JP2001072570A - Skin preparation for external use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a skin preparation which is used for external use, can effectively utilize fish skins which are industrial wastes, and can sufficiently exhibit the effect of a moisture-retaining ingredient. SOLUTION: This skin preparation for external use is formulated with a hydrolyzed elastin solution originated from fish skins, and a moisture-retaining ingredient. The moisture-retaining ingredient includes amino acids, peptides, proteins, saccharides, polyhydric alcohols and their salts and their derivatives, ceramides, ceramide-similar structure substances, phospholipids, glycolipids, steroids and alga extracts, except the hydrolyzed elastin solution.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin external preparation, and more particularly, to a skin external preparation comprising a fish skin-derived hydrolyzed elastin solution and one or more selected from moisturizing ingredients. About.

[0002]

2. Description of the Related Art Conventionally, in skin external preparations such as cosmetics, quasi-drugs and topical medicines, amino acids, peptides, proteins, saccharides, polyhydric alcohols and salts thereof and derivatives thereof as skin-protecting components. It contains moisturizing ingredients such as ceramides, ceramide-like structural substances, phospholipids, glycolipids, steroids, and algal extracts. However, a skin external preparation containing these moisturizing ingredients does not have a sufficient moisturizing effect or requires a considerably large amount in order to obtain a sufficient effect, and imparts an undesirable odor or color to the skin external preparation. There was something that could be wrong.

[0003] Elastin is a main component of elastic fiber,
An insoluble protein that is present in highly elastic organs such as ligaments and skin. This elastin has been expected to be incorporated into cosmetics as a skin protection and moisturizing agent. However,
Since elastin is insoluble, it has been difficult to incorporate it in a cosmetic formulation as it is. Therefore, attempts have been made to solubilize and mix elastin. For example,
Cosmetic products containing soluble hydrolyzed elastin (JP-A-53-72832), hair and skin cosmetics containing water-soluble natural elastin and / or elastin hydrolyzate solubilized with enzymes (JP-A-54-728) 10523
8), elastin for cosmetics solubilized by elastase (JP-A-58-192812), skin cosmetics using soluble elastin and / or solubilized elastin in combination with a humectant and / or a physiologically active substance (JP-A-59-1982). 13930
8), an oil-in-water emulsion for skin containing an elastin hydrolyzate as an emulsifier (JP-A-59-23100)
7), a composition for skin and hair containing elastin derived from bovine ligament having a molecular weight of 15,000 to 300,000 (JP-A-60-258107), and an elastin hydrolyzate having a molecular weight of 200,000 or more was compounded as an emulsifier. A method of stabilizing an elastin hydrolyzate aqueous solution with an emulsified composition (JP-A-63-302934), 1,3-butylene glycol and propylene glycol (JP-A-2-16721)
Techniques such as 1) are disclosed. However, most of these elastin hydrolysates are based on domestic animals such as cattle, pigs, and chickens.

It is already known that fish skin is rich in elastin. However, fish skin generated from the fishery processing industry is regarded as industrial waste and is disposed of in large quantities throughout the year. Recent research on the effective use of industrial wastes has disclosed a technique for hydrolyzing elastin from fish skin and isolating it together with collagen (Japanese Patent Laid-Open No. 5-202097).

[0005]

SUMMARY OF THE INVENTION It is an object of the present invention to provide a skin external preparation which can effectively utilize fish skin, which has been an industrial waste, and can sufficiently exert the effect of a moisturizing component. .

[0006]

Means for Solving the Problems The present inventor conducted a study in view of the above-mentioned problems, and as a result, by adding a hydrolyzed elastin solution derived from fish skin and a specific moisturizing component to an external preparation for skin, the moisturizing component was obtained. It has been found that the effect of the above can be sufficiently exerted with a small amount of the compound, and the present invention has been completed.

[0007]

Embodiments of the present invention will be described.

