JP2003528617A5 - - Google Patents
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- Publication number
- JP2003528617A5 JP2003528617A5 JP2001570810A JP2001570810A JP2003528617A5 JP 2003528617 A5 JP2003528617 A5 JP 2003528617A5 JP 2001570810 A JP2001570810 A JP 2001570810A JP 2001570810 A JP2001570810 A JP 2001570810A JP 2003528617 A5 JP2003528617 A5 JP 2003528617A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- polynucleotide
- linker
- antibody linker
- polynucleotide molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108091033319 polynucleotide Proteins 0.000 description 28
- 102000040430 polynucleotide Human genes 0.000 description 28
- 239000002157 polynucleotide Substances 0.000 description 28
- 238000000034 method Methods 0.000 description 26
- 108090000623 proteins and genes Proteins 0.000 description 13
- 210000001161 mammalian embryo Anatomy 0.000 description 8
- 238000000338 in vitro Methods 0.000 description 7
- 238000001727 in vivo Methods 0.000 description 7
- 241001465754 Metazoa Species 0.000 description 6
- 230000004720 fertilization Effects 0.000 description 6
- 230000003993 interaction Effects 0.000 description 6
- 108020004414 DNA Proteins 0.000 description 4
- 102000053602 DNA Human genes 0.000 description 4
- 230000008878 coupling Effects 0.000 description 4
- 238000010168 coupling process Methods 0.000 description 4
- 238000005859 coupling reaction Methods 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 230000009878 intermolecular interaction Effects 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- 208000035240 Disease Resistance Diseases 0.000 description 1
- 102000018997 Growth Hormone Human genes 0.000 description 1
- 108010051696 Growth Hormone Proteins 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000000122 growth hormone Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/537,861 US7067308B1 (en) | 2000-03-28 | 2000-03-28 | Vector for genetically modifying non-human animals |
| US09/537,861 | 2000-03-28 | ||
| PCT/US2001/007018 WO2001073094A2 (en) | 2000-03-28 | 2001-03-05 | Novel sperm-dna complexes for genetically modifying non-human animals |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003528617A JP2003528617A (ja) | 2003-09-30 |
| JP2003528617A5 true JP2003528617A5 (https=) | 2008-04-03 |
Family
ID=24144410
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001570810A Pending JP2003528617A (ja) | 2000-03-28 | 2001-03-05 | ヒト以外の動物を遺伝子修飾するための新規なベクター |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7067308B1 (https=) |
| EP (2) | EP1268836B1 (https=) |
| JP (1) | JP2003528617A (https=) |
| CN (1) | CN1432067A (https=) |
| AR (1) | AR028298A1 (https=) |
| AT (1) | ATE348184T1 (https=) |
| AU (1) | AU2001245438A1 (https=) |
| DE (1) | DE60125156T2 (https=) |
| PE (1) | PE20011214A1 (https=) |
| WO (1) | WO2001073094A2 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7053187B2 (en) * | 2000-03-28 | 2006-05-30 | Gioagri Corporation | Sperm-specific monoclonal antibody, mAbC |
| US7067308B1 (en) * | 2000-03-28 | 2006-06-27 | Bioagri Corporation | Vector for genetically modifying non-human animals |
| US7527966B2 (en) | 2002-06-26 | 2009-05-05 | Transgenrx, Inc. | Gene regulation in transgenic animals using a transposon-based vector |
| MX2009012317A (es) | 2007-05-16 | 2010-04-01 | Mat Malta Advanced Technologie | Tratamiento y prevencion de influenza. |
| WO2010036976A2 (en) | 2008-09-25 | 2010-04-01 | Transgenrx, Inc. | Novel vectors for production of antibodies |
| US9157097B2 (en) | 2008-09-25 | 2015-10-13 | Proteovec Holding, L.L.C. | Vectors for production of growth hormone |
| ES2924287T3 (es) * | 2009-04-08 | 2022-10-05 | Univ California | Conjugados de ADN-células |
| EP2417263B1 (en) | 2009-04-09 | 2015-09-23 | ProteoVec Holding L.L.C. | Production of proteins using transposon-based vectors |
| CN102453720B (zh) * | 2010-10-28 | 2013-01-30 | 华中农业大学 | 一种在猪肌肉组织高效表达的融合启动子 |
| DK3590332T3 (da) * | 2011-10-28 | 2022-05-23 | Regeneron Pharma | Genmodificerede mus, der eksprimerer kimære major histokompatibilitetskompleks (MHC) II-molekyler |
| US20150024497A1 (en) * | 2013-07-19 | 2015-01-22 | Elwha Llc | Methods and Systems for Utilizing Sperm for Molecular Delivery |
| CA3065317A1 (en) | 2017-05-31 | 2018-12-06 | Commonwealth Scientific And Industrial Research Organisation | Trait selection in avians |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5428132A (en) | 1987-10-11 | 1995-06-27 | United States Of America | Conjugate and method for integration of foreign DNA into cells |
| IT1228210B (it) | 1989-01-10 | 1991-06-05 | Consiglio Nazionale Ricerche | Procedimento per la introduzione di dna esogeno nelle cellule somatiche e germinali di animali. |
| IL92529A0 (en) | 1989-12-03 | 1990-08-31 | Yissum Res Dev Co | Generation of transgenic vertebrates by employing transformed sperm cells via artificial insemination |
| US5521291A (en) | 1991-09-30 | 1996-05-28 | Boehringer Ingelheim International, Gmbh | Conjugates for introducing nucleic acid into higher eucaryotic cells |
| US6063630A (en) * | 1991-11-05 | 2000-05-16 | Transkaryotic Therapies, Inc. | Targeted introduction of DNA into primary or secondary cells and their use for gene therapy |
| WO1993024626A1 (en) | 1992-05-28 | 1993-12-09 | Scientific Dimensions Usa, Inc. | Transgenic animal production with biolistically transformed spermatozoa |
| RU2081914C1 (ru) | 1994-07-21 | 1997-06-20 | Андрей Вадимович Кузнецов | Способ введения чужеродной днк в сперматозоиды |
| US5744335A (en) | 1995-09-19 | 1998-04-28 | Mirus Corporation | Process of transfecting a cell with a polynucleotide mixed with an amphipathic compound and a DNA-binding protein |
| JPH10304790A (ja) | 1995-09-29 | 1998-11-17 | Hoechst Japan Ltd | トランスジェニック動物の作成方法 |
| CN1112165C (zh) | 1997-08-15 | 2003-06-25 | 中国农业大学 | 精子介dna转移生产转基因动物的方法 |
| WO1999038991A1 (en) | 1998-01-28 | 1999-08-05 | Takara Shuzo Co., Ltd. | Method for transferring gene into germ cell |
| NZ506341A (en) | 1998-02-09 | 2003-02-28 | Tranxenogen Inc | Genetic manipulation of spermatogonia |
| IL123411A0 (en) | 1998-02-22 | 1998-09-24 | Kimron Veterinary Inst | High efficiency methods and compositions for integrating exogenous dna into genomic dna of sperm |
| CA2340242A1 (en) | 1998-08-11 | 2000-02-24 | Teruhiko Wakayama | Method of performing transgenesis |
| US7053187B2 (en) * | 2000-03-28 | 2006-05-30 | Gioagri Corporation | Sperm-specific monoclonal antibody, mAbC |
| US7067308B1 (en) * | 2000-03-28 | 2006-06-27 | Bioagri Corporation | Vector for genetically modifying non-human animals |
-
2000
- 2000-03-28 US US09/537,861 patent/US7067308B1/en not_active Expired - Fee Related
-
2001
- 2001-03-05 JP JP2001570810A patent/JP2003528617A/ja active Pending
- 2001-03-05 AU AU2001245438A patent/AU2001245438A1/en not_active Abandoned
- 2001-03-05 CN CN01810496A patent/CN1432067A/zh active Pending
- 2001-03-05 AT AT01918350T patent/ATE348184T1/de not_active IP Right Cessation
- 2001-03-05 DE DE60125156T patent/DE60125156T2/de not_active Expired - Lifetime
- 2001-03-05 WO PCT/US2001/007018 patent/WO2001073094A2/en not_active Ceased
- 2001-03-05 EP EP01918350A patent/EP1268836B1/en not_active Expired - Lifetime
- 2001-03-05 EP EP06125927A patent/EP1760155A3/en not_active Withdrawn
- 2001-03-27 PE PE2001000287A patent/PE20011214A1/es not_active Application Discontinuation
- 2001-03-28 AR ARP010101471A patent/AR028298A1/es unknown
-
2006
- 2006-04-20 US US11/407,851 patent/US20070214512A1/en not_active Abandoned
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