JP2003513051A5 - - Google Patents
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- Publication number
- JP2003513051A5 JP2003513051A5 JP2001534423A JP2001534423A JP2003513051A5 JP 2003513051 A5 JP2003513051 A5 JP 2003513051A5 JP 2001534423 A JP2001534423 A JP 2001534423A JP 2001534423 A JP2001534423 A JP 2001534423A JP 2003513051 A5 JP2003513051 A5 JP 2003513051A5
- Authority
- JP
- Japan
- Prior art keywords
- αglc
- βglc
- composition
- toxin
- oligosaccharide sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 description 51
- 150000002482 oligosaccharides Polymers 0.000 description 50
- 101710182223 Toxin B Proteins 0.000 description 27
- 238000000034 method Methods 0.000 description 26
- 125000005647 linker group Chemical group 0.000 description 24
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 21
- 101710182532 Toxin a Proteins 0.000 description 14
- 101710084578 Short neurotoxin 1 Proteins 0.000 description 12
- WQZGKKKJIJFFOK-FPRJBGLDSA-N beta-D-galactose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-FPRJBGLDSA-N 0.000 description 9
- 108010005774 beta-Galactosidase Proteins 0.000 description 9
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 6
- 125000001151 peptidyl group Chemical group 0.000 description 6
- 210000001035 gastrointestinal tract Anatomy 0.000 description 4
- 101000718529 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) Alpha-galactosidase Proteins 0.000 description 3
- 239000003053 toxin Substances 0.000 description 3
- 231100000765 toxin Toxicity 0.000 description 3
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 230000003796 beauty Effects 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/433,944 US6358930B1 (en) | 1998-05-28 | 1999-11-04 | Treatment of C. difficile toxin B associated conditions |
| US09/433,944 | 1999-11-04 | ||
| PCT/CA2000/001312 WO2001032219A2 (en) | 1999-11-04 | 2000-11-03 | Treatment of c. difficile toxin b associated conditions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003513051A JP2003513051A (ja) | 2003-04-08 |
| JP2003513051A5 true JP2003513051A5 (https=) | 2007-12-06 |
Family
ID=23722193
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001534423A Pending JP2003513051A (ja) | 1999-11-04 | 2000-11-03 | Ｃ．ｄｉｆｆｉｃｉｌｅトキシンＢ関連性状態の処置 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6358930B1 (https=) |
| EP (1) | EP1250153A2 (https=) |
| JP (1) | JP2003513051A (https=) |
| AU (1) | AU1261601A (https=) |
| CA (1) | CA2388187A1 (https=) |
| WO (1) | WO2001032219A2 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7682631B2 (en) * | 2003-10-01 | 2010-03-23 | Clemson University | Adhesin-specific nanoparticles and process for using same |
| CA2470090A1 (fr) * | 2004-06-18 | 2005-12-18 | Bio-K Plus International Inc. | Bacteries lactiques et leurs usages dans la prevention de diarrhee associee aux antibiotiques |
| AU2005295708A1 (en) * | 2004-10-13 | 2006-04-27 | Relypsa, Inc. | Pharmaceutical compositions comprising a toxin-binding oligosaccharide and a polymeric particle |
| US20060078534A1 (en) * | 2004-10-13 | 2006-04-13 | Dominique Charmot | Toxin binding compositions |
| US20080107748A1 (en) * | 2006-11-06 | 2008-05-08 | Krishan Kumar Singal | Microcapsules for removing and absorbing a chemical from a mixture |
| GB0821913D0 (en) | 2008-12-02 | 2009-01-07 | Price & Co | Antibacterial compounds |
| WO2011151620A1 (en) * | 2010-06-01 | 2011-12-08 | Summit Corporation Plc | Compounds for the treatment of clostridium difficile associated disease |
| ES2568455T3 (es) | 2010-06-01 | 2016-04-29 | Summit Therapeutics Plc | Compuestos para el tratamiento de enfermedad asociada a Clostridium difficile |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1544908A (en) | 1975-07-08 | 1979-04-25 | Chembiomed Ltd | Artificial oligosaccharide antigenic determinants |
| US4362720A (en) | 1977-04-14 | 1982-12-07 | Chembiomed Ltd. | Synthesis of 2-amino-2-deoxyglycoses and 2-amino-2-deoxyglycosides from glycals |
| US5079353A (en) | 1987-12-02 | 1992-01-07 | Chembiomed, Ltd. | Sialic acid glycosides, antigens, immunoadsorbents, and methods for their preparation |
| AU666128B2 (en) | 1991-08-23 | 1996-02-01 | Alberta Research Council Inc. | Methods and compositions for attenuating antibody-mediated xenograft rejection in human recipients |
| US5484773A (en) | 1994-02-14 | 1996-01-16 | Alberta Research Council | Treatment of antibiotic associated diarrhea |
| US5811409A (en) | 1995-06-05 | 1998-09-22 | Synsorb Biotech, Inc. | Treatment of cholera |
| US5637576A (en) | 1995-06-05 | 1997-06-10 | Synsorb Biotech, Inc. | Treatment of traveller's diarrhea |
| US5846943A (en) * | 1996-11-08 | 1998-12-08 | Synsorb Biotech, Inc. | Solid support matricles containing a toxin binding oligosaccharide |
| US6013635A (en) * | 1998-05-28 | 2000-01-11 | Synsorb Biotech, Inc. | Treatment of C. difficile toxin B associated conditions |
-
1999
- 1999-11-04 US US09/433,944 patent/US6358930B1/en not_active Expired - Fee Related
-
2000
- 2000-11-03 AU AU12616/01A patent/AU1261601A/en not_active Abandoned
- 2000-11-03 WO PCT/CA2000/001312 patent/WO2001032219A2/en not_active Ceased
- 2000-11-03 JP JP2001534423A patent/JP2003513051A/ja active Pending
- 2000-11-03 EP EP00974214A patent/EP1250153A2/en not_active Withdrawn
- 2000-11-03 CA CA002388187A patent/CA2388187A1/en not_active Abandoned
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