JP2003306441A - Skin care preparation - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a skin care preparation which has a synergistically reinforced moisture-retaining effect and an excellent skin dry state-improving effect. <P>SOLUTION: This skin care preparation comprises the extract of a plant belonging to the genus Clintonia in the family Uvulariaceae and one or more moisture-retaining ingredients selected from amino acids, peptides, polyhydric alcohols, higher alcohols and their derivatives, phospholipids, glycolipids and steroids. Clintonia borealis and/or Clintonia udensis are suitably used as the plant belonging to the genus Clintonia. <P>COPYRIGHT: (C)2004,JPO

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for skin which has a synergistically improved moisturizing effect and exhibits a high moisturizing effect.

[0002]

2. Description of the Related Art Conventionally, in skin external preparations such as cosmetics, quasi drugs and external medicines, amino acids, peptides, polyhydric alcohols, higher alcohols and their derivatives, phospholipids, glycolipids, steroids are used as moisturizing ingredients. Contains moisturizing ingredients such as algae and algae extracts. However, in the external preparation for skin containing these moisturizing ingredients, the moisturizing effect is not sufficient, or it is necessary to add a considerably large amount in order to obtain a sufficient effect, which imparts an unpleasant odor or color to the external preparation for skin. There was something that could happen.

[0003]

DISCLOSURE OF THE INVENTION The object of the present invention is to solve the above-mentioned problems and to obtain a skin external preparation having a synergistically improved moisturizing effect and exhibiting a high moisturizing effect.

[0004]

Upon solving the above problems SUMMARY OF THE INVENTION, it was subjected to various studies, Uburariasea (Uvul
The combination of an extract from a plant of the genus ariaceae ( Clintonia ) and a specific moisturizer enhances the moisturizing effect synergistically, and is stable, and is safe for skin irritation and skin sensitization. It was found that an external preparation for skin free from the above problem can be obtained, and the present invention has been completed.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION Embodiments of the present invention will be described.

[0006] Uburariasea used in obtaining the skin external preparation according to the present invention (Uvulariaceae) family clintonia udensis (Clin
Tonia ) plants are sometimes classified in the Liliaceae family and are perennial plants that are isolated and distributed in North America and East Asia. C. andrewsia
na ), Clintonia borealis ( C. borealis ), Clintonia udensis ( C. udensis ), Clintonia umbellulata ( C. umbellulata ), Clintonia uniflora ( C. uniflora ) are known and available. For ease of use, C. borealis ( C. borealis )
s ), Clintonia udensis ( C. udensis ) can be preferably used. For extraction, flowers, fruits, stems, leaves,
Use one or more species selected from each part such as roots, or whole grass.

These may be subjected to the extraction operation as they are, but considering the extraction efficiency, it is preferable to carry out the extraction after performing processing such as shredding, drying and crushing. The extraction is performed by immersing it in an extraction solvent. Stirring to improve extraction efficiency,
You may homogenize in an extraction solvent. As the extraction temperature, it is appropriate to set the temperature to about 5 ° C. to a temperature not higher than the boiling point of the extraction solvent. The extraction time varies depending on the type of extraction solvent and the extraction temperature, but it is suitable to be about 4 hours to 14 days. Alternatively, an extraction method using a supercritical fluid or a subcritical fluid can be used.

Water is most preferably used as the extraction solvent, but in addition to this, lower alcohols such as methanol, ethanol, propanol and isopropanol, 1,
Polyhydric alcohols such as 3-butylene glycol, propylene glycol, dipropylene glycol and glycerin,
Ethers such as diethyl ether and dipropyl ether, esters such as ethyl acetate and butyl acetate, polar organic solvents such as ketones such as acetone and ethyl methyl ketone, physiological saline, phosphate buffer, phosphate buffer Physiological saline, petroleum ether, n-hexane, n-
One or two selected from hydrocarbons such as pentane, n-butane, n-octane and cyclohexane, non-polar or low polar solvents such as carbon tetrachloride, chloroform, dichloromethane, trichloroethylene, benzene and toluene.
More than one solvent can be preferably used. Further, a supercritical fluid or a subcritical fluid such as water, carbon dioxide, ethylene, propylene, ethanol, methanol, ammonia or the like may be used for the extraction, and in this case, the above-mentioned solvent may be used as an entrainer.

