JP2004233357A - アレイ上における試料の分離を保つための、表面エネルギー遷移を伴うマルチアレイ - Google Patents

アレイ上における試料の分離を保つための、表面エネルギー遷移を伴うマルチアレイ Download PDF

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JP2004233357A
JP2004233357A JP2004019217A JP2004019217A JP2004233357A JP 2004233357 A JP2004233357 A JP 2004233357A JP 2004019217 A JP2004019217 A JP 2004019217A JP 2004019217 A JP2004019217 A JP 2004019217A JP 2004233357 A JP2004233357 A JP 2004233357A
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array
region
features
arrays
inter
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JP2004233357A5 (https=
Inventor
Eric M Leproust
エリック・エム・ルプルースト
P Karen Michael
マイケル・ピー・カレン
Bill J Peck
ビル・ジェイ・ペック
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Agilent Technologies Inc
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Agilent Technologies Inc
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    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
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    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
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    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
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    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Nanotechnology (AREA)
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  • Crystallography & Structural Chemistry (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2004019217A 2003-01-31 2004-01-28 アレイ上における試料の分離を保つための、表面エネルギー遷移を伴うマルチアレイ Pending JP2004233357A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/355,705 US20040152083A1 (en) 2003-01-31 2003-01-31 Multiple arrays with surface energy transition to maintain separation of samples on the arrays

Publications (2)

Publication Number Publication Date
JP2004233357A true JP2004233357A (ja) 2004-08-19
JP2004233357A5 JP2004233357A5 (https=) 2007-03-08

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Country Status (4)

Country Link
US (1) US20040152083A1 (https=)
EP (1) EP1442789A1 (https=)
JP (1) JP2004233357A (https=)
CN (1) CN1521275A (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007132866A (ja) * 2005-11-11 2007-05-31 Toyota Central Res & Dev Lab Inc 反応アレイ

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3860174B2 (ja) * 2004-03-01 2006-12-20 倉敷紡績株式会社 同時多検体ハイブリダイゼーション方法
US20050277122A1 (en) * 2004-06-14 2005-12-15 Fredrick Joseph P Devices and methods for contacting fluid with a chemical array
DE102004034486B4 (de) * 2004-07-16 2007-08-23 Infineon Technologies Ag Verfahren zum Nachweis von Lumineszenzlicht aus einer porösen Trägerstruktur
US12070731B2 (en) * 2004-08-04 2024-08-27 Life Technologies Corporation Methods and systems for aligning dispensing arrays with microfluidic sample arrays
JP2010500171A (ja) 2006-08-15 2010-01-07 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 複数の物質を基板上に放出することによりバイオアッセイ用基板を製造するインクジェット装置及びそのような基板を製造する方法
RU2009114839A (ru) * 2006-09-21 2010-10-27 Конинклейке Филипс Электроникс Н.В. (Nl) Струйное устройство и способ изготовления подложки биологической пробы с использованием печатающей головки и средства для ускоренного движения
KR100834745B1 (ko) 2006-12-20 2008-06-09 삼성전자주식회사 분석 친화적 레이아웃에 기반한 올리고머 프로브 어레이칩, 이의 제조에 사용되는 마스크 및 이의 혼성화 분석방법
WO2009027932A1 (en) * 2007-08-27 2009-03-05 Koninklijke Philips Electronics N.V. Assay substrate and a method for preparation
JP4667490B2 (ja) * 2008-07-09 2011-04-13 三菱電機株式会社 加熱調理器
US9063136B2 (en) * 2009-08-02 2015-06-23 Qvella Corporation Cell concentration, capture and lysis devices and methods of use thereof
CN107233853B (zh) * 2017-06-18 2023-05-09 天津大学 试剂预定义的液滴阵列生成器及制作方法和液滴生成方法
DE102020215979A1 (de) * 2020-12-16 2022-06-23 Robert Bosch Gesellschaft mit beschränkter Haftung Verfahren und Vorrichtung zum Zuordnen eines spezifischen Reagenz zu einem Reaktionsplatz
CN114622287A (zh) * 2022-03-17 2022-06-14 药明激创(佛山)生物科技有限公司 一种基于多肽微阵列的抗原表位筛选方法及装置

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0063810B1 (en) * 1981-04-29 1986-03-05 Ciba-Geigy Ag New devices and kits for immunological analysis
US4591570A (en) * 1983-02-02 1986-05-27 Centocor, Inc. Matrix of antibody-coated spots for determination of antigens
US5700637A (en) * 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5688642A (en) * 1994-12-01 1997-11-18 The United States Of America As Represented By The Secretary Of The Navy Selective attachment of nucleic acid molecules to patterned self-assembled surfaces
US5624711A (en) * 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
DE19628928A1 (de) * 1996-07-18 1998-01-22 Basf Ag Feste Träger für analytische Meßverfahren, ein Verfahren zu ihrer Herstellung sowie ihre Verwendung
US6238869B1 (en) * 1997-12-19 2001-05-29 High Throughput Genomics, Inc. High throughput assay system
US6258454B1 (en) * 1998-09-01 2001-07-10 Agilent Technologies Inc. Functionalization of substrate surfaces with silane mixtures
US6180351B1 (en) * 1999-07-22 2001-01-30 Agilent Technologies Inc. Chemical array fabrication with identifier
KR20020097181A (ko) * 2000-02-22 2002-12-31 제노스펙트라 인코포레이티드 마이크로어레이 제작 기술 및 장치
EP1307285A2 (en) * 2000-08-03 2003-05-07 Massachusetts Institute Of Technology Microarrays of functional biomolecules, and uses therefor
US20030190612A1 (en) * 2000-08-31 2003-10-09 Nobuko Yamamoto Detecting method and detection substrate for use therein
DE10043042C2 (de) * 2000-09-01 2003-04-17 Bruker Daltonik Gmbh Verfahren zum Belegen eines Probenträgers mit Biomolekülen für die massenspektrometrische Analyse
US20030087292A1 (en) * 2001-10-04 2003-05-08 Shiping Chen Methods and systems for promoting interactions between probes and target molecules in fluid in microarrays
US20030082294A1 (en) * 2001-10-31 2003-05-01 Laurakay Bruhn Surface treatment method for bio-arrays
US7157229B2 (en) * 2002-01-31 2007-01-02 Nimblegen Systems, Inc. Prepatterned substrate for optical synthesis of DNA probes
KR100455293B1 (ko) * 2002-05-15 2004-11-06 삼성전자주식회사 친수성 영역과 소수성 영역으로 구성되는 생물분자용어레이 판의 제조방법
US7498176B2 (en) * 2002-09-27 2009-03-03 Roche Nimblegen, Inc. Microarray with hydrophobic barriers

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007132866A (ja) * 2005-11-11 2007-05-31 Toyota Central Res & Dev Lab Inc 反応アレイ

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