JP2003506024A - 肝細胞増殖因子/細胞分散因子(HGF)又はその受容体c−met、及びインテグリン類に対する核酸リガンド - Google Patents

肝細胞増殖因子/細胞分散因子(HGF)又はその受容体c−met、及びインテグリン類に対する核酸リガンド

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JP2003506024A
JP2003506024A JP2001513966A JP2001513966A JP2003506024A JP 2003506024 A JP2003506024 A JP 2003506024A JP 2001513966 A JP2001513966 A JP 2001513966A JP 2001513966 A JP2001513966 A JP 2001513966A JP 2003506024 A JP2003506024 A JP 2003506024A
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nucleic acid
acid ligand
hgf
ligand
nucleic acids
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JP2003506024A5 (enExample
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ラックマン,ジュディ
ゴールド,ラリー
スティーブンス,アンドリュー
ジャンジック,ネボイサ
ラビン,ロス
ロチュリー,マイケル
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ギリード・サイエンシズ・インコーポレーテッド
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Priority claimed from US09/364,543 external-priority patent/US6331394B1/en
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Publication of JP2003506024A publication Critical patent/JP2003506024A/ja
Publication of JP2003506024A5 publication Critical patent/JP2003506024A5/ja
Pending legal-status Critical Current

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    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/16Aptamers
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/32Chemical structure of the sugar
    • C12N2310/3222'-R Modification
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475Assays involving growth factors
    • G01N2333/4753Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II

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JP2001513966A 1990-06-11 2000-07-24 肝細胞増殖因子/細胞分散因子(HGF)又はその受容体c−met、及びインテグリン類に対する核酸リガンド Pending JP2003506024A (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US53642890A 1990-06-11 1990-06-11
US09/364,543 1999-07-29
US09/364,539 US6344321B1 (en) 1990-06-11 1999-07-29 Nucleic acid ligands which bind to hepatocyte growth factor/scatter factor (HGF/SF) or its receptor c-met
US09/364,539 1999-07-29
US09/364,543 US6331394B1 (en) 1991-06-10 1999-07-29 Nucleic acid ligands to integrins
PCT/US2000/020139 WO2001009159A1 (en) 1990-06-11 2000-07-24 Nucleic acid ligands to hepatocyte growth factor/scatter factor (hgf/sf) or its receptor c-met and to integrins

Publications (2)

Publication Number Publication Date
JP2003506024A true JP2003506024A (ja) 2003-02-18
JP2003506024A5 JP2003506024A5 (enExample) 2007-09-13

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JP2001513966A Pending JP2003506024A (ja) 1990-06-11 2000-07-24 肝細胞増殖因子/細胞分散因子(HGF)又はその受容体c−met、及びインテグリン類に対する核酸リガンド

Country Status (5)

Country Link
US (2) US6344321B1 (enExample)
EP (1) EP1203007B1 (enExample)
JP (1) JP2003506024A (enExample)
CA (1) CA2381004A1 (enExample)
WO (1) WO2001009159A1 (enExample)

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WO2007004748A1 (ja) * 2005-07-05 2007-01-11 Ribomic Inc. 免疫グロブリンgに結合する核酸とその利用法
JP2007532662A (ja) * 2004-04-13 2007-11-15 (オーエスアイ)アイテツク・インコーポレーテツド 高分子量の立体的な基へ抱合された核酸アプタマー
WO2008062882A1 (en) * 2006-11-24 2008-05-29 Nec Soft, Ltd. NUCLEIC ACID MOLECULE CAPABLE OF BINDING TO RABBIT-DERIVED IgG ANTIBODY
JPWO2007004748A1 (ja) * 2005-07-05 2009-01-29 株式会社リボミック 免疫グロブリンgに結合する核酸とその利用法
JP2009523430A (ja) * 2006-01-17 2009-06-25 ソマロジック・インコーポレーテッド 試験試料の多重化分析
WO2012014890A1 (ja) * 2010-07-26 2012-02-02 Necソフト株式会社 c-Met結合核酸分子およびその用途
JPWO2013118877A1 (ja) * 2012-02-10 2015-05-11 株式会社ジャパニック 非ヒト幹細胞の培養上清を原材料とする化粧品又は皮膚再生促進剤、及びタンパク質のイオン導入方法
JP2015519548A (ja) * 2012-04-18 2015-07-09 レミン ワン, インテグリンβサブユニットの静脈血栓塞栓の診断における使用

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CA2936534C (en) 2001-07-23 2021-01-26 The Board Of Trustees Of Leland Stanford Junior University Methods and compositions for rnai mediated inhibition of gene expression in mammals
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EP1620547B1 (en) * 2003-04-21 2014-06-18 Archemix LLC Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
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US20110092452A1 (en) * 2008-03-05 2011-04-21 The Regents Of The University Of Michigan Compositions and methods for diagnosing and treating pancreatic cancer
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Cited By (14)

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Publication number Priority date Publication date Assignee Title
JP2007532662A (ja) * 2004-04-13 2007-11-15 (オーエスアイ)アイテツク・インコーポレーテツド 高分子量の立体的な基へ抱合された核酸アプタマー
JPWO2007004748A1 (ja) * 2005-07-05 2009-01-29 株式会社リボミック 免疫グロブリンgに結合する核酸とその利用法
WO2007004748A1 (ja) * 2005-07-05 2007-01-11 Ribomic Inc. 免疫グロブリンgに結合する核酸とその利用法
JP2015027301A (ja) * 2006-01-17 2015-02-12 ソマロジック・インコーポレーテッド 試験試料の多重化分析
JP2009523430A (ja) * 2006-01-17 2009-06-25 ソマロジック・インコーポレーテッド 試験試料の多重化分析
JP2017104122A (ja) * 2006-01-17 2017-06-15 ソマロジック・インコーポレーテッド 試験試料の多重化分析
WO2008062882A1 (en) * 2006-11-24 2008-05-29 Nec Soft, Ltd. NUCLEIC ACID MOLECULE CAPABLE OF BINDING TO RABBIT-DERIVED IgG ANTIBODY
JP2008125484A (ja) * 2006-11-24 2008-06-05 Nec Soft Ltd ウサギ由来のIgG抗体に結合性を有する核酸分子
US8283457B2 (en) 2006-11-24 2012-10-09 Nec Soft, Ltd. Nucleic acid molecule capable of binding to rabbit-derived IgG antibody
WO2012014890A1 (ja) * 2010-07-26 2012-02-02 Necソフト株式会社 c-Met結合核酸分子およびその用途
US8822667B2 (en) 2010-07-26 2014-09-02 Nec Solution Innovators, Ltd. Nucleic acid molecule capable of binding to c-Met and use thereof
JPWO2012014890A1 (ja) * 2010-07-26 2013-09-12 Necソフト株式会社 c−Met結合核酸分子およびその用途
JPWO2013118877A1 (ja) * 2012-02-10 2015-05-11 株式会社ジャパニック 非ヒト幹細胞の培養上清を原材料とする化粧品又は皮膚再生促進剤、及びタンパク質のイオン導入方法
JP2015519548A (ja) * 2012-04-18 2015-07-09 レミン ワン, インテグリンβサブユニットの静脈血栓塞栓の診断における使用

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CA2381004A1 (en) 2001-02-08
US6344321B1 (en) 2002-02-05
WO2001009159A1 (en) 2001-02-08

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