The extract can be added to the base of the external preparation as it is, but the concentrated and dried product can be redissolved in water or a polar solvent, or can be purified or fractionated by decolorization, deodorization, desalting, etc. You may use it after performing a process. For storage, it is preferable to freeze-dry after purification and dissolve in a solvent before use. Alternatively, they can be encapsulated in vesicles such as liposomes or microcapsules.

The amount of the plant extract of the genus Swallowweed ( Clintonia ) of the family Uvulariaceae belonging to the external preparation for skin is not particularly limited. As 0.00
It is preferably in the range of 01 to 10% by weight, more preferably 0.001 to 5% by weight.

In the present invention, Uvulariacea ( Uvulariacea)
e ) Plant extracts of the genus Clintonia , amino acids, peptides, polyhydric alcohols and salts thereof, and one or more moisturizing ingredients selected from their derivatives, phospholipids, glycolipids and steroids Used together.

There are no particular restrictions on the type or origin of the amino acid used in the present invention, and glycine, threonine, tyrosine, valine, leucine, arginine, proline, aspartic acid, glutamic acid, lysine, threonine, histidine,
Examples thereof include alanine, serine, glycine, salts thereof, and derivatives thereof. Among the above amino acids, their salts and their derivatives, trimethylglycine is most preferable from the viewpoint of the effect of the present invention.

These amino acids, their salts and their derivatives may be used alone or in combination of two or more, and 0.0001 to
It is preferable to add 10% by weight, particularly 0.001 to 8
It is preferable to add the composition in a weight percentage.

The kind and origin of the peptide used in the present invention is not particularly limited, and glutathione and salts thereof and derivatives thereof, collagen, elastin, albumin, sericin, fibroin and hydrolyzates thereof and salts thereof, and these And the like.

These peptides can be used alone or in combination of two or more, and it is preferable to add 0.0001 to 10% by weight in the whole composition, and particularly 0.001 to 8%. It is preferable to add the composition in a weight percentage.

The type and base of the polyhydric alcohol and its derivative used in the present invention are not particularly limited, and glycerin, diglycerin, polyglycerin, erythritol, arabitol, xylitol, 1,3-butylene glycol, 1,2-pentane. Examples include diol, polyethylene glycol, dipropylene glycol, propylene glycol and the like.

These polyhydric alcohols can be used singly or in combination of two or more, and it is preferable to add 0.01 to 90% by weight in the whole composition,
It is particularly preferable to add 0.01 to 50% by weight, more preferably 0.05 to 20% by weight.

The phospholipids and glycolipids used in the present invention include phosphatidic acid, choline phosphoglyceride, ethanolamine phosphoglyceride, N-acylphosphatidylethanolamine, serine phosphoglyceride, glycerol phosphoglyceride, glycerophosphoric acid phosphoglyceride, phosphatidyl glycerol phosphonate. Glycerophospholipids such as glycerides, sphingomyelin, ceramide phosphoethanolamine, ceramide phosphoglycerol,
Ceramide phosphoglycerol phosphate, ceramide phosphoinositol and other sphingolipids, glycosylceramide, galactosylceramide sulfate, lactosylsulfatide, ganglioside and other sphingolipids, glycosyldiacylglycerol, phosphoglyceroglycolipids, glucuronic acid-containing glyceroglycolipids, sulfoglyceros Glyceroglycolipids such as glycolipids are exemplified.

These phospholipids and glycolipids can be used alone or in combination of two or more, and it is preferable to add 0.0001 to 20% by weight in the whole composition, and particularly to 0.1. It is preferable to add from 01 to 10 wt%.

The steroids used in the present invention are not particularly limited in kind and origin as long as they are used in ordinary external preparations for skin, and cholesterol, cholestanol, fatty acid cholesteryl, ergosterol, sitosterol, phytosterols. Examples thereof include sterols and derivatives thereof, bile acids such as lithocholic acid and deoxycholic acid and derivatives thereof, sapogenins, alkaloids and the like.

