JP2003522172A - 抗腫瘍剤としてのｃ１０エステル置換タキサン - Google Patents

抗腫瘍剤としてのｃ１０エステル置換タキサン

Info

Publication number
JP2003522172A
JP2003522172A JP2001557864A JP2001557864A JP2003522172A JP 2003522172 A JP2003522172 A JP 2003522172A JP 2001557864 A JP2001557864 A JP 2001557864A JP 2001557864 A JP2001557864 A JP 2001557864A JP 2003522172 A JP2003522172 A JP 2003522172A
Authority
JP
Japan
Prior art keywords
pyridyl
furyl
thienyl
taxane
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001557864A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003522172A5 (https=
Inventor
ロバート・エイ・ホルトン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Florida State University Research Foundation Inc
Original Assignee
Florida State University Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Florida State University Research Foundation Inc filed Critical Florida State University Research Foundation Inc
Publication of JP2003522172A publication Critical patent/JP2003522172A/ja
Publication of JP2003522172A5 publication Critical patent/JP2003522172A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
    • B65D83/75—Aerosol containers not provided for in groups B65D83/16 - B65D83/74
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2001557864A 2000-02-02 2001-02-02 抗腫瘍剤としてのｃ１０エステル置換タキサン Pending JP2003522172A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17978200P 2000-02-02 2000-02-02
US60/179,782 2000-02-02
PCT/US2001/003623 WO2001057032A1 (en) 2000-02-02 2001-02-02 C10 ester substituted taxanes as antitumor agents

Publications (2)

Publication Number Publication Date
JP2003522172A true JP2003522172A (ja) 2003-07-22
JP2003522172A5 JP2003522172A5 (https=) 2008-02-14

Family

ID=22657972

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001557864A Pending JP2003522172A (ja) 2000-02-02 2001-02-02 抗腫瘍剤としてのｃ１０エステル置換タキサン

Country Status (25)

Country Link
EP (1) EP1165553B1 (https=)
JP (1) JP2003522172A (https=)
CN (1) CN1380882A (https=)
AT (1) ATE432928T1 (https=)
AU (1) AU782150B2 (https=)
BG (1) BG64889B1 (https=)
BR (1) BR0104354A (https=)
CA (1) CA2368274C (https=)
CZ (1) CZ20013430A3 (https=)
DE (1) DE60138853D1 (https=)
GE (1) GEP20043323B (https=)
HU (1) HUP0600302A2 (https=)
IL (1) IL145638A (https=)
MX (1) MXPA01009905A (https=)
NO (1) NO327910B1 (https=)
NZ (1) NZ514382A (https=)
PL (1) PL202957B1 (https=)
RO (1) RO121270B1 (https=)
RU (1) RU2262506C2 (https=)
SK (1) SK13692001A3 (https=)
TR (1) TR200102858T1 (https=)
TW (1) TWI299732B (https=)
UA (1) UA75039C2 (https=)
WO (1) WO2001057032A1 (https=)
ZA (1) ZA200108055B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011517455A (ja) * 2008-03-31 2011-06-09 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド Ｃ（１０）エチルエステルおよびｃ（１０）シクロプロピルエステル置換タキサン

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6649632B2 (en) 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
CA2354471A1 (en) * 2001-07-31 2003-01-31 Florida State University Research Foundation, Inc. C10 ester substituted taxanes
SG129990A1 (en) * 2001-08-01 2007-03-20 Univ Florida State Res Found C10 ester substituted taxanes
HN2005000054A (es) 2004-02-13 2009-02-18 Florida State University Foundation Inc Taxanos sustituidos con esteres de ciclopentilo en c10
JP2008530122A (ja) * 2005-02-14 2008-08-07 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド Ｃ１０シクロプロピルエステル置換タキサン組成物

