DE60125217T2 - Transdermale pharmazeutische zusammensetzung zur wirkstoffverabreichung - Google Patents
Transdermale pharmazeutische zusammensetzung zur wirkstoffverabreichung Download PDFInfo
- Publication number
- DE60125217T2 DE60125217T2 DE60125217T DE60125217T DE60125217T2 DE 60125217 T2 DE60125217 T2 DE 60125217T2 DE 60125217 T DE60125217 T DE 60125217T DE 60125217 T DE60125217 T DE 60125217T DE 60125217 T2 DE60125217 T2 DE 60125217T2
- Authority
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- Germany
- Prior art keywords
- nitrite
- pharmacologically acceptable
- anesthetic
- skin
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Diabetes (AREA)
- Anesthesiology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0021317 | 2000-08-30 | ||
| GBGB0021317.3A GB0021317D0 (en) | 2000-08-30 | 2000-08-30 | Transdermal pharmaceutical delivery composition |
| PCT/GB2001/003863 WO2002017881A2 (en) | 2000-08-30 | 2001-08-30 | Transdermal pharmaceutical delivery composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60125217D1 DE60125217D1 (de) | 2007-01-25 |
| DE60125217T2 true DE60125217T2 (de) | 2007-10-25 |
Family
ID=9898548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60125217T Expired - Lifetime DE60125217T2 (de) | 2000-08-30 | 2001-08-30 | Transdermale pharmazeutische zusammensetzung zur wirkstoffverabreichung |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US8128964B2 (https=) |
| EP (1) | EP1328252B1 (https=) |
| JP (1) | JP4869540B2 (https=) |
| AT (1) | ATE347879T1 (https=) |
| AU (2) | AU8419101A (https=) |
| DE (1) | DE60125217T2 (https=) |
| ES (1) | ES2275716T3 (https=) |
| GB (1) | GB0021317D0 (https=) |
| WO (1) | WO2002017881A2 (https=) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0021317D0 (en) * | 2000-08-30 | 2000-10-18 | Queen Mary & Westfield College | Transdermal pharmaceutical delivery composition |
| ES2294543T3 (es) | 2003-07-09 | 2008-04-01 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Heal | Uso de sales de nitrilo para el tratamiento de afecciones cardiovasculares. |
| WO2006084911A2 (en) * | 2005-02-11 | 2006-08-17 | Nolabs Ab | Improved device for application of medicaments, manufacturing method therefor, and method of treatment |
| WO2006125123A2 (en) * | 2005-05-19 | 2006-11-23 | University Of Cincinnati | Methods for treating bacterial respiratory tract infections in an individual using acidified nitrite |
| ES2731298T3 (es) | 2005-05-27 | 2019-11-14 | Univ North Carolina Chapel Hill | Partículas de liberación de óxido nítrico para agentes terapéuticos de óxido nítrico y aplicaciones biomédicas |
| GB0607402D0 (en) | 2006-04-12 | 2006-05-24 | Barts & London Nhs Trust | Therapeutic composition and use |
| US8445018B2 (en) * | 2006-09-15 | 2013-05-21 | Cima Labs Inc. | Abuse resistant drug formulation |
| US20090112197A1 (en) | 2007-10-30 | 2009-04-30 | Searete Llc | Devices configured to facilitate release of nitric oxide |
| US8642093B2 (en) | 2007-10-30 | 2014-02-04 | The Invention Science Fund I, Llc | Methods and systems for use of photolyzable nitric oxide donors |
| US20110190604A1 (en) * | 2006-12-22 | 2011-08-04 | Hyde Roderick A | Nitric oxide sensors and systems |
| US7862598B2 (en) * | 2007-10-30 | 2011-01-04 | The Invention Science Fund I, Llc | Devices and systems that deliver nitric oxide |
| US8221690B2 (en) | 2007-10-30 | 2012-07-17 | The Invention Science Fund I, Llc | Systems and devices that utilize photolyzable nitric oxide donors |
| US20090110933A1 (en) * | 2007-10-30 | 2009-04-30 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems and devices related to nitric oxide releasing materials |
| US20090130233A1 (en) * | 2007-10-24 | 2009-05-21 | Baker Christopher G | Two part lotion |
| US10080823B2 (en) | 2007-10-30 | 2018-09-25 | Gearbox Llc | Substrates for nitric oxide releasing devices |
| US8349262B2 (en) | 2007-10-30 | 2013-01-08 | The Invention Science Fund I, Llc | Nitric oxide permeable housings |
| US7897399B2 (en) | 2007-10-30 | 2011-03-01 | The Invention Science Fund I, Llc | Nitric oxide sensors and systems |
