JP2003519194A5 - - Google Patents
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- Publication number
- JP2003519194A5 JP2003519194A5 JP2001549678A JP2001549678A JP2003519194A5 JP 2003519194 A5 JP2003519194 A5 JP 2003519194A5 JP 2001549678 A JP2001549678 A JP 2001549678A JP 2001549678 A JP2001549678 A JP 2001549678A JP 2003519194 A5 JP2003519194 A5 JP 2003519194A5
- Authority
- JP
- Japan
- Prior art keywords
- polymer
- peptide
- poly
- tyrosine
- derived
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 description 27
- 229920000642 polymer Polymers 0.000 description 26
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 15
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 15
- 239000000203 mixture Substances 0.000 description 13
- 238000009472 formulation Methods 0.000 description 11
- 150000001875 compounds Chemical class 0.000 description 9
- WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 description 8
- 229910052739 hydrogen Inorganic materials 0.000 description 7
- 239000001257 hydrogen Substances 0.000 description 7
- 230000003993 interaction Effects 0.000 description 6
- 229920001230 polyarylate Polymers 0.000 description 6
- 238000011068 loading method Methods 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 229920001223 polyethylene glycol Polymers 0.000 description 5
- 102000004196 processed proteins & peptides Human genes 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- XKZQKPRCPNGNFR-UHFFFAOYSA-N 2-(3-hydroxyphenyl)phenol Chemical class OC1=CC=CC(C=2C(=CC=CC=2)O)=C1 XKZQKPRCPNGNFR-UHFFFAOYSA-N 0.000 description 3
- 125000000524 functional group Chemical group 0.000 description 3
- 229920000747 poly(lactic acid) Polymers 0.000 description 3
- 239000004626 polylactic acid Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- PJRSUKFWFKUDTH-JWDJOUOUSA-N (2s)-6-amino-2-[[2-[[(2s)-2-[[(2s,3s)-2-[[(2s)-2-[[2-[[(2s)-2-[[(2s)-6-amino-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[(2-aminoacetyl)amino]-4-methylsulfanylbutanoyl]amino]propanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]propanoyl]amino]acetyl]amino]propanoyl Chemical compound CSCC[C@H](NC(=O)CN)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(N)=O PJRSUKFWFKUDTH-JWDJOUOUSA-N 0.000 description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 230000000975 bioactive effect Effects 0.000 description 2
- 229920000249 biocompatible polymer Polymers 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 125000004494 ethyl ester group Chemical group 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 102000006495 integrins Human genes 0.000 description 2
- 108010044426 integrins Proteins 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 108010021753 peptide-Gly-Leu-amide Proteins 0.000 description 2
- 229920000233 poly(alkylene oxides) Polymers 0.000 description 2
- 229920002635 polyurethane Polymers 0.000 description 2
- 239000004814 polyurethane Substances 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 208000034530 PLAA-associated neurodevelopmental disease Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 125000005907 alkyl ester group Chemical group 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- LEUOKLJWUZRRGH-SFHVURJKSA-N ethyl (2S)-3-(4-carboxyoxyphenyl)-2-[3-(4-hydroxyphenyl)propanoylamino]propanoate Chemical compound C(C)OC([C@@H](NC(CCC1=CC=C(C=C1)O)=O)CC1=CC=C(C=C1)OC(O)=O)=O LEUOKLJWUZRRGH-SFHVURJKSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229920001002 functional polymer Polymers 0.000 description 1
