JP2003516940A5 - - Google Patents
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- Publication number
- JP2003516940A5 JP2003516940A5 JP2001537971A JP2001537971A JP2003516940A5 JP 2003516940 A5 JP2003516940 A5 JP 2003516940A5 JP 2001537971 A JP2001537971 A JP 2001537971A JP 2001537971 A JP2001537971 A JP 2001537971A JP 2003516940 A5 JP2003516940 A5 JP 2003516940A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- igm
- lymphocyte
- producing
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000000781 anti-lymphocytic effect Effects 0.000 description 11
- 210000000628 antibody-producing cell Anatomy 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 8
- 108020003175 receptors Proteins 0.000 description 8
- 102000005962 receptors Human genes 0.000 description 8
- 210000004698 lymphocyte Anatomy 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 241000700605 Viruses Species 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 102000009410 Chemokine receptor Human genes 0.000 description 3
- 108050000299 Chemokine receptor Proteins 0.000 description 3
- 239000000427 antigen Substances 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 230000001404 mediated effect Effects 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 102000019034 Chemokines Human genes 0.000 description 1
- 108010012236 Chemokines Proteins 0.000 description 1
- 206010018364 Glomerulonephritis Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 241000713772 Human immunodeficiency virus 1 Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 206010047115 Vasculitis Diseases 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000000923 atherogenic effect Effects 0.000 description 1
- 238000012832 cell culture technique Methods 0.000 description 1
- 210000004408 hybridoma Anatomy 0.000 description 1
- 230000016784 immunoglobulin production Effects 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000007972 injectable composition Substances 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 239000003226 mitogen Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 201000000306 sarcoidosis Diseases 0.000 description 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43969099A | 1999-11-15 | 1999-11-15 | |
| US09/439,690 | 1999-11-15 | ||
| US09/684,813 | 2000-10-10 | ||
| US09/684,813 US6610834B1 (en) | 1998-11-18 | 2000-10-10 | Human IgM antibodies to chemokine receptors |
| PCT/US2000/031051 WO2001035980A1 (en) | 1999-11-14 | 2000-11-14 | HUMAN IgM ANTIBODIES TO CHEMOKINE RECEPTORS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003516940A JP2003516940A (ja) | 2003-05-20 |
| JP2003516940A5 true JP2003516940A5 (https=) | 2007-12-06 |
Family
ID=27032133
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001537971A Pending JP2003516940A (ja) | 1999-11-15 | 2000-11-14 | ケモカイン受容体に対するヒトＩｇＭ抗体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6610834B1 (https=) |
| EP (1) | EP1231930B1 (https=) |
| JP (1) | JP2003516940A (https=) |
| AT (1) | ATE464909T1 (https=) |
| AU (1) | AU1599601A (https=) |
| CA (1) | CA2389851A1 (https=) |
| DE (1) | DE60044259D1 (https=) |
| WO (1) | WO2001035980A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080118522A1 (en) * | 1998-11-18 | 2008-05-22 | Lobo Peter I | Naturally occuring IgM antibodies that bind lymphocytes |
| US20030099645A1 (en) * | 2000-10-10 | 2003-05-29 | Lobo Peter Isaac | Naturally occuring IgM antibodies that bind to membrane receptors on lymphocytes |
| CN1997893A (zh) * | 2004-04-16 | 2007-07-11 | 健泰科生物技术公司 | 抗体测定法 |
| EP1817054A1 (en) * | 2004-12-01 | 2007-08-15 | Peter I. Lobo | Naturally occuring igm antibodies that bind lymphocytes |