The hydrolyzed elastin solution derived from fish skin used in the present invention is a solution obtained by hydrolyzing fish skin using an acid or alkali, or a proteolytic enzyme such as elastase, pepsin or trypsin. At that time, the pH of the fish skin-derived hydrolyzed elastin solution should be adjusted in consideration of the effect on other components and the preparation to be mixed in the external preparation for skin.
It is preferable to adjust to a range of 5 to 4.5. The type of fish from which the fish skin-derived hydrolyzed elastin solution is obtained is not particularly limited. For example, cod, mackerel, salmon, herring, Thai,
Tuna, sardines and the like can be mentioned.

The hydrolyzed elastin solution derived from fish skin used in the present invention is, for example, crushed cod skin, mixed with purified water, heated at 95 ° C. for 1 hour, and added elastase to the solution at 40 ° C. for 30 hours. Time partial hydrolysis, then 95
It can be prepared by heating at 1 ° C. for 1 hour to stop the enzymatic reaction, adjusting the pH to 4.0, and performing sterile filtration with a membrane filter.

The amount of the hydrolyzed elastin solution derived from fish skin used in the present invention in the external preparation for skin is considered to be 0.0001 to 5.0% by weight in consideration of its effect and stability of the preparation. Is preferred.

In the present invention, amino acids, peptides, proteins, saccharides, polyhydric alcohols and salts thereof other than hydrolyzed elastin and their derivatives, ceramides, ceramide-like structural substances, phospholipids, glycolipids, and steroids are used as moisturizing components. , Or one or more selected from algae extracts.

The type and base of amino acids used as the moisturizing component are not particularly limited, and glycine, threonine, tyrosine, valine, leucine, arginine, proline, aspartic acid, glutamic acid, lysine, threonine, histidine, alanine, serine, glycine. And their salts and their derivatives.

These amino acids, their salts and their derivatives can be used singly or in combination of two or more.
It is preferable to mix 10% by weight, especially 0.001 to 8
It is preferable to mix by weight%.

The types and bases of proteins and peptides used as moisturizing ingredients are not particularly limited, and glutathione and salts thereof, derivatives thereof, collagen, albumin, sericin, fibroin, hydrolysates thereof, salts thereof and These derivatives are exemplified.

These proteins and peptides can be used singly or in combination of two or more. It is preferable to add 0.0001 to 10% by weight to the total composition, and particularly preferable to use 0.001 to 10% by weight. It is preferable to mix 〜8% by weight.

The type and base of the saccharide used as the moisturizing component are not particularly limited, and monosaccharides such as galactose, fructose, glucose, mannose, ribose, sialic acid, glucosamine, 2-deoxyglucose, gluconic acid, glucuronic acid, and the like can be used. Its derivatives, agarobiose, maltose, dextrin, cellobiose, trehalose,
Oligosaccharides such as saccharose, acetyllactosamine, glucuronoxylose, galacturonorhamnose, glucosylmannitol, galactinol and derivatives thereof,
Glucan, carrageenan, polygalacturonic acid, keratosulfate, keratan sulfate, chondroitin, chondroitin
Examples thereof include polysaccharides such as -4-sulfuric acid, dermatan sulfate, chondroitin-6-sulfate, ticuronic acid, hyaluronic acid, heparitin sulfate, heparin, and alginic acid, salts thereof, and derivatives thereof.

These saccharides can be used alone or in combination of two or more. It is preferable to add 0.001 to 20% by weight to the total composition, and particularly preferable to use 0.001 to 10% by weight. It is preferable to mix by weight%. Among these saccharides, hyaluronic acid and salts thereof are preferably used.

The type and origin of the polyhydric alcohol and its derivatives used as moisturizing components are not particularly limited, and sugar alcohols such as glycerin, diglycerin, polyglycerin, erythritol, arabitol, xylitol, and 1,3-butylene Glycol, 1,2-pentanediol,
Examples include polyethylene glycol, dipropylene glycol, and propylene glycol.

