JP2003500363A - 滲出を伴う中耳炎を有するヒトにおけるｂｐｉタンパク質産物の治療的使用 - Google Patents
滲出を伴う中耳炎を有するヒトにおけるｂｐｉタンパク質産物の治療的使用Info
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- JP2003500363A JP2003500363A JP2000619451A JP2000619451A JP2003500363A JP 2003500363 A JP2003500363 A JP 2003500363A JP 2000619451 A JP2000619451 A JP 2000619451A JP 2000619451 A JP2000619451 A JP 2000619451A JP 2003500363 A JP2003500363 A JP 2003500363A
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- bpi
- protein product
- bpi protein
- ome
- middle ear
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- 230000003389 potentiating effect Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 208000002574 reactive arthritis Diseases 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- 210000001533 respiratory mucosa Anatomy 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000003106 tissue adhesive Substances 0.000 description 1
- 229950003937 tolonium Drugs 0.000 description 1
- HNONEKILPDHFOL-UHFFFAOYSA-M tolonium chloride Chemical compound [Cl-].C1=C(C)C(N)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 HNONEKILPDHFOL-UHFFFAOYSA-M 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 238000011277 treatment modality Methods 0.000 description 1
- 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A61K38/1751—Bactericidal/permeability-increasing protein [BPI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Marine Sciences & Fisheries (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13614899P | 1999-05-24 | 1999-05-24 | |
| US60/136,148 | 1999-05-24 | ||
| PCT/US2000/014496 WO2000071149A2 (en) | 1999-05-24 | 2000-05-24 | Therapeutic uses of bpi protein products in humans with otitis media with effusion |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003500363A true JP2003500363A (ja) | 2003-01-07 |
| JP2003500363A5 JP2003500363A5 (https=) | 2007-07-19 |
Family
ID=22471532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000619451A Pending JP2003500363A (ja) | 1999-05-24 | 2000-05-24 | 滲出を伴う中耳炎を有するヒトにおけるｂｐｉタンパク質産物の治療的使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6670327B1 (https=) |
| EP (1) | EP1181039A2 (https=) |
| JP (1) | JP2003500363A (https=) |
| AU (1) | AU5292300A (https=) |
| CA (1) | CA2373262A1 (https=) |
| WO (1) | WO2000071149A2 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5198541A (en) * | 1987-08-11 | 1993-03-30 | New York University | Dna encoding bactericidal/permeability-increasing proteins |
| WO2004052236A2 (en) * | 2002-12-06 | 2004-06-24 | Arriva Pharmaceuticals, Inc. | Methods and compositions for treatment of otitis media |
| KR101235507B1 (ko) * | 2003-02-28 | 2013-02-20 | 추가이 세이야쿠 가부시키가이샤 | 단백질을 함유하는 안정화 제제 |
| AU2005282571A1 (en) * | 2004-09-03 | 2006-03-16 | Piedmont Pharmaceuticals, Llc | Methods for transmembrane treatment and prevention of otitis media |
| US20070173463A1 (en) * | 2006-01-20 | 2007-07-26 | Brechtelsbauer Paul B | Method and composition for treating otitis media |
| AU2007221150B2 (en) * | 2006-02-27 | 2012-09-20 | Ahm Technologies, Inc. | Eustachian tube device and method |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02504515A (ja) * | 1987-08-11 | 1990-12-20 | ニューヨーク ユニバーシティ | 生物学的に活性な殺菌性／透過性増大蛋白質断片 |
| JPH10500101A (ja) * | 1994-05-26 | 1998-01-06 | アボツト・ラボラトリーズ | インフルエンザ菌のヒト細胞への付着の阻害 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5198541A (en) * | 1987-08-11 | 1993-03-30 | New York University | Dna encoding bactericidal/permeability-increasing proteins |
| US5171739A (en) * | 1989-02-14 | 1992-12-15 | Incyte Pharmaceuticals, Inc. | Treatment of endotoxin-associated shock and preventation thereof using a BPI protein |
| US6121427A (en) * | 1994-10-24 | 2000-09-19 | Connaught Laboratories Limited | Major outer membrane protein CD of branhamella |
| US6013631A (en) * | 1998-06-19 | 2000-01-11 | Xoma Corporation | Bactericidal/permeability-increasing protein (BPI) deletion analogs |
| US6350742B1 (en) * | 1998-09-11 | 2002-02-26 | Carter-Wallace, Inc. | Compositions and methods for treating infections of the ear |
-
2000
- 2000-05-24 JP JP2000619451A patent/JP2003500363A/ja active Pending
- 2000-05-24 WO PCT/US2000/014496 patent/WO2000071149A2/en not_active Ceased
- 2000-05-24 AU AU52923/00A patent/AU5292300A/en not_active Abandoned
- 2000-05-24 CA CA002373262A patent/CA2373262A1/en not_active Abandoned
- 2000-05-24 EP EP00937797A patent/EP1181039A2/en not_active Withdrawn
- 2000-06-05 US US09/586,850 patent/US6670327B1/en not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02504515A (ja) * | 1987-08-11 | 1990-12-20 | ニューヨーク ユニバーシティ | 生物学的に活性な殺菌性／透過性増大蛋白質断片 |
| JPH10500101A (ja) * | 1994-05-26 | 1998-01-06 | アボツト・ラボラトリーズ | インフルエンザ菌のヒト細胞への付着の阻害 |
Non-Patent Citations (1)
| Title |
|---|
| JPN6010021243, Ｍｉｔｃｈｅｌｌ Ｂ． Ｍｉｌｌｅｒ, Ａｒｃｈ． Ｏｔｏｌａｒｙｎｇｏｌ． Ｈｅａｄ Ｎｅｃｋ Ｓｕｒｇ．, 1990, Ｖｏｌ．１１６, Ｐａｇｅｓ ３３５−３３７ * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1181039A2 (en) | 2002-02-27 |
| WO2000071149A3 (en) | 2001-06-28 |
| WO2000071149A2 (en) | 2000-11-30 |
| CA2373262A1 (en) | 2000-11-30 |
| AU5292300A (en) | 2000-12-12 |
| US6670327B1 (en) | 2003-12-30 |
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