JP2004501650A5 - - Google Patents
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- Publication number
- JP2004501650A5 JP2004501650A5 JP2002506221A JP2002506221A JP2004501650A5 JP 2004501650 A5 JP2004501650 A5 JP 2004501650A5 JP 2002506221 A JP2002506221 A JP 2002506221A JP 2002506221 A JP2002506221 A JP 2002506221A JP 2004501650 A5 JP2004501650 A5 JP 2004501650A5
- Authority
- JP
- Japan
- Prior art keywords
- adenovirus
- vector according
- region
- adenovirus vector
- genome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000701161 unidentified adenovirus Species 0.000 description 80
- 239000013598 vector Substances 0.000 description 48
- 102100040247 Tumor necrosis factor Human genes 0.000 description 16
- 108091028043 Nucleic acid sequence Proteins 0.000 description 12
- 150000007523 nucleic acids Chemical group 0.000 description 12
- 125000006850 spacer group Chemical group 0.000 description 11
- 125000000539 amino acid group Chemical group 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 241000700605 Viruses Species 0.000 description 4
- 230000002950 deficient Effects 0.000 description 4
- 230000008488 polyadenylation Effects 0.000 description 4
- 230000005855 radiation Effects 0.000 description 4
- 239000004475 Arginine Substances 0.000 description 3
- 108091026890 Coding region Proteins 0.000 description 3
- 101710145505 Fiber protein Proteins 0.000 description 3
- 239000004472 Lysine Substances 0.000 description 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 3
- 230000001939 inductive effect Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 101100444898 Mus musculus Egr1 gene Proteins 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 230000005030 transcription termination Effects 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000012830 cancer therapeutic Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/604,694 US6579522B1 (en) | 2000-06-27 | 2000-06-27 | Replication deficient adenoviral TNF vector |
| PCT/US2001/020536 WO2002000906A2 (en) | 2000-06-27 | 2001-06-27 | Replication deficient adenoviral tnf vector |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012022529A Division JP2012139220A (ja) | 2000-06-27 | 2012-02-03 | 複製欠損アデノウイルスｔｎｆベクター |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004501650A JP2004501650A (ja) | 2004-01-22 |
| JP2004501650A5 true JP2004501650A5 (https=) | 2008-07-31 |
Family
ID=24420637
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002506221A Pending JP2004501650A (ja) | 2000-06-27 | 2001-06-27 | 複製欠損アデノウイルスｔｎｆベクター |
| JP2012022529A Pending JP2012139220A (ja) | 2000-06-27 | 2012-02-03 | 複製欠損アデノウイルスｔｎｆベクター |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012022529A Pending JP2012139220A (ja) | 2000-06-27 | 2012-02-03 | 複製欠損アデノウイルスｔｎｆベクター |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6579522B1 (https=) |
| EP (1) | EP1294918B1 (https=) |
| JP (2) | JP2004501650A (https=) |
| AT (1) | ATE306555T1 (https=) |
| AU (2) | AU7154901A (https=) |
| CA (1) | CA2412637A1 (https=) |
| DE (1) | DE60114006T2 (https=) |
| WO (1) | WO2002000906A2 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1180159T3 (da) * | 1999-05-28 | 2008-11-17 | Targeted Genetics Corp | Fremgangsmåder og sammensætninger til at sænke niveauet af Tumor-Nekrose-Faktor (TNF) i TNF-associerede lidelser |
| US6579522B1 (en) * | 2000-06-27 | 2003-06-17 | Genvec, Inc. | Replication deficient adenoviral TNF vector |
| US20030086903A1 (en) | 2001-11-02 | 2003-05-08 | Genvec, Inc. | Therapeutic regimen for treating cancer |
| US6845929B2 (en) * | 2002-03-22 | 2005-01-25 | Ali Dolatabadi | High efficiency nozzle for thermal spray of high quality, low oxide content coatings |
| US20030223962A1 (en) * | 2002-06-03 | 2003-12-04 | Cornell Research Foundation, Inc. | Delivery of gene products to the lung parenchyma via gene transfer to the pleura |
| DE602004025726D1 (de) * | 2003-11-14 | 2010-04-08 | Genvec Inc | Pharmazeutische verbindung zur behandlung von lokal fortgeschrittenem primär inoperablen pankreaskarzinom (lapc). |
| CN101507822B (zh) * | 2003-11-24 | 2012-06-06 | 坎吉有限公司 | 皮肤瘢痕形成的减少 |
| EP1784493A2 (en) * | 2004-09-01 | 2007-05-16 | The Government of the United States of America as Represented by The Department of Health and Human Services | Adenoviral vectors able to transduce apcs, potential use in immune response generation |
| AU2006297112B2 (en) * | 2005-10-01 | 2013-04-18 | Charles Stout | Regulatable fusion promoters |
| DE602008004476D1 (de) * | 2007-03-09 | 2011-02-24 | Vectorlogics Inc | Zellen für adenovirusvektor- und proteinherstellung |
| US9605844B2 (en) * | 2009-09-01 | 2017-03-28 | Cree, Inc. | Lighting device with heat dissipation elements |
| WO2011054811A1 (en) | 2009-11-03 | 2011-05-12 | Santaris Pharma A/S | Rna antagonists targeting hsp27 combination therapy |
| WO2012006145A2 (en) * | 2010-06-29 | 2012-01-12 | The Johns Hopkins University | Com positions and methods for retargeting virus constructs |
| KR101429696B1 (ko) | 2012-11-21 | 2014-08-13 | 국립암센터 | 안전성 및 항암활성이 증가된 재조합 아데노바이러스 및 이의 용도 |
| SG11201507393TA (en) | 2013-03-14 | 2015-10-29 | Salk Inst For Biological Studi | Oncolytic adenovirus compositions |
| KR102608590B1 (ko) | 2014-09-24 | 2023-12-01 | 솔크 인스티튜트 포 바이올로지칼 스터디즈 | 종양 살상 바이러스 및 이의 사용방법 |
| WO2017147265A1 (en) | 2016-02-23 | 2017-08-31 | Salk Institute For Biological Studies | High throughput assay for measuring adenovirus replication kinetics |
| WO2017147269A1 (en) | 2016-02-23 | 2017-08-31 | Salk Institute For Biological Studies | Exogenous gene expression in therapeutic adenovirus for minimal impact on viral kinetics |
| EP3532082A4 (en) | 2016-12-12 | 2020-08-26 | Salk Institute for Biological Studies | SYNTHETIC ADENOVIRUS TUMOR TARGETING AND THEIR USES |
| CN112292449A (zh) | 2018-04-09 | 2021-01-29 | 萨克生物研究学院 | 具有增强的复制特性的溶瘤腺病毒组合物 |
| WO2024233783A1 (en) | 2023-05-09 | 2024-11-14 | Cornell University | Expression cassette coding for vascular endothelial growth factor |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5833975A (en) * | 1989-03-08 | 1998-11-10 | Virogenetics Corporation | Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence |
| US4879226A (en) | 1984-04-06 | 1989-11-07 | Asahi Kasei Kogyo Kabushiki Kaisha | Novel human physiologically active polypeptide |
| US5206152A (en) | 1988-04-08 | 1993-04-27 | Arch Development Corporation | Cloning and expression of early growth regulatory protein genes |
| US5763209A (en) | 1988-09-26 | 1998-06-09 | Arch Development Corporation | Methods and materials relating to the functional domains of DNA binding proteins |
| JP3443119B2 (ja) * | 1989-08-07 | 2003-09-02 | ペプテック リミテッド | 腫瘍壊死因子結合リガンド |
| CA2055168A1 (en) | 1990-11-21 | 1992-05-22 | Walter Fiers | Tnf-muteins |
| US6605712B1 (en) | 1990-12-20 | 2003-08-12 | Arch Development Corporation | Gene transcription and ionizing radiation: methods and compositions |
| WO1992011033A1 (en) | 1990-12-20 | 1992-07-09 | Arch Development Corporation | Control of gene expression by ionizing radiation |
| US5358866A (en) | 1991-07-03 | 1994-10-25 | The United States Of America As Represented By The Department Of Health And Human Services | Cytosine deaminase negative selection system for gene transfer techniques and therapies |
| US5968735A (en) | 1992-11-12 | 1999-10-19 | Max Delbruck-Centrum Fur Molekular Medizin Berlin | Vector for the expression of therapy-relevant genes |
| FR2709309B1 (fr) | 1993-08-25 | 1995-11-10 | Centre Nat Rech Scient | Compositions cellulaires, préparation et utilisations thérapeutiques. |
| US5641755A (en) | 1994-02-04 | 1997-06-24 | Arch Development Corp. | Regulation of x-ray mediated gene expression |
| US5571797A (en) | 1994-05-11 | 1996-11-05 | Arch Development Corporation | Method of inducing gene expression by ionizing radiation |
| US5851806A (en) * | 1994-06-10 | 1998-12-22 | Genvec, Inc. | Complementary adenoviral systems and cell lines |
