11-23 | University Of Cincinnati | Methods for treating bacterial respiratory tract infections in an individual using acidified nitrite |
| ES2731298T3 (es) | 2005-05-27 | 2019-11-14 | Univ North Carolina Chapel Hill | Partículas de liberación de óxido nítrico para agentes terapéuticos de óxido nítrico y aplicaciones biomédicas |
| GB0607402D0 (en) | 2006-04-12 | 2006-05-24 | Barts & London Nhs Trust | Therapeutic composition and use |
| US8445018B2 (en) * | 2006-09-15 | 2013-05-21 | Cima Labs Inc. | Abuse resistant drug formulation |
| US20090112197A1 (en) | 2007-10-30 | 2009-04-30 | Searete Llc | Devices configured to facilitate release of nitric oxide |
| US8642093B2 (en) | 2007-10-30 | 2014-02-04 | The Invention Science Fund I, Llc | Methods and systems for use of photolyzable nitric oxide donors |
| US20110190604A1 (en) * | 2006-12-22 | 2011-08-04 | Hyde Roderick A | Nitric oxide sensors and systems |
| US7862598B2 (en) * | 2007-10-30 | 2011-01-04 | The Invention Science Fund I, Llc | Devices and systems that deliver nitric oxide |
| US8221690B2 (en) | 2007-10-30 | 2012-07-17 | The Invention Science Fund I, Llc | Systems and devices that utilize photolyzable nitric oxide donors |
| US20090110933A1 (en) * | 2007-10-30 | 2009-04-30 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems and devices related to nitric oxide releasing materials |
| US20090130233A1 (en) * | 2007-10-24 | 2009-05-21 | Baker Christopher G | Two part lotion |
| US10080823B2 (en) | 2007-10-30 | 2018-09-25 | Gearbox Llc | Substrates for nitric oxide releasing devices |
| US8349262B2 (en) | 2007-10-30 | 2013-01-08 | The Invention Science Fund I, Llc | Nitric oxide permeable housings |
| US7897399B2 (en) | 2007-10-30 | 2011-03-01 | The Invention Science Fund I, Llc | Nitric oxide sensors and systems |
| US8877508B2 (en) * | 2007-10-30 | 2014-11-04 | The Invention Science Fund I, Llc | Devices and systems that deliver nitric oxide |
| US8980332B2 (en) | 2007-10-30 | 2015-03-17 | The Invention Science Fund I, Llc | Methods and systems for use of photolyzable nitric oxide donors |
| US8303995B1 (en) * | 2008-06-13 | 2012-11-06 | Board Of Regents, The University Of Texas System | Nitrite formulations and their use as nitric oxide prodrugs |
| BRPI0913809B1 (pt) * | 2008-10-02 | 2019-02-05 | Mylan Inc | método para produzir continuamente um laminado adesivo sensível á pressão multicamada |
| EP2334279A4 (en) * | 2008-10-16 | 2013-03-20 | Novan Inc | STAIN OXIDE RELEASING PARTICLES FOR MOUTH CARE APPLICATIONS |
| GB0901456D0 (en) * | 2009-01-29 | 2009-03-11 | Insense Ltd | Treatment of psoriasis |
| US9241999B2 (en) * | 2009-06-15 | 2016-01-26 | Board Of Regents Of The University Of Texas System | Method of producing physiological and therapeutic levels of nitric oxide through an oral delivery system |
| WO2011022652A1 (en) | 2009-08-21 | 2011-02-24 | Novan, Inc. | Topical gels |
| CA2771389C (en) | 2009-08-21 | 2019-04-09 | Novan, Inc. | Wound dressings, methods of using the same and methods of forming the same |
| BR112012008508A2 (pt) * | 2009-10-13 | 2017-06-13 | Novan Inc | revestimento de sol-gel, substrato, método para produzir um revestimento de sol-gel |
