JP2004505036A5 - - Google Patents
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- Publication number
- JP2004505036A5 JP2004505036A5 JP2002515232A JP2002515232A JP2004505036A5 JP 2004505036 A5 JP2004505036 A5 JP 2004505036A5 JP 2002515232 A JP2002515232 A JP 2002515232A JP 2002515232 A JP2002515232 A JP 2002515232A JP 2004505036 A5 JP2004505036 A5 JP 2004505036A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- emphysema
- solvate
- hydrate
- cis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010014561 Emphysema Diseases 0.000 claims 9
- SHGAZHPCJJPHSC-NUEINMDLSA-N Isotretinoin Chemical compound OC(=O)C=C(C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-NUEINMDLSA-N 0.000 claims 8
- 229960005280 Isotretinoin Drugs 0.000 claims 8
- 239000000651 prodrug Substances 0.000 claims 8
- 229940002612 prodrugs Drugs 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 239000011780 sodium chloride Substances 0.000 claims 8
- 239000012453 solvate Substances 0.000 claims 8
- -1 hydrate Substances 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 239000003937 drug carrier Substances 0.000 claims 4
- 239000000443 aerosol Substances 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- TXEYQDLBPFQVAA-UHFFFAOYSA-N Tetrafluoromethane Chemical compound FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000006199 nebulizer Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Claims (11)
- 肺気腫の処置のための、治療活性量の１３−cis−レチノイン酸、又はその薬剤学的に許容しうる塩、水和物、溶媒和物、若しくはプロドラッグを含むことを特徴とする医薬の製造のための、このような化合物の使用。
- 治療活性量が、約０．１μgと約１０．０mgの間である、請求項１記載の１３−cis−レチノイン酸、又はその薬剤学的に許容しうる塩、水和物、溶媒和物、若しくはプロドラッグの使用。
- 肺気腫が、中心小葉性肺気腫又は遠位小葉性肺気腫である、請求項１又は２記載の１３−cis−レチノイン酸、又はその薬剤学的に許容しうる塩、水和物、溶媒和物、若しくはプロドラッグの使用。
- 医薬が、電気流体力学的エーロゾル装置で投与される、請求項１、２又は３記載の１３−cis−レチノイン酸、又はその薬剤学的に許容しうる塩、水和物、溶媒和物、若しくはプロドラッグの使用。
- 肺気腫の１つの症候を軽減するのに充分である量の１３−cis−レチノイン酸、又はその薬剤学的に許容しうる塩、水和物、溶媒和物、若しくはプロドラッグ、及び薬剤学的に許容しうる担体を含むことを特徴とする、肺気腫に罹患した哺乳動物を治療するのに適した薬剤組成物。
- 薬剤学的に許容しうる担体が、電気流体力学的エーロゾル装置、エーロゾル装置又はネブライザー装置に適している、請求項５記載の薬剤組成物。
- １３−cis−レチノイン酸、又はその薬剤学的に許容しうる塩、水和物、溶媒和物、若しくはプロドラッグの量が、約０．１μgと約１０．０mgの間である、請求項５記載の薬剤組成物。
- 薬剤学的に許容しうる担体が、液体である、請求項６記載の薬剤組成物。
- 薬剤学的に許容しうる担体が、水、アルコール、ポリエチレングリコール及びペルフルオロカーボンよりなる群から選択される、請求項８記載の薬剤組成物。
- １３−cis−レチノイン酸、又はその薬剤学的に許容しうる塩、水和物、溶媒和物、若しくはプロドラッグの量が、約１．０μgと約１００．０μgの間である、請求項８記載の薬剤組成物。
- 肺気腫のリスクのあるヒトにおける肺気腫を予防するのに適した薬剤組成物であって、肺気腫を予防するのに充分である量の１３−cis−レチノイン酸、又はその薬剤学的に許容しうる塩、水和物、溶媒和物、若しくはプロドラッグ及び薬剤学的に許容しうる担体を含むことを特徴とする組成物。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/631,151 US6339107B1 (en) | 2000-08-02 | 2000-08-02 | Methods for treatment of Emphysema using 13-cis retinoic acid |
| PCT/EP2001/008484 WO2002009679A2 (en) | 2000-08-02 | 2001-07-23 | Use of 13-cis retinoic acid for the treatment of emphysema |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004505036A JP2004505036A (ja) | 2004-02-19 |
| JP2004505036A5 true JP2004505036A5 (ja) | 2005-03-03 |
Family
ID=24529991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002515232A Pending JP2004505036A (ja) | 2000-08-02 | 2001-07-23 | 肺気腫の治療のための１３−ｃｉｓ−レチノイン酸の使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6339107B1 (ja) |
| EP (1) | EP1307187B1 (ja) |
| JP (1) | JP2004505036A (ja) |
