WO1993000113A1 - A composition for treating a soft tissue injury - Google Patents

A composition for treating a soft tissue injury Download PDF

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Publication number
WO1993000113A1
WO1993000113A1 PCT/AU1992/000292 AU9200292W WO9300113A1 WO 1993000113 A1 WO1993000113 A1 WO 1993000113A1 AU 9200292 W AU9200292 W AU 9200292W WO 9300113 A1 WO9300113 A1 WO 9300113A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition according
composition
chemical
ammonia
soft tissue
Prior art date
Application number
PCT/AU1992/000292
Other languages
French (fr)
Inventor
Victor Patrick Davidson
Mark Anthony Dux
Original Assignee
Victor Patrick Davidson
Mark Anthony Dux
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Victor Patrick Davidson, Mark Anthony Dux filed Critical Victor Patrick Davidson
Publication of WO1993000113A1 publication Critical patent/WO1993000113A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/02—Ammonia; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus

Definitions

  • a Composition for Treating a Soft Tissue Injury is particularly concerned with treatment of injured ligaments or other soft tissue injuries such as shin soreness of horses legs.
  • injured ligaments or other soft tissue injuries such as shin soreness of horses legs.
  • a race horse injures a leg whether this be by way of strained ligaments or other soft tissue injury, it is necessary to rest the race horse and hope that the injury will heal itself. In many cases, the injury will not heal itself and the race horse is prevented from racing again. It follows therefore, that there is a need for a composition for treatment of soft tissue leg injuries of horses which treatment ultimately leads to healing of the soft tissue injury.
  • a composition for treating an injured ligament comprising a chemical for initiating swelling of soft tissue adjacent an injured region and an antiseptic which is arranged to pass through the swollen soft tissue to the injured region, the composition in use being arranged to draw affected material from the injured region through the surrounding soft tissue to promote healing of the injured region.
  • the affected material is serum.
  • the composition comprises a coagulant which is arranged to be carried through the swollen soft tissue to the injured region to reduce bleeding at the injured region.
  • the composition increases blood flow in the injured region.
  • the antiseptic preferably is carried by a carrier substance through the swollen soft tissue.
  • the antiseptic is also a coagulant.
  • the chemical for initiating swelling desirably acts to draw affected material from the injured region.
  • the composition may be arranged to be applied to the soft tissue surrounding the injured region.
  • the chemical is alkaline.
  • the composition may comprise an oil.
  • the oil may- act as a carrier for the antiseptic and coagulant and desirably act as a barrier to the chemical.
  • the chemical increases blood flow to the injured region.
  • the composition may permit exchange of gases through the soft tissue surrounding the injured region.
  • composition increase blood flow to the injured region.
  • the composition may increase movement of platelets to the injured region.
  • the composition accelerates repair of cells in the injured region.
  • the chemical may comprise ammonia in solution, preferably, NH4oH.
  • the antiseptic comprises eucalyptus oil.
  • the eucalyptus oil may comprise a carrier substance.
  • the chemical preferably comprises cloudy ammonia.
  • the chemical may comprise NH4oH and an alkaline substance.
  • the chemical may comprise NH4oH and soap flakes or detergent.
  • the chemical comprises soap flakes or an other alkaline substance in a proportion which makes up less than 5% of the composition by volume or by weight.
  • the NH4oH may contain a binding agent or a surfactant such as soap flakes.
  • the composition contains 3 to 85 millilitres of eucalyptus oil, 5 to 95 millilitres of cloudy ammonia and 0 to 40 millilitres of ammonia solution per 100 millilitres of composition.
  • composition comprising 5 to 97% H4oH and 3 to 95% eucalyptus oil.
  • the composition also contains 5 to 95% cloudy ammonia.
  • the composition comprises an alkaline chemical such as NaoH.
  • the alkaline • chemical is present in the composition in only a small amount less than 5% by volume of the overall composition.
  • the composition comprises 0 to 95% by volume cloudy a ⁇ imonia.
  • composition in accordance with the present invention can be made with the component shown in table 1.
  • the overall concentration of ammonia is approximately 6.16% W/W H3 and in a 100ml solution eucalyptus oil comprises 11.54ml, cloudy ammonia 76.92ml and ammonia solution 11.54ml.
  • the ingredients may be varied according to the information shown in table 2.
  • the overall percentage of ammonia (assay NH3 W/W) can vary between 2% to 10%.
  • the eucalyptus oil is poured into a glass bottle, then the cloudy ammonia solution is added and the bottle is sealed with an air tight seal and the bottle is then shaken until the contents are blended.
  • the bottle is then allowed to sit out of direct sunlight in a cool spot for 3 to 6 weeks and the contents are blended by shaking twice a day for one week, then once a day until sufficiently blended or mixed and thus mature.
  • the cloudy ammonia normally contains 30% NH3 and water and soap flakes.
  • the cloudy ammonia acts to swell soft tissue surrounding an injured region and also acts as a carrier for the eucalyptus oil.
  • the eucalyptus oil can be bought off the shelf and is produced by companies such as Fauldings and Double D and is an antiseptic and also acts as a coagulant to stop bleeding in the region of the injury and as a soothing agent.
  • the ammonia solution is added to provide the desired concentration of NH4oH in order to provide swelling of the soft tissue and to carry the eucalyptus oil to the injured region.
  • Cloudy ammonia can normally be bought off a supermarket shelf and one brand is named Castle and is produced by Ajax Chemicals Pty Ltd.
  • the cloudy ammonia normally contains NH4oH in 3.7% W/W.
  • the solution described above can be applied to a horses leg injury in the following manner.
  • the part of the leg which is injured is clipped to remove hair and the solution is applied by a sponge, roller, paint brush, spray or hand.
  • the horse After the solution is applied to the leg, the horse must be tied up for approximately 20 to 30 minutes to prevent it interfering with the treated region of its leg.
  • the composition in solution When the composition in solution is applied in the above manner, healing of the injured region is substantially increased and straightening of tendons or ligaments which would otherwise heal with a bow or kink along their length.
  • the recovery period is dependent upon the type of injury but is increased substantially and the composition is very effective in removing affected material such as, serum from the injured region to the exterior of the soft tissue and in addition, allows the antiseptic coagulant to enter the injured region although it is applied to the external surface of the skin adjacent the injured region.

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Cosmetics (AREA)

Abstract

A composition for treating an injured ligament of a horse comprising a chemical such as NH4oH for initiating swelling of soft tissue adjacent an injured region and an antiseptic such as eucalyptus oil which is arranged to pass through the swollen soft tissue to the injured region. The composition when used, draws affected material from the injured region through the surrounding soft tissue to promote healing of the injured region.

Description

A Composition for Treating a Soft Tissue Injury The present invention is particularly concerned with treatment of injured ligaments or other soft tissue injuries such as shin soreness of horses legs. Typically, if a race horse injures a leg whether this be by way of strained ligaments or other soft tissue injury, it is necessary to rest the race horse and hope that the injury will heal itself. In many cases, the injury will not heal itself and the race horse is prevented from racing again. It follows therefore, that there is a need for a composition for treatment of soft tissue leg injuries of horses which treatment ultimately leads to healing of the soft tissue injury.
In accordance with the present invention there is provided a composition for treating an injured ligament, comprising a chemical for initiating swelling of soft tissue adjacent an injured region and an antiseptic which is arranged to pass through the swollen soft tissue to the injured region, the composition in use being arranged to draw affected material from the injured region through the surrounding soft tissue to promote healing of the injured region.
Preferably, the affected material is serum. Preferably, the composition comprises a coagulant which is arranged to be carried through the swollen soft tissue to the injured region to reduce bleeding at the injured region.
Preferably, the composition increases blood flow in the injured region. The antiseptic, preferably is carried by a carrier substance through the swollen soft tissue.
It is further preferred that the antiseptic is also a coagulant. The chemical for initiating swelling, desirably acts to draw affected material from the injured region. The composition may be arranged to be applied to the soft tissue surrounding the injured region.
According to one embodiment of the present invention, the chemical is alkaline. The composition may comprise an oil. The oil may- act as a carrier for the antiseptic and coagulant and desirably act as a barrier to the chemical.
Preferably, the chemical increases blood flow to the injured region.
The composition may permit exchange of gases through the soft tissue surrounding the injured region.
It is preferred that the composition increase blood flow to the injured region. The composition may increase movement of platelets to the injured region.
Optionally, the composition accelerates repair of cells in the injured region.
According to a further embodiment of the present invention, the chemical may comprise ammonia in solution, preferably, NH4oH.
Desirably, the antiseptic comprises eucalyptus oil.
The eucalyptus oil may comprise a carrier substance.
The chemical, preferably comprises cloudy ammonia.
The chemical may comprise NH4oH and an alkaline substance. Alternatively, the chemical may comprise NH4oH and soap flakes or detergent.
According to another embodiment of the present invention, the chemical comprises soap flakes or an other alkaline substance in a proportion which makes up less than 5% of the composition by volume or by weight.
The NH4oH may contain a binding agent or a surfactant such as soap flakes.
It is preferred that the composition contains 3 to 85 millilitres of eucalyptus oil, 5 to 95 millilitres of cloudy ammonia and 0 to 40 millilitres of ammonia solution per 100 millilitres of composition.
According to another aspect of the present invention there is provided a composition comprising 5 to 97% H4oH and 3 to 95% eucalyptus oil.
Preferably, the composition also contains 5 to 95% cloudy ammonia.
