JP2003506041A - ヒトｐ５３変異およびヒトｐ５３変異の機能的同定のための酵母遺伝子系 - Google Patents

ヒトｐ５３変異およびヒトｐ５３変異の機能的同定のための酵母遺伝子系

Info

Publication number
JP2003506041A
JP2003506041A JP2001514117A JP2001514117A JP2003506041A JP 2003506041 A JP2003506041 A JP 2003506041A JP 2001514117 A JP2001514117 A JP 2001514117A JP 2001514117 A JP2001514117 A JP 2001514117A JP 2003506041 A JP2003506041 A JP 2003506041A
Authority
JP
Japan
Prior art keywords
human
mutation
colonies
yeast
mutant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001514117A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003506041A5 (enExample
Inventor
マイケル・エイ・レズニック
アルベルト・インガ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Government of the United States of America
Original Assignee
Government of the United States of America
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Government of the United States of America filed Critical Government of the United States of America
Publication of JP2003506041A publication Critical patent/JP2003506041A/ja
Publication of JP2003506041A5 publication Critical patent/JP2003506041A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4746—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used p53
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2001514117A 1999-07-30 2000-07-28 ヒトｐ５３変異およびヒトｐ５３変異の機能的同定のための酵母遺伝子系 Pending JP2003506041A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14663499P 1999-07-30 1999-07-30
US60/146,634 1999-07-30
PCT/US2000/020538 WO2001009325A2 (en) 1999-07-30 2000-07-28 Human p53 mutations and a genetic system in yeast for functional indentification of human p53 mutations

Publications (2)

Publication Number Publication Date
JP2003506041A true JP2003506041A (ja) 2003-02-18
JP2003506041A5 JP2003506041A5 (enExample) 2007-07-12

Family

ID=22518261

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001514117A Pending JP2003506041A (ja) 1999-07-30 2000-07-28 ヒトｐ５３変異およびヒトｐ５３変異の機能的同定のための酵母遺伝子系

Country Status (5)

Country Link
EP (1) EP1204745A2 (enExample)
JP (1) JP2003506041A (enExample)
AU (1) AU784293B2 (enExample)
CA (1) CA2380631A1 (enExample)
WO (1) WO2001009325A2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7256260B1 (en) 1999-07-30 2007-08-14 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services, Nih Human p53 mutations and a genetic system in yeast for functional identification of human p53 mutations
AU2008257791B2 (en) * 2007-05-31 2013-03-28 Academisch Ziekenhuis Leiden H.O.D.N. Lumc P53 peptide vaccine
CN110257467A (zh) * 2019-07-22 2019-09-20 福州市皮肤病防治院 一种检测肿瘤抑制因子p53显性抑制突变的试剂盒及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996016989A1 (en) * 1994-11-28 1996-06-06 The Wistar Institute Of Anatomy And Biology p53 PROTEINS WITH ALTERED TETRAMERIZATION DOMAINS
JPH08506001A (ja) * 1992-10-01 1996-07-02 ザ ゼネラル ホスピタル コーポレーション 腫瘍サプレッサー遺伝子の機能検査

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69532767T2 (de) * 1994-11-28 2004-08-12 Thomas Jefferson University Peptid umfassend eine Sequenz aus einer Fusionsverbindungsstelle in einem mutierten EGF-Rezeptor vom Typ III
US5840579A (en) * 1996-05-01 1998-11-24 The Johns Hopkins University Nucleic acids encoding p53 mutations which suppress p53 cancer mutations
US6429298B1 (en) * 1998-10-13 2002-08-06 Board Of Regents, The University Of Texas System Assays for identifying functional alterations in the p53 tumor suppressor
JP2003520023A (ja) * 1999-05-12 2003-07-02 ゼンコー ｐ５３活性および変更された四量体化ドメインを有する新規の核酸およびタンパク質

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08506001A (ja) * 1992-10-01 1996-07-02 ザ ゼネラル ホスピタル コーポレーション 腫瘍サプレッサー遺伝子の機能検査
WO1996016989A1 (en) * 1994-11-28 1996-06-06 The Wistar Institute Of Anatomy And Biology p53 PROTEINS WITH ALTERED TETRAMERIZATION DOMAINS

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN6010018101, Ｊ． Ｂａｃｔｅｒｉｏｌ．， １９８３， Ｖｏｌ．１５３， ｐ．１４０５−１４１４ *
JPN6010018102, Ｇｅｎｅ， １９８９， Ｖｏｌ．８３， ｐ．５７−６４ *

Also Published As

Publication number Publication date
AU6239500A (en) 2001-02-19
AU784293B2 (en) 2006-03-02
WO2001009325A3 (en) 2001-08-30
EP1204745A2 (en) 2002-05-15
WO2001009325A9 (en) 2002-08-08
WO2001009325A2 (en) 2001-02-08
CA2380631A1 (en) 2001-02-08

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