DE3875931T2 - Verbesserung des eindringens in die haut durch verwendung von mischungen der freien base mit dem sauren additionssalz von wirkstoffen. - Google Patents

Verbesserung des eindringens in die haut durch verwendung von mischungen der freien base mit dem sauren additionssalz von wirkstoffen.

Info

Publication number
DE3875931T2
DE3875931T2 DE8888121046T DE3875931T DE3875931T2 DE 3875931 T2 DE3875931 T2 DE 3875931T2 DE 8888121046 T DE8888121046 T DE 8888121046T DE 3875931 T DE3875931 T DE 3875931T DE 3875931 T2 DE3875931 T2 DE 3875931T2
Authority
DE
Germany
Prior art keywords
free base
acid addition
addition salt
intraction
blend
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8888121046T
Other languages
English (en)
Other versions
DE3875931D1 (de
Inventor
Dinesh C Patel
Yunik Chang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Actavis Laboratories UT Inc
Original Assignee
Theratech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theratech Inc filed Critical Theratech Inc
Publication of DE3875931D1 publication Critical patent/DE3875931D1/de
Application granted granted Critical
Publication of DE3875931T2 publication Critical patent/DE3875931T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
DE8888121046T 1987-12-21 1988-12-15 Verbesserung des eindringens in die haut durch verwendung von mischungen der freien base mit dem sauren additionssalz von wirkstoffen. Expired - Fee Related DE3875931T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/136,115 US4888354A (en) 1987-12-21 1987-12-21 Skin penetration enhancement using free base and acid addition salt combinations of active agents

Publications (2)

Publication Number Publication Date
DE3875931D1 DE3875931D1 (de) 1992-12-17
DE3875931T2 true DE3875931T2 (de) 1993-03-25

Family

ID=22471370

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888121046T Expired - Fee Related DE3875931T2 (de) 1987-12-21 1988-12-15 Verbesserung des eindringens in die haut durch verwendung von mischungen der freien base mit dem sauren additionssalz von wirkstoffen.

Country Status (9)

Country Link
US (1) US4888354A (de)
EP (1) EP0321870B1 (de)
JP (1) JP2856407B2 (de)
KR (1) KR970007898B1 (de)
AT (1) ATE82137T1 (de)
CA (1) CA1332713C (de)
DE (1) DE3875931T2 (de)
ES (1) ES2052682T3 (de)
GR (1) GR3006499T3 (de)

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Also Published As

Publication number Publication date
JP2856407B2 (ja) 1999-02-10
CA1332713C (en) 1994-10-25
KR970007898B1 (ko) 1997-05-17
GR3006499T3 (de) 1993-06-21
ES2052682T3 (es) 1994-07-16
KR890009374A (ko) 1989-08-01
ATE82137T1 (de) 1992-11-15
JPH02104516A (ja) 1990-04-17
DE3875931D1 (de) 1992-12-17
EP0321870A1 (de) 1989-06-28
US4888354A (en) 1989-12-19
EP0321870B1 (de) 1992-11-11

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