JP2003509041A5 - - Google Patents
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- Publication number
- JP2003509041A5 JP2003509041A5 JP2001523643A JP2001523643A JP2003509041A5 JP 2003509041 A5 JP2003509041 A5 JP 2003509041A5 JP 2001523643 A JP2001523643 A JP 2001523643A JP 2001523643 A JP2001523643 A JP 2001523643A JP 2003509041 A5 JP2003509041 A5 JP 2003509041A5
- Authority
- JP
- Japan
- Prior art keywords
- dpp8
- seq
- substrate
- molecule
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102100036968 Dipeptidyl peptidase 8 Human genes 0.000 description 20
- 101000804947 Homo sapiens Dipeptidyl peptidase 8 Proteins 0.000 description 20
- 239000000758 substrate Substances 0.000 description 19
- 108090000765 processed proteins & peptides Proteins 0.000 description 10
- 238000003776 cleavage reaction Methods 0.000 description 7
- 108020004707 nucleic acids Proteins 0.000 description 7
- 102000039446 nucleic acids Human genes 0.000 description 7
- 150000007523 nucleic acids Chemical class 0.000 description 7
- 230000007017 scission Effects 0.000 description 7
- 125000003275 alpha amino acid group Chemical group 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 108091005804 Peptidases Proteins 0.000 description 5
- 239000004365 Protease Substances 0.000 description 5
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 5
- 230000002401 inhibitory effect Effects 0.000 description 5
- 239000012634 fragment Substances 0.000 description 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 108020001507 fusion proteins Proteins 0.000 description 3
- 102000037865 fusion proteins Human genes 0.000 description 3
- 101150112076 DPP8 gene Proteins 0.000 description 2
- 101100010317 Homo sapiens DPP8 gene Proteins 0.000 description 2
- 210000001744 T-lymphocyte Anatomy 0.000 description 2
- 230000003197 catalytic effect Effects 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- 210000004408 hybridoma Anatomy 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- 108091026898 Leader sequence (mRNA) Proteins 0.000 description 1
- 108091036066 Three prime untranslated region Proteins 0.000 description 1
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 210000003917 human chromosome Anatomy 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPQ2762 | 1999-09-10 | ||
| AUPQ2762A AUPQ276299A0 (en) | 1999-09-10 | 1999-09-10 | Peptide and nucleic acid molecule |
| AU2762 | 1999-09-10 | ||
| AUPQ5709 | 2000-02-18 | ||
| AUPQ5709A AUPQ570900A0 (en) | 2000-02-18 | 2000-02-18 | Peptide and nucleic acid molecule |
| AU5709 | 2000-02-18 | ||
| PCT/AU2000/001085 WO2001019866A1 (en) | 1999-09-10 | 2000-09-11 | Dipeptidyl peptidases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003509041A JP2003509041A (ja) | 2003-03-11 |
| JP2003509041A5 true JP2003509041A5 (enExample) | 2007-07-26 |
| JP4748908B2 JP4748908B2 (ja) | 2011-08-17 |
Family
ID=25646142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001523643A Expired - Fee Related JP4748908B2 (ja) | 1999-09-10 | 2000-09-11 | ジペプチジルペプチダーゼ |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6881564B1 (enExample) |
| EP (1) | EP1214344B1 (enExample) |
| JP (1) | JP4748908B2 (enExample) |
| AT (1) | ATE332366T1 (enExample) |
| CA (1) | CA2384135A1 (enExample) |
| DE (1) | DE60029230T2 (enExample) |
| DK (1) | DK1214344T3 (enExample) |
| ES (1) | ES2269178T3 (enExample) |