| RU2445918C1 (ru) * | 2010-07-15 | 2012-03-27 | Федеральное государственное образовательное учреждение высшего профессионального образования Санкт-Петербургский государственный университет | Способ неинвазивной дифференциальной диагностики патологии лимфатических и венозных сосудов нижних конечностей |
| PT2533773E (pt) | 2010-10-21 | 2015-12-01 | Kipax Ab | Dispositivo de administração de óxido nítrico por via cutânea tópica |
| US8591876B2 (en) | 2010-12-15 | 2013-11-26 | Novan, Inc. | Methods of decreasing sebum production in the skin |
| WO2012118829A2 (en) | 2011-02-28 | 2012-09-07 | Novan, Inc. | Tertiary s-nitrosothiol-modified nitricoxide-releasing xerogels and methods of using the same |
| EP2691087A2 (en) | 2011-03-31 | 2014-02-05 | László Gábor Szabó | Pharmaceutical composition containing no, process for the preparation and use thereof |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| BR112014012444B1 (pt) | 2011-11-23 | 2021-12-14 | Therapeuticsmd, Inc | Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US10517817B2 (en) | 2013-05-09 | 2019-12-31 | Syk Technologies, Llc | Deep topical systemic nitric oxide therapy apparatus and method |
| GB201309092D0 (en) * | 2013-05-20 | 2013-07-03 | Edixomed Ltd | Transdermal delivery system |
| GB201309091D0 (en) * | 2013-05-20 | 2013-07-03 | Edixomed Ltd | Dressing system |
| US11406769B2 (en) * | 2014-01-31 | 2022-08-09 | Galderma Holding SA | Lubrication of an injection needle |
| RU2016143081A (ru) | 2014-05-22 | 2018-06-26 | Терапьютиксмд, Инк. | Натуральные комбинированные гормонозаместительные составы и терапии |
| US10322082B2 (en) | 2014-07-11 | 2019-06-18 | Novan, Inc. | Topical antiviral compositions and methods of using the same |
| CN106659675B (zh) | 2014-07-11 | 2023-07-04 | 诺万公司 | 局部抗病毒组合物和其使用方法 |
| WO2016010988A1 (en) | 2014-07-14 | 2016-01-21 | Novan, Inc. | Nitric oxide releasing nail coating compositions, nitric oxide releasing nail coatings, and methods of using the same |
| GB201420761D0 (en) | 2014-11-21 | 2015-01-07 | Edixomed Ltd And First Water Ltd | Dressing system |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| US10849864B2 (en) | 2015-07-28 | 2020-12-01 | Novan, Inc. | Combinations and methods for the treatment and/or prevention of fungal infections |
| GB201520990D0 (en) | 2015-11-27 | 2016-01-13 | Edixomed Ltd | Dressing system |
| WO2017132275A1 (en) | 2016-01-27 | 2017-08-03 | Syk Technologies, Llc | Nitric oxide topical application apparatus and methods |
| US9931349B2 (en) | 2016-04-01 | 2018-04-03 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
| US10149843B1 (en) | 2017-02-07 | 2018-12-11 | Gneus Lifescineces Inc. | Pharmaceutical compositions and methods of using the same |
| US10231961B1 (en) | 2017-02-07 | 2019-03-19 | Genus Lifesciences Inc. | Pharmaceutical compositions and methods of using the same |
| US10413505B1 (en) | 2017-02-07 | 2019-09-17 | Genus Lifesciences Inc. | Pharmaceutical compositions and methods of using the same |
| BR112021023632A2 (pt) | 2019-06-04 | 2022-04-19 | Thirty Respiratory Ltd | Métodos e composições para gerar óxido nítrico e usos do mesmo para entregar óxido nítrico através do trato respiratório |
| BR112021023832A8 (pt) * | 2019-06-04 | 2023-02-28 | Thirty Holdings Ltd | Métodos e composições para geração de óxido nítrico e usos dos mesmos |
