JP2003513901A5 - - Google Patents
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- Publication number
- JP2003513901A5 JP2003513901A5 JP2001536115A JP2001536115A JP2003513901A5 JP 2003513901 A5 JP2003513901 A5 JP 2003513901A5 JP 2001536115 A JP2001536115 A JP 2001536115A JP 2001536115 A JP2001536115 A JP 2001536115A JP 2003513901 A5 JP2003513901 A5 JP 2003513901A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- peptide
- substance
- forming
- membrane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 description 20
- 108090000623 proteins and genes Proteins 0.000 description 18
- 102000004169 proteins and genes Human genes 0.000 description 18
- 108090000765 processed proteins & peptides Proteins 0.000 description 17
- 239000000126 substance Substances 0.000 description 13
- 239000002502 liposome Substances 0.000 description 7
- 239000002609 medium Substances 0.000 description 6
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 description 5
- 150000008104 phosphatidylethanolamines Chemical class 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 4
- 239000013522 chelant Substances 0.000 description 3
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 description 2
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 2
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 description 2
- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 150000003973 alkyl amines Chemical class 0.000 description 2
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 description 2
- 239000012062 aqueous buffer Substances 0.000 description 2
- 239000012736 aqueous medium Substances 0.000 description 2
- 150000004697 chelate complex Chemical class 0.000 description 2
- 239000003638 chemical reducing agent Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- MGFYIUFZLHCRTH-UHFFFAOYSA-N nitrilotriacetic acid Chemical class OC(=O)CN(CC(O)=O)CC(O)=O MGFYIUFZLHCRTH-UHFFFAOYSA-N 0.000 description 2
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 2
- 150000003408 sphingolipids Chemical class 0.000 description 2
- 125000004149 thio group Chemical group *S* 0.000 description 2
- QGVQZRDQPDLHHV-DPAQBDIFSA-N (3s,8s,9s,10r,13r,14s,17r)-10,13-dimethyl-17-[(2r)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthrene-3-thiol Chemical compound C1C=C2C[C@@H](S)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 QGVQZRDQPDLHHV-DPAQBDIFSA-N 0.000 description 1
- PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 description 1
- 101000925662 Enterobacteria phage PRD1 Endolysin Proteins 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 125000005210 alkyl ammonium group Chemical group 0.000 description 1
- 150000001356 alkyl thiols Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 150000001841 cholesterols Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- ZGSPNIOCEDOHGS-UHFFFAOYSA-L disodium [3-[2,3-di(octadeca-9,12-dienoyloxy)propoxy-oxidophosphoryl]oxy-2-hydroxypropyl] 2,3-di(octadeca-9,12-dienoyloxy)propyl phosphate Chemical compound [Na+].[Na+].CCCCCC=CCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCC=CCCCCC)COP([O-])(=O)OCC(O)COP([O-])(=O)OCC(OC(=O)CCCCCCCC=CCC=CCCCCC)COC(=O)CCCCCCCC=CCC=CCCCCC ZGSPNIOCEDOHGS-UHFFFAOYSA-L 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 150000002466 imines Chemical class 0.000 description 1
- NBZBKCUXIYYUSX-UHFFFAOYSA-N iminodiacetic acid Chemical compound OC(=O)CNCC(O)=O NBZBKCUXIYYUSX-UHFFFAOYSA-N 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 150000003905 phosphatidylinositols Chemical class 0.000 description 1