| AU (1) | AU2001289726A1 (ja) |
| DE (1) | DE60130661T2 (ja) |
| ES (1) | ES2292620T3 (ja) |
| WO (1) | WO2002009679A2 (ja) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6720001B2 (en) * | 1999-10-18 | 2004-04-13 | Lipocine, Inc. | Emulsion compositions for polyfunctional active ingredients |
| US6339107B1 (en) * | 2000-08-02 | 2002-01-15 | Syntex (U.S.A.) Llc | Methods for treatment of Emphysema using 13-cis retinoic acid |
| BR0208303A (pt) * | 2001-03-22 | 2004-03-09 | Battelle Memorial Institute | Formações liquidas para pulverização eletroidrodin mica contendo polìmero e partìculas suspensas |
| CA2464346A1 (en) * | 2001-10-30 | 2003-05-08 | Nektar Therapeutics Al, Corporation | Water-soluble polymer conjugates of retinoic acid |
| US20030185762A1 (en) * | 2002-03-22 | 2003-10-02 | Cowan Siu Man L. | Highly aqueous liquid carrier formulations |
| WO2004022042A1 (en) * | 2002-09-06 | 2004-03-18 | Oregon Health And Science University | Effect of vitamin a gel on paranasal sinus mucosal regeneration |
| JPWO2006025395A1 (ja) * | 2004-08-31 | 2008-05-08 | 慶彦 清水 | キャリアフリーの細胞増殖因子を用いた慢性閉塞性肺疾患に対する医薬および処置システム |
| WO2006079209A1 (en) * | 2005-01-26 | 2006-08-03 | The University Of British Columbia | Pulmonary compositions comprising a vitamin a compound and a surfactant and uses thereof |
| WO2007104030A1 (en) * | 2006-03-08 | 2007-09-13 | Kinemed, Inc. | Retinoids and related compounds for the treatment of neuroinflammatory conditions, diseases and disorders |
| US20070254025A1 (en) * | 2006-04-27 | 2007-11-01 | Cronk Peter J | Oral contraceptive and acne medication combination and treatment of acne with reduced side effects |
| US20070254858A1 (en) * | 2006-04-27 | 2007-11-01 | Cronk Peter J | Contraceptive and Acne Medication Combination and Treatment of Acne and Other Diseases with Reduced Side Effects |
| SG176097A1 (en) | 2009-05-20 | 2011-12-29 | Ranbaxy Lab Ltd | Topical retinoid solutions |
| CA2762391C (en) * | 2009-05-20 | 2017-02-07 | Ranbaxy Laboratories Limited | Liquid dosage forms of isotretinoin |
| US10022348B2 (en) | 2009-05-20 | 2018-07-17 | Sun Pharmaceutical Industries Limited | Topical solution of isotretinoin |
| EP2938329A4 (en) * | 2012-12-27 | 2016-08-10 | Microdose Therapeutx Inc | METHODS AND COMPOSITIONS FOR OXYBUTYNINE ADMINISTRATION |
| US11026932B2 (en) | 2015-09-10 | 2021-06-08 | National University Corporation Okayama University | Medicinal composition for preventing or treating inflammatory respiratory disease |
| CN113372368B (zh) * | 2020-03-09 | 2022-04-12 | 苏州爱科百发生物医药技术有限公司 | 一种弹性蛋白酶抑制剂前药及其用途 |
| WO2023168608A1 (en) * | 2022-03-08 | 2023-09-14 | Mastery Biotech Co., Ltd. | Pharmaceutical composition including retinoic acid and carbohydrate and use thereof |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB334585A (en) * | 1929-06-06 | 1930-09-08 | British Glues And Chemicals Lt | Improvements in or relating to the separation of solids from liquids |
| AU531759B2 (en) | 1978-04-17 | 1983-09-08 | Ici Ltd. | Electrostatic spraying |
| GB8504253D0 (en) | 1985-02-19 | 1985-03-20 | Ici Plc | Electrostatic spraying apparatus |
