JP2003528617A - ヒト以外の動物を遺伝子修飾するための新規なベクター - Google Patents

ヒト以外の動物を遺伝子修飾するための新規なベクター

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Publication number
JP2003528617A
JP2003528617A JP2001570810A JP2001570810A JP2003528617A JP 2003528617 A JP2003528617 A JP 2003528617A JP 2001570810 A JP2001570810 A JP 2001570810A JP 2001570810 A JP2001570810 A JP 2001570810A JP 2003528617 A JP2003528617 A JP 2003528617A
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JP
Japan
Prior art keywords
linker
human
cell
animal
sperm
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001570810A
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English (en)
Japanese (ja)
Other versions
JP2003528617A5 (https=
Inventor
ワン，カンシェン
Original Assignee
バイオアグリ コーポレーション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by バイオアグリ コーポレーション filed Critical バイオアグリ コーポレーション
Publication of JP2003528617A publication Critical patent/JP2003528617A/ja
Publication of JP2003528617A5 publication Critical patent/JP2003528617A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0006—Modification of the membrane of cells, e.g. cell decoration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0608—Germ cells
    • C12N5/061—Sperm cells, spermatogonia
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Environmental Sciences (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Developmental Biology & Embryology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Public Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2001570810A 2000-03-28 2001-03-05 ヒト以外の動物を遺伝子修飾するための新規なベクター Pending JP2003528617A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/537,861 US7067308B1 (en) 2000-03-28 2000-03-28 Vector for genetically modifying non-human animals
US09/537,861 2000-03-28
PCT/US2001/007018 WO2001073094A2 (en) 2000-03-28 2001-03-05 Novel sperm-dna complexes for genetically modifying non-human animals

Publications (2)

Publication Number Publication Date
JP2003528617A true JP2003528617A (ja) 2003-09-30
JP2003528617A5 JP2003528617A5 (https=) 2008-04-03

Family

ID=24144410

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001570810A Pending JP2003528617A (ja) 2000-03-28 2001-03-05 ヒト以外の動物を遺伝子修飾するための新規なベクター

Country Status (10)

Country Link
US (2) US7067308B1 (https=)
EP (2) EP1268836B1 (https=)
JP (1) JP2003528617A (https=)
CN (1) CN1432067A (https=)
AR (1) AR028298A1 (https=)
AT (1) ATE348184T1 (https=)
AU (1) AU2001245438A1 (https=)
DE (1) DE60125156T2 (https=)
PE (1) PE20011214A1 (https=)
WO (1) WO2001073094A2 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7053187B2 (en) * 2000-03-28 2006-05-30 Gioagri Corporation Sperm-specific monoclonal antibody, mAbC
US7067308B1 (en) * 2000-03-28 2006-06-27 Bioagri Corporation Vector for genetically modifying non-human animals
US7527966B2 (en) 2002-06-26 2009-05-05 Transgenrx, Inc. Gene regulation in transgenic animals using a transposon-based vector
MX2009012317A (es) 2007-05-16 2010-04-01 Mat Malta Advanced Technologie Tratamiento y prevencion de influenza.
WO2010036976A2 (en) 2008-09-25 2010-04-01 Transgenrx, Inc. Novel vectors for production of antibodies
US9157097B2 (en) 2008-09-25 2015-10-13 Proteovec Holding, L.L.C. Vectors for production of growth hormone
ES2924287T3 (es) * 2009-04-08 2022-10-05 Univ California Conjugados de ADN-células
EP2417263B1 (en) 2009-04-09 2015-09-23 ProteoVec Holding L.L.C. Production of proteins using transposon-based vectors
CN102453720B (zh) * 2010-10-28 2013-01-30 华中农业大学 一种在猪肌肉组织高效表达的融合启动子
DK3590332T3 (da) * 2011-10-28 2022-05-23 Regeneron Pharma Genmodificerede mus, der eksprimerer kimære major histokompatibilitetskompleks (MHC) II-molekyler
US20150024497A1 (en) * 2013-07-19 2015-01-22 Elwha Llc Methods and Systems for Utilizing Sperm for Molecular Delivery
CA3065317A1 (en) 2017-05-31 2018-12-06 Commonwealth Scientific And Industrial Research Organisation Trait selection in avians

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5428132A (en) * 1987-10-11 1995-06-27 United States Of America Conjugate and method for integration of foreign DNA into cells
WO1997011597A1 (fr) * 1995-09-29 1997-04-03 Hoechst Marion Roussel Ltd. Obtention d'un animal transgenique