| US8877508B2 (en) * | 2007-10-30 | 2014-11-04 | The Invention Science Fund I, Llc | Devices and systems that deliver nitric oxide |
| US8980332B2 (en) | 2007-10-30 | 2015-03-17 | The Invention Science Fund I, Llc | Methods and systems for use of photolyzable nitric oxide donors |
| US8303995B1 (en) * | 2008-06-13 | 2012-11-06 | Board Of Regents, The University Of Texas System | Nitrite formulations and their use as nitric oxide prodrugs |
| BRPI0913809B1 (pt) * | 2008-10-02 | 2019-02-05 | Mylan Inc | método para produzir continuamente um laminado adesivo sensível á pressão multicamada |
| EP2334279A4 (en) * | 2008-10-16 | 2013-03-20 | Novan Inc | STAIN OXIDE RELEASING PARTICLES FOR MOUTH CARE APPLICATIONS |
| GB0901456D0 (en) * | 2009-01-29 | 2009-03-11 | Insense Ltd | Treatment of psoriasis |
| US9241999B2 (en) * | 2009-06-15 | 2016-01-26 | Board Of Regents Of The University Of Texas System | Method of producing physiological and therapeutic levels of nitric oxide through an oral delivery system |
| WO2011022652A1 (en) | 2009-08-21 | 2011-02-24 | Novan, Inc. | Topical gels |
| CA2771389C (en) | 2009-08-21 | 2019-04-09 | Novan, Inc. | Wound dressings, methods of using the same and methods of forming the same |
| BR112012008508A2 (pt) * | 2009-10-13 | 2017-06-13 | Novan Inc | revestimento de sol-gel, substrato, método para produzir um revestimento de sol-gel |
| RU2445918C1 (ru) * | 2010-07-15 | 2012-03-27 | Федеральное государственное образовательное учреждение высшего профессионального образования Санкт-Петербургский государственный университет | Способ неинвазивной дифференциальной диагностики патологии лимфатических и венозных сосудов нижних конечностей |
| PT2533773E (pt) | 2010-10-21 | 2015-12-01 | Kipax Ab | Dispositivo de administração de óxido nítrico por via cutânea tópica |
| US8591876B2 (en) | 2010-12-15 | 2013-11-26 | Novan, Inc. | Methods of decreasing sebum production in the skin |
| WO2012118829A2 (en) | 2011-02-28 | 2012-09-07 | Novan, Inc. | Tertiary s-nitrosothiol-modified nitricoxide-releasing xerogels and methods of using the same |
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| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US10517817B2 (en) | 2013-05-09 | 2019-12-31 | Syk Technologies, Llc | Deep topical systemic nitric oxide therapy apparatus and method |
| GB201309092D0 (en) * | 2013-05-20 | 2013-07-03 | Edixomed Ltd | Transdermal delivery system |
| GB201309091D0 (en) * | 2013-05-20 | 2013-07-03 | Edixomed Ltd | Dressing system |
| US11406769B2 (en) * | 2014-01-31 | 2022-08-09 | Galderma Holding SA | Lubrication of an injection needle |
| RU2016143081A (ru) | 2014-05-22 | 2018-06-26 | Терапьютиксмд, Инк. | Натуральные комбинированные гормонозаместительные составы и терапии |
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| CN106659675B (zh) | 2014-07-11 | 2023-07-04 | 诺万公司 | 局部抗病毒组合物和其使用方法 |
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| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| US10849864B2 (en) | 2015-07-28 | 2020-12-01 | Novan, Inc. | Combinations and methods for the treatment and/or prevention of fungal infections |
| GB201520990D0 (en) | 2015-11-27 | 2016-01-13 | Edixomed Ltd | Dressing system |
| WO2017132275A1 (en) | 2016-01-27 | 2017-08-03 | Syk Technologies, Llc | Nitric oxide topical application apparatus and methods |
| US9931349B2 (en) | 2016-04-01 | 2018-04-03 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
| US10149843B1 (en) | 2017-02-07 | 2018-12-11 | Gneus Lifescineces Inc. | Pharmaceutical compositions and methods of using the same |
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| BR112021023632A2 (pt) | 2019-06-04 | 2022-04-19 | Thirty Respiratory Ltd | Métodos e composições para gerar óxido nítrico e usos do mesmo para entregar óxido nítrico através do trato respiratório |
| BR112021023832A8 (pt) * | 2019-06-04 | 2023-02-28 | Thirty Holdings Ltd | Métodos e composições para geração de óxido nítrico e usos dos mesmos |
| US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
| JP2023526583A (ja) | 2020-04-23 | 2023-06-22 | サーティー レスピラトリー リミテッド | 結核を治療及び抑制するための方法及び組成物 |
