JP2004500366A5 - - Google Patents
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- Publication number
- JP2004500366A5 JP2004500366A5 JP2001548141A JP2001548141A JP2004500366A5 JP 2004500366 A5 JP2004500366 A5 JP 2004500366A5 JP 2001548141 A JP2001548141 A JP 2001548141A JP 2001548141 A JP2001548141 A JP 2001548141A JP 2004500366 A5 JP2004500366 A5 JP 2004500366A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- binding
- polypeptide
- neutralizing antibody
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 description 36
- 238000000034 method Methods 0.000 description 25
- 241000711549 Hepacivirus C Species 0.000 description 12
- 230000003472 neutralizing effect Effects 0.000 description 11
- 229920001184 polypeptide Polymers 0.000 description 11
- 102000004196 processed proteins & peptides Human genes 0.000 description 11
- 108090000765 processed proteins & peptides Proteins 0.000 description 11
- 108010076039 Polyproteins Proteins 0.000 description 6
- 150000001413 amino acids Chemical class 0.000 description 6
- 239000000427 antigen Substances 0.000 description 6
- 108091007433 antigens Proteins 0.000 description 6
- 102000036639 antigens Human genes 0.000 description 6
- 238000010790 dilution Methods 0.000 description 6
- 239000012895 dilution Substances 0.000 description 6
- 239000002157 polynucleotide Substances 0.000 description 5
- 102000040430 polynucleotide Human genes 0.000 description 3
- 108091033319 polynucleotide Proteins 0.000 description 3
- 102000008482 12E7 Antigen Human genes 0.000 description 2
- 108010020567 12E7 Antigen Proteins 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 239000010419 fine particle Substances 0.000 description 2
- 230000028996 humoral immune response Effects 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 241000700199 Cavia porcellus Species 0.000 description 1
- 241000282553 Macaca Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241000282577 Pan troglodytes Species 0.000 description 1
- 241001504519 Papio ursinus Species 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16823499P | 1999-12-01 | 1999-12-01 | |
| US18505500P | 2000-02-25 | 2000-02-25 | |
| PCT/US2000/042541 WO2001047551A2 (en) | 1999-12-01 | 2000-12-01 | Eliciting antibodies specific for hepatitis c virus (hcv) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004500366A JP2004500366A (ja) | 2004-01-08 |
| JP2004500366A5 true JP2004500366A5 (https=) | 2008-01-10 |
Family
ID=26863907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001548141A Pending JP2004500366A (ja) | 1999-12-01 | 2000-12-01 | Ｃ型肝炎ウイルス（ｈｃｖ）について特異的な抗体を誘発すること |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US7329408B2 (https=) |
| EP (1) | EP1233782B1 (https=) |
| JP (1) | JP2004500366A (https=) |
| AT (1) | ATE413190T1 (https=) |
| AU (1) | AU5442501A (https=) |
| CA (1) | CA2393251C (https=) |
| CY (1) | CY1108734T1 (https=) |
| DE (1) | DE60040755D1 (https=) |
| DK (1) | DK1233782T3 (https=) |
| ES (1) | ES2319727T3 (https=) |
| PT (1) | PT1233782E (https=) |
| WO (1) | WO2001047551A2 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2389206C (en) * | 1999-10-27 | 2011-01-04 | Chiron Corporation | Activation of hcv-specific t cells |
| JP2004500366A (ja) * | 1999-12-01 | 2004-01-08 | カイロン コーポレイション | Ｃ型肝炎ウイルス（ｈｃｖ）について特異的な抗体を誘発すること |
| AUPQ797700A0 (en) * | 2000-06-06 | 2000-06-29 | Austin Research Institute, The | Vaccine |
| CZ20033515A3 (cs) * | 2001-06-29 | 2005-01-12 | Chiron Corporation | Kompozice vakcíny HCV E1E2 |
| CU23244A1 (es) * | 2001-07-16 | 2007-10-17 | Ct Ingenieria Genetica Biotech | Formulacion vacunal potenciada por la combinacion de un adn con un antigeno |
| CA2461380C (en) | 2001-10-11 | 2011-03-22 | Merck & Co., Inc. | Hepatitis c virus vaccine |
| AU2003299994A1 (en) * | 2002-12-27 | 2004-07-29 | Chiron Corporation | Immunogenic compositions containing phospholpid |
| US20050191358A1 (en) * | 2003-01-14 | 2005-09-01 | Derek O' Hagan | Microparticles with adsorbed polynucleotide-containing species |
| WO2004071414A2 (en) * | 2003-02-05 | 2004-08-26 | Genzyme Corporation | Therapeutic anti-hcv (al9) compounds |
| US20040203084A1 (en) * | 2003-04-10 | 2004-10-14 | Doug Levinson | Profiling conformational variants, antibody compositions and methods of using the same |
| CA2523266A1 (en) * | 2003-04-25 | 2004-11-11 | Chiron Corporation | Compositions comprising cationic microparticles and hcv e1e2 dna and methods of use thereof |
| EP1631264B8 (en) * | 2003-06-02 | 2017-05-24 | GlaxoSmithKline Biologicals SA | Immunogenic compositions based on microparticles comprising adsorbed toxoid and a polysaccharide-containing antigen |