| TW200720289A (en) | 2005-04-01 | 2007-06-01 | Hoffmann La Roche | Antibodies against CCR5 and uses thereof |
| JP2009531283A (ja) | 2006-02-02 | 2009-09-03 | アラーガン、インコーポレイテッド | 眼系疾患の処置のための組成物および方法 |
| TW200817438A (en) * | 2006-08-17 | 2008-04-16 | Hoffmann La Roche | A conjugate of an antibody against CCR5 and an antifusogenic peptide |
| EP2054086A1 (en) | 2006-08-17 | 2009-05-06 | F. Hoffmann-Roche AG | A conjugate of an antibody against ccr5 and an antifusogenic peptide |
| CN101516914A (zh) | 2006-09-29 | 2009-08-26 | 霍夫曼-拉罗奇有限公司 | 针对ccr5的抗体及其应用 |
| US20090143288A1 (en) * | 2007-03-13 | 2009-06-04 | Roche Palo Alto Llc | Peptide-complement conjugates |
| GB201002238D0 (en) | 2010-02-10 | 2010-03-31 | Affitech As | Antibodies |
| WO2013024022A1 (en) | 2011-08-12 | 2013-02-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treatment of pulmonary hypertension |
| WO2017140794A1 (en) * | 2016-02-16 | 2017-08-24 | Celltrend Gmbh | Anti-cxc chemokine receptor antibodies and c-x-c chemokines for the diagnosis of autoimmune disease and graft-versus-host disease |
| US11629196B2 (en) | 2020-04-27 | 2023-04-18 | Incelldx, Inc. | Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8605316D0 (en) * | 1986-03-04 | 1986-04-09 | Royal Free Hosp School Med | Immunosuppression |
| US5215913A (en) * | 1987-11-30 | 1993-06-01 | Roger Williams General Hospital | IgG-1 human monoclonal antibody reactive with an HIV-1 antigen and methods of use |
| US5606026A (en) * | 1988-03-25 | 1997-02-25 | The Institute For Human Genetics And Biochemistry | Natural human IgM antibodies immunoreactive with the Tat protein of HIV-1 |
| ES2156149T3 (es) * | 1992-12-04 | 2001-06-16 | Medical Res Council | Proteinas de union multivalente y multiespecificas, su fabricacion y su uso. |
| US5959085A (en) * | 1993-11-23 | 1999-09-28 | Schering Corporation | Human monoclonal antibodies against human cytokines and methods of making and using such antibodies |
| US5961976A (en) * | 1996-06-03 | 1999-10-05 | United Biomedical, Inc. | Antibodies against a host cell antigen complex for pre- and post-exposure protection from infection by HIV |
| US5994515A (en) * | 1996-06-25 | 1999-11-30 | Trustees Of The University Of Pennsylvania | Antibodies directed against cellular coreceptors for human immunodeficiency virus and methods of using the same |
| WO1997049424A1 (en) * | 1996-06-25 | 1997-12-31 | The Trustees Of The University Of Pennsylvania | Antibodies directed against cellular coreceptors for human immunodeficiency virus and methods of using the same |
| US6057102A (en) * | 1996-08-08 | 2000-05-02 | The Aaron Diamond Aids Research Center | HIV coreceptor mutants |
| US6100387A (en) | 1997-02-28 | 2000-08-08 | Genetics Institute, Inc. | Chimeric polypeptides containing chemokine domains |
| US6312689B1 (en) * | 1998-07-23 | 2001-11-06 | Millennium Pharmaceuticals, Inc. | Anti-CCR2 antibodies and methods of use therefor |
| JP2000229997A (ja) * | 1999-02-10 | 2000-08-22 | Nissui Pharm Co Ltd | 環状ペプチド及びエイズワクチン |
-
2000
- 2000-10-10 US US09/684,813 patent/US6610834B1/en not_active Expired - Fee Related
- 2000-11-14 AU AU15996/01A patent/AU1599601A/en not_active Abandoned
- 2000-11-14 JP JP2001537971A patent/JP2003516940A/ja active Pending
- 2000-11-14 EP EP00978542A patent/EP1231930B1/en not_active Expired - Lifetime
- 2000-11-14 WO PCT/US2000/031051 patent/WO2001035980A1/en not_active Ceased
- 2000-11-14 AT AT00978542T patent/ATE464909T1/de not_active IP Right Cessation
- 2000-11-14 CA CA002389851A patent/CA2389851A1/en not_active Abandoned
- 2000-11-14 DE DE60044259T patent/DE60044259D1/de not_active Expired - Lifetime
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