JP2003519164A5 - - Google Patents
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- Publication number
- JP2003519164A5 JP2003519164A5 JP2001549618A JP2001549618A JP2003519164A5 JP 2003519164 A5 JP2003519164 A5 JP 2003519164A5 JP 2001549618 A JP2001549618 A JP 2001549618A JP 2001549618 A JP2001549618 A JP 2001549618A JP 2003519164 A5 JP2003519164 A5 JP 2003519164A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- release
- polymer
- formulation
- dth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 description 13
- 229920000642 polymer Polymers 0.000 description 11
- 150000001875 compounds Chemical class 0.000 description 9
- 230000000975 bioactive effect Effects 0.000 description 6
- 238000009472 formulation Methods 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 229920001230 polyarylate Polymers 0.000 description 6
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 5
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 5
- XKZQKPRCPNGNFR-UHFFFAOYSA-N 2-(3-hydroxyphenyl)phenol Chemical compound OC1=CC=CC(C=2C(=CC=CC=2)O)=C1 XKZQKPRCPNGNFR-UHFFFAOYSA-N 0.000 description 4
- WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 description 4
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 4
- 230000009477 glass transition Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000000178 monomer Substances 0.000 description 4
- 230000003111 delayed effect Effects 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- 235000011037 adipic acid Nutrition 0.000 description 2
- 239000001361 adipic acid Substances 0.000 description 2
- 125000003262 carboxylic acid ester group Chemical group [H]C([H])([*:2])OC(=O)C([H])([H])[*:1] 0.000 description 2
- 125000002843 carboxylic acid group Chemical group 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000003053 immunization Effects 0.000 description 2
- 238000002649 immunization Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- RZICEOJUAFHYFO-UHFFFAOYSA-N 1-hydroperoxyhexane Chemical compound CCCCCCOO RZICEOJUAFHYFO-UHFFFAOYSA-N 0.000 description 1
- 229940124718 AIDS vaccine Drugs 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 239000002254 cytotoxic agent Substances 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 229960000814 tetanus toxoid Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17413799P | 1999-12-31 | 1999-12-31 | |
| US60/174,137 | 1999-12-31 | ||
| PCT/US2001/000030 WO2001049249A2 (en) | 1999-12-31 | 2001-01-02 | Pharmaceutical formulation for regulating the timed release of biologically active compounds based on a polymer matrix |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003519164A JP2003519164A (ja) | 2003-06-17 |
| JP2003519164A5 true JP2003519164A5 (https=) | 2011-04-28 |
Family
ID=22634986
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001549618A Pending JP2003519164A (ja) | 1999-12-31 | 2001-01-02 | ポリマーマトリクスに基づく生理活性化合物徐放調節用医薬製剤 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1263453A4 (https=) |
| JP (1) | JP2003519164A (https=) |
| AU (1) | AU784226B2 (https=) |
| CA (1) | CA2396037A1 (https=) |
| WO (1) | WO2001049249A2 (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7326425B2 (en) | 1999-12-31 | 2008-02-05 | Rutgers, The State University | Pharmaceutical formulation composed of a polymer blend and an active compound for time-controlled release |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| AU2004287875B2 (en) | 2003-11-05 | 2011-06-02 | Bausch + Lomb Ireland Limited | Modulators of cellular adhesion |
| DK2444079T3 (en) | 2005-05-17 | 2017-01-30 | Sarcode Bioscience Inc | Compositions and Methods for the Treatment of Eye Diseases |
| US8315700B2 (en) | 2006-02-08 | 2012-11-20 | Tyrx, Inc. | Preventing biofilm formation on implantable medical devices |
| EP2114298B1 (en) | 2006-02-08 | 2022-10-19 | Medtronic, Inc. | Temporarily stiffened mesh prostheses |
| US9265865B2 (en) | 2006-06-30 | 2016-02-23 | Boston Scientific Scimed, Inc. | Stent having time-release indicator |
| US9023114B2 (en) | 2006-11-06 | 2015-05-05 | Tyrx, Inc. | Resorbable pouches for implantable medical devices |
| MX2009004821A (es) | 2006-11-06 | 2009-11-23 | Tyrx Pharma Inc | Bolsas de malla para dispositivos medicos implantables. |
| AU2008232682B2 (en) | 2007-03-29 | 2013-03-21 | Medtronic, Inc. | Biodegradable, polymer coverings for breast implants |
| MX2009011785A (es) | 2007-05-02 | 2010-03-04 | Tyrx Pharma Inc | Polimeros de dihidroxibenzoato y usos de los mismos. |
