JP2003506455A - 発蛍光性化合物およびその使用 - Google Patents
発蛍光性化合物およびその使用Info
- Publication number
- JP2003506455A JP2003506455A JP2001515689A JP2001515689A JP2003506455A JP 2003506455 A JP2003506455 A JP 2003506455A JP 2001515689 A JP2001515689 A JP 2001515689A JP 2001515689 A JP2001515689 A JP 2001515689A JP 2003506455 A JP2003506455 A JP 2003506455A
- Authority
- JP
- Japan
- Prior art keywords
- group
- enzyme
- compound
- light
- fluorescent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- IFGCUJZIWBUILZ-UHFFFAOYSA-N sodium 2-[[2-[[hydroxy-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyphosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid Chemical compound [Na+].C=1NC2=CC=CC=C2C=1CC(C(O)=O)NC(=O)C(CC(C)C)NP(O)(=O)OC1OC(C)C(O)C(O)C1O IFGCUJZIWBUILZ-UHFFFAOYSA-N 0.000 description 1
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- 229940054269 sodium pyruvate Drugs 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
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- 229940037648 staphylococcus simulans Drugs 0.000 description 1
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- 229940115922 streptococcus uberis Drugs 0.000 description 1
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- WPLOVIFNBMNBPD-ATHMIXSHSA-N subtilin Chemical compound CC1SCC(NC2=O)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(C(C)CC)C(=O)NC(=C)C(=O)NC(CCCCN)C(O)=O)CSC(C)C2NC(=O)C(CC(C)C)NC(=O)C1NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C1NC(=O)C(=C/C)/NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C2NC(=O)CNC(=O)C3CCCN3C(=O)C(NC(=O)C3NC(=O)C(CC(C)C)NC(=O)C(=C)NC(=O)C(CCC(O)=O)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)CC=4C5=CC=CC=C5NC=4)CSC3)C(C)SC2)C(C)C)C(C)SC1)CC1=CC=CC=C1 WPLOVIFNBMNBPD-ATHMIXSHSA-N 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
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- 229960000874 thyrotropin Drugs 0.000 description 1
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- 239000003204 tranquilizing agent Substances 0.000 description 1
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- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 239000012581 transferrin Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 239000002753 trypsin inhibitor Substances 0.000 description 1
- 108010050327 trypticase-soy broth Proteins 0.000 description 1
- 150000003672 ureas Chemical class 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 108010079570 uropepsin Proteins 0.000 description 1
- 229960004295 valine Drugs 0.000 description 1
- 229960003726 vasopressin Drugs 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
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- 235000019155 vitamin A Nutrition 0.000 description 1
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- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
- 244000000190 yeast pathogen Species 0.000 description 1
- 150000008494 α-glucosides Chemical class 0.000 description 1
- SFVVQRJOGUKCEG-OPQSFPLASA-N β-MSH Chemical compound C1C[C@@H](O)[C@H]2C(COC(=O)[C@@](O)([C@@H](C)O)C(C)C)=CCN21 SFVVQRJOGUKCEG-OPQSFPLASA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/06—Benzopyran radicals
- C07H17/065—Benzo[b]pyrans
- C07H17/075—Benzo[b]pyran-2-ones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
- C12Q2334/20—Coumarin derivatives
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/924—Hydrolases (3) acting on glycosyl compounds (3.2)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Saccharide Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14730799P | 1999-08-05 | 1999-08-05 | |
| US60/147,307 | 1999-08-05 | ||
| US09/611,686 US6372895B1 (en) | 2000-07-07 | 2000-07-07 | Fluorogenic compounds |
| US09/611,686 | 2000-07-07 | ||
| PCT/US2000/020715 WO2001010881A1 (en) | 1999-08-05 | 2000-07-28 | Fluorogenic compounds and uses therefor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003506455A true JP2003506455A (ja) | 2003-02-18 |
| JP2003506455A5 JP2003506455A5 (https=) | 2007-07-26 |
Family
ID=26844800
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001515689A Pending JP2003506455A (ja) | 1999-08-05 | 2000-07-28 | 発蛍光性化合物およびその使用 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1204671B1 (https=) |
| JP (1) | JP2003506455A (https=) |
| AU (1) | AU6614100A (https=) |
| BR (1) | BR0012937A (https=) |
| DE (1) | DE60006970T2 (https=) |
| WO (1) | WO2001010881A1 (https=) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005071056A1 (ja) * | 2004-01-23 | 2005-08-04 | Kitakyushu Foundation For The Advancement Of Industry, Science And Technology | バイオチップ及びそれを用いた試料溶液の機能性検査方法 |
