JP2004505932A5 - - Google Patents

Info

Publication number

JP2004505932A5

JP2004505932A5 JP2002517105A JP2002517105A JP2004505932A5 JP 2004505932 A5 JP2004505932 A5 JP 2004505932A5 JP 2002517105 A JP2002517105 A JP 2002517105A JP 2002517105 A JP2002517105 A JP 2002517105A JP 2004505932 A5 JP2004505932 A5 JP 2004505932A5

Authority

JP

Japan

Prior art keywords

product

lactoferrin

labeled

tumor

product according

Prior art date

2001-08-07

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 108010063045 Lactoferrin Proteins 0.000 claims 18
• 102100032241 Lactotransferrin Human genes 0.000 claims 18
• 229940078795 lactoferrin Drugs 0.000 claims 17
• 235000021242 lactoferrin Nutrition 0.000 claims 17
• CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 claims 16
• 238000000034 method Methods 0.000 claims 10
• 206010028980 Neoplasm Diseases 0.000 claims 8
• 239000003638 chemical reducing agent Substances 0.000 claims 7
• 238000003384 imaging method Methods 0.000 claims 4
• 208000003174 Brain Neoplasms Diseases 0.000 claims 3
• 239000002872 contrast media Substances 0.000 claims 3
• 238000003745 diagnosis Methods 0.000 claims 3
• 239000007951 isotonicity adjuster Substances 0.000 claims 3
• 239000002904 solvent Substances 0.000 claims 3
• WXTMDXOMEHJXQO-UHFFFAOYSA-N 2,5-dihydroxybenzoic acid Chemical group OC(=O)C1=CC(O)=CC=C1O WXTMDXOMEHJXQO-UHFFFAOYSA-N 0.000 claims 2
• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
• 102000014914 Carrier Proteins Human genes 0.000 claims 2
• 108010078791 Carrier Proteins Proteins 0.000 claims 2
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
• 239000013011 aqueous formulation Substances 0.000 claims 2
• 239000007864 aqueous solution Substances 0.000 claims 2
• 239000002184 metal Substances 0.000 claims 2
• 229910052751 metal Inorganic materials 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 102000007474 Multiprotein Complexes Human genes 0.000 claims 1
• 108010085220 Multiprotein Complexes Proteins 0.000 claims 1
• 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 1
• 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 1
• 230000002159 abnormal effect Effects 0.000 claims 1
• 239000003125 aqueous solvent Substances 0.000 claims 1
• 229960005070 ascorbic acid Drugs 0.000 claims 1
• 235000010323 ascorbic acid Nutrition 0.000 claims 1
• 239000011668 ascorbic acid Substances 0.000 claims 1
• 239000008280 blood Substances 0.000 claims 1
• 210000004369 blood Anatomy 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 229960005219 gentisic acid Drugs 0.000 claims 1
• 238000001727 in vivo Methods 0.000 claims 1
• 229910052742 iron Inorganic materials 0.000 claims 1
• 238000002372 labelling Methods 0.000 claims 1
• 239000000843 powder Substances 0.000 claims 1
• 210000002966 serum Anatomy 0.000 claims 1
• 239000011780 sodium chloride Substances 0.000 claims 1
• -1 tin (II) compound Chemical class 0.000 claims 1