These polyhydric alcohols can be used alone or in combination of two or more. It is preferred that 0.01 to 90% by weight be blended in the whole composition.
In particular, it is preferable to add 0.01 to 50% by weight, more preferably 0.05 to 20% by weight.

The ceramides, ceramide-like structural substances, glycerophospholipids, sphingolipids, glycosphingolipids, and glyceroglycolipids used in the present invention are not particularly limited as long as they are lipids used in ordinary skin external preparations. The source does not matter.

For example, ceramides and ceramide-like structural substances include the following general formulas (1) to (6)

Embedded image [Wherein, R ¹ and R ² are the same or different and each represent a straight-chain or branched-chain saturated or unsaturated hydrocarbon group having 8 to 26 carbon atoms which may be substituted by a hydroxyl group]

Embedded image [In the formula, R ³ represents a linear or branched saturated or unsaturated hydrocarbon group having 10 to 26 carbon atoms, and R ⁴ represents a C 9 to ² carbon atom.
5 represents a straight-chain or branched-chain saturated or unsaturated hydrocarbon group; ^Xl and ^Yl represent a hydrogen atom or a hydroxyl group;
Or 1 represents a number, c represents an integer of 0 to 4, b and d
Represents an integer of 0 to 3]

Embedded image [Wherein, R ⁵ and R ⁶ are the same or different and each have 1 to 4 carbon atoms.
0 represents a linear or branched saturated or unsaturated, optionally hydroxylated hydrocarbon group, and R ⁷ has 1 to 1 carbon atoms.
6 represents a linear or branched alkylene group or a single bond, and R ⁸ represents a hydrogen atom, a linear or branched alkoxy group having 1 to 12 carbon atoms or a 2,3-dihydroxypropyloxy group. However, when R ⁷ is a single bond, R ⁸ is a hydrogen atom. ]

Embedded image [In the formula, R ⁹ represents a hydrocarbon group which may be hydroxylated having 4 to 40 carbon atoms, R ¹⁰ represents a linear or branched alkylene group having 3 to 6 carbon atoms, and R ¹¹ represents a carbon atom. Number 1
It represents 12 straight-chain or branched-chain alkoxy groups. ]

Embedded image [Wherein, R ⁵ , R ⁶ , R ¹⁰ , and R ¹¹ have the same meaning as described above. ]

Embedded image [Wherein, R ⁵ , R ⁶ and R ⁷ have the same meaning as described above;
¹² represents a hydrogen atom, a linear or branched alkoxy group having 1 to 12 carbon atoms or a 2,3-epoxypropyloxy group. However, when R ⁷ is a single bond, R ¹² is a hydrogen atom.]
And the compound represented by is exemplified.

Examples of the phospholipids and glycolipids include glyceroline such as phosphatidic acid, choline phosphoglyceride, ethanolamine phosphoglyceride, N-acylphosphatidylethanolamine, serine phosphoglyceride, glycerol phosphoglyceride, glycerophosphate phosphoglyceride, phosphatidylglycerol phosphoglyceride and the like. Sphingolipids such as lipids, sphingomyelin, ceramide phosphoethanolamine, ceramide phosphoglycerol, ceramide phosphoglycerol phosphate, ceramide phosphoinositol, glycosphingolipids such as glycosylceramide, galactosylceramide sulfate, lactosylsulfatide, ganglioside, and glycosyldiacylglycerol , Phosphoglyceroglycolipid, glucuronic acid-containing glyceroglycolipid, Glycoglycerolipids such Hogurisero glycolipids are exemplified.

These ceramides, ceramide-like structural substances, phospholipids and glycolipids can be used alone or in combination of two or more.
It is preferable that the content is 0.01 to 20% by weight.
It is preferable to mix 10 to 10% by weight.