| JP2013031456A (ja) * | 2004-09-16 | 2013-02-14 | Biomerieux | エステラーゼ活性を用いたＳｔｒｅｐｔｏｃｏｃｃｕｓａｇａｌａｃｔｉａｅの検出方法 |
| WO2018043733A1 (ja) * | 2016-09-05 | 2018-03-08 | 国立研究開発法人科学技術振興機構 | 病原性微生物検出のための方法及びキット |
| US11008603B2 (en) | 2016-09-05 | 2021-05-18 | Japan Science And Technology Agency | Method and kit for detecting pathogenic microorganism |
| US12173348B2 (en) | 2018-03-02 | 2024-12-24 | Japan Science And Technology Agency | Method for detecting enzymatic reaction product |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003291024A1 (en) * | 2002-11-13 | 2004-06-03 | Rigel Pharmaceuticals, Inc. | Rhodanine derivatives and pharmaceutical compositions containing them |
| FR2926563B1 (fr) * | 2008-01-21 | 2013-04-26 | Biomerieux Sa | Procede de detection et/ou d'identification de clostridium difficile |
| DE102008034008B4 (de) * | 2008-07-21 | 2010-07-01 | Carl Zeiss Surgical Gmbh | Filtersatz zur Beobachtung von Fluoreszenzstrahlung in biologischem Gewebe |
| WO2013013853A1 (en) * | 2011-05-17 | 2013-01-31 | Fresenius Kabi Anti Infectives S.R.L | Method for testing and monitoring the sterility of plant production units |
| TWI619809B (zh) * | 2012-08-24 | 2018-04-01 | 佐竹股份有限公司 | 微生物之檢查方法及其裝置 |
| US8945837B2 (en) | 2013-03-15 | 2015-02-03 | American Sterilizer Company | Sterilization indicator including a simplified genetically engineered biological indicator |
| US20180237821A1 (en) * | 2017-02-23 | 2018-08-23 | Ethicon, Inc. | Apparatus and method to read biological indicator |
| US20190261897A1 (en) * | 2017-11-28 | 2019-08-29 | Alan D. Kersey | Apparatus and method for assessment of cancer margin |
| CN109932363B (zh) * | 2019-04-02 | 2021-09-28 | 济南大学 | 一种识别铁离子的比色探针及其制备和应用 |
| EP4534684A1 (fr) * | 2023-10-03 | 2025-04-09 | Biomérieux | Detection et identification de levures du genre candida, methodes et outils de microbiologie pour ce faire |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62120396A (ja) * | 1985-11-19 | 1987-06-01 | バイエル・アクチエンゲゼルシヤフト | 新規な配糖体、その製造法、並びに糖類分解酵素の光度及び螢光測定法及びそのための試薬 |
| WO1994024119A1 (fr) * | 1993-04-13 | 1994-10-27 | Morinaga Milk Industry Co., Ltd. | Derive de coumarine et son utilisation |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4259233A (en) * | 1979-10-23 | 1981-03-31 | Miles Laboratories, Inc. | β-Galactosyl-umbelliferone-labeled protein and polypeptide conjugates |
| US5236827A (en) * | 1988-06-20 | 1993-08-17 | Becton, Dickinson And Company | Device for enhancing fluorescence and kinetics and methods of using the device |
| US5252484A (en) * | 1988-11-29 | 1993-10-12 | Minnesota Mining And Manufacturing Company | Rapid read-out biological indicator |
-
2000
- 2000-07-28 BR BR0012937-2A patent/BR0012937A/pt not_active IP Right Cessation
- 2000-07-28 AU AU66141/00A patent/AU6614100A/en not_active Abandoned
- 2000-07-28 JP JP2001515689A patent/JP2003506455A/ja active Pending
- 2000-07-28 WO PCT/US2000/020715 patent/WO2001010881A1/en not_active Ceased
- 2000-07-28 DE DE60006970T patent/DE60006970T2/de not_active Expired - Fee Related
- 2000-07-28 EP EP00953743A patent/EP1204671B1/en not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62120396A (ja) * | 1985-11-19 | 1987-06-01 | バイエル・アクチエンゲゼルシヤフト | 新規な配糖体、その製造法、並びに糖類分解酵素の光度及び螢光測定法及びそのための試薬 |
| WO1994024119A1 (fr) * | 1993-04-13 | 1994-10-27 | Morinaga Milk Industry Co., Ltd. | Derive de coumarine et son utilisation |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005071056A1 (ja) * | 2004-01-23 | 2005-08-04 | Kitakyushu Foundation For The Advancement Of Industry, Science And Technology | バイオチップ及びそれを用いた試料溶液の機能性検査方法 |
| JPWO2005071056A1 (ja) * | 2004-01-23 | 2007-11-01 | 国立大学法人九州工業大学 | バイオチップ及びそれを用いた試料溶液の機能性検査方法 |
| JP2013031456A (ja) * | 2004-09-16 | 2013-02-14 | Biomerieux | エステラーゼ活性を用いたＳｔｒｅｐｔｏｃｏｃｃｕｓａｇａｌａｃｔｉａｅの検出方法 |
| WO2018043733A1 (ja) * | 2016-09-05 | 2018-03-08 | 国立研究開発法人科学技術振興機構 | 病原性微生物検出のための方法及びキット |
| US11008603B2 (en) | 2016-09-05 | 2021-05-18 | Japan Science And Technology Agency | Method and kit for detecting pathogenic microorganism |
| US12173348B2 (en) | 2018-03-02 | 2024-12-24 | Japan Science And Technology Agency | Method for detecting enzymatic reaction product |
Also Published As
| Publication number | Publication date |
|---|---|
| BR0012937A (pt) | 2002-04-30 |
| DE60006970T2 (de) | 2004-10-28 |
| AU6614100A (en) | 2001-03-05 |
| WO2001010881A1 (en) | 2001-02-15 |
| EP1204671A1 (en) | 2002-05-15 |
| DE60006970D1 (de) | 2004-01-15 |
| EP1204671B1 (en) | 2003-12-03 |
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