JP2003531854A - アポトーシスの予防方法 - Google Patents
アポトーシスの予防方法Info
- Publication number
- JP2003531854A JP2003531854A JP2001579793A JP2001579793A JP2003531854A JP 2003531854 A JP2003531854 A JP 2003531854A JP 2001579793 A JP2001579793 A JP 2001579793A JP 2001579793 A JP2001579793 A JP 2001579793A JP 2003531854 A JP2003531854 A JP 2003531854A
- Authority
- JP
- Japan
- Prior art keywords
- heparin
- ischemia
- reperfusion
- anticoagulant
- hep
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/561,663 US6489311B1 (en) | 2000-05-02 | 2000-05-02 | Method for the prevention of apoptosis |
| US09/561,663 | 2000-05-02 | ||
| PCT/US2001/040639 WO2001082918A2 (en) | 2000-05-02 | 2001-04-30 | Method for the prevention of apoptosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003531854A true JP2003531854A (ja) | 2003-10-28 |
| JP2003531854A5 JP2003531854A5 (https=) | 2008-08-07 |
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| Country | Link |
|---|---|
| US (1) | US6489311B1 (https=) |
| EP (1) | EP1289508A2 (https=) |
| JP (1) | JP2003531854A (https=) |
| AU (2) | AU2001259811B2 (https=) |
| CA (1) | CA2407806C (https=) |
| WO (1) | WO2001082918A2 (https=) |
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| CN1197587C (zh) * | 2000-06-09 | 2005-04-20 | 中国科学院上海细胞生物学研究所 | N－位脱硫酸肝素在预防和治疗炎症中的应用 |
| EP1501565B1 (de) * | 2002-05-09 | 2006-11-02 | Hemoteq GmbH | Verbindungen und verfahren zur hemokompatiblen beschichtung von oberflächen |
| US7468358B2 (en) * | 2004-06-16 | 2008-12-23 | Paringenix, Inc. | Method and medicament for sulfated polysaccharide treatment of heparin-induced thrombocytopenia (HIT) syndrome |
| US20050282775A1 (en) * | 2004-06-16 | 2005-12-22 | Paringenix, Inc. | Method and medicament for sulfated polysaccharide treatment of inflammation without inducing platelet activation and heparin-induced thrombocytopenia syndrome |
| US20060040896A1 (en) * | 2004-08-18 | 2006-02-23 | Paringenix, Inc. | Method and medicament for anticoagulation using a sulfated polysaccharide with enhanced anti-inflammatory activity |
| CA2678587A1 (en) * | 2007-02-28 | 2008-09-04 | Paringenix, Inc. | O-desulfated heparins treating acute exacerbations of chronic obstructive pulmonary disease |
| WO2009015183A1 (en) * | 2007-07-23 | 2009-01-29 | University Of Utah Research Foundation | Method for blocking ligation of the receptor for advanced glycation end-products (rage) |
| WO2009117677A2 (en) * | 2008-03-21 | 2009-09-24 | University Of Utah Research Foundation | Methods for controlling intracellular calcium levels associated with an ischemic event |
| JP5749651B2 (ja) * | 2008-11-04 | 2015-07-15 | インデックス・ファーマシューティカルズ・アクチエボラーグ | 多形核細胞の動員および／または遊走を減少させる化合物および方法 |
| CN104411316B (zh) | 2012-05-09 | 2018-05-01 | 坎泰克斯制药股份有限公司 | 骨髓抑制的治疗 |
| GB201219696D0 (en) | 2012-11-01 | 2012-12-12 | Univ Liverpool | Agents for the prevention and/or treatment of central nervous system damamge |
| AU2013353573B2 (en) | 2012-12-06 | 2019-01-17 | Enlivex Therapeutics R&D Ltd | Therapeutic apoptotic cell preparations, method for producing same and uses thereof |
| US20170096549A1 (en) | 2014-03-17 | 2017-04-06 | Cantex Pharmaceuticals, Inc. | Multivalent cation formulations of partially desulfated heparins |
| US10052346B2 (en) | 2015-02-17 | 2018-08-21 | Cantex Pharmaceuticals, Inc. | Treatment of myelodysplastic syndromes with 2-O and,or 3-O desulfated heparinoids |
| US11304976B2 (en) | 2015-02-18 | 2022-04-19 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11318163B2 (en) | 2015-02-18 | 2022-05-03 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11497767B2 (en) | 2015-02-18 | 2022-11-15 | Enlivex Therapeutics R&D Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| CN109069539A (zh) | 2016-02-18 | 2018-12-21 | 恩立夫克治疗有限责任公司 | 用于癌症治疗的联合免疫疗法和细胞因子控制疗法 |