- 229920001600 hydrophobic polymer Polymers 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 229920002627 poly(phosphazenes) Polymers 0.000 description 1
- 229920001610 polycaprolactone Polymers 0.000 description 1
- 239000004632 polycaprolactone Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- -1 polyimino carbonates Polymers 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 229920005604 random copolymer Polymers 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 150000003667 tyrosine derivatives Chemical class 0.000 description 1
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17413399P | 1999-12-31 | 1999-12-31 | |
| US60/174,133 | 1999-12-31 | ||
| PCT/US2001/000045 WO2001049311A1 (en) | 1999-12-31 | 2001-01-02 | Pharmaceutical formulation composed of a polymer blend and an active compound for time-controlled release |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011227233A Division JP2012025772A (ja) | 1999-12-31 | 2011-10-14 | ポリマー混合物および活性化合物からなる徐放用医薬製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003519194A JP2003519194A (ja) | 2003-06-17 |
| JP2003519194A5 true JP2003519194A5 (https=) | 2011-06-30 |
| JP4917726B2 JP4917726B2 (ja) | 2012-04-18 |
Family
ID=22634967
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001549678A Expired - Lifetime JP4917726B2 (ja) | 1999-12-31 | 2001-01-02 | ポリマー混合物および活性化合物からなる徐放用医薬製剤 |
| JP2011227233A Pending JP2012025772A (ja) | 1999-12-31 | 2011-10-14 | ポリマー混合物および活性化合物からなる徐放用医薬製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011227233A Pending JP2012025772A (ja) | 1999-12-31 | 2011-10-14 | ポリマー混合物および活性化合物からなる徐放用医薬製剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7326425B2 (https=) |
| EP (1) | EP1251864A4 (https=) |
| JP (2) | JP4917726B2 (https=) |
| AU (1) | AU775905B2 (https=) |
| CA (1) | CA2395892C (https=) |
| WO (1) | WO2001049311A1 (https=) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7326425B2 (en) * | 1999-12-31 | 2008-02-05 | Rutgers, The State University | Pharmaceutical formulation composed of a polymer blend and an active compound for time-controlled release |
| AUPR839001A0 (en) * | 2001-10-19 | 2001-11-15 | Eli Lilly And Company | Dosage form, device and methods of treatment |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| AU2004287875B2 (en) | 2003-11-05 | 2011-06-02 | Bausch + Lomb Ireland Limited | Modulators of cellular adhesion |
| EP1555278A1 (en) * | 2004-01-15 | 2005-07-20 | Innocore Technologies B.V. | Biodegradable multi-block co-polymers |
| US8980300B2 (en) | 2004-08-05 | 2015-03-17 | Advanced Cardiovascular Systems, Inc. | Plasticizers for coating compositions |
| US7858077B2 (en) * | 2005-01-28 | 2010-12-28 | Bezwada Biomedical Llc | Functionalized phenolic esters and amides and polymers therefrom |
| US7691364B2 (en) * | 2005-01-28 | 2010-04-06 | Bezwada Biomedical, Llc | Functionalized drugs and polymers derived therefrom |
| DK2444079T3 (en) | 2005-05-17 | 2017-01-30 | Sarcode Bioscience Inc | Compositions and Methods for the Treatment of Eye Diseases |
| EP1951260A4 (en) | 2005-10-21 | 2009-11-11 | Bezwada Biomedical Llc | FUNCTIONALIZED PHENOLIC COMPOUNDS AND POURABLE ARTICLES THEREOF |
| US8007526B2 (en) | 2005-12-01 | 2011-08-30 | Bezwada Biomedical, Llc | Difunctionalized aromatic compounds and polymers therefrom |
| US7935843B2 (en) | 2005-12-09 | 2011-05-03 | Bezwada Biomedical, Llc | Functionalized diphenolics and absorbable polymers therefrom |
| EP2114298B1 (en) | 2006-02-08 | 2022-10-19 | Medtronic, Inc. | Temporarily stiffened mesh prostheses |
