JP2003514766A - 活性剤としてルイス酸を用いるオリゴヌクレオチド合成 - Google Patents

活性剤としてルイス酸を用いるオリゴヌクレオチド合成

Info

Publication number
JP2003514766A
JP2003514766A JP2001502438A JP2001502438A JP2003514766A JP 2003514766 A JP2003514766 A JP 2003514766A JP 2001502438 A JP2001502438 A JP 2001502438A JP 2001502438 A JP2001502438 A JP 2001502438A JP 2003514766 A JP2003514766 A JP 2003514766A
Authority
JP
Japan
Prior art keywords
group
chloride
alkoxy
composition
magnesium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2001502438A
Other languages
English (en)
Japanese (ja)
Inventor
ワン，シウ・シー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of JP2003514766A publication Critical patent/JP2003514766A/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2001502438A 1999-06-03 2000-05-08 活性剤としてルイス酸を用いるオリゴヌクレオチド合成 Withdrawn JP2003514766A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32505599A 1999-06-03 1999-06-03
US09/325,055 1999-06-03
PCT/US2000/012530 WO2000075157A1 (fr) 1999-06-03 2000-05-08 Synthese d'oligonucleotides utilisant des acides de lewis comme activateurs

Publications (1)

Publication Number Publication Date
JP2003514766A true JP2003514766A (ja) 2003-04-22

Family

ID=23266253

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001502438A Withdrawn JP2003514766A (ja) 1999-06-03 2000-05-08 活性剤としてルイス酸を用いるオリゴヌクレオチド合成

Country Status (5)

Country Link
EP (1) EP1181301A1 (fr)
JP (1) JP2003514766A (fr)
CA (1) CA2376016A1 (fr)
MX (1) MXPA01012444A (fr)
WO (1) WO2000075157A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010204050A (ja) * 2009-03-05 2010-09-16 Shimadzu Corp マトリックス支援レーザ脱離イオン化質量分析用マトリックス

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2773773C (fr) 2009-09-21 2019-04-23 Gilead Sciences, Inc. Procedes et intermediaires pour preparer des analogues de carba-nucleoside 1'-substitues
SG186830A1 (en) 2010-07-22 2013-02-28 Gilead Sciences Inc Methods and compounds for treating paramyxoviridae virus infections
TWI687432B (zh) * 2014-10-29 2020-03-11 美商基利科學股份有限公司 絲狀病毒科病毒感染之治療
LT3785717T (lt) 2015-09-16 2022-04-11 Gilead Sciences, Inc. Coronaviridae infekcijų gydymo būdai
US10682368B2 (en) 2017-03-14 2020-06-16 Gilead Sciences, Inc. Methods of treating feline coronavirus infections
CN111093627B (zh) 2017-07-11 2024-03-08 吉利德科学公司 用于治疗病毒感染的包含rna聚合酶抑制剂和环糊精的组合物
TWI789695B (zh) 2020-01-27 2023-01-11 美商基利科學股份有限公司 治療sars cov-2感染之方法
AU2021234308C1 (en) 2020-03-12 2024-02-22 Gilead Sciences, Inc. Methods of preparing 1'-cyano nucleosides
WO2021207049A1 (fr) 2020-04-06 2021-10-14 Gilead Sciences, Inc. Formulations d'inhalation d'analogues de carbanucléosides à substitution 1'-cyano
TW202203941A (zh) 2020-05-29 2022-02-01 美商基利科學股份有限公司 瑞德西韋之治療方法
CN115996928A (zh) 2020-06-24 2023-04-21 吉利德科学公司 1’-氰基核苷类似物及其用途
TW202233204A (zh) 2020-08-27 2022-09-01 美商基利科學股份有限公司 用於治療病毒感染之化合物及方法
WO2023167944A1 (fr) 2022-03-02 2023-09-07 Gilead Sciences, Inc. Composés et méthodes pour traiter des infections virales

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08301878A (ja) * 1995-04-28 1996-11-19 Toagosei Co Ltd 三フッ化ホウ素配位化合物およびオリゴヌクレオチドの合成方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010204050A (ja) * 2009-03-05 2010-09-16 Shimadzu Corp マトリックス支援レーザ脱離イオン化質量分析用マトリックス

Also Published As

Publication number Publication date
EP1181301A1 (fr) 2002-02-27
MXPA01012444A (es) 2002-07-30
WO2000075157A1 (fr) 2000-12-14
CA2376016A1 (fr) 2000-12-14

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Effective date: 20070807