JP2003535310A - テストサンプル中の分子事象を検出・同定（識別）するためのシステムおよび方法 - Google Patents
テストサンプル中の分子事象を検出・同定（識別）するためのシステムおよび方法Info
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Classifications
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
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- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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- B01L2200/06—Fluid handling related problems
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- G—PHYSICS
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Landscapes
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- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| US15917599P | 1999-10-13 | 1999-10-13 | |
| US60/159,175 | 1999-10-13 | ||
| US19170200P | 2000-03-23 | 2000-03-23 | |
| US60/191,702 | 2000-03-23 | ||
| PCT/US2000/028491 WO2001027610A2 (en) | 1999-10-13 | 2000-10-13 | System and method for detecting and identifying molecular events in a test sample |
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| JP2003535310A true JP2003535310A (ja) | 2003-11-25 |
| JP2003535310A5 JP2003535310A5 (enExample) | 2005-11-17 |
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| JP2001530570A Pending JP2003535310A (ja) | 1999-10-13 | 2000-10-13 | テストサンプル中の分子事象を検出・同定（識別）するためのシステムおよび方法 |
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| EP (1) | EP1224453A2 (enExample) |
| JP (1) | JP2003535310A (enExample) |
| KR (1) | KR20020071853A (enExample) |
| CN (1) | CN1425133A (enExample) |
| AU (3) | AU8023500A (enExample) |
| CA (1) | CA2386193A1 (enExample) |
| IL (1) | IL149001A0 (enExample) |
| MX (1) | MXPA02003815A (enExample) |
| NO (1) | NO20021687L (enExample) |
| WO (1) | WO2001027610A2 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005505754A (ja) * | 2001-07-25 | 2005-02-24 | ザ トラスティーズ オブ プリンストン ユニバーシテイ | 高スループットのマクロ分子分析用のナノチャンネル・アレイ並びにその準備および使用 |
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Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6586946B2 (en) | 2000-11-13 | 2003-07-01 | Signature Bioscience, Inc. | System and method for detecting and identifying molecular events in a test sample using a resonant test structure |
| WO2002066983A2 (en) * | 2001-02-01 | 2002-08-29 | Signature Bioscience, Inc. | Bioassay device for detecting molecular events |
| US20020168659A1 (en) * | 2001-02-12 | 2002-11-14 | Signature Bioscience Inc. | System and method for characterizing the permittivity of molecular events |
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| GB0605273D0 (en) * | 2006-03-16 | 2006-04-26 | Council Cent Lab Res Councils | Fluid robe |
| US10746680B2 (en) * | 2006-11-16 | 2020-08-18 | General Electric Company | Sensing system and method |
| CA2682275C (en) | 2007-03-28 | 2017-05-09 | Bionanomatrix, Inc. | Methods of macromolecular analysis using nanochannel arrays |
| GB0716202D0 (en) * | 2007-08-11 | 2007-09-26 | Microvisk Ltd | Improved fluid probe |
| US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
| GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
| EP2885418A4 (en) | 2012-08-14 | 2016-03-02 | 10X Genomics Inc | MICROCAPSE COMPOSITIONS AND METHOD THEREFOR |
| US11591637B2 (en) | 2012-08-14 | 2023-02-28 | 10X Genomics, Inc. | Compositions and methods for sample processing |
| US10400280B2 (en) | 2012-08-14 | 2019-09-03 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10323279B2 (en) | 2012-08-14 | 2019-06-18 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10221442B2 (en) | 2012-08-14 | 2019-03-05 | 10X Genomics, Inc. | Compositions and methods for sample processing |