The steroids used in the present invention are not particularly limited in type and origin as long as they are used in ordinary skin external preparations. Cholesterol, cholestanol, fatty acid cholesteryl ester, ergosterol, sitosterol, etc. Sterols and derivatives thereof,
Examples thereof include bile acids such as lithocholic acid and deoxycholic acid and derivatives thereof, sapogenins, alkaloids and the like.

These steroids may be used alone,
Alternatively, two or more kinds can be used in combination, and it is preferable to mix 0.0001 to 20% by weight, more preferably 0.001 to 10% by weight, in the whole composition.

The algal extract used in the present invention is not particularly limited as long as it is an algal extract used in a usual external preparation for skin. As the algae from which the extract is obtained, one selected from green algae, brown algae, and red algae may be used alone, or two or more may be used. preferable. The site from which the extract is collected is not particularly limited, but is preferably extracted from whole algae or mekabu (spores or adult leaves). Algae may be used fresh or dried. The extraction solvent is not particularly limited, and may be water, ethanol, methanol, isopropanol, isobutanol,
Monohydric alcohols such as n-hexanol, methyl amyl alcohol, 2-ethyl butanol, n-octyl alcohol, glycerin, ethylene glycol, ethylene glycol monomethyl ether, propylene glycol, propylene glycol monomethyl ether, propylene glycol monoethyl ether, triethylene Glycol,
Polyhydric alcohols such as 1,3-butylene glycol and hexylene glycol or derivatives thereof, ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, and methyl-n-propyl ketone; esters such as ethyl acetate and isopropyl acetate; ethyl ether And ethers such as isopropyl ether, n-butyl ether and the like. Further, a polar solvent to which an inorganic salt such as a phosphate buffered saline is added, and a solvent to which a surfactant is added can be used, and there is no particular limitation.

Further, as the extraction method, there are a method of extracting by impregnation at room temperature, in a cooled or heated state, a method of extracting using a distillation method such as steam distillation, a method of pressing an alga to obtain an extract, and the like. For example, these methods may be used alone or in combination of two or more.

The ratio of the algae to the solvent at the time of extraction is not particularly limited, but is 0.1 to 1000 times by weight of the solvent to algae 1, especially 0.5 to 100 times by weight in terms of extraction operation and efficiency. preferable. The extraction pressure and temperature are 0 ° C under normal pressure.
To the boiling point of the solvent or less, and the extraction time varies depending on the extraction temperature and the like, but is preferably in the range of 2 hours to 2 weeks.

The algal extract thus obtained can be used as it is, but as long as its effects are not lost, purification procedures such as deodorization, decolorization, concentration, etc. may be added, or column chromatography may be performed. It may be used as a fraction using chromatography or the like. These extracts, purified products, and fractionated products can be dried by removing the solvent therefrom, and can be used in a form solubilized in a solvent such as alcohol or in an emulsion form. it can.

The seaweed extract can be used alone or in combination of two or more. The amount of the seaweed extract in the external preparation for skin is considered in view of its effect, odor and color tone when added. , 0.001 to 30% by weight.

These moisturizing components can be used alone or in combination of two or more.

In the present invention, a skin external preparation containing a fish skin-derived hydrolyzed elastin solution and a specific moisturizing component can be provided. Examples of the skin external preparation include lotions, emulsions, creams, ointments and the like. Can be taken. Further, lotions such as flexible lotion, astringent lotion, and lotion for washing, creams such as emollient cream, moisture cream, massage cream, cleansing cream, makeup cream, emollient emulsion, moisture emulsion, nourishing Emulsions such as emulsions and cleansing emulsions, packs such as jelly packs, peel-off packs, wash-off packs, powder packs, serums, and facial cleansers can be provided as cosmetics in various formulations.

In the present invention, other active ingredients such as other cell activators, whitening ingredients, anti-inflammatory agents, ultraviolet absorbers and the like can be used in combination, and sunscreen cosmetics, antiaging cosmetics, whitening cosmetics, etc. It can also be provided as medicated cosmetics such as preparations or quasi-drugs.

