JP2003502365A - Ｒａｓアンタゴニストによる非悪性疾患処置 - Google Patents
Ｒａｓアンタゴニストによる非悪性疾患処置Info
- Publication number
- JP2003502365A JP2003502365A JP2001504367A JP2001504367A JP2003502365A JP 2003502365 A JP2003502365 A JP 2003502365A JP 2001504367 A JP2001504367 A JP 2001504367A JP 2001504367 A JP2001504367 A JP 2001504367A JP 2003502365 A JP2003502365 A JP 2003502365A
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- fts
- ras
- mice
- cells
- treated
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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Landscapes
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- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14019299P | 1999-06-18 | 1999-06-18 | |
| US60/140,192 | 1999-06-18 | ||
| PCT/US2000/016863 WO2000078303A1 (en) | 1999-06-18 | 2000-06-19 | Non-malignant disease treatment with ras antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003502365A true JP2003502365A (ja) | 2003-01-21 |
| JP2003502365A5 JP2003502365A5 (https=) | 2007-08-02 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2001504367A Pending JP2003502365A (ja) | 1999-06-18 | 2000-06-19 | Ｒａｓアンタゴニストによる非悪性疾患処置 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6462086B1 (https=) |
| EP (1) | EP1187605A4 (https=) |
| JP (1) | JP2003502365A (https=) |
| AU (1) | AU5497000A (https=) |
| CA (1) | CA2377254C (https=) |
| WO (1) | WO2000078303A1 (https=) |
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| EP1483283A4 (en) | 2002-03-13 | 2007-04-11 | Signum Biosciences Inc | MODULATION OF PROTEIN METHYLATION AND PHOSPHOPROTEIN PHOSPHATE |
| WO2004103352A1 (en) * | 2003-05-23 | 2004-12-02 | Ramot At Tel Aviv University, Ltd. | Ras antagonists for treating neurodegenerative disorders |
| CA2535944A1 (en) * | 2003-08-22 | 2005-03-03 | University Of Virginia Patent Foundation | Blockade of mtor to prevent a hormonal adaptive response |
| US20050216049A1 (en) * | 2004-03-29 | 2005-09-29 | Jones Donald K | Vascular occlusive device with elastomeric bioresorbable coating |
| US7416757B2 (en) * | 2004-04-08 | 2008-08-26 | Cordis Neurovascular, Inc. | Method of making active embolic coil |
| US8338648B2 (en) * | 2004-06-12 | 2012-12-25 | Signum Biosciences, Inc. | Topical compositions and methods for epithelial-related conditions |
| EP2301528B1 (en) * | 2004-08-18 | 2013-04-03 | Kadmon Corporation, LLC | Use of FTS for treating malignant disorders |
| US7923041B2 (en) | 2005-02-03 | 2011-04-12 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
| CA2601777A1 (en) | 2005-02-03 | 2006-08-10 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
| WO2007064448A2 (en) * | 2005-11-28 | 2007-06-07 | Ramot At Tel Aviv University, Ltd. | Cancer treatment using fts and 2-deoxyglucose |
| WO2007116396A1 (en) * | 2006-04-11 | 2007-10-18 | Ramot At Tel Aviv University Ltd. | Treatment of hematological malignancies with fts and a bcr-abl tyrosine kinase inhibitor |
| WO2008126094A1 (en) * | 2007-04-17 | 2008-10-23 | Ramot At Tel Aviv University Ltd. | Treatment of myocarditis using fts |
| EP2523668A1 (en) * | 2010-01-13 | 2012-11-21 | Ramot at Tel-Aviv University Ltd | Treatment of multiple sclerosis |
| WO2012104846A1 (en) * | 2011-01-07 | 2012-08-09 | Ramot At Tel-Aviv University Ltd. | Ras inhibitors for treating diseases or pathological conditions characterized insulin resistance |
| ES2642843T3 (es) * | 2011-10-07 | 2017-11-20 | Pisces Therapeutics Llc | Tratamiento de enfermedad maligna y no maligna con antagonistas de Ras |
| US9738614B2 (en) | 2011-10-07 | 2017-08-22 | Pisces Therapeutics, Llc | Malignant and non-malignant disease treatment with Ras antagonists |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19644422A1 (de) * | 1996-10-25 | 1998-04-30 | Stefan Dr Schulz | Verwendung von Terpenen zur immunsuppressiven, antileukämischen und antiretroviralen Therapie |
| WO1999013079A1 (en) * | 1997-09-11 | 1999-03-18 | Beth Israel Deaconess Medical Center | Rin2, a novel inhibitor of ras-mediated signaling |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994028009A1 (en) * | 1993-06-01 | 1994-12-08 | Ludwig Institute For Cancer Research | Fragments of neurofibromin (nf1) and method to reverse activated ras induced malignant transformation in mammalian cells |
| IL107587A (en) * | 1993-11-12 | 1998-08-16 | Univ Ramot | Farnesyl geranyl or geranyl-geranyl derivatives pharmaceutical compositions containing them and methods for their preparation |
| US6011029A (en) * | 1996-02-26 | 2000-01-04 | Bristol-Myers Squibb Company | Inhibitors of farnesyl protein transferase |
| WO1998002436A1 (en) * | 1996-07-15 | 1998-01-22 | Bristol-Myers Squibb Company | Thiadioxobenzodiazepine inhibitors of farnesyl protein transferase |
| AU735366B2 (en) * | 1997-09-29 | 2001-07-05 | Bristol-Myers Squibb Company | Inhibitors of farnesyl protein transferase |
-
2000
- 2000-06-19 US US09/597,332 patent/US6462086B1/en not_active Expired - Lifetime
- 2000-06-19 CA CA002377254A patent/CA2377254C/en not_active Expired - Fee Related
- 2000-06-19 WO PCT/US2000/016863 patent/WO2000078303A1/en not_active Ceased
- 2000-06-19 EP EP00939967A patent/EP1187605A4/en not_active Ceased
- 2000-06-19 JP JP2001504367A patent/JP2003502365A/ja active Pending
- 2000-06-19 AU AU54970/00A patent/AU5497000A/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19644422A1 (de) * | 1996-10-25 | 1998-04-30 | Stefan Dr Schulz | Verwendung von Terpenen zur immunsuppressiven, antileukämischen und antiretroviralen Therapie |
| WO1999013079A1 (en) * | 1997-09-11 | 1999-03-18 | Beth Israel Deaconess Medical Center | Rin2, a novel inhibitor of ras-mediated signaling |
Also Published As
| Publication number | Publication date |
|---|---|
| US6462086B1 (en) | 2002-10-08 |
| AU5497000A (en) | 2001-01-09 |
| EP1187605A4 (en) | 2004-05-26 |
| CA2377254A1 (en) | 2000-12-28 |
| WO2000078303A1 (en) | 2000-12-28 |
| CA2377254C (en) | 2009-08-18 |
| EP1187605A1 (en) | 2002-03-20 |
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