Alternatively, the composition comprises an alkaline chemical such as NaoH.
Preferably, the alkaline • chemical is present in the composition in only a small amount less than 5% by volume of the overall composition.
Preferably, the composition comprises 0 to 95% by volume cloudy aπimonia.
Preferred embodiments of the present invention will now be described by way of example only.
In its most preferred form, the composition in accordance with the present invention can be made with the component shown in table 1.
Quantity Ingredients
150ml Eucalyptus Oil (Linament Quality)
1 litre Cloudy Ammonia (Assay-2.88% NH3 W/W)
150ml 28% Ammonia Solution (Assay-28%-30% NH3 W/W)
The overall concentration of ammonia, is approximately 6.16% W/W H3 and in a 100ml solution eucalyptus oil comprises 11.54ml, cloudy ammonia 76.92ml and ammonia solution 11.54ml.
The ingredients may be varied according to the information shown in table 2.
Variation Ingredient Variation Range (%) Range (mis)
3-85 Eucalyptus Oil 3-85
0-95 Cloudy Ammonia 0-95 0-40 Ammonia Solution 0-40
The overall percentage of ammonia (assay NH3 W/W) can vary between 2% to 10%. A method of mixing the above ingredients will now be described.
The eucalyptus oil is poured into a glass bottle, then the cloudy ammonia solution is added and the bottle is sealed with an air tight seal and the bottle is then shaken until the contents are blended. The bottle is then allowed to sit out of direct sunlight in a cool spot for 3 to 6 weeks and the contents are blended by shaking twice a day for one week, then once a day until sufficiently blended or mixed and thus mature.
When the solution is ready for use, the strong ammonia solution is added and the bottle is once again shaken. The contents of the bottle are then ready for use. The cloudy ammonia normally contains 30% NH3 and water and soap flakes.
The ingredients described above can be • varied. Cloudy ammonia for instance, can be replaced by peanut oil or olive oil as long as the ammonia solution is still retained.
Considering each of the components of the composition individually, it is generally considered that the cloudy ammonia acts to swell soft tissue surrounding an injured region and also acts as a carrier for the eucalyptus oil. The eucalyptus oil can be bought off the shelf and is produced by companies such as Fauldings and Double D and is an antiseptic and also acts as a coagulant to stop bleeding in the region of the injury and as a soothing agent. The ammonia solution is added to provide the desired concentration of NH4oH in order to provide swelling of the soft tissue and to carry the eucalyptus oil to the injured region.
Cloudy ammonia can normally be bought off a supermarket shelf and one brand is named Castle and is produced by Ajax Chemicals Pty Ltd. The cloudy ammonia normally contains NH4oH in 3.7% W/W. The ammonia solution can also be brought from Ajax Chemicals Pty Ltd under the name Uni-Var Analytical Reagent. In this form, the ammonia solution is 28% NH4oH = 35.05, NH3 = 17.03. The NH3 is 28% to 30% W/W, 250 to 265 g/1.
The solution described above can be applied to a horses leg injury in the following manner. The part of the leg which is injured is clipped to remove hair and the solution is applied by a sponge, roller, paint brush, spray or hand. After the solution is applied to the leg, the horse must be tied up for approximately 20 to 30 minutes to prevent it interfering with the treated region of its leg.
When the composition in solution is applied in the above manner, healing of the injured region is substantially increased and straightening of tendons or ligaments which would otherwise heal with a bow or kink along their length. The recovery period is dependent upon the type of injury but is increased substantially and the composition is very effective in removing affected material such as, serum from the injured region to the exterior of the soft tissue and in addition, allows the antiseptic coagulant to enter the injured region although it is applied to the external surface of the skin adjacent the injured region.

