CA2384135A1 - Dipeptidyl peptidases - Google Patents

Dipeptidyl peptidases Download PDF

Info

Publication number
CA2384135A1
CA2384135A1 CA002384135A CA2384135A CA2384135A1 CA 2384135 A1 CA2384135 A1 CA 2384135A1 CA 002384135 A CA002384135 A CA 002384135A CA 2384135 A CA2384135 A CA 2384135A CA 2384135 A1 CA2384135 A1 CA 2384135A1
Authority
CA
Canada
Prior art keywords
dpp8
pro
seq
leu
substrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002384135A
Other languages
English (en)
French (fr)
Inventor
Catherine Anne Abbott
Mark Douglas Gorell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Sydney
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AUPQ2762A external-priority patent/AUPQ276299A0/en
Priority claimed from AUPQ5709A external-priority patent/AUPQ570900A0/en
Application filed by Individual filed Critical Individual
Publication of CA2384135A1 publication Critical patent/CA2384135A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/948Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
CA002384135A 1999-09-10 2000-09-11 Dipeptidyl peptidases Abandoned CA2384135A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AUPQ2762 1999-09-10
AUPQ2762A AUPQ276299A0 (en) 1999-09-10 1999-09-10 Peptide and nucleic acid molecule
AUPQ5709 2000-02-18
AUPQ5709A AUPQ570900A0 (en) 2000-02-18 2000-02-18 Peptide and nucleic acid molecule
PCT/AU2000/001085 WO2001019866A1 (en) 1999-09-10 2000-09-11 Dipeptidyl peptidases

Publications (1)

Publication Number Publication Date
CA2384135A1 true CA2384135A1 (en) 2001-03-22

Family

ID=25646142

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002384135A Abandoned CA2384135A1 (en) 1999-09-10 2000-09-11 Dipeptidyl peptidases

Country Status (9)