| ATE336587T1 (de) | 1994-06-10 | 2006-09-15 | Genvec Inc | Adenoviren-vektor systeme und zelllinien |
| US5962424A (en) | 1995-02-21 | 1999-10-05 | Arch Development Corporation | Methods and compositions for targeting selectins |
| US6127525A (en) * | 1995-02-21 | 2000-10-03 | Cornell Research Foundation, Inc. | Chimeric adenoviral coat protein and methods of using same |
| AU4994596A (en) | 1995-03-01 | 1996-09-18 | Cornell Research Foundation Inc. | Interdependent adenoviral vectors and methods of using same |
| WO1996033746A1 (en) | 1995-04-28 | 1996-10-31 | Genetic Therapy, Inc. | Treatment of tumors with cells expressing interferons, tumor necrosis factors, or other cytokines |
| US6281010B1 (en) * | 1995-06-05 | 2001-08-28 | The Trustees Of The University Of Pennsylvania | Adenovirus gene therapy vehicle and cell line |
| JPH11513390A (ja) * | 1995-10-06 | 1999-11-16 | アーチ デベロップメント コーポレイション | 細胞殺傷のウイルス増強のための方法および組成物 |
| EE9800160A (et) | 1995-11-28 | 1998-12-15 | Genvec, Inc. | Vektorid ja meetodid geenide ülekandmiseks rakkudesse |
| EP0979101B1 (en) | 1996-07-03 | 2010-10-27 | Merial, Inc. | Recombinant canine adenovirus 2 (cav2) containing exogenous dna |
| CA2232743A1 (en) | 1997-04-02 | 1998-10-02 | Smithkline Beecham Corporation | A tnf homologue, tl5 |
| US6100086A (en) | 1997-04-14 | 2000-08-08 | Genzyme Corporation | Transgene expression systems |
| US5981275A (en) | 1997-04-14 | 1999-11-09 | Genzyme Corporation | Transgene expression system for increased persistence |
| IL120979A0 (en) | 1997-06-02 | 1997-11-20 | Interpharm Lab Ltd | Glycosylated TNF |
| US6171787B1 (en) | 1997-06-26 | 2001-01-09 | Abbott Laboratories | Member of the TNF family useful for treatment and diagnosis of disease |
| CA2308511C (en) | 1997-10-29 | 2016-01-19 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Use of transfected or transduced mammalian cells for treating bone pathologies |
| DE19747718A1 (de) | 1997-10-29 | 1999-05-06 | Baltzer Axel Wilhelm August Dr | Verfahren zur Therapie knochenresorbierender Erkrankungen mit der molekularbiologischen Methode der Gentherapie |
| KR20010031762A (ko) | 1997-11-03 | 2001-04-16 | 추후제출 | 유전자요법을 위한 과열 유도 발현 벡터 및 그의 이용 방법 |
| WO1999046371A2 (en) | 1998-03-11 | 1999-09-16 | Board Of Regents, The University Of Texas System | Induction of apoptotic or cytotoxic gene expression by adenoviral mediated gene codelivery |
| JP2002506651A (ja) | 1998-03-16 | 2002-03-05 | イントロジェン・セラピューティクス，インコーポレイテッド | 多重遺伝子ベクター |
| AU772963B2 (en) | 1998-04-24 | 2004-05-13 | Onyx Pharmaceuticals | Adenoviral vectors for treating disease |
| AU762615B2 (en) | 1998-06-15 | 2003-07-03 | Arch Development Corporation | Combination of radiotherapy and anti-angiogenic factors |
| WO2000035455A1 (en) * | 1998-12-15 | 2000-06-22 | Telik, Inc. | Heteroaryl-aryl ureas as igf-1 receptor antagonists |
| US6579522B1 (en) * | 2000-06-27 | 2003-06-17 | Genvec, Inc. | Replication deficient adenoviral TNF vector |
| US20030086903A1 (en) * | 2001-11-02 | 2003-05-08 | Genvec, Inc. | Therapeutic regimen for treating cancer |
-
2000
- 2000-06-27 US US09/604,694 patent/US6579522B1/en not_active Expired - Fee Related
-
2001
- 2001-06-27 AU AU7154901A patent/AU7154901A/xx active Pending
- 2001-06-27 AT AT01950575T patent/ATE306555T1/de not_active IP Right Cessation
- 2001-06-27 CA CA002412637A patent/CA2412637A1/en not_active Abandoned
- 2001-06-27 DE DE60114006T patent/DE60114006T2/de not_active Expired - Lifetime
- 2001-06-27 EP EP01950575A patent/EP1294918B1/en not_active Expired - Lifetime
- 2001-06-27 WO PCT/US2001/020536 patent/WO2002000906A2/en not_active Ceased
- 2001-06-27 AU AU2001271549A patent/AU2001271549B2/en not_active Ceased
- 2001-06-27 JP JP2002506221A patent/JP2004501650A/ja active Pending
-
2003
- 2003-04-25 US US10/424,638 patent/US20030175245A1/en not_active Abandoned
-
2012
- 2012-02-03 JP JP2012022529A patent/JP2012139220A/ja active Pending
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