| US8591531B2 (en) | 2006-02-08 | 2013-11-26 | Tyrx, Inc. | Mesh pouches for implantable medical devices |
| US8315700B2 (en) | 2006-02-08 | 2012-11-20 | Tyrx, Inc. | Preventing biofilm formation on implantable medical devices |
| US9028859B2 (en) * | 2006-07-07 | 2015-05-12 | Advanced Cardiovascular Systems, Inc. | Phase-separated block copolymer coatings for implantable medical devices |
| US20100166854A1 (en) * | 2006-10-30 | 2010-07-01 | Rutgers, The State University Of New Jersey | Electrospun matrices for delivery of hydrophilic and lipophilic compounds |
| MX2009004821A (es) | 2006-11-06 | 2009-11-23 | Tyrx Pharma Inc | Bolsas de malla para dispositivos medicos implantables. |
| US9023114B2 (en) | 2006-11-06 | 2015-05-05 | Tyrx, Inc. | Resorbable pouches for implantable medical devices |
| AU2008232682B2 (en) | 2007-03-29 | 2013-03-21 | Medtronic, Inc. | Biodegradable, polymer coverings for breast implants |
| MX2009011785A (es) * | 2007-05-02 | 2010-03-04 | Tyrx Pharma Inc | Polimeros de dihidroxibenzoato y usos de los mismos. |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| EP2527360B1 (en) | 2007-06-04 | 2015-10-28 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US20090004243A1 (en) | 2007-06-29 | 2009-01-01 | Pacetti Stephen D | Biodegradable triblock copolymers for implantable devices |
| US8217134B2 (en) | 2007-08-30 | 2012-07-10 | Bezwada Biomedical, Llc | Controlled release of biologically active compounds |
| US8026285B2 (en) * | 2007-09-04 | 2011-09-27 | Bezwada Biomedical, Llc | Control release of biologically active compounds from multi-armed oligomers |
| US8048980B2 (en) * | 2007-09-17 | 2011-11-01 | Bezwada Biomedical, Llc | Hydrolysable linkers and cross-linkers for absorbable polymers |
| ES2630406T3 (es) | 2007-10-19 | 2017-08-21 | Sarcode Bioscience Inc. | Composición y procedimientos para el tratamiento de la retinopatía diabética |
| EP2276508A4 (en) * | 2008-04-15 | 2011-12-28 | Sarcode Bioscience Inc | ADMINISTRATION OF LFA-1 ANTAGONISTS TO THE GASTROINTESTINAL SYSTEM |
| US8080562B2 (en) | 2008-04-15 | 2011-12-20 | Sarcode Bioscience Inc. | Crystalline pharmaceutical and methods of preparation and use thereof |
| EP2810951B1 (en) | 2008-06-04 | 2017-03-15 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US8652525B2 (en) * | 2008-07-10 | 2014-02-18 | Tyrx, Inc. | NSAID delivery from polyarylates |
| EP3241839B1 (en) | 2008-07-16 | 2019-09-04 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| EP2946770A1 (en) | 2008-08-29 | 2015-11-25 | Genzyme Corporation | Controlled-released peptide formulations |
| CA2737769C (en) | 2008-09-22 | 2014-02-04 | Medtronic, Inc. | Linear polyesteramides from aminophenolic esters |
| EP2349981A4 (en) * | 2008-10-11 | 2016-11-30 | Univ Rutgers | BIOKOMPATIBLE POLYMERS FOR MEDICAL DEVICES |
| US9839628B2 (en) | 2009-06-01 | 2017-12-12 | Tyrx, Inc. | Compositions and methods for preventing sternal wound infections |
| US8409279B2 (en) | 2009-10-01 | 2013-04-02 | Lipose Corporation | Breast implant implantation method and apparatus |
| US8378105B2 (en) * | 2009-10-21 | 2013-02-19 | Sarcode Bioscience Inc. | Crystalline pharmaceutical and methods of preparation and use thereof |
| JP6031033B2 (ja) | 2010-08-25 | 2016-11-24 | タイレックス・インコーポレイテッドＴｙｒｘ Ｉｎｃ． | 医療デバイスの新規なコーティング |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| AU2011326417A1 (en) | 2010-11-12 | 2013-05-09 | Tyrx, Inc. | Anchorage devices comprising an active pharmaceutical ingredient |