[0034]

EXAMPLES First, a production example of a hydrolyzed elastin solution derived from fish skin used in Examples of the present invention will be described.

[Production Example 1] Cod skin-derived elastin solution The frozen cod skin is ground and mixed with 3 times by weight of purified water. After heating this mixture to 95 ° C., it is allowed to stand and cool. Elastase is added and reacted at 40 ° C. for 30 hours to partially hydrolyze. The enzyme reaction is then stopped by heating at 95 ° C. for 1 hour and filtered to remove unhydrolysates and residual fat. Furthermore, sterilization filtration was performed using a membrane filter, and an elastin solution derived from cod skin was obtained. The pH of this elastin solution derived from cod skin is 4.0.
Met.

The characteristics of the present invention will be described in detail with reference to Examples using the elastin solution derived from cod skin shown in Production Example 1. The algae extract used in the examples of the present invention was used after immersing all algae of algae in a 10 times by weight solvent at room temperature for 2 days and then filtering.

Using the moisturizing component used in the present invention and the cod skin-derived elastin solution shown in Production Example 1, a skin cream was prepared according to the following formulation. Table 1 shows the moisturizing components used. Furthermore, the cod skin-derived elastin solution and the moisturizing component shown in Production Example 1 were blended in the amounts shown in Table 2 to prepare skin creams, which were used as Comparative Examples 1 to 3.

[Examples 1 to 9, Comparative Examples 1 to 3] Cream for skin (1) Beeswax 6.0 (% by weight) (2) Cetanol 5.0 (3) Reduced lanolin 8.0 ( 4) Squalane 37.5 (5) Fatty acid glycerin 4.0 (6) Lipophilic glyceryl monostearate 2.0 (7) Polyoxyethylene (20EO) sorbitan monolaurate 2.0 (8) Propylene glycol 0 (9) Methyl parahydroxybenzoate 0.1 (10) Purified water Amount shown in Table 1 (11) Elastin solution derived from cod skin (Production Example 1) 0.5 (12) Moisturizing component shown in Table 1 Suitable amount (13) Fragrance 0.2 Production method: The oil phase components (1) to (7) are mixed and dissolved to make uniform, and heated to 75 ° C. On the other hand, the aqueous phase components (8) to (10) are mixed and dissolved and heated to 75 ° C. Next, after the oil phase component is added to the water phase component and pre-emulsified, the mixture is uniformly emulsified by a homomixer. Then cool down at 50 ° C (11) ~
(13) is added and mixed.

[0039]

[Table 1]

[0040]

[Table 2]

The above Examples 1 to 9 and Comparative Examples 1 to
For No. 3, the effect of improving skin dryness was examined. To improve skin dryness, 20 male and female panelists in their 40s and 60s who are worried about the dryness of the skin can use it twice a day for one month, blind, for one month. A questionnaire survey was conducted on the later skin condition. The skin condition is shown in Table 3 by the number of panels who answered that the skin after one month had improved moisture, firmness and flexibility compared to before use.

[0042]

[Table 3]

As shown in Table 3, the continuous use of the skin cream using the hydrolyzed elastin solution and the moisturizing component remarkably improved the moisture, firmness and flexibility of the skin. . On the other hand, in Comparative Examples 1 and 2 in which sodium hyaluronate or a hydrolyzed elastin solution was blended alone, the effect of improving skin moisture, firmness, and flexibility was observed as compared with Comparative Example 3 in which neither was blended. However, the effect of improving the skin was remarkably recognized in Examples containing both components in half amounts.

Next, another embodiment of the present invention will be described.

Example 10 Hair restorer (1) Purified water 50.0 (% by weight) (2) Ethanol 46.7 (3) Cod skin-derived elastin solution (Production Example 1) 0.3 (4) Brown algae 50 Weight% ethanol extract 3.0 Production method: Mix and homogenize components (1) to (4).

