JP2004275194A5 - - Google Patents
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- Publication number
- JP2004275194A5 JP2004275194A5 JP2004198470A JP2004198470A JP2004275194A5 JP 2004275194 A5 JP2004275194 A5 JP 2004275194A5 JP 2004198470 A JP2004198470 A JP 2004198470A JP 2004198470 A JP2004198470 A JP 2004198470A JP 2004275194 A5 JP2004275194 A5 JP 2004275194A5
- Authority
- JP
- Japan
- Prior art keywords
- dna
- gene
- molecule
- rna
- nucleoside
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108020004414 DNA Proteins 0.000 claims description 107
- 108090000623 proteins and genes Proteins 0.000 claims description 101
- 239000000126 substance Substances 0.000 claims description 82
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 68
- 238000000034 method Methods 0.000 claims description 48
- 150000007523 nucleic acids Chemical class 0.000 claims description 47
- 125000006850 spacer group Chemical group 0.000 claims description 46
- 239000002777 nucleoside Substances 0.000 claims description 40
- 150000003833 nucleoside derivatives Chemical class 0.000 claims description 40
- 230000014616 translation Effects 0.000 claims description 36
- 150000001413 amino acids Chemical class 0.000 claims description 33
- 108020004707 nucleic acids Proteins 0.000 claims description 26
- 102000039446 nucleic acids Human genes 0.000 claims description 26
- 238000001243 protein synthesis Methods 0.000 claims description 22
- 238000010276 construction Methods 0.000 claims description 21
- 239000002202 Polyethylene glycol Substances 0.000 claims description 19
- 229920001223 polyethylene glycol Polymers 0.000 claims description 19
- RXWNCPJZOCPEPQ-NVWDDTSBSA-N puromycin Chemical group C1=CC(OC)=CC=C1C[C@H](N)C(=O)N[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(=C3N=C2)N(C)C)O[C@@H]1CO RXWNCPJZOCPEPQ-NVWDDTSBSA-N 0.000 claims description 16
- 230000003321 amplification Effects 0.000 claims description 15
- 230000001055 chewing effect Effects 0.000 claims description 15
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 15
- 102000004169 proteins and genes Human genes 0.000 claims description 15
- 238000013519 translation Methods 0.000 claims description 14
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims description 8
- 108020004999 messenger RNA Proteins 0.000 claims description 8
- 229950010131 puromycin Drugs 0.000 claims description 8
- RYSMHWILUNYBFW-GRIPGOBMSA-N 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine Chemical compound C1=NC=2C(N(C)C)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](N)[C@H]1O RYSMHWILUNYBFW-GRIPGOBMSA-N 0.000 claims description 6
- 102000004190 Enzymes Human genes 0.000 claims description 6
- 108090000790 Enzymes Proteins 0.000 claims description 6
- 108091081024 Start codon Proteins 0.000 claims description 6
- 238000013518 transcription Methods 0.000 claims description 6
- 230000005026 transcription initiation Effects 0.000 claims description 6
- 230000014621 translational initiation Effects 0.000 claims description 6
- 108700026220 vif Genes Proteins 0.000 claims description 6
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims description 4
- 229960005305 adenosine Drugs 0.000 claims description 4
- 230000003993 interaction Effects 0.000 claims description 4
- 239000002773 nucleotide Substances 0.000 claims description 4
- 125000003729 nucleotide group Chemical group 0.000 claims description 4
- 229920000642 polymer Polymers 0.000 claims description 3
- 108020001775 protein parts Proteins 0.000 claims description 3
- 238000010187 selection method Methods 0.000 claims description 3
- 238000010839 reverse transcription Methods 0.000 claims description 2
- 239000007790 solid phase Substances 0.000 claims description 2
- 229920002521 macromolecule Polymers 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 108020004705 Codon Proteins 0.000 description 8
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 2
- 108700039691 Genetic Promoter Regions Proteins 0.000 description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 2
- 239000004472 Lysine Substances 0.000 description 2
- 108091060545 Nonsense suppressor Proteins 0.000 description 2
- 238000000137 annealing Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000004925 denaturation Methods 0.000 description 2
- 230000036425 denaturation Effects 0.000 description 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 108020005098 Anticodon Proteins 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 108020005038 Terminator Codon Proteins 0.000 description 1
- 108020004566 Transfer RNA Proteins 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- YOBAEOGBNPPUQV-UHFFFAOYSA-N iron;trihydrate Chemical compound O.O.O.[Fe].[Fe] YOBAEOGBNPPUQV-UHFFFAOYSA-N 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 102000013498 tau Proteins Human genes 0.000 description 1
- 108010026424 tau Proteins Proteins 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004198470A JP3683902B2 (ja) | 1996-10-17 | 2004-07-05 | 遺伝子型と表現型の対応付け分子及びその利用 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27485596 | 1996-10-17 | ||
| JP2004198470A JP3683902B2 (ja) | 1996-10-17 | 2004-07-05 | 遺伝子型と表現型の対応付け分子及びその利用 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP51820298A Division JP3683282B2 (ja) | 1996-10-17 | 1997-10-17 | 遺伝子型と表現型の対応付け分子及びその利用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004275194A JP2004275194A (ja) | 2004-10-07 |
| JP2004275194A5 true JP2004275194A5 (enExample) | 2005-06-02 |
| JP3683902B2 JP3683902B2 (ja) | 2005-08-17 |
Family
ID=33301364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004198470A Expired - Lifetime JP3683902B2 (ja) | 1996-10-17 | 2004-07-05 | 遺伝子型と表現型の対応付け分子及びその利用 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3683902B2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4979992B2 (ja) * | 2006-06-16 | 2012-07-18 | 独立行政法人科学技術振興機構 | カテプシンe特異的阻害剤 |
| WO2011049157A1 (ja) | 2009-10-22 | 2011-04-28 | ペプチドリーム株式会社 | ペプチド翻訳合成におけるrapidディスプレイ法 |
| EP2647720B1 (en) | 2010-12-03 | 2019-06-19 | The University of Tokyo | Peptide library production method, peptide library, and screening method |
| EP2647721B1 (en) | 2010-12-03 | 2019-02-27 | The University of Tokyo | Peptide with safer secondary structure, peptide library, and production methods for same |
| WO2014119600A1 (ja) | 2013-01-30 | 2014-08-07 | ペプチドリーム株式会社 | Flexible Display法 |
-
2004
- 2004-07-05 JP JP2004198470A patent/JP3683902B2/ja not_active Expired - Lifetime
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