| JP2012131714A (ja) * | 2010-12-20 | 2012-07-12 | Kureha Corp | 遅放性バリア材、その製造方法、およびそれを用いた包装容器 |
| AU2012283875B2 (en) | 2011-07-20 | 2016-05-12 | Medtronic, Inc. | Drug eluting mesh to prevent infection of indwelling transdermal devices |
| CA2879982C (en) | 2012-07-25 | 2020-09-01 | Sarcode Bioscience Inc. | Lfa-1 inhibitor and polymorph thereof |
| US9545446B2 (en) | 2013-02-25 | 2017-01-17 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
| WO2014137454A1 (en) | 2013-03-07 | 2014-09-12 | Tyrx, Inc. | Methods and compositions to inhibit the assemblage of microbial cells irreversibly associated with surfaces of medical devices |
| CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| CA2905438A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| CN106061494A (zh) | 2013-10-10 | 2016-10-26 | 辛纳吉制药公司 | 可用于治疗阿片样物质诱导的功能障碍的鸟苷酸环化酶的激动剂 |
| WO2015069305A1 (en) | 2013-11-08 | 2015-05-14 | Tyrx, Inc. | Antimicrobial compositions and methods for preventing infection in surgical incision sites |
| WO2017123634A1 (en) | 2016-01-11 | 2017-07-20 | Synergy Pharmaceuticals, Inc. | Formulations and methods for treating ulcerative colitis |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5198507A (en) * | 1990-06-12 | 1993-03-30 | Rutgers, The State University Of New Jersey | Synthesis of amino acid-derived bioerodible polymers |
| US5587507A (en) * | 1995-03-31 | 1996-12-24 | Rutgers, The State University | Synthesis of tyrosine derived diphenol monomers |
| US5877224A (en) * | 1995-07-28 | 1999-03-02 | Rutgers, The State University Of New Jersey | Polymeric drug formulations |
| US5658995A (en) * | 1995-11-27 | 1997-08-19 | Rutgers, The State University | Copolymers of tyrosine-based polycarbonate and poly(alkylene oxide) |
| US6120491A (en) * | 1997-11-07 | 2000-09-19 | The State University Rutgers | Biodegradable, anionic polymers derived from the amino acid L-tyrosine |
| MXPA99007662A (es) * | 1997-02-18 | 2002-07-22 | Univ Rutgers | Monomeros derivados de hidroxiacidos, y polimeros preparados a partir de los mismos. |
| US5912225A (en) * | 1997-04-14 | 1999-06-15 | Johns Hopkins Univ. School Of Medicine | Biodegradable poly (phosphoester-co-desaminotyrosyl L-tyrosine ester) compounds, compositions, articles and methods for making and using the same |
| EP1073688B1 (en) | 1998-04-13 | 2015-03-04 | Rutgers, The State University | The construction of copolymer libraries |
| EP1263453A4 (en) * | 1999-12-31 | 2008-02-20 | Univ Rutgers | PHARMACEUTICAL FORMULATION CONSISTING OF A POLYMERMATRIX, FOR REGULATING THE TIME-CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE SUBSTANCES |
| US7326425B2 (en) * | 1999-12-31 | 2008-02-05 | Rutgers, The State University | Pharmaceutical formulation composed of a polymer blend and an active compound for time-controlled release |
-
2001
- 2001-01-02 US US10/169,350 patent/US7326425B2/en not_active Expired - Lifetime
- 2001-01-02 WO PCT/US2001/000045 patent/WO2001049311A1/en not_active Ceased
- 2001-01-02 CA CA2395892A patent/CA2395892C/en not_active Expired - Lifetime
- 2001-01-02 JP JP2001549678A patent/JP4917726B2/ja not_active Expired - Lifetime
- 2001-01-02 EP EP01900819A patent/EP1251864A4/en not_active Ceased
- 2001-01-02 AU AU26237/01A patent/AU775905B2/en not_active Expired
-
2008
- 2008-01-07 US US11/970,028 patent/US8653030B2/en not_active Expired - Fee Related
-
2011
- 2011-10-14 JP JP2011227233A patent/JP2012025772A/ja active Pending
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