- 150000003014 phosphoric acid esters Chemical class 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19954843A DE19954843C2 (de) | 1999-11-09 | 1999-11-09 | Verfahren zur Verkapselung von Proteinen oder Peptiden in Liposomen, mit dem Verfahren hergestellte Liposomen und deren Verwendung |
| DE19954843.9 | 1999-11-09 | ||
| PCT/EP2000/011079 WO2001034115A2 (de) | 1999-11-09 | 2000-11-09 | Verfahren zur verkapselung von proteinen oder peptiden in liposomen, mit dem verfahren hergestellte liposomen und deren verwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003513901A JP2003513901A (ja) | 2003-04-15 |
| JP2003513901A5 true JP2003513901A5 (https=) | 2007-12-20 |
Family
ID=7929069
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001536115A Pending JP2003513901A (ja) | 1999-11-09 | 2000-11-09 | タンパク質又はペプチドをリポソームに封入するための方法及びこの方法で調製されたリポソーム及びその使用 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1227794B1 (https=) |
| JP (1) | JP2003513901A (https=) |
| AT (1) | ATE311175T1 (https=) |
| AU (1) | AU1393301A (https=) |
| DE (2) | DE19954843C2 (https=) |
| DK (1) | DK1227794T3 (https=) |
| WO (1) | WO2001034115A2 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10152145A1 (de) * | 2001-10-19 | 2003-05-22 | Novosom Ag | Stabilisierung von Liposomen und Emulsionen |
| EP1585504A4 (en) * | 2002-11-06 | 2009-07-15 | Azaya Therapeutics Inc | Protein stabilized liposomal formulations of pharmaceutical active ingredients |
| WO2004100927A2 (de) * | 2003-05-12 | 2004-11-25 | Novosom Ag | Injizierbare depots aus liposomalen aggregaten zum wirkstoffdelivery |
| US20090297592A1 (en) * | 2005-05-11 | 2009-12-03 | Jcr Pharmaceuticals Co., Ltd. | Lipid Vesicle Composition |
| CN103071209A (zh) | 2005-11-17 | 2013-05-01 | 周吉尼克斯股份有限公司 | 用无针注射递送粘稠制剂 |
| US8268347B1 (en) | 2006-10-24 | 2012-09-18 | Aradigm Corporation | Dual action, inhaled formulations providing both an immediate and sustained release profile |
| ES2563061T3 (es) | 2008-04-28 | 2016-03-10 | Zogenix, Inc. | Nuevas formulaciones para el tratamiento de la migraña |
| PL2474306T3 (pl) | 2009-08-31 | 2017-06-30 | Nanocarrier Co., Ltd. | Kompozycja w postaci cząstek stałych i zawierająca ją kompozycja lecznicza |
| JP4653242B1 (ja) | 2010-02-12 | 2011-03-16 | ナノキャリア株式会社 | 粒子状医薬組成物 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235871A (en) * | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4342826A (en) * | 1980-02-04 | 1982-08-03 | Collaborative Research, Inc. | Immunoassay products and methods |
| JPS5782310A (en) * | 1980-11-11 | 1982-05-22 | Tanabe Seiyaku Co Ltd | Production of liposome preparation |
| US4933121A (en) * | 1986-12-10 | 1990-06-12 | Ciba Corning Diagnostics Corp. | Process for forming liposomes |
| JPH06271460A (ja) * | 1993-03-22 | 1994-09-27 | Nippon Oil & Fats Co Ltd | リポソーム分散液の製造方法 |
| JPH0717874A (ja) * | 1993-06-18 | 1995-01-20 | Terumo Corp | ヘモグロビン内包リポソーム |
| EP0918539B1 (en) * | 1996-02-16 | 2005-10-19 | Biomira Usa Inc. | Vaccine for b-cell malignancies |
| US6287590B1 (en) * | 1997-10-02 | 2001-09-11 | Esperion Therapeutics, Inc. | Peptide/lipid complex formation by co-lyophilization |
-
1999
- 1999-11-09 DE DE19954843A patent/DE19954843C2/de not_active Expired - Fee Related
-
2000
- 2000-11-09 WO PCT/EP2000/011079 patent/WO2001034115A2/de not_active Ceased
- 2000-11-09 EP EP00976017A patent/EP1227794B1/de not_active Expired - Lifetime
- 2000-11-09 JP JP2001536115A patent/JP2003513901A/ja active Pending
- 2000-11-09 DK DK00976017T patent/DK1227794T3/da active
- 2000-11-09 DE DE50011769T patent/DE50011769D1/de not_active Expired - Fee Related
- 2000-11-09 AU AU13933/01A patent/AU1393301A/en not_active Abandoned
- 2000-11-09 AT AT00976017T patent/ATE311175T1/de not_active IP Right Cessation
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