JP2003512351A5 - - Google Patents

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Publication number
JP2003512351A5
JP2003512351A5 JP2001531790A JP2001531790A JP2003512351A5 JP 2003512351 A5 JP2003512351 A5 JP 2003512351A5 JP 2001531790 A JP2001531790 A JP 2001531790A JP 2001531790 A JP2001531790 A JP 2001531790A JP 2003512351 A5 JP2003512351 A5 JP 2003512351A5
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JP
Japan
Prior art keywords
compound
condensation reaction
alkyl
citramalic acid
undergoing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2001531790A
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English (en)
Japanese (ja)
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JP5112583B2 (ja
JP2003512351A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2000/041233 external-priority patent/WO2001028990A2/en
Publication of JP2003512351A publication Critical patent/JP2003512351A/ja
Publication of JP2003512351A5 publication Critical patent/JP2003512351A5/ja
Application granted granted Critical
Publication of JP5112583B2 publication Critical patent/JP5112583B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2001531790A 1999-10-19 2000-10-18 カソデックス、その誘導体およびその中間体の鏡像体を非対照的に合成する方法 Expired - Fee Related JP5112583B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16041299P 1999-10-19 1999-10-19
US60/160,412 1999-10-19
PCT/US2000/041233 WO2001028990A2 (en) 1999-10-19 2000-10-18 Methods of asymmetrically synthesizing enantiomers of casodex, its derivatives and intermediates thereof

Publications (3)

Publication Number Publication Date
JP2003512351A JP2003512351A (ja) 2003-04-02
JP2003512351A5 true JP2003512351A5 (https=) 2007-11-29
JP5112583B2 JP5112583B2 (ja) 2013-01-09

Family

ID=22576803

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001531790A Expired - Fee Related JP5112583B2 (ja) 1999-10-19 2000-10-18 カソデックス、その誘導体およびその中間体の鏡像体を非対照的に合成する方法

Country Status (18)

Country Link
US (2) US6583306B1 (https=)
EP (1) EP1222165A2 (https=)
JP (1) JP5112583B2 (https=)
KR (1) KR20020091047A (https=)
CN (1) CN1409702A (https=)
AU (1) AU1968601A (https=)
BR (1) BR0014889A (https=)
CA (1) CA2387570A1 (https=)
CZ (1) CZ20021340A3 (https=)
HK (1) HK1048298A1 (https=)
HU (1) HUP0203785A2 (https=)
IL (2) IL149056A0 (https=)
MX (1) MXPA02003884A (https=)
NO (1) NO20021831L (https=)
NZ (1) NZ518392A (https=)
PL (1) PL354620A1 (https=)
WO (1) WO2001028990A2 (https=)
ZA (1) ZA200202947B (https=)