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08506324A (ja) * 1993-01-29 1996-07-09 フロリダ・ステート・ユニバーシティー Ｃ７タキサン誘導体およびそれを含有する薬剤組成物
JPH08508255A (ja) * 1993-03-22 1996-09-03 フロリダ・ステート・ユニバーシティー フリルまたはチエニル置換側鎖を有するタキサン
JPH08508471A (ja) * 1993-03-22 1996-09-10 フロリダ・ステート・ユニバーシティー ピリジル置換側鎖を有するタキサン
JPH08508470A (ja) * 1993-03-22 1996-09-10 フロリダ・ステート・ユニバーシティー アミノ置換側鎖を有するタキサン
JPH10508022A (ja) * 1994-10-28 1998-08-04 ザ リサーチ ファウンデーション オブ ステート ユニバーシティ オブ ニューヨーク タキソイド誘導体、それらの製造、およびそれらの抗腫瘍薬としての使用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5243045A (en) * 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5250683A (en) * 1991-09-23 1993-10-05 Florida State University Certain substituted taxanes and pharmaceutical compositions containing them
US5475011A (en) * 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
US6100411A (en) * 1994-10-28 2000-08-08 The Research Foundation Of State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
ES2151277T3 (es) * 1996-05-22 2000-12-16 Protarga Inc Composiciones que comprenden conjugados de acido cis-docosahexaenoico y taxotere.
US5795909A (en) * 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
WO1999032473A1 (en) * 1997-12-19 1999-07-01 Kabushiki Kaisha Yakult Honsha Taxane derivatives
JP2003026673A (ja) * 1999-03-05 2003-01-29 Asahi Kasei Corp 骨形成促進剤

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08506324A (ja) * 1993-01-29 1996-07-09 フロリダ・ステート・ユニバーシティー Ｃ７タキサン誘導体およびそれを含有する薬剤組成物
JPH08508255A (ja) * 1993-03-22 1996-09-03 フロリダ・ステート・ユニバーシティー フリルまたはチエニル置換側鎖を有するタキサン
JPH08508471A (ja) * 1993-03-22 1996-09-10 フロリダ・ステート・ユニバーシティー ピリジル置換側鎖を有するタキサン
JPH08508469A (ja) * 1993-03-22 1996-09-10 フロリダ・ステート・ユニバーシティー アルコキシ、アルケンオキシまたはアリールオキシ置換側鎖を有するタキサンおよびそれを含有する薬剤組成物
JPH08508470A (ja) * 1993-03-22 1996-09-10 フロリダ・ステート・ユニバーシティー アミノ置換側鎖を有するタキサン
JPH10508022A (ja) * 1994-10-28 1998-08-04 ザ リサーチ ファウンデーション オブ ステート ユニバーシティ オブ ニューヨーク タキソイド誘導体、それらの製造、およびそれらの抗腫瘍薬としての使用

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011517455A (ja) * 2008-03-31 2011-06-09 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド Ｃ（１０）エチルエステルおよびｃ（１０）シクロプロピルエステル置換タキサン

Also Published As

Publication number Publication date
UA75039C2 (en) 2006-03-15
IL145638A0 (en) 2002-06-30
BG64889B1 (bg) 2006-08-31
RO121270B1 (ro) 2007-02-28
CA2368274C (en) 2009-10-13
EP1165553A1 (en) 2002-01-02
RU2262506C2 (ru) 2005-10-20
AU3480901A (en) 2001-08-14
NO20014754L (no) 2001-11-29
NO20014754D0 (no) 2001-10-01
TR200102858T1 (tr) 2002-12-23
GEP20043323B (en) 2004-02-10
MXPA01009905A (es) 2003-08-20
CA2368274A1 (en) 2001-08-09
NO327910B1 (no) 2009-10-19
SK13692001A3 (sk) 2002-07-02
HUP0600302A2 (en) 2006-07-28
ATE432928T1 (de) 2009-06-15
CZ20013430A3 (cs) 2002-04-17
PL202957B1 (pl) 2009-08-31
BG105965A (en) 2002-07-31
AU782150B2 (en) 2005-07-07
DE60138853D1 (de) 2009-07-16
WO2001057032A1 (en) 2001-08-09
BR0104354A (pt) 2002-01-02
PL351380A1 (en) 2003-04-07
NZ514382A (en) 2004-05-28
IL145638A (en) 2011-05-31
TWI299732B (en) 2008-08-11
EP1165553B1 (en) 2009-06-03
ZA200108055B (en) 2003-12-01
CN1380882A (zh) 2002-11-20

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