JP2004502720A5 - - Google Patents
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- Publication number
- JP2004502720A5 JP2004502720A5 JP2002508415A JP2002508415A JP2004502720A5 JP 2004502720 A5 JP2004502720 A5 JP 2004502720A5 JP 2002508415 A JP2002508415 A JP 2002508415A JP 2002508415 A JP2002508415 A JP 2002508415A JP 2004502720 A5 JP2004502720 A5 JP 2004502720A5
- Authority
- JP
- Japan
- Prior art keywords
- particulate carrier
- carrier according
- polymer
- poly
- particulate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920002988 biodegradable polymer Polymers 0.000 description 4
- 239000004621 biodegradable polymer Substances 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 229960002897 heparin Drugs 0.000 description 3
- 229920000669 heparin Polymers 0.000 description 3
- 239000011859 microparticle Substances 0.000 description 3
- 239000002105 nanoparticle Substances 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 229920001610 polycaprolactone Polymers 0.000 description 3
- 229920002851 polycationic polymer Polymers 0.000 description 3
- 229920000728 polyester Polymers 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 239000003055 low molecular weight heparin Substances 0.000 description 2
- 229940127215 low-molecular weight heparin Drugs 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 125000005395 methacrylic acid group Chemical group 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- USFMMZYROHDWPJ-UHFFFAOYSA-N trimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azanium Chemical compound CC(=C)C(=O)OCC[N+](C)(C)C USFMMZYROHDWPJ-UHFFFAOYSA-N 0.000 description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 229920003151 Eudragit® RL polymer Polymers 0.000 description 1
- 229920003152 Eudragit® RS polymer Polymers 0.000 description 1
- 229920003134 Eudragit® polymer Polymers 0.000 description 1
- 229920002732 Polyanhydride Polymers 0.000 description 1
- 108010039918 Polylysine Proteins 0.000 description 1
- 229920001710 Polyorthoester Polymers 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 1
- 150000001241 acetals Chemical class 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 125000005397 methacrylic acid ester group Chemical group 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000002745 poly(ortho ester) Substances 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000656 polylysine Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0008902A FR2811227A1 (fr) | 2000-07-07 | 2000-07-07 | Vecteurs particulaires destines a ameliorer l'absorption orale de principes actifs |
| FR00/08902 | 2000-07-07 | ||
| PCT/FR2001/002159 WO2002003960A1 (fr) | 2000-07-07 | 2001-07-05 | Vecteurs particulaires destines a ameliorer l'absorption orale de principes actifs |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004502720A JP2004502720A (ja) | 2004-01-29 |
| JP2004502720A5 true JP2004502720A5 (https=) | 2008-01-24 |
| JP5175017B2 JP5175017B2 (ja) | 2013-04-03 |
Family
ID=8852251
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002508415A Expired - Fee Related JP5175017B2 (ja) | 2000-07-07 | 2001-07-05 | 有効成分の経口吸収を改善するための粒子状担体 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8052998B2 (https=) |
| EP (1) | EP1313453B1 (https=) |
| JP (1) | JP5175017B2 (https=) |
| KR (1) | KR20030038655A (https=) |
| CN (1) | CN1440277A (https=) |
| AT (1) | ATE395906T1 (https=) |
| AU (1) | AU2002218745A1 (https=) |
| BR (1) | BRPI0112080B1 (https=) |
| CA (1) | CA2415414C (https=) |
| DE (1) | DE60134147D1 (https=) |
| DK (1) | DK1313453T3 (https=) |
| ES (1) | ES2305121T3 (https=) |
| FR (1) | FR2811227A1 (https=) |
| MX (1) | MXPA03000193A (https=) |
| PT (1) | PT1313453E (https=) |
| RU (1) | RU2003103596A (https=) |
| WO (1) | WO2002003960A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8652504B2 (en) | 2005-09-22 | 2014-02-18 | Medivas, Llc | Solid polymer delivery compositions and methods for use thereof |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8257744B2 (en) * | 2000-07-07 | 2012-09-04 | Laboratorios Farmacéuticos Rovi, S.A. | Pharmaceutical forms for the release of active compounds |
| EP2060253A1 (en) * | 2007-11-14 | 2009-05-20 | Laboratorios Farmaceuticos Rovi, S.A. | Pharmaceutical forms for the release of active compounds |
| BE1015608A6 (fr) * | 2003-07-15 | 2005-06-07 | Messadek Jallal | Traitement des arterites. |
| ES2278314T3 (es) * | 2003-04-17 | 2007-08-01 | Jallal Messadek | Formulaciones orales para la liberacion controlada de la betaina. |
| US20060128657A1 (en) * | 2003-08-04 | 2006-06-15 | Jallal Messadek | Selected betaines and their uses |
| WO2006088647A1 (en) * | 2005-02-17 | 2006-08-24 | Medivas, Llc | Polymer particle delivery compositions and methods of use |
| EP1730516A1 (en) * | 2004-03-30 | 2006-12-13 | Pfizer Products Incorporated | Method and device for evaluation of pharmaceutical compositions |
| BE1016128A6 (fr) * | 2004-07-22 | 2006-03-07 | Messadek Jallal | Combinaisons therapeutiques |
| WO2006050581A2 (en) * | 2004-11-10 | 2006-05-18 | Jallal Messadek | Betaine as agent against arthropod - or mosquito -borne diseases |
| ATE540690T1 (de) * | 2005-04-27 | 2012-01-15 | Jallal Messadek | Insulinkombinationen |
| WO2008065502A1 (en) * | 2006-11-29 | 2008-06-05 | Pfizer Products Inc. | Pharmaceutical compositions based on a) nanoparticles comprising enteric polymers and b) casein |
| WO2008125940A2 (en) * | 2007-04-17 | 2008-10-23 | Pfizer Products Inc. | Nanoparticles comprising non-crystalline drug |
| US8703204B2 (en) * | 2007-05-03 | 2014-04-22 | Bend Research, Inc. | Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and anon-ionizable polymer |
| WO2008135852A2 (en) * | 2007-05-03 | 2008-11-13 | Pfizer Products Inc. | Pharmaceutical compositions comprising nanoparticles and casein |
| US8309129B2 (en) * | 2007-05-03 | 2012-11-13 | Bend Research, Inc. | Nanoparticles comprising a drug, ethylcellulose, and a bile salt |
| WO2008149230A2 (en) | 2007-06-04 | 2008-12-11 | Pfizer Products Inc. | Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glycol succinate |
| EP2162120B1 (en) * | 2007-06-04 | 2016-05-04 | Bend Research, Inc | Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer |
| US20100215747A1 (en) * | 2007-07-13 | 2010-08-26 | Corey Jay Bloom | Nanoparticles comprising ionizable, poorly water soluble cellulosic polymers |
| US8802156B2 (en) | 2007-11-14 | 2014-08-12 | Laboratorios Farmacéuticos Rovi, S.A. | Pharmaceutical forms for the release of active compounds |
| EP2213282A1 (en) * | 2009-01-30 | 2010-08-04 | Laboratorios Farmaceuticos Rovi, S.A. | Pharmaceutical forms for the release of active compounds |
| WO2009065193A1 (en) * | 2007-11-21 | 2009-05-28 | Jallal Messadek | Treatment of aspirin resistance with betaine and/or betaine enriched molasses |
| WO2009073216A1 (en) * | 2007-12-06 | 2009-06-11 | Bend Research, Inc. | Nanoparticles comprising a non-ionizable polymer and an amine-functionalized methacrylate copolymer |
| EP2231169B1 (en) * | 2007-12-06 | 2016-05-04 | Bend Research, Inc. | Pharmaceutical compositions comprising nanoparticles and a resuspending material |
| US9101547B2 (en) * | 2011-08-04 | 2015-08-11 | Nano And Advanced Materials Institute Limited | Enteric-coated capsule containing cationic nanoparticles for oral insulin delivery |
| DE102012019029A1 (de) | 2012-09-27 | 2014-03-27 | Alf Lamprecht | Arzneiformulierungen zur oralen Gabe von therapeutischen Substanzen und Verfahren zur Herstellung |
| CA3015172A1 (en) | 2016-02-18 | 2017-08-24 | Privo Technologies, Inc. | Two-stage microparticle-based therapeutic delivery system and method |