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US6995284B2 (en) 2000-08-24 2006-02-07 The University Of Tennessee Research Foundation Synthesis of selective androgen receptor modulators
US7759520B2 (en) 1996-11-27 2010-07-20 University Of Tennessee Research Foundation Synthesis of selective androgen receptor modulators
US6071957A (en) 1996-11-27 2000-06-06 The University Of Tennessee Research Corporation Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer
US7622503B2 (en) 2000-08-24 2009-11-24 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US7547728B2 (en) 2001-12-06 2009-06-16 University Of Tennessee Research Foundation Treating muscle wasting with selective androgen receptor modulators
US8445534B2 (en) 2000-08-24 2013-05-21 University Of Tennessee Research Foundation Treating androgen decline in aging male (ADAM)-associated conditions with SARMs
US7253210B2 (en) 2002-10-15 2007-08-07 University Of Tennessee Research Foundation Methylene-bridged selective androgen receptor modulators and methods of use thereof
US6998500B2 (en) 2000-08-24 2006-02-14 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US6838484B2 (en) 2000-08-24 2005-01-04 University Of Tennessee Research Foundation Formulations comprising selective androgen receptor modulators
US7026500B2 (en) 2000-08-24 2006-04-11 University Of Tennessee Research Foundation Halogenated selective androgen receptor modulators and methods of use thereof
US8008348B2 (en) 2001-12-06 2011-08-30 University Of Tennessee Research Foundation Treating muscle wasting with selective androgen receptor modulators
WO2002100339A2 (en) * 2001-06-13 2002-12-19 Biogal Gyogyszergyar Rt. Novel process for preparing rac-bicalutamide and its intermediates
US8853266B2 (en) 2001-12-06 2014-10-07 University Of Tennessee Research Foundation Selective androgen receptor modulators for treating diabetes
CN1602299A (zh) * 2001-12-13 2005-03-30 住友化学工业株式会社 比卡鲁胺晶体及其制造方法
PT1480634E (pt) 2002-02-07 2011-10-12 Univ Tennessee Res Foundation Moduladores selectivos do receptor do androgénio (sarms) para o tratamento da hiperplasia benigna da próstata
US7772433B2 (en) 2002-02-28 2010-08-10 University Of Tennessee Research Foundation SARMS and method of use thereof
US7803970B2 (en) 2002-02-28 2010-09-28 University Of Tennessee Research Foundation Multi-substitued selective androgen receptor modulators and methods of use thereof
US7344700B2 (en) 2002-02-28 2008-03-18 University Of Tennessee Research Corporation Radiolabeled selective androgen receptor modulators and their use in prostate cancer imaging and therapy
EP1487458B1 (en) 2002-02-28 2011-11-16 University Of Tennessee Research Foundation Multi-substituted selective androgen receptor modulators and methods of use thereof
DE10222104A1 (de) * 2002-05-17 2003-12-04 Helm Ag Verfahren zur Herstellung von N-(4'-Cyano-3'-trifluormethyl)-3-(4"-fluorphenylsulfonyl)-2-hydroxy-2-methylpropionamid
US7741371B2 (en) 2002-06-17 2010-06-22 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
GEP20074191B (en) 2002-06-17 2007-09-10 Univ Tennessee Res Foundation N-bridged selective androgen receptor modulators and methods of use thereof
DE50213170D1 (de) * 2002-09-04 2009-02-12 Fraunhofer Ges Forschung Verwendung eines Mittel zur Therapie der Herzhypertrophie
US20040063782A1 (en) * 2002-09-27 2004-04-01 Westheim Raymond J.H. Bicalutamide forms
US6818766B2 (en) 2002-10-02 2004-11-16 Synthon Bv Process for making bicalutamide and intermediates thereof
US8309603B2 (en) 2004-06-07 2012-11-13 University Of Tennessee Research Foundation SARMs and method of use thereof
JP4322621B2 (ja) 2003-10-16 2009-09-02 住友化学株式会社 ４’−シアノ−３−［（４−フルオロフェニル）スルホニル］−２−ヒドロキシ−２−メチル−３’−トリフルオロメチルプロピオンアニリドの製造方法
CA2522874A1 (en) 2003-12-16 2005-07-07 Gtx, Inc. Prodrugs of selective androgen receptor modulators and methods of use thereof
US9884038B2 (en) 2004-06-07 2018-02-06 University Of Tennessee Research Foundation Selective androgen receptor modulator and methods of use thereof
US9889110B2 (en) 2004-06-07 2018-02-13 University Of Tennessee Research Foundation Selective androgen receptor modulator for treating hormone-related conditions
WO2008013791A2 (en) * 2006-07-24 2008-01-31 University Of Delaware Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal
US9730908B2 (en) 2006-08-24 2017-08-15 University Of Tennessee Research Foundation SARMs and method of use thereof
US9844528B2 (en) 2006-08-24 2017-12-19 University Of Tennessee Research Foundation SARMs and method of use thereof
CN101528214B (zh) 2006-08-24 2013-06-05 田纳西大学研究基金会 取代的n-酰基苯胺及其使用方法
US10010521B2 (en) 2006-08-24 2018-07-03 University Of Tennessee Research Foundation SARMs and method of use thereof
US7968603B2 (en) 2007-09-11 2011-06-28 University Of Tennessee Research Foundation Solid forms of selective androgen receptor modulators
US8741951B2 (en) 2009-04-10 2014-06-03 CNR—Consiglio Nazionale Delle Ricerche Non-steroidal compounds for androgen receptor modulation
ITBO20090236A1 (it) * 2009-04-10 2010-10-11 Consiglio Nazionale Ricerche Procedimento per la sintesi di composti per il trattamento del tumore alla prostata
US8450374B2 (en) * 2009-06-29 2013-05-28 University Of Delaware Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal
CN103539710A (zh) * 2012-07-02 2014-01-29 国药一心制药有限公司 一种（r）-比卡鲁胺的合成方法
US10314807B2 (en) 2012-07-13 2019-06-11 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US10987334B2 (en) 2012-07-13 2021-04-27 University Of Tennessee Research Foundation Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs)
US9744149B2 (en) 2012-07-13 2017-08-29 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US10258596B2 (en) 2012-07-13 2019-04-16 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US9622992B2 (en) 2012-07-13 2017-04-18 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US9969683B2 (en) 2012-07-13 2018-05-15 Gtx, Inc. Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS)
PT2872482T (pt) 2012-07-13 2020-09-22 Oncternal Therapeutics Inc Método de tratamento de cancro de mama com modulador seletivo do recetor de andrógeno (sarm)

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WO1998055153A1 (en) 1997-06-04 1998-12-10 The University Of Tennessee Research Corporation Non-steroidal radiolabeled agonist/antagonist compounds and their use in prostate cancer imaging
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US6252762B1 (en) * 1999-04-21 2001-06-26 Telcordia Technologies, Inc. Rechargeable hybrid battery/supercapacitor system
US6331992B1 (en) * 2000-04-07 2001-12-18 Stratos Lightwave, Inc. Small format optical subassembly
AU2002231027A1 (en) * 2000-12-13 2002-06-24 Teraconnect, Inc. A packaging system for two-dimensional optoelectronic arrays
US6821032B2 (en) * 2002-05-28 2004-11-23 Intel Corporation Methods of sealing electronic, optical and electro-optical packages and related package and substrate designs

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