Claims

THE CLAIMS DEFINING THE INVENTION ARE AS FOLLOWS:
1. A composition for treating an injured ligament, comprising a chemical for initiating swelling of soft tissue adjacent an injured region and an antiseptic which is arranged to pass through the swollen soft tissue to the injured region, the composition in use being arranged to draw affected material from the injured region through the surrounding soft tissue to promote healing of the injured region.
2. A composition according to claim 1 further comprising a coagulant which is arranged to be carried through the swollen soft tissue to the injured region to reduce bleeding at the injured region.
3. A composition according to claim 1 or 2 which in use, increases blood flow in the injured region.
4. A composition as claimed in any one of the preceding claims further comprising a carrier substance for carrying the antiseptic through the swollen soft tissue.
5. A composition according to any one of the preceding claims wherein the antiseptic is a coagulant.
6. A composition according to any one of the preceding claims wherein the chemical for initiating swelling acts to draw effected material from the injured region.
7. A composition according to any one of the preceding claims wherein the chemical is alkaline.
8. A composition according to any one of the preceding claims wherein the composition comprises an oil.
9. A composition according to claim 8 wherein the oil acts as a carrier for the antiseptic and as a coagulant.
10. A composition according to claim 9 wherein the oil acts as a barrier to the chemical.
11. A composition according to any one of the preceding claims wherein the chemical increases blood flow to the injured region.
12. A composition according to any one of the preceding claims comprising a component which permits exchange of gases through the soft tissue surrounding the injured region.
13. A composition according to any one of the preceding claims wherein the chemical comprises ammonia in solution.
14. A composition according to claim 13 wherein the chemical is NH4oH.
15. A composition according to any one of the preceding claims wherein the antiseptic comprises eucalyptus oil.
16. A composition according to claim 15 wherein the eucalyptus oil comprises a carrier substance.
17. A composition according to any one of the preceding claims wherein the chemical comprises cloudy ammonia.
18. A composition according to any one of the preceding claims wherein the chemical comprises an alkaline substance in addition to NH4oH.
19. A composition according to claim 18 wherein the alkaline substance comprises soap flakes or detergent.
20. A composition according to claim 20 wherein the chemical comprises soap flakes or another alkaline substance in a proportion which makes up less than 5% of the composition by volume or by weight.
21. A composition according to claim 20 wherein the NH4oH contains a binding agent or a surfactant.
22. A composition according to claim 1 comprising 3 to 85 millilitres of eucalyptus oil, 5 to 95 millilitres of cloudy ammonia and 0 to 40 millilitres of ammonia solution per 100 millilitres of composition.
23. A composition for treating an injured ligament, comprising 5 to 97% NH4oH and 3 to 95% eucalyptus oil.
24. A composition according to claim 23 further comprising 5 to 95% cloudy ammonia.
25. A composition according to claim 23 and 24 wherein the composition comprises 5 to 97% by volume NH4oH, 3 to 95% by volume eucalyptus oil and 0 to 95% by volume cloudy ammonia.
26. A composition according to claim 23 wherein a 1.3 litre sample of the composition comprises 150 millilitres eucalyptus oil of linament quality, 1 litre of cloudy ammonia of Assay-2.88% NH3 W/W and 150 millilitres of 28% ammonia solution of Assay-28%-30% NH3 W/W.
27. A composition substantially as hereinbefore described with reference to table 1 or table 2.
PCT/AU1992/000292 1991-06-21 1992-06-17 A composition for treating a soft tissue injury WO1993000113A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPK684291 1991-06-21
AUPK6842 1991-06-21

