JP2003532737A5 - - Google Patents
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- Publication number
- JP2003532737A5 JP2003532737A5 JP2001582354A JP2001582354A JP2003532737A5 JP 2003532737 A5 JP2003532737 A5 JP 2003532737A5 JP 2001582354 A JP2001582354 A JP 2001582354A JP 2001582354 A JP2001582354 A JP 2001582354A JP 2003532737 A5 JP2003532737 A5 JP 2003532737A5
- Authority
- JP
- Japan
- Prior art keywords
- hydroxy
- pregna
- methoxy
- triene
- hydroxymethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 description 13
- -1 methoxy, ethoxy, propoxy, vinyl Chemical group 0.000 description 9
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 description 6
- 125000006239 protecting group Chemical group 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- 125000003545 alkoxy group Chemical group 0.000 description 2
- 125000004432 carbon atoms Chemical group C* 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N (3β)-Cholest-5-en-3-ol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 1
- 125000004973 1-butenyl group Chemical group C(=CCC)* 0.000 description 1
- 125000004066 1-hydroxyethyl group Chemical group [H]OC([H])([*])C([H])([H])[H] 0.000 description 1
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 description 1
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 description 1
- 206010001897 Alzheimer's disease Diseases 0.000 description 1
- 208000006673 Asthma Diseases 0.000 description 1
- 206010003816 Autoimmune disease Diseases 0.000 description 1
- 208000003432 Bone Disease Diseases 0.000 description 1
- 206010057668 Cognitive disease Diseases 0.000 description 1
- 206010018651 Graft versus host disease Diseases 0.000 description 1
- 206010020718 Hyperplasia Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010037162 Psoriatic arthropathy Diseases 0.000 description 1
- 206010039073 Rheumatoid arthritis Diseases 0.000 description 1
- 206010039966 Senile dementia Diseases 0.000 description 1
- 208000006641 Skin Disease Diseases 0.000 description 1
- 206010052779 Transplant rejections Diseases 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 125000000304 alkynyl group Chemical group 0.000 description 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 description 1
- 239000004037 angiogenesis inhibitor Substances 0.000 description 1
- 201000009596 autoimmune hypersensitivity disease Diseases 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 201000008325 diseases of cellular proliferation Diseases 0.000 description 1
- 125000006232 ethoxy propyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000005448 ethoxyethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])C([H])([H])* 0.000 description 1
- 125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 238000005755 formation reaction Methods 0.000 description 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 1
- 200000000018 inflammatory disease Diseases 0.000 description 1
- XOBKSJJDNFUZPF-UHFFFAOYSA-N methoxyethyl Chemical group CCOC XOBKSJJDNFUZPF-UHFFFAOYSA-N 0.000 description 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 description 1
- 230000001613 neoplastic Effects 0.000 description 1
- OZAIFHULBGXAKX-UHFFFAOYSA-N precursor Substances N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 description 1
- 201000001263 psoriatic arthritis Diseases 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20346200P | 2000-05-11 | 2000-05-11 | |
| US60/203,462 | 2000-05-11 | ||
| PCT/GB2001/002103 WO2001085755A1 (en) | 2000-05-11 | 2001-05-11 | 2-substituted pregna-1, 3, 5 (10) -triene and chola-1, 3, 5 (10)-triene derivatives and their biological activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003532737A JP2003532737A (ja) | 2003-11-05 |
