JP2003534805A - 変化した親和性を有する改変ウシアデノウイルス - Google Patents
変化した親和性を有する改変ウシアデノウイルスInfo
- Publication number
- JP2003534805A JP2003534805A JP2002500739A JP2002500739A JP2003534805A JP 2003534805 A JP2003534805 A JP 2003534805A JP 2002500739 A JP2002500739 A JP 2002500739A JP 2002500739 A JP2002500739 A JP 2002500739A JP 2003534805 A JP2003534805 A JP 2003534805A
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- adenovirus
- protein
- fragment
- vector
- fiber
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
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- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10345—Special targeting system for viral vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10361—Methods of inactivation or attenuation
- C12N2710/10362—Methods of inactivation or attenuation by genetic engineering
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
- C12N2810/6009—Vectors comprising as targeting moiety peptide derived from defined protein from viruses dsDNA viruses
- C12N2810/6018—Adenoviridae
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- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Communicable Diseases (AREA)
- Oncology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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| US20867800P | 2000-05-31 | 2000-05-31 | |
| US60/208,678 | 2000-05-31 | ||
| PCT/CA2001/000798 WO2001092547A2 (en) | 2000-05-31 | 2001-05-31 | Modified bovine adenovirus having altered tropism |
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| JP2003534805A true JP2003534805A (ja) | 2003-11-25 |
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| EP (1) | EP1285079A2 (OSRAM) |
| JP (1) | JP2003534805A (OSRAM) |
| AU (2) | AU6368901A (OSRAM) |
| CA (1) | CA2410665C (OSRAM) |
| WO (1) | WO2001092547A2 (OSRAM) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US5820868A (en) | 1993-12-09 | 1998-10-13 | Veterinary Infectious Disease Organization | Recombinant protein production in bovine adenovirus expression vector system |
| US20030220284A1 (en) * | 2002-02-22 | 2003-11-27 | Patricia Yotnda | Delivery of adenoviral DNA in a liposomal formulation for treatment of disease |
| FR2842823A1 (fr) * | 2002-07-25 | 2004-01-30 | Inst Nat Sante Rech Med | Adenovirus modifies pour le ciblage des lymphocytes b |
| EP1631582A2 (en) * | 2003-06-10 | 2006-03-08 | University of Saskatchewan | Chimeric adenovirus capsid proteins |
| WO2006058231A2 (en) * | 2004-11-24 | 2006-06-01 | Nanovector Limited | Viral vectors |
| US8163544B2 (en) | 2006-07-28 | 2012-04-24 | Commonwealth Scientific And Industrial Research Organisation | Methods and compositions for increasing tissue tropism of recombinant adenoviral vectors |
| KR100812636B1 (ko) | 2006-10-24 | 2008-03-13 | 주식회사 단바이오텍 | 항원 결정기를 포함하는 재조합 개 아데노바이러스 섬유단백질 및 이에 대한 항체 |
| KR20120052369A (ko) * | 2009-07-31 | 2012-05-23 | 팍스박스, 인코포레이티드 | 아데노바이러스계 벡터 |
| SG11201507393TA (en) | 2013-03-14 | 2015-10-29 | Salk Inst For Biological Studi | Oncolytic adenovirus compositions |
| PL3198009T3 (pl) | 2014-09-24 | 2022-01-24 | Salk Institute For Biological Studies | Onkolityczne wirusy nowotworowe i sposoby zastosowania |
| JP7015551B2 (ja) | 2016-02-23 | 2022-02-15 | ソーク インスティテュート フォー バイオロジカル スタディーズ | ウイルス動態への影響を最小限にするための治療用アデノウイルスにおける外因性遺伝子発現 |
| JP7054527B2 (ja) | 2016-02-23 | 2022-04-14 | ソーク インスティテュート フォー バイオロジカル スタディーズ | アデノウイルスの複製動態を測定するための高スループットアッセイ |
| WO2018111767A1 (en) | 2016-12-12 | 2018-06-21 | Salk Institute For Biological Studies | Tumor-targeting synthetic adenoviruses and uses thereof |
| CA3095660A1 (en) * | 2018-02-15 | 2019-08-22 | Tomas Bjorklund | Modified viral capsids |
| JP7430395B2 (ja) | 2018-04-09 | 2024-02-13 | ソーク インスティテュート フォー バイオロジカル スタディーズ | 複製特質が増強された腫瘍溶解性アデノウイルス組成物 |
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| WO1998013499A2 (en) * | 1996-09-25 | 1998-04-02 | Novartis Ag | Packaging cell lines for use in facilitating the development of high-capacity adenoviral vectors |
| WO1998022609A1 (en) * | 1996-11-20 | 1998-05-28 | Genzyme Corporation | Chimeric adenoviral vectors |
| WO1998044121A1 (fr) * | 1997-04-02 | 1998-10-08 | Transgene S.A. | Fibre adenovirale modifiee et adenovirus cibles |
| WO1998059063A2 (en) * | 1997-06-23 | 1998-12-30 | University Of Saskatchewan | Bovine adenovirus type 3 genome |
| JPH11501219A (ja) * | 1995-11-28 | 1999-02-02 | ジェンベク、インコーポレイティッド | 細胞への遣伝子導入のためのベクターおよび方法 |
| JPH11511139A (ja) * | 1995-08-14 | 1999-09-28 | コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガニゼーション | ヒツジアデノウイルスベクターを用いた遺伝子治療 |
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| WO2000026395A2 (en) * | 1998-11-02 | 2000-05-11 | University Of Saskatchewan | Bovine cells expressing adenovirus essential functions for propagation of recombinant adenoviral vectors |
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- 2001-05-31 CA CA2410665A patent/CA2410665C/en not_active Expired - Lifetime
- 2001-05-31 AU AU6368901A patent/AU6368901A/xx active Pending
- 2001-05-31 EP EP01937902A patent/EP1285079A2/en not_active Withdrawn
- 2001-05-31 AU AU2001263689A patent/AU2001263689B2/en not_active Ceased
- 2001-05-31 WO PCT/CA2001/000798 patent/WO2001092547A2/en not_active Ceased
- 2001-05-31 US US09/871,212 patent/US6849446B2/en not_active Expired - Lifetime
- 2001-05-31 JP JP2002500739A patent/JP2003534805A/ja active Pending
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| US20020034519A1 (en) | 2002-03-21 |
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| WO2001092547A9 (en) | 2003-04-10 |
| CA2410665C (en) | 2017-11-07 |
| CA2410665A1 (en) | 2001-12-06 |
| EP1285079A2 (en) | 2003-02-26 |
| AU2001263689B2 (en) | 2007-03-22 |
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