| WO (1) | WO2001019866A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9813233A (pt) * | 1997-09-29 | 2000-08-22 | Point Therapeutics Inc | Estimulação de células hematopoéticas in vitro |
| US6979697B1 (en) * | 1998-08-21 | 2005-12-27 | Point Therapeutics, Inc. | Regulation of substrate activity |
| WO2001019866A1 (en) * | 1999-09-10 | 2001-03-22 | The University Of Sydney | Dipeptidyl peptidases |
| EP1280922A2 (en) * | 2000-04-18 | 2003-02-05 | Millennium Pharmaceuticals, Inc. | 21953, a human prolyl oligopeptidase family member and uses thereof |
| US20040047853A1 (en) * | 2000-06-09 | 2004-03-11 | Dahl Soren W | Purified proenzyme of dipeptidyl peptidase i (pro-dppi) |
| IL155245A0 (en) * | 2000-10-12 | 2003-11-23 | Ferring Bv | Novel serine protease genes related to dppiv |
| AUPR107800A0 (en) | 2000-10-27 | 2000-11-23 | University Of Sydney, The | Peptide and nucleic acid molecule ii |
| DE10100053A1 (de) * | 2001-01-02 | 2002-08-22 | Keyneurotek Ag I G | Verwendung von Enzyminhibitoren der Dipeptidylpeptidase IV sowie der Aminopeptidase N und pharmazeutischen Zubereitungen daraus zur Prävention und/oder Therapie Ischämie-bedingter akuter und chronischer neurodegenerativer Prozesse und Erkrankungen |
| WO2002066627A1 (en) * | 2001-02-16 | 2002-08-29 | Bayer Aktiengesellschaft | Regulation of human dipeptidyl peptidase 8 |
| DE10150203A1 (de) | 2001-10-12 | 2003-04-17 | Probiodrug Ag | Peptidylketone als Inhibitoren der DPIV |
| IL158923A0 (en) | 2001-06-27 | 2004-05-12 | Smithkline Beecham Corp | Fluoropyrrolidines as dipeptidyl peptidase inhibitors |
| JP4771661B2 (ja) | 2001-11-26 | 2011-09-14 | トラスティーズ オブ タフツ カレッジ | Ｐｏｓｔ−プロリン開裂酵素の擬ペプチド性阻害剤 |
| DK1528931T3 (da) | 2002-08-09 | 2008-09-08 | Prosidion Ltd | Dipeptidylpeptidase-IV-inhibitorer til reduktion af hastigheden af kronisk vægtforögelse |
| JP2007511467A (ja) | 2003-05-14 | 2007-05-10 | タケダ サン ディエゴ インコーポレイテッド | ジペプチジルペプチダーゼインヒビター |
| US7169926B1 (en) | 2003-08-13 | 2007-01-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| WO2005016911A1 (en) | 2003-08-13 | 2005-02-24 | Takeda Pharmaceutical Company Limited | 4-pyrimidone derivatives and their use as peptidyl peptidase inhibitors |
| US7678909B1 (en) | 2003-08-13 | 2010-03-16 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| US7732446B1 (en) | 2004-03-11 | 2010-06-08 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| WO2005106021A1 (en) * | 2004-04-28 | 2005-11-10 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with dipeptidyl-peptidase 8 (dpp8) |
| WO2005108997A1 (en) * | 2004-05-11 | 2005-11-17 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with dipeptidyl-peptidase 6 (dpp6) |
| EP1753730A1 (en) | 2004-06-04 | 2007-02-21 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| WO2006019965A2 (en) | 2004-07-16 | 2006-02-23 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
| US20060063719A1 (en) * | 2004-09-21 | 2006-03-23 | Point Therapeutics, Inc. | Methods for treating diabetes |
| WO2007033350A1 (en) | 2005-09-14 | 2007-03-22 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors for treating diabetes |
| EP1924567B1 (en) | 2005-09-16 | 2012-08-22 | Takeda Pharmaceutical Company Limited | Process for the preparation of pyrimidinedione derivatives |
| WO2007054577A1 (en) | 2005-11-14 | 2007-05-18 | Probiodrug Ag | Cyclopropyl-fused pyrrolidine derivatives as dipeptidyl peptidase iv inhibitors |
