JP2004506005A5 - - Google Patents
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- JP2004506005A5 JP2004506005A5 JP2002518935A JP2002518935A JP2004506005A5 JP 2004506005 A5 JP2004506005 A5 JP 2004506005A5 JP 2002518935 A JP2002518935 A JP 2002518935A JP 2002518935 A JP2002518935 A JP 2002518935A JP 2004506005 A5 JP2004506005 A5 JP 2004506005A5
- Authority
- JP
- Japan
- Prior art keywords
- use according
- ala
- energy
- sebaceous gland
- medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- ZGXJTSGNIOSYLO-UHFFFAOYSA-N aminolevulinic acid Chemical compound NCC(=O)CCC(O)=O ZGXJTSGNIOSYLO-UHFFFAOYSA-N 0.000 claims description 10
- 229960002749 aminolevulinic acid Drugs 0.000 claims description 10
- 206010061511 Sebaceous gland disease Diseases 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 6
- 206010000496 Acne Diseases 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 208000002874 Acne Vulgaris Diseases 0.000 claims description 2
- 206010011985 Decubitus ulcer Diseases 0.000 claims description 2
- 208000004210 Pressure Ulcer Diseases 0.000 claims description 2
- 241001303601 Rosacea Species 0.000 claims description 2
- 206010048810 Sebaceous hyperplasia Diseases 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 239000002502 liposome Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000003504 photosensitizing agent Substances 0.000 claims description 2
- 201000004700 rosacea Diseases 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 210000003491 Skin Anatomy 0.000 claims 1
- 230000000699 topical Effects 0.000 description 1
Description
【特許請求の範囲】
【請求項1】 皮脂腺障害を処置または予防するための医薬の製造における5−アミノレブリン酸(ALA)およびその誘導体の使用であって、該ALAおよびその誘導体が、前記皮脂腺障害を罹患している皮膚の部分への局所的送達のために、かつ約1J/m2 〜200J/m2 のエネルギーに暴露することにより作動可能な光感作剤に転換するために配合されている使用。
【請求項2】 前記エネルギーは25J/m2 〜200J/m2 、好ましくは約100J/m2 である請求項1記載の使用。
【請求項3】 前記エネルギーの源は
i)レーザー、例えばパルス化色素レーザーまたはレーザーダイオードアレイ、および
ii)太陽光
から選ばれる請求項1または請求項2記載の使用。
【請求項4】 前記エネルギーは320nm〜700nm、好ましくは550nm〜700nm、さらに好ましくは550nm〜600nmの範囲の波長を有する請求項1〜請求項3のいずれか一項記載の使用。
【請求項5】 前記ALAおよびその誘導体は製薬用担体に懸濁されている請求項1〜請求項4のいずれか一項記載の使用。
【請求項6】 前記成薬用担体はリポソームおよび水溶液から選ばれる請求項1〜請求項5のいずれか一項記載の使用。
【請求項7】 前記皮脂腺障害は尋常性挫瘡、しゅさ性挫瘡および皮脂腺過形成の少なくとも1種を含む請求項1〜請求項6のいずれか一項記載の使用。
【請求項8】 前記皮脂腺障害は挫瘡である請求項7記載の使用。
【請求項9】 前記ALAおよびその誘導体は前記医薬中に0.1重量%〜30重量%、好ましくは0.1重量%〜20重量%、さらに好ましくは10重量%〜20重量%の量で存在する請求項8記載の使用。
【請求項10】 前記医薬はUVAまたはUVB範囲のUV放射線を吸収する物質をさらに含む請求項1〜請求項9のいずれか一項記載の使用。
【請求項1】 皮脂腺障害を処置または予防するための医薬の製造における5−アミノレブリン酸(ALA)およびその誘導体の使用であって、該ALAおよびその誘導体が、前記皮脂腺障害を罹患している皮膚の部分への局所的送達のために、かつ約1J/m2 〜200J/m2 のエネルギーに暴露することにより作動可能な光感作剤に転換するために配合されている使用。
【請求項2】 前記エネルギーは25J/m2 〜200J/m2 、好ましくは約100J/m2 である請求項1記載の使用。
【請求項3】 前記エネルギーの源は
i)レーザー、例えばパルス化色素レーザーまたはレーザーダイオードアレイ、および
ii)太陽光
から選ばれる請求項1または請求項2記載の使用。
【請求項4】 前記エネルギーは320nm〜700nm、好ましくは550nm〜700nm、さらに好ましくは550nm〜600nmの範囲の波長を有する請求項1〜請求項3のいずれか一項記載の使用。
【請求項5】 前記ALAおよびその誘導体は製薬用担体に懸濁されている請求項1〜請求項4のいずれか一項記載の使用。
【請求項6】 前記成薬用担体はリポソームおよび水溶液から選ばれる請求項1〜請求項5のいずれか一項記載の使用。