| US9951386B2 (en) | 2014-06-26 | 2018-04-24 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US9701998B2 (en) | 2012-12-14 | 2017-07-11 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10752949B2 (en) | 2012-08-14 | 2020-08-25 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10273541B2 (en) | 2012-08-14 | 2019-04-30 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| EP3511423B2 (en) | 2012-10-17 | 2024-05-29 | Spatial Transcriptomics AB | Methods and product for optimising localised or spatial detection of gene expression in a tissue sample |
| GB201219016D0 (en) * | 2012-10-23 | 2012-12-05 | Liverpool John Moores University | Electromagnetic wave sensing |
| US10533221B2 (en) | 2012-12-14 | 2020-01-14 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| WO2014093676A1 (en) | 2012-12-14 | 2014-06-19 | 10X Technologies, Inc. | Methods and systems for processing polynucleotides |
| US9791453B2 (en) * | 2012-12-26 | 2017-10-17 | International Business Machines Corporation | Methods for determining binding capability of target ligands with G protein-coupled receptors using translocation through nanochannels |
| KR20230003659A (ko) | 2013-02-08 | 2023-01-06 | 10엑스 제노믹스, 인크. | 폴리뉴클레오티드 바코드 생성 |
| LT3013983T (lt) | 2013-06-25 | 2023-05-10 | Prognosys Biosciences, Inc. | Erdviniai koduoti biologiniai tyrimai, naudojant mikrofluidinį įrenginį |
| US10024851B2 (en) | 2013-10-15 | 2018-07-17 | International Business Machines Corporation | Use of disulfide bonds to form a reversible and reusable coating for nanofluidic devices |
| US9303310B2 (en) | 2013-10-15 | 2016-04-05 | International Business Machines Corporation | Nanofluidic sensor comprising spatially separated functional sensing components |
| US9255321B2 (en) | 2013-10-15 | 2016-02-09 | Globalfoundries Inc. | Directed surface functionalization on selected surface areas of topographical features with nanometer resolution |
| EP4219010A1 (en) | 2014-04-10 | 2023-08-02 | 10X Genomics, Inc. | Methods for encapsulating and partitioning reagents |
| WO2015200869A1 (en) | 2014-06-26 | 2015-12-30 | 10X Genomics, Inc. | Analysis of nucleic acid sequences |
| US12312640B2 (en) | 2014-06-26 | 2025-05-27 | 10X Genomics, Inc. | Analysis of nucleic acid sequences |
| US9921181B2 (en) | 2014-06-26 | 2018-03-20 | International Business Machines Corporation | Detection of translocation events using graphene-based nanopore assemblies |
| MX2016016902A (es) | 2014-06-26 | 2017-03-27 | 10X Genomics Inc | Metodos para analizar acidos nucleicos de celulas individuales o poblaciones de celulas. |
| JP2017532042A (ja) | 2014-10-29 | 2017-11-02 | １０エックス ゲノミクス，インコーポレイテッド | 標的化核酸配列決定のための方法及び組成物 |
| US9975122B2 (en) | 2014-11-05 | 2018-05-22 | 10X Genomics, Inc. | Instrument systems for integrated sample processing |
| TWI569017B (zh) * | 2014-11-14 | 2017-02-01 | Nippon Mektron Kk | Coaxial probe holding mechanism and electrical characteristics check device |
| EP3244992B1 (en) | 2015-01-12 | 2023-03-08 | 10X Genomics, Inc. | Processes for barcoding nucleic acids |
| CA2975958A1 (en) | 2015-02-24 | 2016-09-01 | 10X Genomics, Inc. | Methods for targeted nucleic acid sequence coverage |
| US10697000B2 (en) | 2015-02-24 | 2020-06-30 | 10X Genomics, Inc. | Partition processing methods and systems |
| SG11201707515SA (en) | 2015-04-10 | 2017-10-30 | Spatial Transcriptomics Ab | Spatially distinguished, multiplex nucleic acid analysis of biological specimens |
| PT3882357T (pt) | 2015-12-04 | 2022-09-05 | 10X Genomics Inc | Métodos e composições para análise de ácidos nucleicos |
| JP7097297B2 (ja) * | 2015-12-23 | 2022-07-07 | ヴァイキング ジェネティクス エフエムビーエー | 極低温ストローおよび凍結保存された標本を識別するためのシステム |
| WO2017197343A2 (en) | 2016-05-12 | 2017-11-16 | 10X Genomics, Inc. | Microfluidic on-chip filters |