Example 11 Whitening Solution (1) Squalane 5.0 (% by weight) (2) White Vaseline 2.0 (3) Beeswax 0.5 (4) Sorbitan Sesquioleate 0.8 (5) Poly Oxyethylene oleyl ether (20EO) 1.2 (6) Methyl paraoxybenzoate 0.1 (7) Propylene glycol 5.0 (8) Purified water 58.6 (9) Carboxyvinyl polymer (1% by weight aqueous solution) 0 (10) Potassium hydroxide 0.1 (11) Elastin solution derived from cod skin (Production Example 1) 0.5 (12) Ethanol 5.0 (13) Sodium hyaluronate 1.0 (14) Perfume 0.2 Production method : The oil phase components (1) to (5) are mixed and heated to 75 ° C. to dissolve and homogenize. On the other hand, the aqueous phase components (6) to (8) are mixed and dissolved, heated to 75 ° C., and the oil phase component is added and pre-emulsified. After adding (9), the mixture is emulsified uniformly with a homomixer, and (10) is added to adjust the pH. 40 after cooling
Add (11) to (14) at ℃ and mix.

[Example 12] Skin lotion (1) Ethanol 10.0 (wt%) (2) Hydroxyethylcellulose 1.0 (3) Cod skin-derived elastin solution (Production Example 1) 0.5 (4) Paraoxyl Methyl benzoate 0.1 (5) Glycerin 10.0 (6) Purified water 78.4 Production method: Mix (1) to (6) to make uniform.

Example 13 Skin Emulsion (1) Stearic acid 0.2 (% by weight) (2) Cetanol 1.5 (3) Vaseline 3.0 (4) Liquid paraffin 7.0 (5) Polyoxy Ethylene (10EO) monooleate 1.5 (6) Tocopherol acetate 0.5 (7) Glycerin 5.0 (8) Methyl paraoxybenzoate 0.1 (9) Triethanolamine 1.0 (10) Purified water 77.2 (11) Cod skin-derived elastin solution (Production Example 1) 1.0 (12) Red algae 50% by weight ethanol extract 2.0 Production method: mixing and heating oil phase components (1) to (6) Dissolve uniformly and keep at 70 ° C. On the other hand, the aqueous phase components (7) to (10) are mixed and heated to be uniform, and the temperature is set to 70 ° C. The oil phase component is gradually added to the aqueous phase component while stirring to emulsify, and after cooling, the components (11) and (12) are added and mixed at 40 ° C.

[Example 14] Gel for skin (1) Purified water 88.3 (% by weight) (2) Carboxyvinyl polymer 0.5 (3) Dipropylene glycol 10.0 (4) Methyl paraoxybenzoate 0 1 (5) Potassium hydroxide 0.1 (6) Cod skin-derived elastin solution (Production Example 1) 1.0 Production method: (2) is uniformly dissolved in (1), and then (4) in (3) Is dissolved and added, and then (5) is added to increase the viscosity, and the component (6) is added.

Example 15 Skin Cream (1) Beeswax 6.0 (% by weight) (2) Cetanol 5.0 (3) Reduced Lanolin 8.0 (4) Squalane 29.5 (5) Lipophilic type Glyceryl monostearate 4.0 (6) Polyoxyethylene (20EO) sorbitan monolaurate 5.0 (7) Propylene glycol 8.0 (8) Methyl paraoxybenzoate 0.1 (9) Purified water 33.4 (10) Cod skin-derived elastin solution (Production Example 1) 1.0 Production method: The oil phase components (1) to (6) are mixed and dissolved, and heated to 75 ° C. On the other hand, the aqueous phase components (7) to (9) are mixed and dissolved and heated to 75 ° C. Next, the oil phase component is added to the water phase component and pre-emulsified, and then uniformly emulsified by a homomixer. After cooling, the component (10) is added and mixed at 40 ° C.

