JP2003501022A - イオンチャネルコンダクタンスを測定するための方法およびその組成物 - Google Patents
イオンチャネルコンダクタンスを測定するための方法およびその組成物Info
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- JP2003501022A JP2003501022A JP2001500744A JP2001500744A JP2003501022A JP 2003501022 A JP2003501022 A JP 2003501022A JP 2001500744 A JP2001500744 A JP 2001500744A JP 2001500744 A JP2001500744 A JP 2001500744A JP 2003501022 A JP2003501022 A JP 2003501022A
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- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
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- 238000005215 recombination Methods 0.000 description 1
- 230000003362 replicative effect Effects 0.000 description 1
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- 239000000523 sample Substances 0.000 description 1
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- 230000001953 sensory effect Effects 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 238000002741 site-directed mutagenesis Methods 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 229940063675 spermine Drugs 0.000 description 1
- 208000020431 spinal cord injury Diseases 0.000 description 1
- 210000000331 sympathetic ganglia Anatomy 0.000 description 1
- CFMYXEVWODSLAX-QOZOJKKESA-N tetrodotoxin Chemical compound O([C@@]([C@H]1O)(O)O[C@H]2[C@@]3(O)CO)[C@H]3[C@@H](O)[C@]11[C@H]2[C@@H](O)N=C(N)N1 CFMYXEVWODSLAX-QOZOJKKESA-N 0.000 description 1
- 229950010357 tetrodotoxin Drugs 0.000 description 1
- CFMYXEVWODSLAX-UHFFFAOYSA-N tetrodotoxin Natural products C12C(O)NC(=N)NC2(C2O)C(O)C3C(CO)(O)C1OC2(O)O3 CFMYXEVWODSLAX-UHFFFAOYSA-N 0.000 description 1
- 108010093171 tetrodotoxin-binding protein Proteins 0.000 description 1
- 230000003461 thalamocortical effect Effects 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 230000005030 transcription termination Effects 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 230000002463 transducing effect Effects 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 239000012096 transfection reagent Substances 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
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- 230000002792 vascular Effects 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
- 230000001196 vasorelaxation Effects 0.000 description 1
- 210000004515 ventral tegmental area Anatomy 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 108091023044 voltage-gated calcium channel activity Proteins 0.000 description 1
- 102000038650 voltage-gated calcium channel activity Human genes 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Thin Film Transistor (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13617499P | 1999-05-27 | 1999-05-27 | |
| US60/136,174 | 1999-05-27 | ||
| PCT/US2000/011862 WO2000073431A2 (en) | 1999-05-27 | 2000-05-25 | Methods and compositions for measuring ion channel conductance |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003501022A true JP2003501022A (ja) | 2003-01-14 |
| JP2003501022A5 JP2003501022A5 (cg-RX-API-DMAC7.html) | 2007-07-12 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2001500744A Withdrawn JP2003501022A (ja) | 1999-05-27 | 2000-05-25 | イオンチャネルコンダクタンスを測定するための方法およびその組成物 |
Country Status (5)
| Country | Link |
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| US (1) | US20070238168A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1180142A2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2003501022A (cg-RX-API-DMAC7.html) |
| AU (1) | AU4980200A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2000073431A2 (cg-RX-API-DMAC7.html) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008516604A (ja) * | 2004-10-15 | 2008-05-22 | モネル ケミカル センシズ センター | 哺乳動物の味覚細胞の培養方法 |
| JP2009186183A (ja) * | 2008-02-01 | 2009-08-20 | Seikagaku Kogyo Co Ltd | 関節痛の評価方法 |
| JP2012504966A (ja) * | 2008-10-09 | 2012-03-01 | ハワード ヒューズ メディカル インスティチュート | 新規なキメラリガンド開口型イオンチャネルおよびその使用方法 |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7214686B2 (en) | 1997-06-30 | 2007-05-08 | Targacept, Inc. | Pharmaceutical compositions and methods for effecting dopamine release |
| AU784644B2 (en) * | 1999-12-14 | 2006-05-18 | Pharmacia & Upjohn Company | Human ion channels |
| GB0003069D0 (en) * | 2000-02-11 | 2000-03-29 | Cambridge Drug Discovery Ltd | Improved assay |
| DE10006309A1 (de) | 2000-02-12 | 2001-08-23 | Aventis Pharma Gmbh | Verfahren zur Identifizierung von Substanzen, die die Aktivität von hyperpolarisationsaktivierten Kationen-kanälen modulieren |
| WO2002016358A2 (en) | 2000-08-18 | 2002-02-28 | Pharmacia & Upjohn Company | Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands) |
| WO2002016357A2 (en) | 2000-08-18 | 2002-02-28 | Pharmacia & Upjohn Company | Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands) |
| US6492385B2 (en) | 2000-08-18 | 2002-12-10 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
| WO2002017358A2 (en) | 2000-08-21 | 2002-02-28 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists) |
| US6599916B2 (en) | 2000-08-21 | 2003-07-29 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
| WO2002061074A1 (fr) * | 2001-01-30 | 2002-08-08 | Takeda Chemical Industries, Ltd. | Nouvelle proteine et adn la comprenant |
| PE20021019A1 (es) | 2001-04-19 | 2002-11-13 | Upjohn Co | Grupos azabiciclicos sustituidos |
| AR036041A1 (es) | 2001-06-12 | 2004-08-04 | Upjohn Co | Compuestos aromaticos heterociclicos sustituidos con quinuclidina y composiciones farmaceuticas que los contienen |
| AR036040A1 (es) | 2001-06-12 | 2004-08-04 | Upjohn Co | Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen |
| WO2003018585A1 (en) | 2001-08-24 | 2003-03-06 | Pharmacia & Upjohn Company | Substituted-heteroaryl-7-aza[2.2.1]bicycloheptanes for the treatment of disease |
| KR100614900B1 (ko) | 2001-10-02 | 2006-08-25 | 파마시아 앤드 업존 캄파니 엘엘씨 | 질병의 치료를 위한 아자비시클릭-치환된 융합-헤테로아릴화합물 |
| US6849620B2 (en) | 2001-10-26 | 2005-02-01 | Pfizer Inc | N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease |
| CA2466375A1 (en) | 2001-11-08 | 2003-05-15 | Pharmacia & Upjohn Company | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease |
| EP1442037A1 (en) | 2001-11-09 | 2004-08-04 | PHARMACIA & UPJOHN COMPANY | Azabicyclic-phenyl-fused-heterocyclic compounds and their use as alpha7 nachr ligands |
| AU2003210730A1 (en) | 2002-02-15 | 2003-09-09 | Pharmacia And Upjohn Company | Azabicyclo-substituted benzoylamides and thioamides for treatment of cns-related disorders |
| CA2476624A1 (en) | 2002-02-19 | 2003-08-28 | Pharmacia & Upjohn Company | Azabicyclic compounds for the treatment of disease |
| US6858613B2 (en) | 2002-02-19 | 2005-02-22 | Pfizer Inc. | Fused bicyclic-N-bridged-heteroaromatic carboxamides for the treatment of disease |
| BR0307874A (pt) * | 2002-02-20 | 2004-12-28 | Upjohn Co | Atividade de compostos azabicìclicos com receptor de acetilcolina nicotìnica alfa7 |
| CA2487236A1 (en) | 2002-05-09 | 2003-11-20 | Memory Pharmaceuticals Corporation | Qm-7 and qt-6 cells transfected with mutant cell surface expressed channel receptors and assays using the transfected cells |
| EP1542999A1 (en) | 2002-08-01 | 2005-06-22 | Pharmacia & Upjohn Company LLC | 1h-pyrazole and 1h-pyrrole-azabicyclic compounds with alfa-7 nachr activity |
| EP1581558A2 (en) * | 2003-01-07 | 2005-10-05 | Neuromed Technologies, Inc. | Fluorescence based t-type channel assay |
| ATE482959T1 (de) | 2005-08-22 | 2010-10-15 | Targacept Inc | Heteroarylsubstituierte diazatricycloalkane, verfahren zu deren herstellung und deren anwendung |
| US20110098312A1 (en) | 2008-05-12 | 2011-04-28 | Targacept ,Inc | Methods for preventing the development of retinopathy by the oral administration of nnr ligands |
| BR112012027282B1 (pt) | 2010-04-26 | 2020-09-29 | Novartis Ag | Meio de cultura de células aperfeiçoado e processo para a produção de um polipeptídeo recombinante |
| JP2021503960A (ja) | 2017-11-27 | 2021-02-15 | コーダ バイオセラピューティクス， インコーポレイテッド | 神経疾患のための組成物および方法 |
| CN111378025A (zh) * | 2020-03-26 | 2020-07-07 | 集美大学 | 河豚毒素结合蛋白tfPSTBP2、核苷酸序列、其多克隆抗体及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5670113A (en) * | 1991-12-20 | 1997-09-23 | Sibia Neurosciences, Inc. | Automated analysis equipment and assay method for detecting cell surface protein and/or cytoplasmic receptor function using same |
| GB2286397C (en) * | 1993-03-08 | 1997-09-10 | Sibia Neurosciences Inc | Human neuronal nicotinic acetylcholine receptor compositions and methods of applying same |
| US6323000B2 (en) * | 1996-12-20 | 2001-11-27 | Clark A. Briggs | Variant human α7 acetylcholine receptor subunit, and methods of production and uses thereof |
| AU9673198A (en) * | 1997-10-02 | 1999-04-27 | Aclara Biosciences, Inc. | Capillary assays involving separation of free and bound species |
-
2000
- 2000-05-25 AU AU49802/00A patent/AU4980200A/en not_active Abandoned
- 2000-05-25 EP EP00932007A patent/EP1180142A2/en not_active Withdrawn
- 2000-05-25 WO PCT/US2000/011862 patent/WO2000073431A2/en not_active Ceased
- 2000-05-25 JP JP2001500744A patent/JP2003501022A/ja not_active Withdrawn
-
2007
- 2007-02-12 US US11/705,209 patent/US20070238168A1/en not_active Abandoned
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008516604A (ja) * | 2004-10-15 | 2008-05-22 | モネル ケミカル センシズ センター | 哺乳動物の味覚細胞の培養方法 |
| JP2009186183A (ja) * | 2008-02-01 | 2009-08-20 | Seikagaku Kogyo Co Ltd | 関節痛の評価方法 |
| JP2012504966A (ja) * | 2008-10-09 | 2012-03-01 | ハワード ヒューズ メディカル インスティチュート | 新規なキメラリガンド開口型イオンチャネルおよびその使用方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000073431A2 (en) | 2000-12-07 |
| EP1180142A2 (en) | 2002-02-20 |
| WO2000073431A3 (en) | 2001-05-03 |
| US20070238168A1 (en) | 2007-10-11 |
| AU4980200A (en) | 2000-12-18 |
| WO2000073431B1 (en) | 2001-07-19 |
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