These steroids may be used alone,
Alternatively, two or more kinds can be used in combination, and 0.0001 to 20% by weight is preferably blended in the entire composition, and further 0.001 to 10% by weight is further blended.

These moisturizing components can be used alone or in combination of two or more.

In the present invention, an external preparation for the skin containing an extract of the genus Swallowtail plant and a specific moisturizing component can be provided. The external preparation for the skin should be in the form of lotion, emulsion, cream, ointment or the like. You can In addition, softening lotion, astringent lotion, lotion such as washing lotion, emollient cream, moisturizing cream, massage cream, cleansing cream, cream such as makeup cream, emollient emulsion, moisturizing emulsion, nourishing emulsion , Cosmetics such as cleansing emulsions, jelly-like packs, peel-off packs, wash-out packs, packs such as powder packs, beauty essence, and facial cleanser, hair nourishing agents, hair cosmetics such as shampoo and conditioner Can also be provided.

In the present invention, other active ingredients such as other cell activating agents, whitening ingredients, antioxidants, anti-inflammatory agents, and ultraviolet absorbers can be used in combination, and sunscreen cosmetics and anti-aging agents can be used. It can also be provided as a cosmeceutical such as a cosmetic or a whitening agent or a quasi drug.

[0025]

EXAMPLES The features of the present invention will be described in detail with reference to Examples. Unless otherwise specified, the unit weights in the examples are shown by weight%.

First, the Ubularia sea ( Uv used in the present invention
An extract of the genus Clintonia of the ulariaceae family was prepared in the following manner.

Extract of plant of the genus Swallowtail moto 1 After crushing Clintonia borealis, 500 g of it was immersed in 2,000 mL of purified water, extracted by stirring at 25 ° C. for 7 days, and then filtered to collect a filtrate. It was designated as Plant Extract 1.

Swallow's moto plant extract 2 After crushing Clintonia borearis, 500 g of 5
Immerse in 1000 mL of 0% by volume ethanol aqueous solution, and
It was left still at 7 ° C for 7 days. After that, the insoluble matter was removed by filtration, the filtrate was concentrated under reduced pressure, and further freeze-dried to obtain a swallow moto plant extract 2.

Swallow's moto plant extract 3 After crushing Clintonia udensis, 500 g of 3
0% by volume 1,3-butylene glycol aqueous solution 2.00
The extract was immersed in 0 mL, stirred and extracted at 20 ° C. for 5 days, and then filtered to collect a filtrate, which was designated as an extract 3 of the genus Swallowweed.

Swallow's moto plant extract 4 After crushing Clintonia udensis, 50 g of 40
The mixture was extracted with a supercritical carbon dioxide fluid of 15 MPa and 0.003% ethanol as an entrainer at 0 ° C. for 2 hours, and the obtained crude product was designated as a swallow moto plant extract 4.

A skin cream was prepared using the moisturizing component used in the present invention and an extract of the plant of the genus Swallowtail motophyll according to the following formulation. The moisturizing ingredients used are shown in Table 1.

[Examples 1 to 9] Skin cream (1) Beeswax 6.0 (2) Cetanol 5.0 (3) Reduced lanolin 8.0 (4) Squalane 37.5 (5) Fatty acid glycerin 4 0.0 (6) Lipophilic glyceryl monostearate 2.0 (7) Polyoxyethylene (20EO) sorbitan monolaurate 2.0 (8) Propylene glycol 5.0 (9) Methyl parahydroxybenzoate 0.1 (10) Purified water Amount based on the total amount of 100 (11) Swallow moto plant extract 1 0.5 (12) Moisturizing component shown in Table 1 Amount shown in Table 1 (13) Perfume 0.2 Manufacturing method: (1) The oil phase components (1) to (7) are mixed and dissolved to homogenize, and heated to 75 ° C. On the other hand, the water phase components (8) to (10) are mixed, dissolved and heated to 75 ° C. Next, the oil phase component is added to the above aqueous phase component to carry out preliminary emulsification, and then uniformly emulsified with a homomixer. After that, cool down at 50 ℃ (11) ~
Add (13) and mix.