| JP2003532737A5 true JP2003532737A5 (US07368562-20080506-C00013.png) | 2006-01-05 |
Family
ID=22754111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001582354A Pending JP2003532737A (ja) | 2000-05-11 | 2001-05-11 | ２位置換プレグナ−１，３，５（１０）−トリエン誘導体およびコラン−１，３，５（１０）−トリエン誘導体およびそれらの生物活性 |
Country Status (17)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6908910B2 (en) | 1993-08-06 | 2005-06-21 | The Children's Medical Center Corporation | Estrogenic compounds as anti-mitotic agents |
| US6995278B2 (en) | 2000-08-18 | 2006-02-07 | Entre Med, Inc. | Antiangiogenic agents |
| US7135581B2 (en) | 2000-08-18 | 2006-11-14 | Entremed, Inc. | Antiangiogenic agents |
| AU8838601A (en) * | 2000-11-27 | 2002-06-03 | Entremed Inc | Antiangiogenic agents |
| WO2002092100A1 (en) * | 2001-05-11 | 2002-11-21 | Marsden, John, Christopher | 17-(c(ch3) (ch2) o-3c (r4, r5) n (r6, r7))-substituted 19-nor-pregna-1, 3, 5(10)-triene derivatives and their medical use |
| EA011123B1 (ru) * | 2003-03-24 | 2008-12-30 | Стерикс Лимитед | Производные эстрогена в качестве ингибиторов стероидной сульфатазы |
| EP1756139A4 (en) | 2004-03-12 | 2009-07-29 | Entremed Inc | ANTI-ANGIOGENIC AGENTS |
| WO2007109312A2 (en) | 2006-03-20 | 2007-09-27 | Entremed, Inc. | Disease modifying anti-arthritic activity of 2-methoxyestradiol |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3562260A (en) * | 1965-08-23 | 1971-02-09 | Ormonoterapia Richter Spa | 2-carbonyl-estratrienes and method of their preparation |
| JPS54112849A (en) * | 1978-02-23 | 1979-09-04 | Mitsubishi Chem Ind Ltd | Preparation of steroid derivative |
| JPS54112580A (en) * | 1978-02-23 | 1979-09-03 | Nec Corp | Electroless discharge lamp |
| JPS54112850A (en) * | 1978-02-23 | 1979-09-04 | Mitsubishi Chem Ind Ltd | Steroid derivative and its preparation |
| JPS54117455A (en) * | 1978-03-02 | 1979-09-12 | Mitsubishi Chem Ind Ltd | Novel 19-norsteroid derivative |
| JPS54117456A (en) * | 1978-03-02 | 1979-09-12 | Mitsubishi Chem Ind Ltd | Alkoxysteroid derivative |
| JPS54117454A (en) * | 1978-03-02 | 1979-09-12 | Mitsubishi Chem Ind Ltd | Acylsteroid derivative |
| GB9804861D0 (en) * | 1998-03-06 | 1998-04-29 | Res Inst Medicine Chem | Chemical compounds |
| GB9910934D0 (en) * | 1999-05-11 | 1999-07-14 | Res Inst Medicine Chem | Chemical compounds |
-
2001
- 2001-05-11 ES ES01928120T patent/ES2247102T3/es not_active Expired - Lifetime
- 2001-05-11 AU AU54984/01A patent/AU784563B2/en not_active Ceased
- 2001-05-11 KR KR1020027015057A patent/KR100740354B1/ko not_active IP Right Cessation
- 2001-05-11 EP EP01928120A patent/EP1287017B1/en not_active Expired - Lifetime
- 2001-05-11 AT AT01928120T patent/ATE301130T1/de not_active IP Right Cessation
- 2001-05-11 DE DE60112438T patent/DE60112438T2/de not_active Expired - Fee Related
- 2001-05-11 CZ CZ20023719A patent/CZ298835B6/cs not_active IP Right Cessation
- 2001-05-11 DK DK01928120T patent/DK1287017T3/da active
- 2001-05-11 IL IL15272801A patent/IL152728A0/xx active IP Right Grant
- 2001-05-11 CA CA002408751A patent/CA2408751A1/en not_active Abandoned
- 2001-05-11 JP JP2001582354A patent/JP2003532737A/ja active Pending
- 2001-05-11 CN CNB018124445A patent/CN100338088C/zh not_active Expired - Fee Related
- 2001-05-11 NZ NZ523042A patent/NZ523042A/en unknown
- 2001-05-11 WO PCT/GB2001/002103 patent/WO2001085755A1/en active IP Right Grant
-
2002
- 2002-11-07 ZA ZA200209060A patent/ZA200209060B/en unknown
- 2002-11-10 IL IL152728A patent/IL152728A/en not_active IP Right Cessation
- 2002-11-11 NO NO20025392A patent/NO323857B1/no unknown
-
2003
- 2003-08-27 HK HK03106140A patent/HK1053843A1/xx not_active IP Right Cessation
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