Country Link
US (2) US6881564B1 (enExample)
EP (1) EP1214344B1 (enExample)
JP (1) JP4748908B2 (enExample)
AT (1) ATE332366T1 (enExample)
CA (1) CA2384135A1 (enExample)
DE (1) DE60029230T2 (enExample)
DK (1) DK1214344T3 (enExample)
ES (1) ES2269178T3 (enExample)
WO (1) WO2001019866A1 (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9813233A (pt) * 1997-09-29 2000-08-22 Point Therapeutics Inc Estimulação de células hematopoéticas in vitro
US6979697B1 (en) * 1998-08-21 2005-12-27 Point Therapeutics, Inc. Regulation of substrate activity
WO2001019866A1 (en) * 1999-09-10 2001-03-22 The University Of Sydney Dipeptidyl peptidases
EP1280922A2 (en) * 2000-04-18 2003-02-05 Millennium Pharmaceuticals, Inc. 21953, a human prolyl oligopeptidase family member and uses thereof
US20040047853A1 (en) * 2000-06-09 2004-03-11 Dahl Soren W Purified proenzyme of dipeptidyl peptidase i (pro-dppi)
IL155245A0 (en) * 2000-10-12 2003-11-23 Ferring Bv Novel serine protease genes related to dppiv
AUPR107800A0 (en) 2000-10-27 2000-11-23 University Of Sydney, The Peptide and nucleic acid molecule ii
DE10100053A1 (de) * 2001-01-02 2002-08-22 Keyneurotek Ag I G Verwendung von Enzyminhibitoren der Dipeptidylpeptidase IV sowie der Aminopeptidase N und pharmazeutischen Zubereitungen daraus zur Prävention und/oder Therapie Ischämie-bedingter akuter und chronischer neurodegenerativer Prozesse und Erkrankungen
WO2002066627A1 (en) * 2001-02-16 2002-08-29 Bayer Aktiengesellschaft Regulation of human dipeptidyl peptidase 8
DE10150203A1 (de) 2001-10-12 2003-04-17 Probiodrug Ag Peptidylketone als Inhibitoren der DPIV
IL158923A0 (en) 2001-06-27 2004-05-12 Smithkline Beecham Corp Fluoropyrrolidines as dipeptidyl peptidase inhibitors
JP4771661B2 (ja) 2001-11-26 2011-09-14 トラスティーズ オブ タフツ カレッジ Post−プロリン開裂酵素の擬ペプチド性阻害剤
DK1528931T3 (da) 2002-08-09 2008-09-08 Prosidion Ltd Dipeptidylpeptidase-IV-inhibitorer til reduktion af hastigheden af kronisk vægtforögelse
JP2007511467A (ja) 2003-05-14 2007-05-10 タケダ サン ディエゴ インコーポレイテッド ジペプチジルペプチダーゼインヒビター
US7169926B1 (en) 2003-08-13 2007-01-30 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
WO2005016911A1 (en) 2003-08-13 2005-02-24 Takeda Pharmaceutical Company Limited 4-pyrimidone derivatives and their use as peptidyl peptidase inhibitors
US7678909B1 (en) 2003-08-13 2010-03-16 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7732446B1 (en) 2004-03-11 2010-06-08 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
WO2005106021A1 (en) * 2004-04-28 2005-11-10 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with dipeptidyl-peptidase 8 (dpp8)
WO2005108997A1 (en) * 2004-05-11 2005-11-17 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with dipeptidyl-peptidase 6 (dpp6)
EP1753730A1 (en) 2004-06-04 2007-02-21 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
WO2006019965A2 (en) 2004-07-16 2006-02-23 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
US20060063719A1 (en) * 2004-09-21 2006-03-23 Point Therapeutics, Inc. Methods for treating diabetes
WO2007033350A1 (en) 2005-09-14 2007-03-22 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors for treating diabetes
EP1924567B1 (en) 2005-09-16 2012-08-22 Takeda Pharmaceutical Company Limited Process for the preparation of pyrimidinedione derivatives
WO2007054577A1 (en) 2005-11-14 2007-05-18 Probiodrug Ag Cyclopropyl-fused pyrrolidine derivatives as dipeptidyl peptidase iv inhibitors
WO2007112347A1 (en) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
BRPI0709984A2 (pt) 2006-04-12 2011-08-02 Probiodrug Ag inibidores de enzima
TW200838536A (en) 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
EP3314004A1 (en) * 2015-06-26 2018-05-02 DuPont Nutrition Biosciences ApS Aminopeptidases for protein hydrolyzates
US11613785B2 (en) 2017-01-09 2023-03-28 Onkosxcel Therapeutics, Llc Predictive and diagnostic methods for prostate cancer
DE102018107224A1 (de) * 2018-02-21 2019-08-22 Immatics Biotechnologies Gmbh Peptide und Kombinationen von Peptiden nicht-kanonischen Ursprungs zur Verwendung in der Immuntherapie gegen verschiedene Krebsarten

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4977085A (en) * 1984-02-29 1990-12-11 The Board Of Regents Of The Univ. Of California Cloning and expression of yeast STE13 and Dpp2 genes encoding dipeptidyl aminopeptidase A and B
US5231126A (en) * 1985-04-01 1993-07-27 Shi Guan Yi Beta-crystalline form of isotactic polypropylene and method for forming the same
CN1130406C (zh) * 1997-02-07 2003-12-10 埃克森美孚化学专利公司 结合有聚乙烯大分子单体的丙烯聚合物
US20040132158A1 (en) 1999-01-11 2004-07-08 Incyte Corporation Human peptidases
WO2001019866A1 (en) 1999-09-10 2001-03-22 The University Of Sydney Dipeptidyl peptidases
WO2001046277A2 (en) * 1999-12-22 2001-06-28 Exxonmobil Chemical Patents, Inc. Polypropylene-based adhesive compositions
US20030198953A1 (en) 2000-03-30 2003-10-23 Spytek Kimberly A. Novel proteins and nucleic acids encoding same
IL155245A0 (en) 2000-10-12 2003-11-23 Ferring Bv Novel serine protease genes related to dppiv
US20020123538A1 (en) * 2000-12-29 2002-09-05 Peiguang Zhou Hot-melt adhesive based on blend of amorphous and crystalline polymers for multilayer bonding
US6774069B2 (en) * 2000-12-29 2004-08-10 Kimberly-Clark Worldwide, Inc. Hot-melt adhesive for non-woven elastic composite bonding
US7550528B2 (en) * 2002-10-15 2009-06-23 Exxonmobil Chemical Patents Inc. Functionalized olefin polymers
US7700707B2 (en) * 2002-10-15 2010-04-20 Exxonmobil Chemical Patents Inc. Polyolefin adhesive compositions and articles made therefrom
EP2261292B1 (en) * 2002-10-15 2014-07-23 ExxonMobil Chemical Patents Inc. Polyolefin adhesive compositions
US7223822B2 (en) * 2002-10-15 2007-05-29 Exxonmobil Chemical Patents Inc. Multiple catalyst and reactor system for olefin polymerization and polymers produced therefrom