[0033]

[Table 1]

With respect to the above Examples 1 to 9, the effect of improving skin dryness was examined. In addition, among the formulations of Example 5, the one prepared by substituting purified water for trimethylglycine was Comparative Example 1, and the one prepared by substituting purified water for plant extract 1 of the genus Swallowtail was Comparative Example 2, Genus Swallowtail. A plant prepared by substituting purified water for plant extract 1 and trimethylglycine was used as Comparative Example 3, and was examined at the same time. To improve dry skin, 20 men and women in their 40s and 60s who are concerned about dry skin should be blindly used twice a day for 1 month for 1 month. A questionnaire survey was conducted on the subsequent skin condition. The skin condition is shown in Table 2 by the number of panels that responded that the skin after 1 month was moisturized, firmer and more flexible than before use.

[0035]

[Table 2]

As shown in Table 2, the continuous use of the skin cream in which the extract of the plant of the genus Swallowtail motogen and the moisturizing component trimethylglycine is continuously used, the moisture, firmness and flexibility of the skin are remarkably improved. Was shown.
On the other hand, in Comparative Example 1 and Comparative Example 2 in which an extract of the genus Swallowtail genus or trimethylglycine was blended alone, compared to Comparative Example 3 in which neither was blended, skin moisturizing, firmness, and effect of improving flexibility were obtained. Is recognized,
The effect was more remarkable in the group used in Examples.

Further, another embodiment of the present invention will be described.

[0038] [Example 10] Hair nourishing agent (1) Quantity of purified water as 100 (2) Ethanol 50.0 (3) Swallow moto plant extract 2 0.3 (4) Trimethylglycine 5.0 Manufacturing method: Components (1) to (4) are mixed and homogenized.

Example 11 Emulsion (1) Squalane 5.0 (2) White petrolatum 2.0 (3) Beeswax 0.5 (4) Sorbitan sesquioleate 0.8 (5) Polyoxyethylene oleyl ether ( 20EO) 1.2 (6) Phytosteryl isostearate 3.0 (7) Methyl paraoxybenzoate 0.1 (8) Propylene glycol 5.0 (9) Purified water 100 (10) Carboxyvinyl polymer ( 1 wt% aqueous solution) 20.0 (11) Potassium hydroxide (10 wt% aqueous solution) 1.0 (12) Swallow moto plant extract 3 0.5 (13) Ethanol 5.0 (14) Perfume 0.2 Manufacturing method : Mix the oil phase components (1) to (6) and heat to 75 ° C. to dissolve and homogenize. On the other hand, the water phase components (7) to (9) are mixed and dissolved and heated to 75 ° C., and the above oil phase components are added to carry out preliminary emulsification. After adding (10), homogenize with a homomixer, and add (11) to adjust the pH. 40 after cooling
Add (12) to (14) at ℃ and mix.

[0040] Example 12 Skin lotion (1) Ethanol 10.00 (2) Hydroxyethyl cellulose 1.00 (3) Swallow moto plant extract 1 0.05 (4) Methyl paraoxybenzoate 0.10 (5) Glycerin 10.00 (6) 1,3-butylene glycol 10.00 (7) Amount of purified water as 100 Manufacturing method: (1) to (7) are mixed to make uniform.

Example 13 Skin Emulsion (1) Stearic Acid 0.2 (2) Cetanol 1.5 (3) Vaseline 3.0 (4) Liquid Paraffin 7.0 (5) Polyoxyethylene (10EO) Monooleic acid ester 1.5 (6) Tocopherol acetate 0.5 (7) Glycerin 5.0 (8) Methyl paraoxybenzoate 0.1 (9) Triethanolamine 1.0 (10) Purified water Amount (11) Swallow moto plant extract 1 1.0 (12) Hydrolyzed sericin 1.0 Manufacturing method: Mix the oil phase components of (1) to (6), heat and dissolve uniformly, and heat to 70 ° C. keep. On the other hand, the water phase components (7) to (10) are mixed and heated to homogenize the mixture to 70 ° C. The oil phase component is gradually added to this water phase component while stirring to emulsify, and after cooling, the components (11) and (12) are added and mixed at 40 ° C.

