ATE345819T1 - Kapsidmodifiziertes rekombinantes adenovirusund verfahren zu dessen anwendung - Google Patents
Kapsidmodifiziertes rekombinantes adenovirusund verfahren zu dessen anwendungInfo
- Publication number
- ATE345819T1 ATE345819T1 AT00966810T AT00966810T ATE345819T1 AT E345819 T1 ATE345819 T1 AT E345819T1 AT 00966810 T AT00966810 T AT 00966810T AT 00966810 T AT00966810 T AT 00966810T AT E345819 T1 ATE345819 T1 AT E345819T1
- Authority
- AT
- Austria
- Prior art keywords
- capsid
- recombinant adenovirus
- modified recombinant
- adenoviral vector
- targeted
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10345—Special targeting system for viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/80—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates
- C12N2810/85—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian
- C12N2810/859—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian from immunoglobulins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15610499P | 1999-09-24 | 1999-09-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE345819T1 true ATE345819T1 (de) | 2006-12-15 |
Family
ID=22558110
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00966810T ATE345819T1 (de) | 1999-09-24 | 2000-09-22 | Kapsidmodifiziertes rekombinantes adenovirusund verfahren zu dessen anwendung |
Country Status (8)
Country | Link |
---|---|
US (2) | US6555368B1 (de) |
EP (1) | EP1214098B1 (de) |
JP (1) | JP2003509079A (de) |
AT (1) | ATE345819T1 (de) |
AU (1) | AU773019B2 (de) |
CA (1) | CA2384827A1 (de) |
DE (1) | DE60031994T2 (de) |
WO (1) | WO2001021216A1 (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE345819T1 (de) * | 1999-09-24 | 2006-12-15 | Uab Research Foundation | Kapsidmodifiziertes rekombinantes adenovirusund verfahren zu dessen anwendung |
WO2001058940A2 (en) * | 2000-02-09 | 2001-08-16 | Genvec, Inc. | Adenoviral capsid containing chimeric protein ix |
WO2001092547A2 (en) | 2000-05-31 | 2001-12-06 | University Of Saskatchewan | Modified bovine adenovirus having altered tropism |
US20020151069A1 (en) * | 2001-04-17 | 2002-10-17 | Nikolay Korokhov | Mosaic adenoviral vectors |
CA2448908C (en) * | 2001-05-30 | 2008-03-18 | Transgene S.A. | Adenovirus protein ix, its domains involved in capsid assembly, transcriptional activity and nuclear reorganization |
AU2003251604A1 (en) * | 2002-06-26 | 2004-01-19 | F. C. Thomas Allnutt | Viruses and virus-like particles for multiple antigen and target display |
CA2527721C (en) * | 2003-06-10 | 2016-05-10 | University Of Saskatchewan | Chimeric adenovirus capsid proteins |
US7473418B2 (en) * | 2004-03-25 | 2009-01-06 | Cell Genesys, Inc. | Pan cancer oncolytic vectors and methods of use thereof |
US20060062764A1 (en) * | 2004-08-25 | 2006-03-23 | Seshidar-Reddy Police | Fiber-modified adenoviral vectors for enhanced transduction of tumor cells |
US20060205080A1 (en) * | 2005-03-01 | 2006-09-14 | David Frey | Formulations for therapeutic viruses having enhanced storage stability |
US20060234347A1 (en) * | 2005-04-13 | 2006-10-19 | Harding Thomas C | Targeting multiple angiogenic pathways for cancer therapy using soluble tyrosine kinase receptors |
WO2006119449A2 (en) * | 2005-05-04 | 2006-11-09 | Vectorlogics, Inc. | Modified adenovirus containing a stabilized antibody |