Also Published As

Publication number Publication date
DE60029230D1 (de) 2006-08-17
ATE332366T1 (de) 2006-07-15
DK1214344T3 (da) 2006-11-06
DE60029230T2 (de) 2007-06-06
ES2269178T3 (es) 2007-04-01
WO2001019866A1 (en) 2001-03-22
EP1214344B1 (en) 2006-07-05
JP4748908B2 (ja) 2011-08-17
US6881564B1 (en) 2005-04-19
EP1214344A4 (en) 2004-03-10
US7148338B2 (en) 2006-12-12
US20040191826A1 (en) 2004-09-30
EP1214344A1 (en) 2002-06-19
JP2003509041A (ja) 2003-03-11

Similar Documents

Publication Publication Date Title
EP1214344B1 (en) Dipeptidyl peptidases
Abbott et al. Cloning, expression and chromosomal localization of a novel human dipeptidyl peptidase (DPP) IV homolog, DPP8
Smyth et al. Expression of recombinant human granzyme B. A processing and activation role for dipeptidyl peptidase I.
Ajami et al. Dipeptidyl peptidase 9 has two forms, a broad tissue distribution, cytoplasmic localization and DPIV-like peptidase activity
EP1337629B1 (en) Dipeptidyl peptidases
Hecquet et al. Human bradykinin B2 receptor is activated by kallikrein and other serine proteases
Corvol et al. [18] Peptidyl dipeptidase A: Angiotensin I-converting enzyme
McGuire et al. Generation of active myeloid and lymphoid granule serine proteases requires processing by the granule thiol protease dipeptidyl peptidase I.
US6753176B2 (en) Aggrecan degrading metallo proteases
Jutras et al. Prorenin processing by cathepsin B in vitro and in transfected cells
Bonvouloir et al. Molecular cloning, tissue distribution, and chromosomal localization of MMEL2, a gene coding for a novel human member of the neutral endopeptidase-24.11 family
Abbott et al. The Family of CD26/DPIV and Related Ectopeptidases: The DPIV family
CN101291953A (zh) 突变的timp-3
AU767005B2 (en) Dipeptidyl peptidases
Guay et al. Cloning and expression of rhesus monkey cathepsin K
Umland et al. Mouse ADAM33: two splice variants differ in protein maturation and localization
Gorrell et al. Diverse functions in a conserved structure: the dipeptidyl peptidase IV gene family
Boudjennah et al. Expression of collagenase/gelatinase activity from basement‐membrane fibronectin: Isolation after limited proteolysis of a bovine lens capsule and molecular definition of this thiol‐dependent zinc metalloproteinase
JP2003000249A (ja) クローディンによるMT−MMPsを介したproMMP−2活性化
Bauer Cytosol nonspecific dipeptidase
Soubrier et al. Angiotensin I-converting enzyme (ACE) gene structure and polymorphism: Relation to enzyme function and gene expression
AU2002214788B2 (en) Dipeptidyl peptidases
Williams et al. Biochemical, molecular and genetic aspects of angiotensin!-converting enzyme
CATHERINE The Family of CD26/DPIV and Related Ectopeptidases
AU2002214788A1 (en) Dipeptidyl peptidases

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued