CA2380631A1 - Human p53 mutations and a genetic system in yeast for functional indentification of human p53 mutations - Google Patents
Human p53 mutations and a genetic system in yeast for functional indentification of human p53 mutations Download PDFInfo
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- 239000013589 supplement Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 150000007970 thio esters Chemical class 0.000 description 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
- 229960000187 tissue plasminogen activator Drugs 0.000 description 1
- 238000006257 total synthesis reaction Methods 0.000 description 1
- 230000010474 transient expression Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 230000005751 tumor progression Effects 0.000 description 1
- 230000005760 tumorsuppression Effects 0.000 description 1
- 241000701366 unidentified nuclear polyhedrosis viruses Species 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
- 238000003158 yeast two-hybrid assay Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4746—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used p53
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14663499P | 1999-07-30 | 1999-07-30 | |
| US60/146,634 | 1999-07-30 | ||
| PCT/US2000/020538 WO2001009325A2 (en) | 1999-07-30 | 2000-07-28 | Human p53 mutations and a genetic system in yeast for functional indentification of human p53 mutations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2380631A1 true CA2380631A1 (en) | 2001-02-08 |
Family
ID=22518261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002380631A Abandoned CA2380631A1 (en) | 1999-07-30 | 2000-07-28 | Human p53 mutations and a genetic system in yeast for functional indentification of human p53 mutations |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1204745A2 (enExample) |
| JP (1) | JP2003506041A (enExample) |
| AU (1) | AU784293B2 (enExample) |
| CA (1) | CA2380631A1 (enExample) |
| WO (1) | WO2001009325A2 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7256260B1 (en) | 1999-07-30 | 2007-08-14 | The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services, Nih | Human p53 mutations and a genetic system in yeast for functional identification of human p53 mutations |
| AU2008257791B2 (en) * | 2007-05-31 | 2013-03-28 | Academisch Ziekenhuis Leiden H.O.D.N. Lumc | P53 peptide vaccine |
| CN110257467A (zh) * | 2019-07-22 | 2019-09-20 | 福州市皮肤病防治院 | 一种检测肿瘤抑制因子p53显性抑制突变的试剂盒及其应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994008049A1 (en) * | 1992-10-01 | 1994-04-14 | The General Hospital Corporation | Functional assay for tumor suppressor genes |
| WO1996016989A1 (en) * | 1994-11-28 | 1996-06-06 | The Wistar Institute Of Anatomy And Biology | p53 PROTEINS WITH ALTERED TETRAMERIZATION DOMAINS |
| DE69532767T2 (de) * | 1994-11-28 | 2004-08-12 | Thomas Jefferson University | Peptid umfassend eine Sequenz aus einer Fusionsverbindungsstelle in einem mutierten EGF-Rezeptor vom Typ III |
| US5840579A (en) * | 1996-05-01 | 1998-11-24 | The Johns Hopkins University | Nucleic acids encoding p53 mutations which suppress p53 cancer mutations |
| US6429298B1 (en) * | 1998-10-13 | 2002-08-06 | Board Of Regents, The University Of Texas System | Assays for identifying functional alterations in the p53 tumor suppressor |
| JP2003520023A (ja) * | 1999-05-12 | 2003-07-02 | ゼンコー | ｐ５３活性および変更された四量体化ドメインを有する新規の核酸およびタンパク質 |
-
2000
- 2000-07-28 EP EP00948979A patent/EP1204745A2/en not_active Withdrawn
- 2000-07-28 CA CA002380631A patent/CA2380631A1/en not_active Abandoned
- 2000-07-28 WO PCT/US2000/020538 patent/WO2001009325A2/en not_active Ceased
- 2000-07-28 JP JP2001514117A patent/JP2003506041A/ja active Pending
- 2000-07-28 AU AU62395/00A patent/AU784293B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU6239500A (en) | 2001-02-19 |
| AU784293B2 (en) | 2006-03-02 |
| WO2001009325A3 (en) | 2001-08-30 |
| EP1204745A2 (en) | 2002-05-15 |
| WO2001009325A9 (en) | 2002-08-08 |
| WO2001009325A2 (en) | 2001-02-08 |
| JP2003506041A (ja) | 2003-02-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |