JP2003502365A5 - - Google Patents

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Publication number
JP2003502365A5
JP2003502365A5 JP2001504367A JP2001504367A JP2003502365A5 JP 2003502365 A5 JP2003502365 A5 JP 2003502365A5 JP 2001504367 A JP2001504367 A JP 2001504367A JP 2001504367 A JP2001504367 A JP 2001504367A JP 2003502365 A5 JP2003502365 A5 JP 2003502365A5
Authority
JP
Japan
Prior art keywords
group
ras antagonist
method described
geranyl
fts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001504367A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003502365A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2000/016863 external-priority patent/WO2000078303A1/en
Publication of JP2003502365A publication Critical patent/JP2003502365A/ja
Publication of JP2003502365A5 publication Critical patent/JP2003502365A5/ja
Pending legal-status Critical Current

Links

JP2001504367A 1999-06-18 2000-06-19 Ｒａｓアンタゴニストによる非悪性疾患処置 Pending JP2003502365A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14019299P 1999-06-18 1999-06-18
US60/140,192 1999-06-18
PCT/US2000/016863 WO2000078303A1 (en) 1999-06-18 2000-06-19 Non-malignant disease treatment with ras antagonists

Publications (2)

Publication Number Publication Date
JP2003502365A JP2003502365A (ja) 2003-01-21
JP2003502365A5 true JP2003502365A5 (https=) 2007-08-02

Family

ID=22490144

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001504367A Pending JP2003502365A (ja) 1999-06-18 2000-06-19 Ｒａｓアンタゴニストによる非悪性疾患処置

Country Status (6)

Country Link
US (1) US6462086B1 (https=)
EP (1) EP1187605A4 (https=)
JP (1) JP2003502365A (https=)
AU (1) AU5497000A (https=)
CA (1) CA2377254C (https=)
WO (1) WO2000078303A1 (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1483283A4 (en) 2002-03-13 2007-04-11 Signum Biosciences Inc MODULATION OF PROTEIN METHYLATION AND PHOSPHOPROTEIN PHOSPHATE
WO2004103352A1 (en) * 2003-05-23 2004-12-02 Ramot At Tel Aviv University, Ltd. Ras antagonists for treating neurodegenerative disorders
CA2535944A1 (en) * 2003-08-22 2005-03-03 University Of Virginia Patent Foundation Blockade of mtor to prevent a hormonal adaptive response
US20050216049A1 (en) * 2004-03-29 2005-09-29 Jones Donald K Vascular occlusive device with elastomeric bioresorbable coating
US7416757B2 (en) * 2004-04-08 2008-08-26 Cordis Neurovascular, Inc. Method of making active embolic coil
US8338648B2 (en) * 2004-06-12 2012-12-25 Signum Biosciences, Inc. Topical compositions and methods for epithelial-related conditions
EP2301528B1 (en) * 2004-08-18 2013-04-03 Kadmon Corporation, LLC Use of FTS for treating malignant disorders
US7923041B2 (en) 2005-02-03 2011-04-12 Signum Biosciences, Inc. Compositions and methods for enhancing cognitive function
CA2601777A1 (en) 2005-02-03 2006-08-10 Signum Biosciences, Inc. Compositions and methods for enhancing cognitive function
WO2007064448A2 (en) * 2005-11-28 2007-06-07 Ramot At Tel Aviv University, Ltd. Cancer treatment using fts and 2-deoxyglucose
WO2007116396A1 (en) * 2006-04-11 2007-10-18 Ramot At Tel Aviv University Ltd. Treatment of hematological malignancies with fts and a bcr-abl tyrosine kinase inhibitor
WO2008126094A1 (en) * 2007-04-17 2008-10-23 Ramot At Tel Aviv University Ltd. Treatment of myocarditis using fts
EP2523668A1 (en) * 2010-01-13 2012-11-21 Ramot at Tel-Aviv University Ltd Treatment of multiple sclerosis
WO2012104846A1 (en) * 2011-01-07 2012-08-09 Ramot At Tel-Aviv University Ltd. Ras inhibitors for treating diseases or pathological conditions characterized insulin resistance
ES2642843T3 (es) * 2011-10-07 2017-11-20 Pisces Therapeutics Llc Tratamiento de enfermedad maligna y no maligna con antagonistas de Ras
US9738614B2 (en) 2011-10-07 2017-08-22 Pisces Therapeutics, Llc Malignant and non-malignant disease treatment with Ras antagonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994028009A1 (en) * 1993-06-01 1994-12-08 Ludwig Institute For Cancer Research Fragments of neurofibromin (nf1) and method to reverse activated ras induced malignant transformation in mammalian cells
IL107587A (en) * 1993-11-12 1998-08-16 Univ Ramot Farnesyl geranyl or geranyl-geranyl derivatives pharmaceutical compositions containing them and methods for their preparation
US6011029A (en) * 1996-02-26 2000-01-04 Bristol-Myers Squibb Company Inhibitors of farnesyl protein transferase
WO1998002436A1 (en) * 1996-07-15 1998-01-22 Bristol-Myers Squibb Company Thiadioxobenzodiazepine inhibitors of farnesyl protein transferase
DE19644422C2 (de) * 1996-10-25 2000-06-15 Stefan Schulz Verwendung von Terpenen zur Behandlung von Autoimmunkrankheiten und bei Transplantat-Abstoßungsreaktionen
AU9315698A (en) * 1997-09-11 1999-03-29 Beth Israel Deaconess Medical Center (rin2), a novel inhibitor of ras-mediated signaling
AU735366B2 (en) * 1997-09-29 2001-07-05 Bristol-Myers Squibb Company Inhibitors of farnesyl protein transferase

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