Example 14 Skin Gel Agent (1) Purified Water Amount Based on 100 (2) Carboxyvinyl Polymer 0.5 (3) Dipropylene Glycol 20.0 (4) Methyl Paraoxybenzoate 1 (5) Potassium hydroxide 0.1 (6) Swallow moto plant extract 3 1.0 Manufacturing method: (2) is uniformly dissolved in (1), and then (4) is dissolved in (3) and added. Then, (5) is added to increase the viscosity, and the component (6) is added.

Example 15 Skin Cream (1) Beeswax 6.0 (2) Cetanol 5.0 (3) Reduced Lanolin 8.0 (4) Squalane 29.5 (5) Lipophilic Glycerin Monostearic Acid Ester 4.0 (6) Polyoxyethylene (20EO) sorbitan monolaurate 5.0 (7) Propylene glycol 8.0 (8) Glycerin 5.0 (9) Methyl paraoxybenzoate 0.1 (10) Purified water Amount based on the total amount of 100 (11) Swallow moto plant extract 2 1.0 Manufacturing method: The oil phase components of (1) to (6) are mixed, dissolved and heated to 75 ° C. On the other hand, the water phase components (7) to (10) are mixed, dissolved and heated to 75 ° C. Next, the oil phase component is added to the aqueous phase component to preliminarily emulsify it, then homogenize with a homomixer, and after cooling, the component (11) is added and mixed at 40 ° C.

Example 16 Oil-in-Water Emulsion Ointment (1) White Vaseline 25.0 (2) Stearyl Alcohol 25.0 (3) Glycerin 15.0 (4) Sodium Lauryl Sulfate 1.0 (5) Paraoxy Methyl benzoate 0.1 (6) Purified water Amount based on the total amount of 100 (7) Swallow moto plant extract 2 1.0 Production method: Mix and dissolve the oil phase components of (1) to (4) to homogenize , Heat to 75 ° C. On the other hand, dissolve (5) in (6) to give 7
Heat to 5 ° C, add the oil phase component to this and emulsify,
After cooling, (7) is added and mixed at 40 ° C.

[Example 17] Lotion (1) Ethanol 10.0 (2) 1,3-butylene glycol 20.0 (3) Swallow moto plant extract 3 0.1 (4) Perfume 0.1 (5 ) Purified water Amount with 100 as the total amount Production method: (1) to (4) are sequentially added to (5) and mixed and dissolved uniformly.

Example 18 Water-in-oil emulsion type emollient cream (1) Liquid paraffin 30.0 (2) Microcrystalline wax 2.0 (3) Vaseline 5.0 (4) Diglycerin oleate 5.0 (5) Sodium L-glutamate 1.6 (6) L-serine 0.4 (7) Propylene glycol 3.0 (8) 1,3-Butylene glycol 5.0 (9) Methyl paraoxybenzoate 0.1 ( 10) Purified water Amount based on the total amount of 100 (11) Fragrance 0.1 (12) Swallow moto plant extract 4 0.5 Production method: (5), (6) are dissolved in a part of (10) to give 50 ℃,
Gradually add to (4) heated to 50 ° C. with stirring.
This was mixed in advance and dissolved by heating at 70 ° C (1) ~
Disperse evenly in (3), add (7)-(9) to the rest of (10), heat to 70 ° C, and add with stirring.
Emulsify with a homomixer. After cooling, the components (11) and (12) are added and mixed at 40 ° C.

Example 19 Makeup Base Cream (1) Stearic Acid 12.0 (2) Cetanol 2.0 (3) Glycerin Tri-2-ethylhexanoate 2.5 (4) Self-emulsifying Glycerin Mono Stearic acid ester 2.0 (5) Propylene glycol 11.0 (6) Potassium hydroxide 0.3 (7) Purified water 100 (8) Titanium oxide 1.0 (9) Red iron oxide 0.1 ( 10) Yellow iron oxide 0.4 (11) Perfume 0.1 (12) Swallow moto plant extract 2 1.0 Manufacturing method: Mix the oil phase components (1) to (4) and heat to 75 ° C. Make it uniform. On the other hand, by mixing the water phase components (5) to (7),
It is heated to 75 ° C. and melted to make it uniform, and the pigments (8) to (10) are added thereto and dispersed uniformly by a homomixer. The oil phase component is added to the aqueous phase component, emulsified with a homomixer, then cooled, and the components (11) and (12) are added and mixed at 40 ° C.