| WO2007112347A1 (en) | 2006-03-28 | 2007-10-04 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| BRPI0709984A2 (pt) | 2006-04-12 | 2011-08-02 | Probiodrug Ag | inibidores de enzima |
| TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
| EP3314004A1 (en) * | 2015-06-26 | 2018-05-02 | DuPont Nutrition Biosciences ApS | Aminopeptidases for protein hydrolyzates |
| US11613785B2 (en) | 2017-01-09 | 2023-03-28 | Onkosxcel Therapeutics, Llc | Predictive and diagnostic methods for prostate cancer |
| DE102018107224A1 (de) * | 2018-02-21 | 2019-08-22 | Immatics Biotechnologies Gmbh | Peptide und Kombinationen von Peptiden nicht-kanonischen Ursprungs zur Verwendung in der Immuntherapie gegen verschiedene Krebsarten |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4977085A (en) * | 1984-02-29 | 1990-12-11 | The Board Of Regents Of The Univ. Of California | Cloning and expression of yeast STE13 and Dpp2 genes encoding dipeptidyl aminopeptidase A and B |
| US5231126A (en) * | 1985-04-01 | 1993-07-27 | Shi Guan Yi | Beta-crystalline form of isotactic polypropylene and method for forming the same |
| CN1130406C (zh) * | 1997-02-07 | 2003-12-10 | 埃克森美孚化学专利公司 | 结合有聚乙烯大分子单体的丙烯聚合物 |
| US20040132158A1 (en) | 1999-01-11 | 2004-07-08 | Incyte Corporation | Human peptidases |
| WO2001019866A1 (en) | 1999-09-10 | 2001-03-22 | The University Of Sydney | Dipeptidyl peptidases |
| WO2001046277A2 (en) * | 1999-12-22 | 2001-06-28 | Exxonmobil Chemical Patents, Inc. | Polypropylene-based adhesive compositions |
| US20030198953A1 (en) | 2000-03-30 | 2003-10-23 | Spytek Kimberly A. | Novel proteins and nucleic acids encoding same |
| IL155245A0 (en) | 2000-10-12 | 2003-11-23 | Ferring Bv | Novel serine protease genes related to dppiv |
| US20020123538A1 (en) * | 2000-12-29 | 2002-09-05 | Peiguang Zhou | Hot-melt adhesive based on blend of amorphous and crystalline polymers for multilayer bonding |
| US6774069B2 (en) * | 2000-12-29 | 2004-08-10 | Kimberly-Clark Worldwide, Inc. | Hot-melt adhesive for non-woven elastic composite bonding |
| US7550528B2 (en) * | 2002-10-15 | 2009-06-23 | Exxonmobil Chemical Patents Inc. | Functionalized olefin polymers |
| US7700707B2 (en) * | 2002-10-15 | 2010-04-20 | Exxonmobil Chemical Patents Inc. | Polyolefin adhesive compositions and articles made therefrom |
| EP2261292B1 (en) * | 2002-10-15 | 2014-07-23 | ExxonMobil Chemical Patents Inc. | Polyolefin adhesive compositions |
| US7223822B2 (en) * | 2002-10-15 | 2007-05-29 | Exxonmobil Chemical Patents Inc. | Multiple catalyst and reactor system for olefin polymerization and polymers produced therefrom |
-
2000
- 2000-09-11 WO PCT/AU2000/001085 patent/WO2001019866A1/en not_active Ceased
- 2000-09-11 CA CA002384135A patent/CA2384135A1/en not_active Abandoned
- 2000-09-11 DE DE60029230T patent/DE60029230T2/de not_active Expired - Lifetime
- 2000-09-11 AT AT00962085T patent/ATE332366T1/de active
- 2000-09-11 US US10/070,464 patent/US6881564B1/en not_active Expired - Fee Related
- 2000-09-11 ES ES00962085T patent/ES2269178T3/es not_active Expired - Lifetime
- 2000-09-11 EP EP00962085A patent/EP1214344B1/en not_active Expired - Lifetime
- 2000-09-11 JP JP2001523643A patent/JP4748908B2/ja not_active Expired - Fee Related
- 2000-09-11 DK DK00962085T patent/DK1214344T3/da active
-
2004
- 2004-04-15 US US10/825,632 patent/US7148338B2/en not_active Expired - Fee Related
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