| NZ551319A (en) * | 2004-05-17 | 2010-07-30 | Novartis Vaccines & Diagnostic | Truncated Hepatitis C virus NS5 domain and fusion proteins comprising same |
| AU2005294805B2 (en) | 2004-05-28 | 2012-02-16 | Oryxe | A mixture for transdermal delivery of low and high molecular weight compounds |
| PT1801209E (pt) | 2004-08-24 | 2011-05-26 | Toray Industries | Arn gen?mico do v?rus humano modificado da hepatite c com capacidade de replica??o aut?noma |
| EP1820856B1 (en) * | 2004-11-18 | 2011-04-27 | National University of Corporation Hiroshima University | Method and kit for expressing protein under regulation of the expression from repeated sequence formed by gene amplification and transformant |
| EP1981537B1 (en) * | 2006-01-04 | 2015-08-26 | GlaxoSmithKline Biologicals S.A. | HCV E1E2 MF59-adjuvanted protein plus HCV E1E2 encoding alphavirus vector for eliciting HCV-specific T cells. |
| CA2694397A1 (en) | 2007-07-25 | 2009-01-29 | Japan As Represented By Director-General Of National Institute Of Infect Ious Diseases | Antibody having inhibitory activity on infection with hepatitis c virus (hcv) and use thereof |
| WO2011052735A1 (ja) | 2009-10-30 | 2011-05-05 | 東レ株式会社 | C型肝炎ウイルス（hcv）に対して感染阻害活性を有する抗体及びその用途 |
| CN104324373B (zh) * | 2010-11-26 | 2018-10-09 | 麦克法兰博尼特医学健康研究公司 | 组合物及其制备方法 |
| CN111437395A (zh) | 2013-08-29 | 2020-07-24 | 希望之城 | 细胞穿透缀合物及其使用方法 |
| KR20180053318A (ko) | 2015-09-17 | 2018-05-21 | 제이알엑스 바이오테크놀로지, 인코포레이티드 | 피부 수화 또는 보습을 향상시키기 위한 접근법 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ227011A (en) * | 1987-11-18 | 1992-03-26 | Chiron Corp | Non-a, non-b-hepatitis (hepatitis c) antigens, proteins, nucleotide sequences, vaccines and kits |
| US5350671A (en) | 1987-11-18 | 1994-09-27 | Chiron Corporation | HCV immunoassays employing C domain antigens |
| US5471330A (en) | 1993-07-29 | 1995-11-28 | Honeywell Inc. | Polysilicon pixel electrode |
| EP1510580B1 (en) | 1994-07-29 | 2008-12-10 | Novartis Vaccines and Diagnostics, Inc. | Hepatitis C E2 truncated polypeptide and methods of obtaining the same |
| AU3241095A (en) * | 1994-07-29 | 1996-03-04 | Chiron Corporation | Novel hepatitis c e1 and e2 truncated polypeptides and methods of obtaining the same |
| GB9416671D0 (en) | 1994-08-17 | 1994-10-12 | Biocine Spa | Assay |
| US6019980A (en) * | 1995-06-07 | 2000-02-01 | Connaught Laboratories Limited | Nucleic acid respiratory syncytial virus vaccines |
| DE69608122T3 (de) * | 1995-11-09 | 2011-06-16 | Microbiological Research Authority Camr, Salisbury | Mikroverkapselte dna zur impfung und gentherapie |
| US5939400A (en) * | 1996-02-26 | 1999-08-17 | The Board Of Trustees Of The Leland Stanford Junior University | DNA vaccination for induction of suppressive T cell response |
| CA2288374A1 (en) | 1997-05-06 | 1998-11-12 | Chiron Corporation | Intracellular production of hepatitis c e1 and e2 truncated polypeptides |
| CA2296089A1 (en) * | 1997-07-18 | 1999-01-28 | Connaught Laboratories Limited | Nucleic acid vaccines encoding g protein of respiratory syncytial virus |
| ES2175668T3 (es) * | 1997-12-16 | 2002-11-16 | Chiron Corp | Uso de microparticulas combinadas con emulsiones de aceite en agua submicronicas. |
| CA2389206C (en) | 1999-10-27 | 2011-01-04 | Chiron Corporation | Activation of hcv-specific t cells |
| JP2004500366A (ja) * | 1999-12-01 | 2004-01-08 | カイロン コーポレイション | Ｃ型肝炎ウイルス（ｈｃｖ）について特異的な抗体を誘発すること |
-
2000
- 2000-12-01 JP JP2001548141A patent/JP2004500366A/ja active Pending
- 2000-12-01 US US09/728,423 patent/US7329408B2/en not_active Expired - Lifetime
- 2000-12-01 AT AT00993586T patent/ATE413190T1/de active
- 2000-12-01 CA CA2393251A patent/CA2393251C/en not_active Expired - Fee Related
- 2000-12-01 PT PT00993586T patent/PT1233782E/pt unknown
- 2000-12-01 AU AU54425/01A patent/AU5442501A/en not_active Abandoned
- 2000-12-01 DK DK00993586T patent/DK1233782T3/da active
- 2000-12-01 DE DE60040755T patent/DE60040755D1/de not_active Expired - Lifetime
- 2000-12-01 WO PCT/US2000/042541 patent/WO2001047551A2/en not_active Ceased
- 2000-12-01 ES ES00993586T patent/ES2319727T3/es not_active Expired - Lifetime
- 2000-12-01 EP EP00993586A patent/EP1233782B1/en not_active Expired - Lifetime
-
2007
- 2007-12-13 US US12/001,920 patent/US20080095800A1/en not_active Abandoned
-
2009
- 2009-01-27 CY CY20091100101T patent/CY1108734T1/el unknown
-
2010
- 2010-08-30 US US12/871,035 patent/US20110159039A1/en not_active Abandoned
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