【請求項7】 前記皮脂腺障害は尋常性挫瘡、しゅさ性挫瘡および皮脂腺過形成の少なくとも1種を含む請求項1〜請求項6のいずれか一項記載の使用。
【請求項8】 前記皮脂腺障害は挫瘡である請求項7記載の使用。
【請求項9】 前記ALAおよびその誘導体は前記医薬中に0.1重量%〜30重量%、好ましくは0.1重量%〜20重量%、さらに好ましくは10重量%〜20重量%の量で存在する請求項8記載の使用。
【請求項10】 前記医薬はUVAまたはUVB範囲のUV放射線を吸収する物質をさらに含む請求項1〜請求項9のいずれか一項記載の使用。
Claims (10)
- 皮脂腺障害を処置または予防するための医薬の製造における5−アミノレブリン酸(ALA)の使用であって、該ALAが、前記皮脂腺障害を罹患している皮膚の部分への局所的送達のために、かつ約1J/m 2 〜200J/m 2 のエネルギーに暴露することにより作動可能な光感作剤に転換するために配合されている使用。
- 前記エネルギーは25J/m 2 〜200J/m 2 、好ましくは約100J/m 2 である請求項1記載の使用。
- 前記エネルギーの源は
i)レーザー、例えばパルス化色素レーザーまたはレーザーダイオードアレイ、および
ii)太陽光
から選ばれる請求項1または請求項2記載の使用。 - 前記エネルギーは320nm〜700nm、好ましくは550nm〜700nm、さらに好ましくは550nm〜600nmの範囲の波長を有する請求項1〜請求項3のいずれか一項記載の使用。
- 前記ALAは製薬用担体に懸濁されている請求項1〜請求項4のいずれか一項記載の使用。
- 前記成薬用担体はリポソームおよび水溶液から選ばれる請求項1〜請求項5のいずれか一項記載の使用。
- 前記皮脂腺障害は尋常性挫瘡、しゅさ性挫瘡および皮脂腺過形成の少なくとも1種を含む請求項1〜請求項6のいずれか一項記載の使用。
- 前記皮脂腺障害は挫瘡である請求項7記載の使用。
- 前記ALAは前記医薬中に0.1重量%〜30重量%、好ましくは0.1重量%〜20重量%、さらに好ましくは10重量%〜20重量%の量で存在する請求項8記載の使用。
- 前記医薬はUVAまたはUVB範囲のUV放射線を吸収する物質をさらに含む請求項1〜請求項9のいずれか一項記載の使用。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22569100P | 2000-08-16 | 2000-08-16 | |
PCT/US2001/041691 WO2002013788A1 (en) | 2000-08-16 | 2001-08-13 | Topical aminolevulinic acid-photodynamic therapy for acne vulgaris |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2004506005A JP2004506005A (ja) | 2004-02-26 |
JP2004506005A5 true JP2004506005A5 (ja) | 2011-07-07 |
Family
ID=22845856
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002518935A Pending JP2004506005A (ja) | 2000-08-16 | 2001-08-13 | 尋常性挫瘡用の局所アミノレブリン酸−光力学的治療 |
Country Status (8)
Country | Link |
---|---|
US (4) | US6897238B2 (ja) |
EP (2) | EP1313448B1 (ja) |
JP (1) | JP2004506005A (ja) |
AT (1) | ATE463237T1 (ja) |
AU (1) | AU2001291260A1 (ja) |
CA (1) | CA2422865C (ja) |
DE (1) | DE60141758D1 (ja) |
WO (1) | WO2002013788A1 (ja) |
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2001
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- 2001-08-13 EP EP01971365A patent/EP1313448B1/en not_active Expired - Lifetime
- 2001-08-13 AU AU2001291260A patent/AU2001291260A1/en not_active Abandoned
- 2001-08-13 CA CA2422865A patent/CA2422865C/en not_active Expired - Fee Related
- 2001-08-13 WO PCT/US2001/041691 patent/WO2002013788A1/en active Application Filing
- 2001-08-13 DE DE60141758T patent/DE60141758D1/de not_active Expired - Lifetime
- 2001-08-13 EP EP10180457A patent/EP2269645A3/en not_active Withdrawn
- 2001-08-13 JP JP2002518935A patent/JP2004506005A/ja active Pending
- 2001-08-14 US US09/929,384 patent/US6897238B2/en not_active Expired - Lifetime
-
2004
- 2004-10-20 US US10/970,922 patent/US20050143466A1/en not_active Abandoned
-
2009
- 2009-08-05 US US12/535,937 patent/US20090299268A1/en not_active Abandoned
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2012
- 2012-08-03 US US13/566,442 patent/US20120296263A1/en not_active Abandoned
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