JP2003519240A5 - - Google Patents
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- Publication number
- JP2003519240A5 JP2003519240A5 JP2001550354A JP2001550354A JP2003519240A5 JP 2003519240 A5 JP2003519240 A5 JP 2003519240A5 JP 2001550354 A JP2001550354 A JP 2001550354A JP 2001550354 A JP2001550354 A JP 2001550354A JP 2003519240 A5 JP2003519240 A5 JP 2003519240A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- domain
- cancer vaccine
- cell
- ligand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000004169 proteins and genes Human genes 0.000 description 38
- 108090000623 proteins and genes Proteins 0.000 description 38
- 238000000034 method Methods 0.000 description 28
- 229940022399 cancer vaccine Drugs 0.000 description 13
- 238000009566 cancer vaccine Methods 0.000 description 13
- 210000004027 cell Anatomy 0.000 description 13
- 108010052285 Membrane Proteins Proteins 0.000 description 4
- 102000018697 Membrane Proteins Human genes 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 4
- 239000003112 inhibitor Substances 0.000 description 4
- 108020001507 fusion proteins Proteins 0.000 description 3
- 102000037865 fusion proteins Human genes 0.000 description 3
- 108010082808 4-1BB Ligand Proteins 0.000 description 2
- 108010017987 CD30 Ligand Proteins 0.000 description 2
- 108010029697 CD40 Ligand Proteins 0.000 description 2
- 102100032937 CD40 ligand Human genes 0.000 description 2
- 102100036008 CD48 antigen Human genes 0.000 description 2
- 108010084313 CD58 Antigens Proteins 0.000 description 2
- 101000716130 Homo sapiens CD48 antigen Proteins 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 description 2
- 108010064600 Intercellular Adhesion Molecule-3 Proteins 0.000 description 2
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 description 2
- 101710148794 Intercellular adhesion molecule 2 Proteins 0.000 description 2
- 102100037872 Intercellular adhesion molecule 2 Human genes 0.000 description 2
- 102100037871 Intercellular adhesion molecule 3 Human genes 0.000 description 2
- 235000021314 Palmitic acid Nutrition 0.000 description 2
- 101710120037 Toxin CcdB Proteins 0.000 description 2
- 102100031988 Tumor necrosis factor ligand superfamily member 6 Human genes 0.000 description 2
- 108050002568 Tumor necrosis factor ligand superfamily member 6 Proteins 0.000 description 2
- 102100032100 Tumor necrosis factor ligand superfamily member 8 Human genes 0.000 description 2
- 102100032101 Tumor necrosis factor ligand superfamily member 9 Human genes 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 229960005486 vaccine Drugs 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 230000006052 T cell proliferation Effects 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000004957 immunoregulator effect Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000007781 signaling event Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/476,828 | 2000-01-03 | ||
| US09/476,828 US6316256B1 (en) | 2000-01-03 | 2000-01-03 | Method for protein transfer |
| PCT/US2001/000103 WO2001049825A1 (en) | 2000-01-03 | 2001-01-03 | Methods for protein transfer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003519240A JP2003519240A (ja) | 2003-06-17 |
| JP2003519240A5 true JP2003519240A5 (https=) | 2008-02-14 |
Family
ID=23893419
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001550354A Pending JP2003519240A (ja) | 2000-01-03 | 2001-01-03 | タンパク質を移送する方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US6316256B1 (https=) |
| EP (1) | EP1246901A4 (https=) |
| JP (1) | JP2003519240A (https=) |
| AU (1) | AU2472501A (https=) |
| CA (1) | CA2396399A1 (https=) |
| IL (2) | IL150570A0 (https=) |
| WO (1) | WO2001049825A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7435585B2 (en) * | 2000-01-03 | 2008-10-14 | University Of Pennsylvania | Auto-stimulating cells and methods for making and using the same |
| EA006577B1 (ru) * | 2001-10-16 | 2006-02-24 | Киуи Индженьюити Лимитид | Контроли чувствительности для серологии крови, приготовленные из модифицированных клеток |
| WO2003068977A2 (de) * | 2002-02-10 | 2003-08-21 | Apoxis Sa | Fusionkonstrukte, enthaltend aktive abschnitte von tnf-liganden |
| WO2003106640A2 (en) * | 2002-06-14 | 2003-12-24 | Case Western Reserve University | Cell targeting methods and compositions |
| WO2010141946A1 (en) * | 2009-06-05 | 2010-12-09 | Cell Targeting, Inc. | Peptide-coated cell localization to diseased or damaged tissues and methods related thereto |
| WO2014121099A1 (en) | 2013-01-31 | 2014-08-07 | Thomas Jefferson University | Agonist fusion protein for cd40 ox40 and uses thereof |
| HK1250637A1 (zh) * | 2015-04-02 | 2019-01-11 | Cancure Limited | 用於引发免疫应答的剂和组合物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0463080A4 (en) | 1989-03-15 | 1992-02-12 | Mark L Tykocinsky | Cd8-based pharmaceuticals |
| US5242687A (en) | 1989-03-15 | 1993-09-07 | Tkb Associates Limited Partnership | Method of reducing cellular immune response involving T-cells using CD8-bearing antigen presenting cells |
| US5601828A (en) | 1989-03-15 | 1997-02-11 | Tkb Associates Limited Partnership | CD8 derivatives and methods of use for cellular modulation and enhancement of cellular engraftment |
| US5698679A (en) | 1994-09-19 | 1997-12-16 | National Jewish Center For Immunology And Respiratory Medicine | Product and process for targeting an immune response |
| US5817789A (en) | 1995-06-06 | 1998-10-06 | Transkaryotic Therapies, Inc. | Chimeric proteins for use in transport of a selected substance into cells |
| US5869270A (en) * | 1996-01-31 | 1999-02-09 | Sunol Molecular Corporation | Single chain MHC complexes and uses thereof |
-
2000
- 2000-01-03 US US09/476,828 patent/US6316256B1/en not_active Expired - Fee Related
-
2001
- 2001-01-03 CA CA002396399A patent/CA2396399A1/en not_active Abandoned
- 2001-01-03 WO PCT/US2001/000103 patent/WO2001049825A1/en not_active Ceased
- 2001-01-03 IL IL15057001A patent/IL150570A0/xx active IP Right Grant
- 2001-01-03 JP JP2001550354A patent/JP2003519240A/ja active Pending
- 2001-01-03 EP EP01900311A patent/EP1246901A4/en not_active Ceased
- 2001-01-03 AU AU24725/01A patent/AU2472501A/en not_active Abandoned
- 2001-09-20 US US09/957,056 patent/US20020037583A1/en not_active Abandoned
-
2002
- 2002-07-03 IL IL150570A patent/IL150570A/en not_active IP Right Cessation
-
2004
- 2004-02-10 US US10/775,942 patent/US20040161806A1/en not_active Abandoned
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