JP2003183167A5 - - Google Patents

Info

Publication number

JP2003183167A5

JP2003183167A5 JP2002295694A JP2002295694A JP2003183167A5 JP 2003183167 A5 JP2003183167 A5 JP 2003183167A5 JP 2002295694 A JP2002295694 A JP 2002295694A JP 2002295694 A JP2002295694 A JP 2002295694A JP 2003183167 A5 JP2003183167 A5 JP 2003183167A5

Authority

JP

Japan

Prior art keywords

chondroitin sulfate

derived

aqueous solution

solution

injection

Prior art date

2002-10-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 229920001287 Chondroitin sulfate Polymers 0.000 claims description 27
• 229940059329 chondroitin sulfate Drugs 0.000 claims description 27
• SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims description 25
• 239000007864 aqueous solution Substances 0.000 claims description 19
• 239000000243 solution Substances 0.000 claims description 16
• 241000972773 Aulopiformes Species 0.000 claims description 15
• XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 15
• 235000019515 salmon Nutrition 0.000 claims description 15
• 238000002347 injection Methods 0.000 claims description 14
• 239000007924 injection Substances 0.000 claims description 14
• 229910052742 iron Inorganic materials 0.000 claims description 12
• 239000000084 colloidal system Substances 0.000 claims description 11
• 150000003839 salts Chemical class 0.000 claims description 7
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 6
• 150000008044 alkali metal hydroxides Chemical class 0.000 claims description 5
• 239000000203 mixture Substances 0.000 claims description 5
• ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 4
• RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 4
• BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims description 4
• HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 4
• 229910052802 copper Inorganic materials 0.000 claims description 4
• 239000010949 copper Substances 0.000 claims description 4
• 239000011630 iodine Substances 0.000 claims description 4
• 229910052740 iodine Inorganic materials 0.000 claims description 4
• 239000011669 selenium Substances 0.000 claims description 4
• 229910052711 selenium Inorganic materials 0.000 claims description 4
• 239000011701 zinc Substances 0.000 claims description 4
• 229910052725 zinc Inorganic materials 0.000 claims description 4
• KXKPYJOVDUMHGS-OSRGNVMNSA-N chondroitin sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](OS(O)(=O)=O)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O1 KXKPYJOVDUMHGS-OSRGNVMNSA-N 0.000 claims description 3
• VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims description 2
• 235000011511 Diospyros Nutrition 0.000 claims description 2
• 244000236655 Diospyros kaki Species 0.000 claims description 2
• PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 claims description 2
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 2
• 229910052783 alkali metal Inorganic materials 0.000 claims description 2
• -1 chondroitin sulfate alkali metal salt Chemical class 0.000 claims description 2
• 229910052804 chromium Inorganic materials 0.000 claims description 2
• 239000011651 chromium Substances 0.000 claims description 2
• 229910052748 manganese Inorganic materials 0.000 claims description 2
• 239000011572 manganese Substances 0.000 claims description 2
• WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims description 2
• 229910052717 sulfur Inorganic materials 0.000 claims description 2
• 239000011593 sulfur Substances 0.000 claims description 2
• 206010036790 Productive cough Diseases 0.000 claims 7
• 210000003802 sputum Anatomy 0.000 claims 7
• 208000024794 sputum Diseases 0.000 claims 7
• 238000000034 method Methods 0.000 claims 2
• 229920002567 Chondroitin Polymers 0.000 claims 1
• DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 claims 1
• BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims 1
• 239000011259 mixed solution Substances 0.000 claims 1
• 229940102223 injectable solution Drugs 0.000 description 5
• 238000001802 infusion Methods 0.000 description 2
• 238000004519 manufacturing process Methods 0.000 description 2
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
• 231100000676 disease causative agent Toxicity 0.000 description 1
• 238000009472 formulation Methods 0.000 description 1
• 238000010438 heat treatment Methods 0.000 description 1
• 239000007788 liquid Substances 0.000 description 1
• 230000001681 protective effect Effects 0.000 description 1
• 239000012266 salt solution Substances 0.000 description 1
• 229910052708 sodium Inorganic materials 0.000 description 1
• 239000011734 sodium Substances 0.000 description 1