Publications (1)

Publication Number Publication Date
WO1993000113A1 true WO1993000113A1 (en) 1993-01-07

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003004038A1 (en) * 2001-07-03 2003-01-16 Mendez Pando Hector Topically-applied composition based on ammonium hydroxide
CN104173855A (en) * 2014-08-07 2014-12-03 山东中医药大学 External heat-clearing swelling-diminishing traditional Chinese medicine composition and using method thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU506646A (en) * 1946-07-12 1947-06-12 Improvements in and relating to soaps and medicinal compositions
DE2353386A1 (en) * 1973-10-25 1975-05-07 Helmut Mueller Rheumatism and lumbago treatment compsn. - contg. formic acid, camphor, ammonia, turpentine, templin oil, anisol, ether, olive oil and soap
DE2639346A1 (en) * 1975-09-03 1977-03-17 Kenneth Martin Grout Compsns. for treating insect bites and stings - contg. ammonia and antiseptic
US4172888A (en) * 1978-09-12 1979-10-30 Robert E. Delzell, Sr. Athlete's foot treatment
EP0321870A1 (en) * 1987-12-21 1989-06-28 Theratech, Inc. Skin penetration enhancement using free base and acid addition salt combinations of active agents
EP0343671A2 (en) * 1988-05-27 1989-11-29 Dai-Ichi Kogyo Seiyaku Co., Ltd. Pharmaceutical composition for the treatment of skin wounds

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU506646A (en) * 1946-07-12 1947-06-12 Improvements in and relating to soaps and medicinal compositions
DE2353386A1 (en) * 1973-10-25 1975-05-07 Helmut Mueller Rheumatism and lumbago treatment compsn. - contg. formic acid, camphor, ammonia, turpentine, templin oil, anisol, ether, olive oil and soap
DE2639346A1 (en) * 1975-09-03 1977-03-17 Kenneth Martin Grout Compsns. for treating insect bites and stings - contg. ammonia and antiseptic
US4172888A (en) * 1978-09-12 1979-10-30 Robert E. Delzell, Sr. Athlete's foot treatment
EP0321870A1 (en) * 1987-12-21 1989-06-28 Theratech, Inc. Skin penetration enhancement using free base and acid addition salt combinations of active agents
EP0343671A2 (en) * 1988-05-27 1989-11-29 Dai-Ichi Kogyo Seiyaku Co., Ltd. Pharmaceutical composition for the treatment of skin wounds

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003004038A1 (en) * 2001-07-03 2003-01-16 Mendez Pando Hector Topically-applied composition based on ammonium hydroxide
CN104173855A (en) * 2014-08-07 2014-12-03 山东中医药大学 External heat-clearing swelling-diminishing traditional Chinese medicine composition and using method thereof

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