Example 20 Emulsion foundation (1) Stearic acid 2.0 (2) Squalane 5.0 (3) Octyldodecyl myristate 5.0 (4) Cetanol 1.0 (5) Decaglycerin monoiso Palmitate 9.0 (6) Macadamia nut fatty acid phytosteryl 0.5 (7) 1,3-butylene glycol 8.0 (8) Potassium hydroxide 0.1 (9) Methyl paraoxybenzoate 0.1 (10) Purified Amount of water as 100 (11) Titanium oxide 9.0 (12) Talc 7.4 (13) Red iron oxide 0.5 (14) Yellow iron oxide 1.1 (15) Black iron oxide 0.1 (16) Fragrance 0.1 (17) Swallow moto plant extract 3 0.5 Production method: Mix the oil phase components of (1) to (6) and heat to 75 ° C. to homogenize. On the other hand, by mixing the water phase components (7) to (10),
Heat to 75 ° C to dissolve and homogenize, add the pigments of (11) to (15) to this, homogenize with a homomixer, and then cool, and cool to 40 ° C at (16) and (17). Add and mix the ingredients.

Example 21 Hand Cream (1) Cetanol 4.0 (2) Vaseline 2.0 (3) Liquid Paraffin 10.0 (4) Glycerin Monostearate 1.5 (5) Polyoxyethylene ( 60EO) Glycerin isostearic acid ester 2.5 (6) Tocopherol acetate 0.5 (7) Soybean phospholipid 0.5 (8) Glycerin 20.0 (9) Methyl paraoxybenzoate 0.1 (10) Purified water Amount to be 100 (11) Swallow moto plant extract 1 1.0 Manufacturing method: The oil phase components (1) to (7) are mixed, dissolved and heated to 75 ° C. On the other hand, the water phase components (8) to (10) are mixed, dissolved and heated to 75 ° C. Next, the oil phase component is added to the aqueous phase component to carry out preliminary emulsification, then the mixture is uniformly emulsified with a homomixer and cooled, and the component (11) is added and mixed at 40 ° C.

Using Examples 10 to 21 of the present invention, the effect of improving the dryness of the skin was evaluated. As a result, a good dry state improving effect was observed in all the examples.

[0051]

As described above in detail, according to the present invention, a skin external preparation which synergistically enhances the moisturizing effect and exerts a high effect of improving the dry state of the skin can be obtained.

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61K 31/047 A61K 31/047 31/198 31/198 31/56 31/56 31/715 A61P 17/16 38/00 A61K 37/02 A61P 17/16 37/22 37/20 F term (reference) 4C083 AA082 AA111 AA112 AB032 AB232 AB242 AB432 AC012 AC022 AC071 AC072 AC102 AC111 AC122 AC182 AC242 AC392 AC402 AC442 AC482 AC542 AC581 AC582 AC782 AD092 AD212 AD282 AD391 AD411 AD412 AD432 AD491 AD492 AD512 AD571 AD572 AD632 CC04 CC05 CC11 CC12 CC37 DD23 DD27 DD32. NA14 ZA89 4C206 CA05 CA07 FA53 MA02 MA04 MA83 ZA89

Claims (2)

[Claims] 1. A plant extract of the genus Clintonia of the family Uvulariaceae and one or more selected from amino acids, peptides, polyhydric alcohols, higher alcohols and their derivatives, phospholipids, glycolipids and steroids, or A skin external preparation containing two or more kinds. 2. The plant of the genus Clintonia of the family Uvulariaceae is Clintonia borealis or Clintonia udensis, which is one or two species. The external preparation for skin according to claim 1.