| US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
| JP2023526583A (ja) | 2020-04-23 | 2023-06-22 | サーティー レスピラトリー リミテッド | 結核を治療及び抑制するための方法及び組成物 |
| US20240016831A1 (en) | 2020-04-23 | 2024-01-18 | Thirty Respiratory Limited | Nitric oxide or nitric oxide releasing compositions for use in treating sars-cov and sars-cov-2 |
| US12459820B2 (en) | 2020-06-11 | 2025-11-04 | J. W. Randolph Miller | Stabilized and NO2-inhibited nitric oxide generating gels for inhaled nitric oxide therapy |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58913A (ja) | 1981-06-26 | 1983-01-06 | Nitto Electric Ind Co Ltd | 局所系医薬製剤 |
| RO92445B1 (ro) * | 1985-08-12 | 1987-10-01 | Ludovic L. Elthes | Unguent medicamentos cu actiune antiinflamatoare, cicatrizanta si epitelizanta |
| US5719197A (en) * | 1988-03-04 | 1998-02-17 | Noven Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
| JPH07108849B2 (ja) | 1991-02-08 | 1995-11-22 | 奈良炭化工業株式会社 | 葉面散布用植物成育剤 |
| US5264219A (en) * | 1992-08-07 | 1993-11-23 | Minnesota Mining And Manufacturing Company | Transdermal drug delivery backing |
| US5891846A (en) * | 1994-02-17 | 1999-04-06 | Shiseido Company, Ltd. | Cyclosporin-containing emulsion composition |
| GB9804469D0 (en) | 1998-03-02 | 1998-04-29 | Univ Aberdeen | Antiviral composition |
| BR9507099A (pt) | 1994-02-21 | 1997-09-16 | Aberden University | Forma de dosagem método de esterilização composição esterilizante e suplemento alimentar animal compreendendo nitrito acidificado como um agente anti-microbiano |
| US5648101A (en) * | 1994-11-14 | 1997-07-15 | Tawashi; Rashad | Drug delivery of nitric oxide |
| SE9700617D0 (sv) | 1997-02-21 | 1997-02-21 | Kjell Alving | New composition |
| US5968547A (en) * | 1997-02-24 | 1999-10-19 | Euro-Celtique, S.A. | Method of providing sustained analgesia with buprenorphine |
| US5900249A (en) * | 1998-02-09 | 1999-05-04 | Smith; David J. | Multicomponent pain relief topical medication |
| US6103275A (en) * | 1998-06-10 | 2000-08-15 | Nitric Oxide Solutions | Systems and methods for topical treatment with nitric oxide |
| GB0021317D0 (en) * | 2000-08-30 | 2000-10-18 | Queen Mary & Westfield College | Transdermal pharmaceutical delivery composition |
-
2000
- 2000-08-30 GB GBGB0021317.3A patent/GB0021317D0/en not_active Ceased
-
2001
- 2001-08-30 WO PCT/GB2001/003863 patent/WO2002017881A2/en not_active Ceased
- 2001-08-30 AT AT01963158T patent/ATE347879T1/de not_active IP Right Cessation
- 2001-08-30 AU AU8419101A patent/AU8419101A/xx active Pending
- 2001-08-30 JP JP2002522855A patent/JP4869540B2/ja not_active Expired - Fee Related
- 2001-08-30 DE DE60125217T patent/DE60125217T2/de not_active Expired - Lifetime
- 2001-08-30 US US10/363,439 patent/US8128964B2/en not_active Expired - Fee Related
- 2001-08-30 AU AU2001284191A patent/AU2001284191B2/en not_active Ceased
- 2001-08-30 EP EP01963158A patent/EP1328252B1/en not_active Expired - Lifetime
- 2001-08-30 ES ES01963158T patent/ES2275716T3/es not_active Expired - Lifetime
-
2008
- 2008-09-03 US US12/231,555 patent/US8114442B2/en not_active Expired - Fee Related
-
2012
- 2012-01-27 US US13/360,601 patent/US20120183595A1/en not_active Abandoned
-
2013
- 2013-07-03 US US13/935,070 patent/US20140187481A1/en not_active Abandoned
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