| WO2018151849A1 (en) | 2017-02-17 | 2018-08-23 | Privo Technologies, Inc. | Particle-based multi-layer therapeutic delivery device and method |
| US10478403B1 (en) | 2017-05-03 | 2019-11-19 | Privo Technologies, Inc. | Intraoperative topically-applied non-implantable rapid release patch |
| KR20240041285A (ko) * | 2021-06-01 | 2024-03-29 | 프리보 테크놀로지스, 인코포레이티드 | 향상된 2단계 미세입자 기반 국소 치료제 전달 시스템 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT397345B (de) * | 1990-04-04 | 1994-03-25 | Chemiefaser Lenzing Ag | Pharmazeutisches präparat mit verzögerter wirkstofffreisetzung auf basis von hemicellulosen |
| AU653771B2 (en) * | 1991-01-03 | 1994-10-13 | Alkermes Controlled Therapeutics, Inc. | Stabilization of proteins by cationic biopolymers |
| EP0535937B2 (en) * | 1991-10-01 | 2008-05-21 | Takeda Chemical Industries, Ltd. | Prolonged release microparticle preparation and production of the same |
| GB9202464D0 (en) * | 1992-02-05 | 1992-03-18 | Danbiosyst Uk | Composition for nasal administration |
| DE4220782A1 (de) * | 1992-06-25 | 1994-01-05 | Basf Ag | Verfahren zur Herstellung von festen pharmazeutischen Retardformen |
| US5401516A (en) * | 1992-12-21 | 1995-03-28 | Emisphere Technologies, Inc. | Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof |
| GB9412273D0 (en) * | 1994-06-18 | 1994-08-10 | Univ Nottingham | Administration means |
| CA2214889C (en) * | 1995-03-10 | 2005-05-24 | Hans Koll | Polypeptide-containing pharmaceutical forms of administration in the form of microparticles and a process for the production thereof |
| US5686113A (en) * | 1995-03-21 | 1997-11-11 | Temple University Of The Commonwealth System Of Higher Education | Microcapsules of predetermined peptide(s) specificity (ies), their preparation and uses |
| FR2769853B1 (fr) * | 1997-10-21 | 2000-01-28 | Prographarm Lab | Nouveau procede d'obtention de microspheres et les produits ainsi realises |
| CZ20011629A3 (cs) * | 1998-11-12 | 2001-12-12 | Smithkline Beecham Plc | Farmaceutický prostředek pro upravené uvolňování senzitizéru inzulínu a jiných antidiabetických přípravků |
| WO2000043044A1 (en) * | 1999-01-19 | 2000-07-27 | The Children's Hospital Of Philadelphia | Compositions and methods for controlled delivery of virus vectors |
-
2000
- 2000-07-07 FR FR0008902A patent/FR2811227A1/fr active Pending
-
2001
- 2001-07-05 AT AT01984141T patent/ATE395906T1/de active
- 2001-07-05 CA CA2415414A patent/CA2415414C/fr not_active Expired - Lifetime
- 2001-07-05 DE DE60134147T patent/DE60134147D1/de not_active Expired - Lifetime
- 2001-07-05 WO PCT/FR2001/002159 patent/WO2002003960A1/fr not_active Ceased
- 2001-07-05 AU AU2002218745A patent/AU2002218745A1/en not_active Abandoned
- 2001-07-05 ES ES01984141T patent/ES2305121T3/es not_active Expired - Lifetime
- 2001-07-05 KR KR10-2003-7000198A patent/KR20030038655A/ko not_active Withdrawn
- 2001-07-05 MX MXPA03000193A patent/MXPA03000193A/es active IP Right Grant
- 2001-07-05 EP EP01984141A patent/EP1313453B1/fr not_active Expired - Lifetime
- 2001-07-05 JP JP2002508415A patent/JP5175017B2/ja not_active Expired - Fee Related
- 2001-07-05 DK DK01984141T patent/DK1313453T3/da active
- 2001-07-05 PT PT01984141T patent/PT1313453E/pt unknown
- 2001-07-05 RU RU2003103596/15A patent/RU2003103596A/ru not_active Application Discontinuation
- 2001-07-05 CN CN01812448A patent/CN1440277A/zh active Pending
- 2001-07-05 BR BRPI0112080A patent/BRPI0112080B1/pt not_active IP Right Cessation
- 2001-07-05 US US10/332,351 patent/US8052998B2/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8652504B2 (en) | 2005-09-22 | 2014-02-18 | Medivas, Llc | Solid polymer delivery compositions and methods for use thereof |
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