| EP2527360B1 (en) | 2007-06-04 | 2015-10-28 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| ES2630406T3 (es) | 2007-10-19 | 2017-08-21 | Sarcode Bioscience Inc. | Composición y procedimientos para el tratamiento de la retinopatía diabética |
| US8080562B2 (en) | 2008-04-15 | 2011-12-20 | Sarcode Bioscience Inc. | Crystalline pharmaceutical and methods of preparation and use thereof |
| EP2810951B1 (en) | 2008-06-04 | 2017-03-15 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US8652525B2 (en) | 2008-07-10 | 2014-02-18 | Tyrx, Inc. | NSAID delivery from polyarylates |
| EP3241839B1 (en) | 2008-07-16 | 2019-09-04 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| CA2737769C (en) | 2008-09-22 | 2014-02-04 | Medtronic, Inc. | Linear polyesteramides from aminophenolic esters |
| EP2437724B1 (en) * | 2009-06-01 | 2015-09-30 | Tyrx, Inc. | Compositions and methods for preventing sternal wound infections |
| US9839628B2 (en) | 2009-06-01 | 2017-12-12 | Tyrx, Inc. | Compositions and methods for preventing sternal wound infections |
| WO2011014859A1 (en) * | 2009-07-31 | 2011-02-03 | Rutgers, The State University Of New Jersey | Biocompatible polymers for medical devices |
| US8409279B2 (en) | 2009-10-01 | 2013-04-02 | Lipose Corporation | Breast implant implantation method and apparatus |
| US8378105B2 (en) | 2009-10-21 | 2013-02-19 | Sarcode Bioscience Inc. | Crystalline pharmaceutical and methods of preparation and use thereof |
| JP6031033B2 (ja) | 2010-08-25 | 2016-11-24 | タイレックス・インコーポレイテッドＴｙｒｘ Ｉｎｃ． | 医療デバイスの新規なコーティング |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| AU2011326417A1 (en) | 2010-11-12 | 2013-05-09 | Tyrx, Inc. | Anchorage devices comprising an active pharmaceutical ingredient |
| AU2012283875B2 (en) | 2011-07-20 | 2016-05-12 | Medtronic, Inc. | Drug eluting mesh to prevent infection of indwelling transdermal devices |
| CA2879982C (en) | 2012-07-25 | 2020-09-01 | Sarcode Bioscience Inc. | Lfa-1 inhibitor and polymorph thereof |
| US9545446B2 (en) | 2013-02-25 | 2017-01-17 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
| WO2014137454A1 (en) | 2013-03-07 | 2014-09-12 | Tyrx, Inc. | Methods and compositions to inhibit the assemblage of microbial cells irreversibly associated with surfaces of medical devices |
| CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| CA2905438A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| CN106061494A (zh) | 2013-10-10 | 2016-10-26 | 辛纳吉制药公司 | 可用于治疗阿片样物质诱导的功能障碍的鸟苷酸环化酶的激动剂 |
| WO2015069305A1 (en) | 2013-11-08 | 2015-05-14 | Tyrx, Inc. | Antimicrobial compositions and methods for preventing infection in surgical incision sites |
| EP3177319A1 (en) * | 2014-08-04 | 2017-06-14 | Janssen Sciences Ireland UC | Compacted solid dosage form |
| WO2017123634A1 (en) | 2016-01-11 | 2017-07-20 | Synergy Pharmaceuticals, Inc. | Formulations and methods for treating ulcerative colitis |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5587507A (en) * | 1995-03-31 | 1996-12-24 | Rutgers, The State University | Synthesis of tyrosine derived diphenol monomers |
| US5658995A (en) * | 1995-11-27 | 1997-08-19 | Rutgers, The State University | Copolymers of tyrosine-based polycarbonate and poly(alkylene oxide) |
| US6120491A (en) * | 1997-11-07 | 2000-09-19 | The State University Rutgers | Biodegradable, anionic polymers derived from the amino acid L-tyrosine |
| MXPA99007662A (es) * | 1997-02-18 | 2002-07-22 | Univ Rutgers | Monomeros derivados de hidroxiacidos, y polimeros preparados a partir de los mismos. |
| DE19719817A1 (de) * | 1997-05-13 | 1998-11-19 | Hoechst Ag | Substituierte 6- und 7-Aminotetrahydroisochinolincarbonsäuren |
| ZA9811377B (en) * | 1997-12-12 | 1999-08-27 | Expression Genetics Inc | Positively charged poly[alpha-(omega-aminoalkyl) glycolic acid[ for the delivery of a bioactive agent via tissue and cellular uptake. |
| EP1073688B1 (en) * | 1998-04-13 | 2015-03-04 | Rutgers, The State University | The construction of copolymer libraries |
| JP2002536695A (ja) * | 1999-02-05 | 2002-10-29 | エイリアン・テクノロジイ・コーポレーション | アセンブリを形成するための装置および方法 |
-
2001
- 2001-01-02 EP EP01939971A patent/EP1263453A4/en not_active Ceased
- 2001-01-02 JP JP2001549618A patent/JP2003519164A/ja active Pending
- 2001-01-02 CA CA002396037A patent/CA2396037A1/en not_active Abandoned
- 2001-01-02 WO PCT/US2001/000030 patent/WO2001049249A2/en not_active Ceased
- 2001-01-02 AU AU29255/01A patent/AU784226B2/en not_active Expired
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