| US20240016831A1 (en) | 2020-04-23 | 2024-01-18 | Thirty Respiratory Limited | Nitric oxide or nitric oxide releasing compositions for use in treating sars-cov and sars-cov-2 |
| US12459820B2 (en) | 2020-06-11 | 2025-11-04 | J. W. Randolph Miller | Stabilized and NO2-inhibited nitric oxide generating gels for inhaled nitric oxide therapy |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58913A (ja) | 1981-06-26 | 1983-01-06 | Nitto Electric Ind Co Ltd | 局所系医薬製剤 |
| RO92445B1 (ro) * | 1985-08-12 | 1987-10-01 | Ludovic L. Elthes | Unguent medicamentos cu actiune antiinflamatoare, cicatrizanta si epitelizanta |
| US5719197A (en) * | 1988-03-04 | 1998-02-17 | Noven Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
| JPH07108849B2 (ja) | 1991-02-08 | 1995-11-22 | 奈良炭化工業株式会社 | 葉面散布用植物成育剤 |
| US5264219A (en) * | 1992-08-07 | 1993-11-23 | Minnesota Mining And Manufacturing Company | Transdermal drug delivery backing |
| US5891846A (en) * | 1994-02-17 | 1999-04-06 | Shiseido Company, Ltd. | Cyclosporin-containing emulsion composition |
| GB9804469D0 (en) | 1998-03-02 | 1998-04-29 | Univ Aberdeen | Antiviral composition |
| BR9507099A (pt) | 1994-02-21 | 1997-09-16 | Aberden University | Forma de dosagem método de esterilização composição esterilizante e suplemento alimentar animal compreendendo nitrito acidificado como um agente anti-microbiano |
| US5648101A (en) * | 1994-11-14 | 1997-07-15 | Tawashi; Rashad | Drug delivery of nitric oxide |
| SE9700617D0 (sv) | 1997-02-21 | 1997-02-21 | Kjell Alving | New composition |
| US5968547A (en) * | 1997-02-24 | 1999-10-19 | Euro-Celtique, S.A. | Method of providing sustained analgesia with buprenorphine |
| US5900249A (en) * | 1998-02-09 | 1999-05-04 | Smith; David J. | Multicomponent pain relief topical medication |
| US6103275A (en) * | 1998-06-10 | 2000-08-15 | Nitric Oxide Solutions | Systems and methods for topical treatment with nitric oxide |
| GB0021317D0 (en) * | 2000-08-30 | 2000-10-18 | Queen Mary & Westfield College | Transdermal pharmaceutical delivery composition |
-
2000
- 2000-08-30 GB GBGB0021317.3A patent/GB0021317D0/en not_active Ceased
-
2001
- 2001-08-30 WO PCT/GB2001/003863 patent/WO2002017881A2/en not_active Ceased
- 2001-08-30 AT AT01963158T patent/ATE347879T1/de not_active IP Right Cessation
- 2001-08-30 AU AU8419101A patent/AU8419101A/xx active Pending
- 2001-08-30 JP JP2002522855A patent/JP4869540B2/ja not_active Expired - Fee Related
- 2001-08-30 DE DE60125217T patent/DE60125217T2/de not_active Expired - Lifetime
- 2001-08-30 US US10/363,439 patent/US8128964B2/en not_active Expired - Fee Related
- 2001-08-30 AU AU2001284191A patent/AU2001284191B2/en not_active Ceased
- 2001-08-30 EP EP01963158A patent/EP1328252B1/en not_active Expired - Lifetime
- 2001-08-30 ES ES01963158T patent/ES2275716T3/es not_active Expired - Lifetime
-
2008
- 2008-09-03 US US12/231,555 patent/US8114442B2/en not_active Expired - Fee Related
-
2012
- 2012-01-27 US US13/360,601 patent/US20120183595A1/en not_active Abandoned
-
2013
- 2013-07-03 US US13/935,070 patent/US20140187481A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20040013747A1 (en) | 2004-01-22 |
| US20120183595A1 (en) | 2012-07-19 |
| EP1328252B1 (en) | 2006-12-13 |
| GB0021317D0 (en) | 2000-10-18 |
| AU2001284191B2 (en) | 2006-02-16 |
| US20090036491A1 (en) | 2009-02-05 |
| JP4869540B2 (ja) | 2012-02-08 |
| DE60125217D1 (de) | 2007-01-25 |
| ATE347879T1 (de) | 2007-01-15 |
| WO2002017881A2 (en) | 2002-03-07 |
| EP1328252A2 (en) | 2003-07-23 |
| US8128964B2 (en) | 2012-03-06 |
| ES2275716T3 (es) | 2007-06-16 |
| WO2002017881A3 (en) | 2003-04-17 |
| AU2001284191C1 (en) | 2002-03-13 |
| US8114442B2 (en) | 2012-02-14 |
| AU8419101A (en) | 2002-03-13 |
| JP2004507486A (ja) | 2004-03-11 |
| US20140187481A1 (en) | 2014-07-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8381 | Inventor (new situation) |
Inventor name: TUCKER, ARTHUR, LONDON, GB Inventor name: BENJAMIN, NIGEL DEPARTMENT OF PHARMACOLOGY, LO, GB |
|
| 8364 | No opposition during term of opposition |