[Example 16] Oil-in-water emulsion ointment (1) White petrolatum 25.0 (% by weight) (2) Stearyl alcohol 25.0 (3) Glycerin 15.0 (4) Sodium lauryl sulfate 1.0 (5) Methyl paraoxybenzoate 0.1 (6) Purified water 32.9 (7) Elastin solution derived from cod skin (Production Example 1) 1.0 Production method: mixing oil phase components (1) to (4) Dissolve to homogeneity and heat to 75 ° C. On the other hand, dissolve (5) in (6)
Heat to 5 ° C, add the oil phase component to this and emulsify,
After cooling, add (7) at 40 ° C. and mix.

Example 17 Toner (1) Ethanol 10.0 (% by weight) (2) 1,3-butylene glycol 10.0 (3) Cod skin-derived elastin solution (Production Example 1) 0.5 ( 4) Fragrance 0.1 (5) Purified water 79.4 Production method: (1) to (4) are sequentially added to (5) and uniformly mixed and dissolved.

Example 18 Water-in-oil Emulsifying Emollient Cream (1) Liquid Paraffin 30.0 (% by weight) (2) Microcrystalline Wax 2.0 (3) Vaseline 5.0 (4) Diglyceryl Oleic Acid Ester 5.0 (5) Sodium L-glutamate 1.6 (6) L-Serine 0.4 (7) Propylene glycol 3.0 (8) Methyl parahydroxybenzoate 0.1 (9) Purified water 47.3 ( 10) Fragrance 0.1 (11) Elastin solution derived from cod skin (Preparation Example 1) 0.5 (12) 50% by weight kelp 50% ethanol solution extract 5.0 Production method: (5), (6) Dissolve in part to 50 ° C,
Add slowly to (4) heated to 50 ° C. with stirring.
This was previously mixed and dissolved by heating at 70 ° C. (1)-
(3) is uniformly dispersed, and (7) and (8) are dissolved in the remainder of (9) and heated to 70 ° C. while stirring, and added.
Emulsify with a homomixer. After cooling, at 40 ° C (10) ~
Add and mix component (12).

Example 19 Makeup Base Cream (1) Stearic acid 12.0 (% by weight) (2) Cetanol 2.0 (3) Glyceryl tri-2-ethylhexanoate 2.5 (4) Self Emulsified glyceryl monostearate 2.0 (5) Propylene glycol 10.0 (6) Potassium hydroxide 0.3 (7) Purified water 67.6 (8) Titanium oxide 1.0 (9) Bengala 0.1 (10) Yellow iron oxide 0.4 (11) Fragrance 0.1 (12) Elastin solution derived from cod skin (Production Example 1) 1.0 (13) Sodium hyaluronate 1.0 Production method: (1) to (4) Are mixed and heated to 75 ° C. to make uniform. On the other hand, the aqueous phase components (5) to (7) are mixed,
The mixture is heated to 75 ° C. and dissolved to make the mixture uniform. The pigments (8) to (10) are added to the mixture, and the mixture is uniformly dispersed with a homomixer. The oil phase component is added to the aqueous phase component, emulsified by a homomixer, cooled, and the components (11) to (13) are added and mixed at 40 ° C.

Example 20 Emulsion Foundation (1) Stearic acid 2.0 (% by weight) (2) Squalane 5.0 (3) Octyldodecyl myristate 5.0 (4) Cetanol 1.0 (5) Decaglyceryl monoisopalmitate 9.0 (6) Ceramide-like structural substance described in chemical formula (5) 0.5 (7) 1,3-butylene glycol 8.0 (8) Potassium hydroxide 0.1 (9) ) Methyl paraoxybenzoate 0.1 (10) Purified water 50.6 (11) Titanium oxide 9.0 (12) Talc 7.4 (13) Bengala 0.5 (14) Yellow iron oxide 1.1 (15) Black iron oxide 0.1 (16) Fragrance 0.1 (17) Elastin solution derived from cod skin (Production Example 1) 0.5 Production method: Mix oil phase components (1) to (6) and heat to 75 ° C And make it uniform. On the other hand, the aqueous phase components (7) to (10) are mixed,
The mixture was heated to 75 ° C. and dissolved to make it uniform. The pigments (11) to (15) were added to the mixture, and the mixture was uniformly emulsified by a homomixer, cooled, and cooled at 40 ° C. to (16) and (17). Add and mix the ingredients.