US9868961B2 (en) | 2006-03-30 | 2018-01-16 | The Regents Of The University Of California | Methods and compositions for localized secretion of anti-CTLA-4 antibodies |
US7919079B2 (en) | 2006-03-31 | 2011-04-05 | Biosante Pharmaceuticals, Inc. | Cancer immunotherapy compositions and methods of use |
EP2971008B1 (de) | 2013-03-14 | 2018-07-25 | Salk Institute for Biological Studies | Onkolytische adenoviruszusammensetzungen |
EP3132038A4 (de) | 2014-04-18 | 2017-11-29 | Washington University | Adenovirales targeting, zusammensetzungen und verfahren dafür |
CA3013637A1 (en) | 2016-02-23 | 2017-08-31 | Salk Institute For Biological Studies | High throughput assay for measuring adenovirus replication kinetics |
JP7015551B2 (ja) | 2016-02-23 | 2022-02-15 | ソーク インスティテュート フォー バイオロジカル スタディーズ | ウイルス動態への影響を最小限にするための治療用アデノウイルスにおける外因性遺伝子発現 |
CN110062630A (zh) | 2016-12-12 | 2019-07-26 | 萨克生物研究学院 | 肿瘤靶向合成腺病毒及其用途 |
JP2020504767A (ja) | 2016-12-21 | 2020-02-13 | メムゲン,エルエルシー | 武装した複製可能な腫瘍溶解性アデノウイルス |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08504091A (ja) | 1992-09-22 | 1996-05-07 | メディカル・リサーチ・カウンシル | 外部表面に非ウィルス性ポリペプチドを提示する組換えウィルス |
US5962311A (en) * | 1994-09-08 | 1999-10-05 | Genvec, Inc. | Short-shafted adenoviral fiber and its use |
US5846782A (en) | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
US5871727A (en) | 1995-12-08 | 1999-02-16 | Uab Research Foundation | Targeted adenovirus vectors |
CA2317941A1 (en) | 1998-01-16 | 1999-07-22 | Genzyme Corporation | Adenoviral vectors with modified capsid proteins |
US6955808B2 (en) * | 1999-09-24 | 2005-10-18 | Uab Research Foundation | Capsid-modified recombinant adenovirus and methods of use |
ATE345819T1 (de) * | 1999-09-24 | 2006-12-15 | Uab Research Foundation | Kapsidmodifiziertes rekombinantes adenovirusund verfahren zu dessen anwendung |
WO2001058940A2 (en) * | 2000-02-09 | 2001-08-16 | Genvec, Inc. | Adenoviral capsid containing chimeric protein ix |
-
2000
- 2000-09-22 AT AT00966810T patent/ATE345819T1/de not_active IP Right Cessation
- 2000-09-22 AU AU77098/00A patent/AU773019B2/en not_active Ceased
- 2000-09-22 JP JP2001524639A patent/JP2003509079A/ja not_active Withdrawn
- 2000-09-22 DE DE60031994T patent/DE60031994T2/de not_active Expired - Lifetime
- 2000-09-22 WO PCT/US2000/026079 patent/WO2001021216A1/en active IP Right Grant
- 2000-09-22 CA CA002384827A patent/CA2384827A1/en not_active Abandoned
- 2000-09-22 US US09/668,791 patent/US6555368B1/en not_active Expired - Lifetime
- 2000-09-22 EP EP00966810A patent/EP1214098B1/de not_active Expired - Lifetime
-
2003
- 2003-04-28 US US10/424,409 patent/US20030175244A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU773019B2 (en) | 2004-05-13 |
US20030175244A1 (en) | 2003-09-18 |
EP1214098A1 (de) | 2002-06-19 |
DE60031994T2 (de) | 2007-09-20 |
WO2001021216A1 (en) | 2001-03-29 |
US6555368B1 (en) | 2003-04-29 |
EP1214098B1 (de) | 2006-11-22 |
CA2384827A1 (en) | 2001-03-29 |
JP2003509079A (ja) | 2003-03-11 |
DE60031994D1 (de) | 2007-01-04 |
EP1214098A4 (de) | 2002-10-30 |
AU7709800A (en) | 2001-04-24 |
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Legal Events
Date | Code | Title | Description |
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |