JP2003500071A5 - - Google Patents
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- Publication number
- JP2003500071A5 JP2003500071A5 JP2000620352A JP2000620352A JP2003500071A5 JP 2003500071 A5 JP2003500071 A5 JP 2003500071A5 JP 2000620352 A JP2000620352 A JP 2000620352A JP 2000620352 A JP2000620352 A JP 2000620352A JP 2003500071 A5 JP2003500071 A5 JP 2003500071A5
- Authority
- JP
- Japan
- Prior art keywords
- allele
- alleles
- linkage disequilibrium
- cardiovascular disorder
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108700028369 Alleles Proteins 0.000 description 84
- 101001033249 Homo sapiens Interleukin-1 beta Proteins 0.000 description 21
- 102100039065 Interleukin-1 beta Human genes 0.000 description 21
- 208000024172 Cardiovascular disease Diseases 0.000 description 17
- 238000000034 method Methods 0.000 description 15
- 101001002634 Homo sapiens Interleukin-1 alpha Proteins 0.000 description 12
- 102100020881 Interleukin-1 alpha Human genes 0.000 description 12
- 102100026018 Interleukin-1 receptor antagonist protein Human genes 0.000 description 12
- 101710144554 Interleukin-1 receptor antagonist protein Proteins 0.000 description 12
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 9
- 108091034117 Oligonucleotide Proteins 0.000 description 9
- 238000009396 hybridization Methods 0.000 description 6
- 230000003321 amplification Effects 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 5
- 238000003199 nucleic acid amplification method Methods 0.000 description 5
- 108020004707 nucleic acids Proteins 0.000 description 4
- 150000007523 nucleic acids Chemical class 0.000 description 4
- 102000039446 nucleic acids Human genes 0.000 description 4
- 108091008146 restriction endonucleases Proteins 0.000 description 3
- 101710163270 Nuclease Proteins 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 238000012163 sequencing technique Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 1
- 238000001976 enzyme digestion Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32039599A | 1999-05-26 | 1999-05-26 | |
| US09/320,395 | 1999-05-26 | ||
| US09/431,352 US6524795B1 (en) | 1997-03-10 | 1999-11-01 | Diagnostics for cardiovascular disorders |
| US09/431,352 | 1999-11-01 | ||
| PCT/US2000/014775 WO2000072015A2 (en) | 1999-05-26 | 2000-05-26 | Diagnostics and therapeutics for cardiovascular disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003500071A JP2003500071A (ja) | 2003-01-07 |
| JP2003500071A5 true JP2003500071A5 (enExample) | 2006-03-16 |
Family
ID=26982474
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000620352A Pending JP2003500071A (ja) | 1999-05-26 | 2000-05-26 | 心血管障害のための診断及び治療 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6524795B1 (enExample) |
| EP (2) | EP1192279B1 (enExample) |
| JP (1) | JP2003500071A (enExample) |
| AT (1) | ATE407221T1 (enExample) |
| AU (1) | AU780318B2 (enExample) |
| CA (1) | CA2374916C (enExample) |
| DE (1) | DE60040150D1 (enExample) |
| ES (1) | ES2313894T3 (enExample) |
| IL (1) | IL146631A0 (enExample) |
| WO (1) | WO2000072015A2 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7820383B2 (en) * | 1997-03-10 | 2010-10-26 | Interleukin Genetics, Inc. | Method for diagnosing myocardial infarction |
| US6524795B1 (en) * | 1997-03-10 | 2003-02-25 | Interleukin Genetics, Inc. | Diagnostics for cardiovascular disorders |
| US20050032077A1 (en) * | 1998-03-10 | 2005-02-10 | Duff Gordon W. | Detecting genetic predisposition to sight-threatening diabetic retinopathy |
| US6291180B1 (en) * | 1999-09-29 | 2001-09-18 | American Registry Of Pathology | Ultrasound-mediated high-speed biological reaction and tissue processing |
| US20030124524A1 (en) * | 2000-06-23 | 2003-07-03 | Kenneth Kornman | Screening assays for identifying modulators of the inflammatory or immune response |
| US20060235366A1 (en) * | 2000-12-20 | 2006-10-19 | Fox Hollow Technologies, Inc. | Method of evaluating a treatment for vascular disease |
| US20050154407A1 (en) * | 2000-12-20 | 2005-07-14 | Fox Hollow Technologies, Inc. | Method of evaluating drug efficacy for treating atherosclerosis |
| US20060032508A1 (en) * | 2000-12-20 | 2006-02-16 | Fox Hollow Technologies, Inc. | Method of evaluating a treatment for vascular disease |
| DK1385931T3 (da) * | 2001-05-01 | 2007-10-22 | Gerhard Kamil | Anvendelse af fluid bed-teknologi til brygning |
| US20030152947A1 (en) * | 2001-06-15 | 2003-08-14 | Crossman David C. | Methods for detecting and treating the early onset of aging-related conditions |
| US20040137066A1 (en) * | 2001-11-26 | 2004-07-15 | Swaminathan Jayaraman | Rationally designed therapeutic intravascular implant coating |
| EP1463745A4 (en) * | 2001-11-19 | 2007-11-07 | Interleukin Genetics Inc | FUNCTIONAL POLYMORPHISMS OF THE INTERLEUKIN-1 SITE AFFECTING TRANSCRIPTION AND SUSCEPTIBILITY TO INFLAMMATORY AND INFECTIOUS DISEASES |
| US20080311581A1 (en) * | 2001-11-19 | 2008-12-18 | David Wyllie | Functional polymorphisms of the interleukin-1 locus affecting transcription and susceptibility to inflammatory and infectious diseases |
| US20070264645A1 (en) * | 2002-01-25 | 2007-11-15 | Kenneth Kornman | IL-1 gene cluster and associated inflammatory polymorphisms and haplotypes |
| WO2003064600A2 (en) * | 2002-01-25 | 2003-08-07 | Interleukin Genetics, Inc. | The il-1 gene cluster and associated inflammatory polymorphisms and haplotypes |
| US20040148013A1 (en) * | 2002-04-18 | 2004-07-29 | Epstein Stephen E | Stent-based delivery statins to prevent restenosis |
| US20030220556A1 (en) * | 2002-05-20 | 2003-11-27 | Vespro Ltd. | Method, system and device for tissue characterization |
| US7482116B2 (en) | 2002-06-07 | 2009-01-27 | Dna Genotek Inc. | Compositions and methods for obtaining nucleic acids from sputum |
| BR0314552A (pt) * | 2002-09-30 | 2005-08-09 | Novartis Ag | Métodos para prognosticar elevações de colesterol durante terapia imunossupressora |
| US6979294B1 (en) * | 2002-12-13 | 2005-12-27 | California Institute Of Technology | Split-screen display system and standardized methods for ultrasound image acquisition and processing for improved measurements of vascular structures |
| US20050108045A1 (en) * | 2003-11-17 | 2005-05-19 | Jiao Gong | Method of network hospital of reclassification of diseases that have been made a diagnosis |
| CA2566257A1 (en) * | 2004-05-07 | 2005-11-24 | Applera Corporation | Genetic polymorphisms associated with vascular diseases, methods of detection and uses thereof |
| US8034553B2 (en) * | 2004-06-24 | 2011-10-11 | Kimberly-Clark Worldwide, Inc. | Biomarkers for wound healing |
| US7309589B2 (en) | 2004-08-20 | 2007-12-18 | Vironix Llc | Sensitive detection of bacteria by improved nested polymerase chain reaction targeting the 16S ribosomal RNA gene and identification of bacterial species by amplicon sequencing |
| WO2006093973A2 (en) * | 2005-02-28 | 2006-09-08 | University Of Massachusetts | Biomarkers of vulnerable a therosclerotic plaques and methods of use |
| US7794413B2 (en) * | 2005-04-19 | 2010-09-14 | Ev3, Inc. | Libraries and data structures of materials removed by debulking catheters |
| US20070099239A1 (en) * | 2005-06-24 | 2007-05-03 | Raymond Tabibiazar | Methods and compositions for diagnosis and monitoring of atherosclerotic cardiovascular disease |
| US20060293709A1 (en) * | 2005-06-24 | 2006-12-28 | Bojarski Raymond A | Tissue repair device |
| CN109187944A (zh) * | 2005-08-02 | 2019-01-11 | 埃克斯生物科技公司 | 使用IL-1α自身抗体诊断、治疗和预防血管疾病 |
| US8105775B2 (en) * | 2005-10-25 | 2012-01-31 | Interleukin Genetics, Inc. | IL-1 gene cluster and associated inflammatory polymorphisms and haplotypes |
| WO2008060627A2 (en) * | 2006-11-15 | 2008-05-22 | Interleukin Genetics, Inc. | The il-1 gene cluster, insulin resistance and coronary artery disease associated polymorphisms and haplotypes and methods of using same |
| US20110245283A1 (en) * | 2009-12-21 | 2011-10-06 | Murata Glen H | Methods for predicting the response to statins |
| US8906613B2 (en) * | 2012-02-14 | 2014-12-09 | Lasse Folkersen | Method and kit for performing profiling of endarterectomy patients |
| RU2557916C1 (ru) * | 2013-12-27 | 2015-07-27 | государственное бюджетное образовательное учреждение высшего профессионального образования "Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации | Способ диагностики окклюзирующих поражений сосудов у пациентов с сердечно-сосудистыми заболеваниями |
| US9459201B2 (en) | 2014-09-29 | 2016-10-04 | Zyomed Corp. | Systems and methods for noninvasive blood glucose and other analyte detection and measurement using collision computing |
| CA3011363A1 (en) | 2016-01-12 | 2017-07-20 | Interleukin Genetics, Inc. | Methods for predicting response to treatment |
| US9554738B1 (en) | 2016-03-30 | 2017-01-31 | Zyomed Corp. | Spectroscopic tomography systems and methods for noninvasive detection and measurement of analytes using collision computing |
| US10329620B2 (en) | 2017-01-12 | 2019-06-25 | Cardioforecast Ltd. | Methods and kits for treating cardiovascular disease |
| CA3142662A1 (en) | 2019-06-06 | 2020-12-10 | Sitokine Limited | Compositions and methods for treating lung, colorectal and breast cancer |
| WO2021028469A1 (en) | 2019-08-12 | 2021-02-18 | Sitokine Limited | Compositions and methods for treating cytokine release syndrome and neurotoxicity |
| WO2021205013A1 (en) | 2020-04-09 | 2021-10-14 | Sitokine Limited | Compositions and methods for treating covid-19 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4582788A (en) | 1982-01-22 | 1986-04-15 | Cetus Corporation | HLA typing method and cDNA probes used therein |
| US5110920A (en) | 1982-01-22 | 1992-05-05 | Cetus Corporation | HLA typing method and DNA probes used therein |
| US4623619A (en) | 1982-03-03 | 1986-11-18 | Nordisk Insulinlaboratorium | Method for the determination of liability in human individuals to develop atherosclerosis |
| GB8311018D0 (en) | 1983-04-22 | 1983-05-25 | Amersham Int Plc | Detecting mutations in dna |
| US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| US4833080A (en) | 1985-12-12 | 1989-05-23 | President And Fellows Of Harvard College | Regulation of eucaryotic gene expression |
| US4998617A (en) | 1986-09-15 | 1991-03-12 | Laura Lupton Inc | Facial cosmetic liquid make up kit |
| US5268267A (en) | 1987-08-21 | 1993-12-07 | The General Hospital Corporation | Method for diagnosing small cell carcinoma |
| US4968607A (en) | 1987-11-25 | 1990-11-06 | Immunex Corporation | Interleukin-1 receptors |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5459039A (en) | 1989-05-12 | 1995-10-17 | Duke University | Methods for mapping genetic mutations |
| FR2650840B1 (fr) | 1989-08-11 | 1991-11-29 | Bertin & Cie | Procede rapide de detection et/ou d'identification d'une seule base sur une sequence d'acide nucleique, et ses applications |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US6004744A (en) | 1991-03-05 | 1999-12-21 | Molecular Tool, Inc. | Method for determining nucleotide identity through extension of immobilized primer |
| WO1992015694A1 (en) | 1991-03-08 | 1992-09-17 | The Salk Institute For Biological Studies | Flp-mediated gene modification in mammalian cells, and compositions and cells useful therefor |
| DE69433811T2 (de) | 1993-01-07 | 2005-06-23 | Sequenom, Inc., San Diego | Dns - sequenzierung durch massenspektronomie |
| GB9301453D0 (en) | 1993-01-26 | 1993-03-17 | Clonit Spa | Nucleotide proves |
| US5593826A (en) | 1993-03-22 | 1997-01-14 | Perkin-Elmer Corporation, Applied Biosystems, Inc. | Enzymatic ligation of 3'amino-substituted oligonucleotides |
| US5658729A (en) * | 1994-10-11 | 1997-08-19 | The University Of British Columbia | Method, reagent and kit for evaluating susceptibility to premature atherosclerosis |
| US5686246A (en) * | 1995-08-03 | 1997-11-11 | Kornman; Kenneth S. | Detecting genetic predisposition to periodontal disease |
| US5942390A (en) | 1996-01-12 | 1999-08-24 | Cedars-Sinai Medical Center | Method of diagnosing predisposition for ulcerative colitis in Jewish population by detection of interleukin-1 receptor antagonist polymorphism |
| US5698399A (en) * | 1996-04-05 | 1997-12-16 | Duff; Gordon W. | Detecting genetic predisposition for osteoporosis |
| GB9621129D0 (en) | 1996-10-10 | 1996-11-27 | Duff Gordon W | Detecting genetic predisposition to sight-threatening diabetic retinopathy |
| US6720141B1 (en) * | 1999-11-01 | 2004-04-13 | Interleukin Genetics, Inc. | Diagnostics and therapeutics for restenosis |
| US6210877B1 (en) | 1997-03-10 | 2001-04-03 | Interleukin Genetics, Inc. | Prediction of coronary artery disease |
| US6524795B1 (en) * | 1997-03-10 | 2003-02-25 | Interleukin Genetics, Inc. | Diagnostics for cardiovascular disorders |
| GB9711040D0 (en) * | 1997-05-29 | 1997-07-23 | Duff Gordon W | Prediction of inflammatory disease |
| GB9723553D0 (en) * | 1997-11-07 | 1998-01-07 | Duff Gordon W | Prediction of the risk of chronic obstructive airway disease |
| WO1999054707A2 (en) * | 1998-04-21 | 1999-10-28 | Interleukin Genetics, Inc. | Fetal testing for prediction of low birth weight |
| JP2003500069A (ja) * | 1999-05-24 | 2003-01-07 | インタールーキン ジェネティックス インク | 再狭窄の診断及び治療薬 |
-
1999
- 1999-11-01 US US09/431,352 patent/US6524795B1/en not_active Expired - Lifetime
-
2000
- 2000-05-26 EP EP00939389A patent/EP1192279B1/en not_active Expired - Lifetime
- 2000-05-26 JP JP2000620352A patent/JP2003500071A/ja active Pending
- 2000-05-26 CA CA2374916A patent/CA2374916C/en not_active Expired - Lifetime
- 2000-05-26 WO PCT/US2000/014775 patent/WO2000072015A2/en not_active Ceased
- 2000-05-26 AU AU54480/00A patent/AU780318B2/en not_active Ceased
- 2000-05-26 IL IL14663100A patent/IL146631A0/xx unknown
- 2000-05-26 DE DE60040150T patent/DE60040150D1/de not_active Expired - Lifetime
- 2000-05-26 EP EP08015454A patent/EP2071040A3/en not_active Withdrawn
- 2000-05-26 AT AT00939389T patent/ATE407221T1/de not_active IP Right Cessation
- 2000-05-26 ES ES00939389T patent/ES2313894T3/es not_active Expired - Lifetime
-
2002
- 2002-12-13 US US10/320,360 patent/US20030175764A1/en not_active Abandoned
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