Family Cites Families (14)

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IT1228210B (it) 1989-01-10 1991-06-05 Consiglio Nazionale Ricerche Procedimento per la introduzione di dna esogeno nelle cellule somatiche e germinali di animali.
IL92529A0 (en) 1989-12-03 1990-08-31 Yissum Res Dev Co Generation of transgenic vertebrates by employing transformed sperm cells via artificial insemination
US5521291A (en) 1991-09-30 1996-05-28 Boehringer Ingelheim International, Gmbh Conjugates for introducing nucleic acid into higher eucaryotic cells
US6063630A (en) * 1991-11-05 2000-05-16 Transkaryotic Therapies, Inc. Targeted introduction of DNA into primary or secondary cells and their use for gene therapy
WO1993024626A1 (en) 1992-05-28 1993-12-09 Scientific Dimensions Usa, Inc. Transgenic animal production with biolistically transformed spermatozoa
RU2081914C1 (ru) 1994-07-21 1997-06-20 Андрей Вадимович Кузнецов Способ введения чужеродной днк в сперматозоиды
US5744335A (en) 1995-09-19 1998-04-28 Mirus Corporation Process of transfecting a cell with a polynucleotide mixed with an amphipathic compound and a DNA-binding protein
CN1112165C (zh) 1997-08-15 2003-06-25 中国农业大学 精子介dna转移生产转基因动物的方法
WO1999038991A1 (en) 1998-01-28 1999-08-05 Takara Shuzo Co., Ltd. Method for transferring gene into germ cell
NZ506341A (en) 1998-02-09 2003-02-28 Tranxenogen Inc Genetic manipulation of spermatogonia
IL123411A0 (en) 1998-02-22 1998-09-24 Kimron Veterinary Inst High efficiency methods and compositions for integrating exogenous dna into genomic dna of sperm
CA2340242A1 (en) 1998-08-11 2000-02-24 Teruhiko Wakayama Method of performing transgenesis
US7053187B2 (en) * 2000-03-28 2006-05-30 Gioagri Corporation Sperm-specific monoclonal antibody, mAbC
US7067308B1 (en) * 2000-03-28 2006-06-27 Bioagri Corporation Vector for genetically modifying non-human animals

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5428132A (en) * 1987-10-11 1995-06-27 United States Of America Conjugate and method for integration of foreign DNA into cells
WO1997011597A1 (fr) * 1995-09-29 1997-04-03 Hoechst Marion Roussel Ltd. Obtention d'un animal transgenique

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
JPN6010062545, Ｊ． Ｒｅｐｒｏｄ． Ｆｅｒｔｉｌ．, 1983, ｖｏｌ． ６８, ４９７−５０５ *
JPN6010062546, Ｔｒａｎｓｇｅｎｉｃ Ｒｅｓ．, 1998, ｖｏｌ． ７, １４７−１５５ *
JPN6010062547, Ｈｙｂｒｉｄｏｍａ, 1993, ｖｏｌ． １２, ７０９−７１８ *
JPN6010062548, Ｈｕｍ． Ｒｅｐｒｏｄ．, 1996, ｖｏｌ． １１, ２５９５−２５９９ *
JPN6010062549, Ｊ． Ｒｅｐｒｏｄ． Ｉｍｍｕｎｏｌ．, 1998, ｖｏｌ． １３, ７３−８４ *
JPN6010062550, ＤＮＡ Ｃｅｌｌ Ｂｉｏｌ．, 1997, ｖｏｌ． １６, １０８７−１０９７ *

Also Published As

Publication number Publication date
EP1760155A2 (en) 2007-03-07
EP1268836A2 (en) 2003-01-02
CN1432067A (zh) 2003-07-23
US7067308B1 (en) 2006-06-27
DE60125156D1 (de) 2007-01-25
PE20011214A1 (es) 2001-11-29
WO2001073094A3 (en) 2002-05-30
US20070214512A1 (en) 2007-09-13
ATE348184T1 (de) 2007-01-15
EP1760155A3 (en) 2007-03-14
EP1268836B1 (en) 2006-12-13
WO2001073094A2 (en) 2001-10-04
AR028298A1 (es) 2003-04-30
AU2001245438A1 (en) 2001-10-08
DE60125156T2 (de) 2007-09-20

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