Example 21 Hand Cream (1) Cetanol 4.0 (% by weight) (2) Vaseline 2.0 (3) Liquid paraffin 10.0 (4) Glyceryl monostearate 1.5 (5) Polyoxyethylene (60EO) Glyceryl isostearate 2.5 (6) Tocopherol acetate 0.5 (7) Soybean phospholipid 0.5 (8) Glycerin 20.0 (9) Methyl paraoxybenzoate 0.1 (10) Purified water 57.9 (11) Cod skin-derived elastin solution (Production Example 1) 1.0 Production method: Mix and dissolve the oil phase components (1) to (7) and heat to 75 ° C. On the other hand, the aqueous phase components (8) to (10) are mixed and dissolved and heated to 75 ° C. Next, the oil phase component is added to the water phase component and pre-emulsified, then uniformly emulsified and cooled with a homomixer, and the component (11) is added and mixed at 40 ° C.

[0057]

Effect of the Invention Hydrolyzed elastin solution derived from fish skin,
The external preparation for skin of the present invention in which a specific moisturizing component was used in combination could sufficiently exhibit the effect of the moisturizing component.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI theme coat ゛ (Reference) A61K 7/00 A61K 7/00 K 7/02 7/02 Z 7/06 7/06 31/047 31 / 047 31/164 31/164 31/198 31/198 31/56 31/56 31/66 31/66 31/7016 31/7016 31/728 31/728 35/80 35/80 38/17 A61P 17/16 38/00 A61K 37/12 A61P 17/16 37/18 F term (reference) 4C083 AA082 AA111 AA112 AB032 AB232 AB242 AB432 AC012 AC022 AC061 AC072 AC102 AC111 AC122 AC182 AC242 AC352 AC402 AC422 AC442 AC482 AC542 AC581 AC582 AC641 AC642 AC782 AD092 AD092 AD282 AD332 AD391 AD411 AD412 AD432 AD491 AD492 AD512 AD571 AD572 AD662 CC03 CC04 CC05 CC11 CC12 CC37 DD22 DD23 DD27 DD31 DD32 DD33 DD41 EE07 EE12 EE16 EE22 4C084 AA02 BA43 CA15 CA45 DA40 MA01 MA02 MA63 NA05 NA14 ZA892 A01A01 MA01 DA01 MA03 MA04 MA07 MA08 MA0 9 MA10 MA63 NA05 NA14 ZA89 4C088 AA13 AC15 BA10 MA63 NA05 NA14 ZA89 4C206 AA01 AA02 CA05 FA53 GA04 MA01 MA02 MA03 MA04 MA11 MA21 MA24 MA28 MA83 NA05 NA14 ZA89

Claims (4)

[Claims] 1. A hydrolyzed elastin solution derived from fish skin,
An external preparation for skin containing one or more moisturizing components selected from amino acids, peptides, proteins, saccharides, polyhydric alcohols, higher alcohols and salts thereof and derivatives thereof other than hydrolyzed elastin. 2. A hydrolyzed elastin solution derived from fish skin,
An external preparation for skin containing one or more components selected from ceramides, ceramide-like structural substances, phospholipids, and glycolipids. 3. A hydrolyzed elastin solution derived from fish skin,
An external preparation for skin containing one or more components selected from steroids. 4. A hydrolyzed elastin solution derived from fish skin,
An external preparation for skin containing one or more components selected from algal extracts.