| CN106432548B (zh) * | 2016-09-20 | 2019-02-19 | 海南大学 | 基于硫醇-烯点击化学的脂肪酸化肝素的制备及表征 |
| EP3554257B1 (en) | 2016-12-15 | 2023-07-12 | Société des Produits Nestlé S.A. | Compositions and methods that modulate white blood cells or neutrophils in a companion animal |
| WO2018225072A1 (en) | 2017-06-08 | 2018-12-13 | Enlivex Therapeutics Ltd. | Therapeutic apoptotic cells for cancer therapy |
| EP3883584B1 (en) | 2018-11-19 | 2026-02-18 | Enlivex Therapeutics R&D Ltd | Early apoptotic cells for use treating organ failure in sepsis |
| WO2022015794A1 (en) | 2020-07-14 | 2022-01-20 | Optimvia, Llc | Methods for synthesizing non-anticoagulant heparan sulfate |
| KR20220054870A (ko) | 2019-09-03 | 2022-05-03 | 엔리벡스 테라퓨틱스 리미티드 | 골관절염을 치료하기 위한 치료학적 세포자살성 세포 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994008595A1 (en) * | 1992-10-13 | 1994-04-28 | Virginia Commonwealth University | Use of non-anticoagulant heparin for treating ischemia/reperfusion injury |
| JPH0940581A (ja) * | 1995-05-22 | 1997-02-10 | Seikagaku Kogyo Co Ltd | アポトーシス関連疾患治療剤 |
| WO1999038827A1 (en) * | 1998-02-02 | 1999-08-05 | Merck & Co., Inc. | PLATELET AGGREGATION INHIBITION USING LOW MOLECULAR WEIGHT HEPARIN IN COMBINATION WITH A GP IIb/IIIa ANTAGONIST |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2374910A1 (fr) * | 1976-10-23 | 1978-07-21 | Choay Sa | Preparation a base d'heparine, comprenant des liposomes, procede pour l'obtenir et medicaments contenant de telles preparations |
| US5668118A (en) * | 1992-07-24 | 1997-09-16 | Cavalier Pharmaceuticals | Method of synthesis of 2-O-desulfated Heparin and use thereof for inhibition of elastase and Cathepspin G |
| AU2435795A (en) * | 1994-05-06 | 1995-11-29 | Glycomed Incorporated | O-desulfated heparin derivatives, methods of making and uses thereof |
| EP1223948A2 (en) * | 1999-09-13 | 2002-07-24 | CHARLOTTE-MECKLENBURG HOSPITAL doing business as Carolinas Medical Center | Method of inhibiting nf-kappa-b with heparin, for treating cardiovascular diseases and inflammations |
-
2000
- 2000-05-02 US US09/561,663 patent/US6489311B1/en not_active Expired - Lifetime
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2001
- 2001-04-30 EP EP01933380A patent/EP1289508A2/en not_active Ceased
- 2001-04-30 AU AU2001259811A patent/AU2001259811B2/en not_active Ceased
- 2001-04-30 AU AU5981101A patent/AU5981101A/xx active Pending
- 2001-04-30 JP JP2001579793A patent/JP2003531854A/ja active Pending
- 2001-04-30 CA CA2407806A patent/CA2407806C/en not_active Expired - Fee Related
- 2001-04-30 WO PCT/US2001/040639 patent/WO2001082918A2/en not_active Ceased
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994008595A1 (en) * | 1992-10-13 | 1994-04-28 | Virginia Commonwealth University | Use of non-anticoagulant heparin for treating ischemia/reperfusion injury |
| JPH0940581A (ja) * | 1995-05-22 | 1997-02-10 | Seikagaku Kogyo Co Ltd | アポトーシス関連疾患治療剤 |
| WO1999038827A1 (en) * | 1998-02-02 | 1999-08-05 | Merck & Co., Inc. | PLATELET AGGREGATION INHIBITION USING LOW MOLECULAR WEIGHT HEPARIN IN COMBINATION WITH A GP IIb/IIIa ANTAGONIST |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001082918A8 (en) | 2002-07-11 |
| AU2001259811B2 (en) | 2006-08-24 |
| WO2001082918A9 (en) | 2002-08-08 |
| CA2407806C (en) | 2012-04-17 |
| CA2407806A1 (en) | 2001-11-08 |
| WO2001082918A2 (en) | 2001-11-08 |
| AU5981101A (en) | 2001-11-12 |
| US6489311B1 (en) | 2002-12-03 |
| EP1289508A2 (en) | 2003-03-12 |
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