| IL90069A (en) | 1988-04-26 | 1994-04-12 | Us Health | The use of 31 cysts of retinoic acid in the preparation of a drug for the treatment of congenital conjunctivitis |
| DE3815221C2 (de) | 1988-05-04 | 1995-06-29 | Gradinger F Hermes Pharma | Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen |
| GB9116909D0 (en) * | 1991-08-06 | 1991-09-18 | Salford Ultrafine Chem & Res | Morphine derivatives |
| TW272187B (ja) | 1992-05-20 | 1996-03-11 | Hoffmann La Roche | |
| GB9225098D0 (en) | 1992-12-01 | 1993-01-20 | Coffee Ronald A | Charged droplet spray mixer |
| GB9226717D0 (en) | 1992-12-22 | 1993-02-17 | Coffee Ronald A | Induction-operated electro-hydrodynamic spray device with means of modifying droplet trajectories |
| GB9406255D0 (en) | 1994-03-29 | 1994-05-18 | Electrosols Ltd | Dispensing device |
| GB9406171D0 (en) | 1994-03-29 | 1994-05-18 | Electrosols Ltd | Dispensing device |
| GB9410658D0 (en) | 1994-05-27 | 1994-07-13 | Electrosols Ltd | Dispensing device |
| WO1996028205A1 (en) | 1995-03-14 | 1996-09-19 | Siemens Aktiengesellschaft | Ultrasonic atomizer device with removable precision dosing unit |
| ZA962077B (en) | 1995-03-14 | 1997-03-26 | Siemens Ag | Ultrasonic atomizer device with removable precision dosating unit |
| US6515022B2 (en) * | 1996-04-19 | 2003-02-04 | Sloan-Kettering Institute For Cancer Research | Use of inhaled retinoids in the treatment of lung diseases |
| US6251941B1 (en) | 1996-04-19 | 2001-06-26 | Sloan-Kettering Institute For Cancer Research | Use of inhaled retinoids in the prevention of cancer |
| US5998486A (en) | 1997-07-08 | 1999-12-07 | Georgetown University School Of Medicine | Treatment of emphysema with retinoic acid or other retinoids by inducing formation of gas-exchange units (alveoli) |
| NZ504021A (en) | 1997-10-17 | 2003-04-29 | Systemic Pulmonary Delivery Lt | Method and apparatus for delivering aerosolized medication having air discharged through air tube directly into plume of aerosolized medication |
| BR9908771A (pt) | 1998-03-16 | 2000-12-12 | Inhale Therapeutic Syst | Processos para a liberação de um agente ativo e de insulina para os pulmões de um paciente humano, dispositivo para aumentar a biodisponibilidade de um agente ativo, e, dispositivos para a liberação de um agente ativo e de insulina para os pulmões de um paciente humano |
| US6339107B1 (en) * | 2000-08-02 | 2002-01-15 | Syntex (U.S.A.) Llc | Methods for treatment of Emphysema using 13-cis retinoic acid |
-
2000
- 2000-08-02 US US09/631,151 patent/US6339107B1/en not_active Expired - Fee Related
-
2001
- 2001-07-23 EP EP01969477A patent/EP1307187B1/en not_active Expired - Lifetime
- 2001-07-23 ES ES01969477T patent/ES2292620T3/es not_active Expired - Lifetime
- 2001-07-23 JP JP2002515232A patent/JP2004505036A/ja active Pending
- 2001-07-23 WO PCT/EP2001/008484 patent/WO2002009679A2/en active IP Right Grant
- 2001-07-23 DE DE60130661T patent/DE60130661T2/de not_active Expired - Fee Related
- 2001-07-23 AU AU2001289726A patent/AU2001289726A1/en not_active Abandoned
- 2001-09-26 US US09/966,202 patent/US6794416B2/en not_active Expired - Fee Related
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