| WO2017197338A1 (en) | 2016-05-13 | 2017-11-16 | 10X Genomics, Inc. | Microfluidic systems and methods of use |
| US10815525B2 (en) | 2016-12-22 | 2020-10-27 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10550429B2 (en) | 2016-12-22 | 2020-02-04 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10011872B1 (en) | 2016-12-22 | 2018-07-03 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US12264411B2 (en) | 2017-01-30 | 2025-04-01 | 10X Genomics, Inc. | Methods and systems for analysis |
| CN110214186B (zh) | 2017-01-30 | 2023-11-24 | 10X基因组学有限公司 | 用于基于微滴的单细胞条形编码的方法和系统 |
| CN116064732A (zh) | 2017-05-26 | 2023-05-05 | 10X基因组学有限公司 | 转座酶可接近性染色质的单细胞分析 |
| US10844372B2 (en) | 2017-05-26 | 2020-11-24 | 10X Genomics, Inc. | Single cell analysis of transposase accessible chromatin |
| WO2019099751A1 (en) | 2017-11-15 | 2019-05-23 | 10X Genomics, Inc. | Functionalized gel beads |
| US10829815B2 (en) | 2017-11-17 | 2020-11-10 | 10X Genomics, Inc. | Methods and systems for associating physical and genetic properties of biological particles |
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Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0519250A3 (en) * | 1991-06-10 | 1993-06-02 | Miles Inc. | Microparticle-labeled binding assay analyzed by microwave spectroscopy |
| AU7552194A (en) * | 1993-07-26 | 1995-02-20 | Phase Dynamics, Inc. | System and method for monitoring substances and reactions |
| SE9700828D0 (sv) * | 1997-03-07 | 1997-03-07 | Asea Brown Boveri | Förfarande och anordning för att bestämma ett flertal kvalitetsparametrar vilka beskriver tillståndet hos ett organiskt material |
| GB2342176B (en) * | 1998-02-02 | 2001-05-02 | Signature Bioscience Inc | Method and apparatus for detecting molecular binding events |
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- 2000-10-13 KR KR1020027004757A patent/KR20020071853A/ko not_active Withdrawn
- 2000-10-13 WO PCT/US2000/028491 patent/WO2001027610A2/en not_active Ceased
- 2000-10-13 CA CA002386193A patent/CA2386193A1/en not_active Abandoned
- 2000-10-13 CN CN00817005A patent/CN1425133A/zh active Pending
- 2000-10-13 MX MXPA02003815A patent/MXPA02003815A/es unknown
- 2000-10-13 EP EP00970920A patent/EP1224453A2/en not_active Withdrawn
- 2000-10-13 JP JP2001530570A patent/JP2003535310A/ja active Pending
- 2000-10-13 IL IL14900100A patent/IL149001A0/xx unknown
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2008
- 2008-07-14 AU AU2008203111A patent/AU2008203111A1/en not_active Abandoned
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005505754A (ja) * | 2001-07-25 | 2005-02-24 | ザ トラスティーズ オブ プリンストン ユニバーシテイ | 高スループットのマクロ分子分析用のナノチャンネル・アレイ並びにその準備および使用 |
| JP2009036773A (ja) * | 2001-07-25 | 2009-02-19 | Trustees Of Princeton Univ | 高スループットのマクロ分子分析用のナノチャンネル・アレイ並びにその準備および使用 |
| JP2013050453A (ja) * | 2001-07-25 | 2013-03-14 | Trustees Of Princeton Univ | 高スループットのマクロ分子分析用のナノチャンネル・アレイ並びにその準備および使用 |
| JP2016516195A (ja) * | 2013-03-15 | 2016-06-02 | イナノベイト， インコーポレイテッド | 長期的なアッセイを使用する分析物の測定 |
| JP2020098202A (ja) * | 2013-03-15 | 2020-06-25 | イナノベイト， インコーポレイテッド | アッセイシステムおよびカートリッジデバイス |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001027610A3 (en) | 2002-03-28 |
| AU2008203111A1 (en) | 2008-08-07 |
| AU8023500A (en) | 2001-04-23 |
| MXPA02003815A (es) | 2002-09-30 |
| IL149001A0 (en) | 2002-11-10 |
| NO20021687D0 (no) | 2002-04-10 |
| NO20021687L (no) | 2002-06-12 |
| KR20020071853A (ko) | 2002-09-13 |
| AU2005203756A1 (en) | 2005-09-15 |
| WO2001027610A9 (en) | 2002-08-01 |
| WO2001027610A2 (en) | 2001-04-19 |
| EP1224453A2 (en) | 2002-07-24 |
| CN1425133A (zh) | 2003-06-18 |
| CA2386193A1 (en) | 2001-04-19 |
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